CA2309818C - Buffered drug formulations for transdermal electrotransport delivery - Google Patents

Info

Publication number

CA2309818C

CA2309818C CA002309818A CA2309818A CA2309818C CA 2309818 C CA2309818 C CA 2309818C CA 002309818 A CA002309818 A CA 002309818A CA 2309818 A CA2309818 A CA 2309818A CA 2309818 C CA2309818 C CA 2309818C

Authority

CA

Canada

Prior art keywords

peptide

analgesic

drug delivery

delivery device

glu

Prior art date

1997-11-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Fee Related

Links

• Espacenet
• Global Dossier
• CIPO
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• 239000013583 drug formulation Substances 0.000 title abstract description 14
• 239000003814 drug Substances 0.000 claims abstract description 104
• 229940079593 drug Drugs 0.000 claims abstract description 98
• 239000000872 buffer Substances 0.000 claims abstract description 88
• 239000000203 mixture Substances 0.000 claims abstract description 65
• 238000009472 formulation Methods 0.000 claims abstract description 63
• 108010016626 Dipeptides Proteins 0.000 claims abstract description 30
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 117
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• 238000000034 method Methods 0.000 claims description 43
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• 102000004196 processed proteins & peptides Human genes 0.000 claims description 37
• 239000000243 solution Substances 0.000 claims description 36
• -1 His-Citruline Chemical compound 0.000 claims description 35
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• 108090000623 proteins and genes Proteins 0.000 claims description 34
• 230000000202 analgesic effect Effects 0.000 claims description 33
• 229920001184 polypeptide Polymers 0.000 claims description 32
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• 229940024606 amino acid Drugs 0.000 claims description 20
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• LHCBOXPPRUIAQT-UHFFFAOYSA-N n-phenyl-n-[1-(2-phenylethyl)piperidin-4-yl]propanamide;hydrochloride Chemical compound Cl.C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 LHCBOXPPRUIAQT-UHFFFAOYSA-N 0.000 claims description 9
• GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 claims description 9
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