CA2334267C - Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c - Google Patents

Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c Download PDF

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Publication number
CA2334267C
CA2334267C CA002334267A CA2334267A CA2334267C CA 2334267 C CA2334267 C CA 2334267C CA 002334267 A CA002334267 A CA 002334267A CA 2334267 A CA2334267 A CA 2334267A CA 2334267 C CA2334267 C CA 2334267C
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CA
Canada
Prior art keywords
ifn
ribavirin
peg
treatment
chronic hepatitis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002334267A
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English (en)
French (fr)
Other versions
CA2334267A1 (en
Inventor
Friederike Zahm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8232086&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2334267(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2334267A1 publication Critical patent/CA2334267A1/en
Application granted granted Critical
Publication of CA2334267C publication Critical patent/CA2334267C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Zoology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CA002334267A 1998-06-08 1999-05-29 Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c Expired - Lifetime CA2334267C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP98110433.4 1998-06-08
EP98110433 1998-06-08
PCT/EP1999/003746 WO1999064016A1 (en) 1998-06-08 1999-05-29 Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c

Publications (2)

Publication Number Publication Date
CA2334267A1 CA2334267A1 (en) 1999-12-16
CA2334267C true CA2334267C (en) 2009-02-17

Family

ID=8232086

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002334267A Expired - Lifetime CA2334267C (en) 1998-06-08 1999-05-29 Use of peg-ifn-alpha and ribavirin for the treatment of chronic hepatitis c

Country Status (34)

Country Link
US (3) US20030053986A1 (cg-RX-API-DMAC7.html)
EP (1) EP1087778B1 (cg-RX-API-DMAC7.html)
JP (2) JP3839667B2 (cg-RX-API-DMAC7.html)
KR (2) KR20050055053A (cg-RX-API-DMAC7.html)
CN (1) CN1170543C (cg-RX-API-DMAC7.html)
AR (1) AR019855A1 (cg-RX-API-DMAC7.html)
AT (1) ATE307597T1 (cg-RX-API-DMAC7.html)
AU (1) AU767131B2 (cg-RX-API-DMAC7.html)
BR (1) BR9911076A (cg-RX-API-DMAC7.html)
CA (1) CA2334267C (cg-RX-API-DMAC7.html)
CL (1) CL2010000828A1 (cg-RX-API-DMAC7.html)
CO (1) CO5050297A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ298681B6 (cg-RX-API-DMAC7.html)
DE (1) DE69927971T2 (cg-RX-API-DMAC7.html)
DK (1) DK1087778T3 (cg-RX-API-DMAC7.html)
ES (1) ES2251196T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20000808A2 (cg-RX-API-DMAC7.html)
HU (1) HU228218B1 (cg-RX-API-DMAC7.html)
ID (1) ID29285A (cg-RX-API-DMAC7.html)
IL (2) IL139786A0 (cg-RX-API-DMAC7.html)
MA (1) MA26641A1 (cg-RX-API-DMAC7.html)
MY (1) MY124091A (cg-RX-API-DMAC7.html)
NO (1) NO325598B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ508249A (cg-RX-API-DMAC7.html)
PE (1) PE20000560A1 (cg-RX-API-DMAC7.html)
PL (1) PL192364B1 (cg-RX-API-DMAC7.html)
RS (1) RS50144B (cg-RX-API-DMAC7.html)
RU (1) RU2271217C2 (cg-RX-API-DMAC7.html)
SA (1) SA99200208B1 (cg-RX-API-DMAC7.html)
SI (1) SI1087778T1 (cg-RX-API-DMAC7.html)
TR (1) TR200003635T2 (cg-RX-API-DMAC7.html)
TW (1) TWI241913B (cg-RX-API-DMAC7.html)
WO (1) WO1999064016A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200006814B (cg-RX-API-DMAC7.html)

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ATE307597T1 (de) 2005-11-15
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JP3839667B2 (ja) 2006-11-01
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IL139786A0 (en) 2002-02-10
US20030053986A1 (en) 2003-03-20
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US20070196385A1 (en) 2007-08-23
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