CA2290748A1 - Composes dipeptidiques sulfonyles inhibiteurs de l'adhesion des leucocytes induite par vla-4 - Google Patents
Composes dipeptidiques sulfonyles inhibiteurs de l'adhesion des leucocytes induite par vla-4 Download PDFInfo
- Publication number
- CA2290748A1 CA2290748A1 CA002290748A CA2290748A CA2290748A1 CA 2290748 A1 CA2290748 A1 CA 2290748A1 CA 002290748 A CA002290748 A CA 002290748A CA 2290748 A CA2290748 A CA 2290748A CA 2290748 A1 CA2290748 A1 CA 2290748A1
- Authority
- CA
- Canada
- Prior art keywords
- substituted
- alkyl
- heterocyclic
- sulfonyl
- toluene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Cette invention concerne des composés qui se lient à l'intégrine VLA-4. Certains de ces composés inhibent également l'adhésion des leucocytes et, en particulier, l'adhésion des leucocytes induite par la VLA-4. Ces composés sont utilisés pour traiter des maladies inflammatoires chez un patient mammifère, par exemple, un être humain. Parmi ces maladies, on trouve l'asthme, la maladie d'Alzheimer, l'athérosclérose, le complexe démentiel du SIDA, le diabète, l'affection intestinale inflammatoire, la polyarthrite rhumatoïde, la transplantation de tissus, la métastase tumorale et l'ischémie myocardique. Ces composés peuvent également être administrés pour traiter des maladies cérébrales inflammatoires telles que la sclérose en plaques.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90442397A | 1997-07-31 | 1997-07-31 | |
US08/904,423 | 1997-07-31 | ||
PCT/US1998/016070 WO1999006437A1 (fr) | 1997-07-31 | 1998-07-31 | Composes dipeptidiques sulfonyles inhibiteurs de l'adhesion des leucocytes induite par vla-4 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2290748A1 true CA2290748A1 (fr) | 1999-02-11 |
Family
ID=25419137
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002290748A Abandoned CA2290748A1 (fr) | 1997-07-31 | 1998-07-31 | Composes dipeptidiques sulfonyles inhibiteurs de l'adhesion des leucocytes induite par vla-4 |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0994896A1 (fr) |
JP (1) | JP2001512139A (fr) |
KR (1) | KR20010022405A (fr) |
CN (1) | CN1265672A (fr) |
AU (1) | AU8823498A (fr) |
BR (1) | BR9811594A (fr) |
CA (1) | CA2290748A1 (fr) |
HU (1) | HUP0003921A3 (fr) |
IL (1) | IL133637A0 (fr) |
NO (1) | NO20000452L (fr) |
PL (1) | PL338457A1 (fr) |
WO (1) | WO1999006437A1 (fr) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6903075B1 (en) | 1997-05-29 | 2005-06-07 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
WO1998054207A1 (fr) * | 1997-05-30 | 1998-12-03 | Celltech Therapeutics Limited | Derives anti-inflammatoires de tyrosine |
DK0991619T3 (da) | 1997-06-23 | 2003-12-29 | Tanabe Seiyaku Co | Inhibitorer af alfa 4-beta 1-medieret celleadhæsion |
US6645939B1 (en) | 1997-11-24 | 2003-11-11 | Merck & Co., Inc. | Substituted β-alanine derivatives as cell adhesion inhibitors |
ATE267168T1 (de) * | 1997-11-24 | 2004-06-15 | Merck & Co Inc | Beta-alanin-derivate als zell-adhäsions- inhibitoren |
US6197794B1 (en) * | 1998-01-08 | 2001-03-06 | Celltech Therapeutics Limited | Phenylalanine derivatives |
MY153569A (en) | 1998-01-20 | 2015-02-27 | Mitsubishi Tanabe Pharma Corp | Inhibitors of ?4 mediated cell adhesion |
US6329372B1 (en) | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
EP1056714B1 (fr) | 1998-02-26 | 2004-08-11 | Celltech Therapeutics Limited | Derives de phenylalanine en tant qu'inhibiteurs d'integrines alpha 4 |
US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
GB9811159D0 (en) | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
GB9811969D0 (en) * | 1998-06-03 | 1998-07-29 | Celltech Therapeutics Ltd | Chemical compounds |
US6685617B1 (en) | 1998-06-23 | 2004-02-03 | Pharmacia & Upjohn Company | Inhibitors of α4β1 mediated cell adhesion |
GB9814414D0 (en) | 1998-07-03 | 1998-09-02 | Celltech Therapeutics Ltd | Chemical compounds |
US6339101B1 (en) * | 1998-08-14 | 2002-01-15 | Gpi Nil Holdings, Inc. | N-linked sulfonamides of N-heterocyclic carboxylic acids or isosteres for vision and memory disorders |
US6333340B1 (en) * | 1998-08-14 | 2001-12-25 | Gpi Nil Holdings, Inc. | Small molecule sulfonamides for vision and memory disorders |
GB9821061D0 (en) | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
GB9821222D0 (en) | 1998-09-30 | 1998-11-25 | Celltech Therapeutics Ltd | Chemical compounds |
US7396526B1 (en) | 1998-11-12 | 2008-07-08 | Johnson & Johnson Consumer Companies, Inc. | Skin care composition |
GB9825652D0 (en) | 1998-11-23 | 1999-01-13 | Celltech Therapeutics Ltd | Chemical compounds |
GB9826174D0 (en) | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
WO2000048994A1 (fr) * | 1999-02-18 | 2000-08-24 | F. Hoffmann-La Roche Ag | Derives thioamides |
US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
EP1741428A3 (fr) * | 1999-08-13 | 2007-05-09 | Biogen Idec MA, Inc. | inhibiteurs d'adhésion cellulaire |
US6534513B1 (en) | 1999-09-29 | 2003-03-18 | Celltech R&D Limited | Phenylalkanoic acid derivatives |
US6455539B2 (en) | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
JP2003519697A (ja) | 1999-12-28 | 2003-06-24 | ファイザー・プロダクツ・インク | 炎症性疾患、自己免疫疾患および呼吸器疾患の処置に有用な非ペプチド系のvla−4依存性細胞結合阻害薬 |
WO2001068586A2 (fr) * | 2000-03-14 | 2001-09-20 | Novartis Ag | INHIBITEURS D'INTEGRINES α4β1 ET α4β¿7? |
ATE375330T1 (de) | 2000-04-17 | 2007-10-15 | Ucb Pharma Sa | Enamin-derivate als zell-adhäsionsmoleküle |
US6545013B2 (en) | 2000-05-30 | 2003-04-08 | Celltech R&D Limited | 2,7-naphthyridine derivatives |
US6403608B1 (en) | 2000-05-30 | 2002-06-11 | Celltech R&D, Ltd. | 3-Substituted isoquinolin-1-yl derivatives |
JP2004502762A (ja) | 2000-07-07 | 2004-01-29 | セルテック アール アンド ディ リミテッド | 二環性ヘテロ芳香環を含有するインテグリンアンタゴニストとしてのスクエア酸誘導体 |
AU2001275724A1 (en) | 2000-08-02 | 2002-02-13 | Celltech R&D Limited | 3-substituted isoquinolin-1-yl derivatives |
ATE497385T1 (de) | 2000-08-18 | 2011-02-15 | Ajinomoto Kk | Neue phenylalanin-derivate |
MY129000A (en) | 2000-08-31 | 2007-03-30 | Tanabe Seiyaku Co | INHIBITORS OF a4 MEDIATED CELL ADHESION |
US6607735B2 (en) | 2000-12-21 | 2003-08-19 | Johnson & Johnson Consumer Companies, Inc. | Method for reducing the appearance of dark circles under the eyes |
JP2004526733A (ja) | 2001-03-20 | 2004-09-02 | メルク エンド カムパニー インコーポレーテッド | 強力な細胞接着阻害剤としての置換n−アリールスルホニル−プロリン誘導体 |
US6559174B2 (en) | 2001-03-20 | 2003-05-06 | Merck & Co., Inc. | N-arylsulfonyl aryl aza-bicyclic derivatives as potent cell adhesion inhibitors |
US6855708B2 (en) | 2001-03-20 | 2005-02-15 | Merck & Co., Inc. | N-arylsulfonyl aza-bicyclic derivatives as potent cell adhesion inhibitors |
EP1477482B1 (fr) * | 2002-02-20 | 2010-04-14 | Ajinomoto Co., Inc. | Nouveau derive de phenylalanine |
EP1592386A4 (fr) * | 2003-01-24 | 2007-06-13 | Elan Pharm Inc | Composition et methode destinees a traiter les maladies de demyelinisation et la paralysie par administration d'agents de remyelinisation |
UY28391A1 (es) * | 2003-06-25 | 2004-12-31 | Elan Pharm Inc | Metodos y composiciones para tratar artritis reumatoide |
EP1683525B1 (fr) * | 2003-11-14 | 2017-05-17 | EA Pharma Co., Ltd. | Preparation de derives de phenylalanine a liberation soutenue pour une administration orale |
ES2360064T3 (es) * | 2003-11-14 | 2011-05-31 | Ajinomoto Co., Inc. | Dispersión sólida o preparación de dispersión sólida medicinal de un derivado de fenilalanina. |
EP1968635B1 (fr) * | 2005-12-14 | 2014-09-17 | Ambrx, Inc. | Compositions contenant des acides aminés et polypeptides non naturels, procédés mettant en jeu ceux-ci et utilisations de ceux-ci |
US20100150915A1 (en) | 2007-02-20 | 2010-06-17 | Stewart Edward J | Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist |
CA2721093A1 (fr) | 2008-04-11 | 2009-10-15 | Merrimack Pharmaceuticals, Inc. | Lieurs d'albumine de serum humain, et ses conjugues |
JP6007417B2 (ja) | 2011-05-31 | 2016-10-12 | レセプトス エルエルシー | 新規glp−1受容体安定剤および調節剤 |
AU2012352349B2 (en) * | 2011-12-12 | 2017-08-17 | Receptos Llc | Carboxylic acid derivatives comprising four cycles acting as GLP-1 receptor modulators for therapy of diseases such as diabetes |
KR102271179B1 (ko) | 2013-06-11 | 2021-07-01 | 셀진 인터내셔널 Ii 에스에이알엘 | 신규의 glp-1 수용체 조절제 |
MX2017000972A (es) | 2014-07-25 | 2017-07-27 | Celgene Int Ii Sarl | Nuevos moduladores del receptor de peptido similar a glucagon 1 (glp-1). |
WO2016094729A1 (fr) | 2014-12-10 | 2016-06-16 | Celgene International Ii Sarl | Nouveaux modulateurs du récepteur du glp-1 |
US10308677B2 (en) * | 2014-12-19 | 2019-06-04 | Cem Corporation | Coupling method for peptide synthesis at elevated temperatures |
US9969769B2 (en) | 2014-12-19 | 2018-05-15 | Cem Corporation | Coupling method for peptide synthesis at elevated temperatures |
JP7189369B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ, インコーポレイテッド | アルファ4β7インテグリンの阻害のための化合物 |
US11116760B2 (en) | 2018-10-30 | 2021-09-14 | Gilead Sciences, Inc. | Quinoline derivatives |
JP7189368B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ, インコーポレイテッド | アルファ4ベータ7インテグリンの阻害のための化合物 |
JP7214882B2 (ja) | 2018-10-30 | 2023-01-30 | ギリアード サイエンシーズ, インコーポレイテッド | アルファ4ベータ7インテグリン阻害剤としてのイミダゾピリジン誘導体 |
US11578069B2 (en) | 2019-08-14 | 2023-02-14 | Gilead Sciences, Inc. | Compounds for inhibition of α4 β7 integrin |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2679903B1 (fr) * | 1991-08-02 | 1993-12-03 | Elf Sanofi | Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant. |
JPH04154732A (ja) * | 1990-10-18 | 1992-05-27 | Nippon Kayaku Co Ltd | 光学分割法 |
WO1994007815A2 (fr) * | 1992-09-25 | 1994-04-14 | Abbott Laboratories | Ligands du recepteur du petit peptide anaphylatoxine |
US5648368A (en) * | 1992-12-01 | 1997-07-15 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
AU693143B2 (en) * | 1993-12-06 | 1998-06-25 | Cytel Corporation | CS-1 peptidomimetics, compositions and methods of using the same |
JPH0873422A (ja) * | 1994-09-07 | 1996-03-19 | Kdk Corp | 新規アミノ酸エステルおよび白血球、エステラーゼ又はプロテアーゼの検出方法 |
US6306840B1 (en) * | 1995-01-23 | 2001-10-23 | Biogen, Inc. | Cell adhesion inhibitors |
-
1998
- 1998-07-31 KR KR1020007000985A patent/KR20010022405A/ko not_active Application Discontinuation
- 1998-07-31 CN CN98807721A patent/CN1265672A/zh active Pending
- 1998-07-31 AU AU88234/98A patent/AU8823498A/en not_active Abandoned
- 1998-07-31 WO PCT/US1998/016070 patent/WO1999006437A1/fr not_active Application Discontinuation
- 1998-07-31 IL IL13363798A patent/IL133637A0/xx unknown
- 1998-07-31 JP JP2000505192A patent/JP2001512139A/ja not_active Withdrawn
- 1998-07-31 EP EP98939871A patent/EP0994896A1/fr not_active Withdrawn
- 1998-07-31 HU HU0003921A patent/HUP0003921A3/hu unknown
- 1998-07-31 BR BR9811594-4A patent/BR9811594A/pt not_active IP Right Cessation
- 1998-07-31 CA CA002290748A patent/CA2290748A1/fr not_active Abandoned
- 1998-07-31 PL PL98338457A patent/PL338457A1/xx not_active Application Discontinuation
-
2000
- 2000-01-28 NO NO20000452A patent/NO20000452L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
IL133637A0 (en) | 2001-04-30 |
BR9811594A (pt) | 2000-09-05 |
KR20010022405A (ko) | 2001-03-15 |
PL338457A1 (en) | 2000-11-06 |
HUP0003921A2 (hu) | 2001-02-28 |
EP0994896A1 (fr) | 2000-04-26 |
WO1999006437A1 (fr) | 1999-02-11 |
JP2001512139A (ja) | 2001-08-21 |
NO20000452D0 (no) | 2000-01-28 |
AU8823498A (en) | 1999-02-22 |
NO20000452L (no) | 2000-03-27 |
CN1265672A (zh) | 2000-09-06 |
HUP0003921A3 (en) | 2001-03-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |