EP1592386A4 - Composition et methode destinees a traiter les maladies de demyelinisation et la paralysie par administration d'agents de remyelinisation - Google Patents
Composition et methode destinees a traiter les maladies de demyelinisation et la paralysie par administration d'agents de remyelinisationInfo
- Publication number
- EP1592386A4 EP1592386A4 EP04705266A EP04705266A EP1592386A4 EP 1592386 A4 EP1592386 A4 EP 1592386A4 EP 04705266 A EP04705266 A EP 04705266A EP 04705266 A EP04705266 A EP 04705266A EP 1592386 A4 EP1592386 A4 EP 1592386A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- paralysis
- administration
- treatment
- composition
- demyelinating diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 208000016192 Demyelinating disease Diseases 0.000 title 1
- 206010033799 Paralysis Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44217103P | 2003-01-24 | 2003-01-24 | |
US442171P | 2003-01-24 | ||
US50031603P | 2003-09-05 | 2003-09-05 | |
US500316P | 2003-09-05 | ||
PCT/US2004/002028 WO2004066931A2 (fr) | 2003-01-24 | 2004-01-26 | Composition et methode destinees a traiter les maladies de demyelinisation et la paralysie par administration d'agents de remyelinisation |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1592386A2 EP1592386A2 (fr) | 2005-11-09 |
EP1592386A4 true EP1592386A4 (fr) | 2007-06-13 |
Family
ID=32829779
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19152970.0A Withdrawn EP3527228A1 (fr) | 2003-01-24 | 2004-01-26 | Composition permettant de traiter des maladies dues à la démyélinisation et à la paralysie par administration d'agents de remyélinisation |
EP04705270A Withdrawn EP1592387A4 (fr) | 2003-01-24 | 2004-01-26 | Composition permettant de traiter des maladies dues a la demyelinisation et a la paralysie par administration d'agents de remyelinisation |
EP04705266A Withdrawn EP1592386A4 (fr) | 2003-01-24 | 2004-01-26 | Composition et methode destinees a traiter les maladies de demyelinisation et la paralysie par administration d'agents de remyelinisation |
EP11008463A Withdrawn EP2484381A1 (fr) | 2003-01-24 | 2004-01-26 | Composition permettant de traiter des maladies dues à la démyélinisation et à la paralysie par administration d'agents de remyélinisation |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP19152970.0A Withdrawn EP3527228A1 (fr) | 2003-01-24 | 2004-01-26 | Composition permettant de traiter des maladies dues à la démyélinisation et à la paralysie par administration d'agents de remyélinisation |
EP04705270A Withdrawn EP1592387A4 (fr) | 2003-01-24 | 2004-01-26 | Composition permettant de traiter des maladies dues a la demyelinisation et a la paralysie par administration d'agents de remyelinisation |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP11008463A Withdrawn EP2484381A1 (fr) | 2003-01-24 | 2004-01-26 | Composition permettant de traiter des maladies dues à la démyélinisation et à la paralysie par administration d'agents de remyélinisation |
Country Status (16)
Country | Link |
---|---|
US (2) | US7576101B2 (fr) |
EP (4) | EP3527228A1 (fr) |
JP (4) | JP2006516624A (fr) |
KR (2) | KR20050114212A (fr) |
AU (5) | AU2004207535A1 (fr) |
CA (2) | CA2514125A1 (fr) |
CO (1) | CO5670359A2 (fr) |
IL (1) | IL169770A (fr) |
MX (2) | MXPA05007823A (fr) |
NO (1) | NO20053920L (fr) |
PE (1) | PE20040942A1 (fr) |
RU (1) | RU2412721C2 (fr) |
SK (1) | SK50642005A3 (fr) |
TW (2) | TW201311238A (fr) |
UY (1) | UY28170A1 (fr) |
WO (2) | WO2004066931A2 (fr) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7368421B2 (en) | 2001-06-27 | 2008-05-06 | Probiodrug Ag | Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis |
PT1485127E (pt) * | 2002-02-25 | 2011-09-07 | Elan Pharm Inc | Administração de agentes para o tratamento de inflamação |
UY28170A1 (es) | 2003-01-24 | 2004-07-30 | Elan Pharm Inc | Preparacion y tratamiento para las enfermedades desmielinizantes y paralisis mediante la aplicacion de agentes remielinizantes. |
EP1706399A1 (fr) | 2004-01-23 | 2006-10-04 | Elan Pharmaceuticals, Inc. | Conjugues a base de polyethylene glycol d'acides heterocycloalkyl carboxamido propanoiques |
MY162179A (en) | 2004-04-01 | 2017-05-31 | Elan Pharm Inc | Steroid sparing agents and methods of using same |
US7794700B2 (en) | 2004-07-08 | 2010-09-14 | Elan Pharmaceuticals Inc. | Multimeric VLA-4 antagonists comprising polymer moieties |
CA2478458A1 (fr) * | 2004-08-20 | 2006-02-20 | Michael Panzara | Traitement de la sclerose en plaques pediatrique |
EP1827491A4 (fr) * | 2004-11-19 | 2010-07-14 | Biogen Idec Inc | Traitement de la sclerose en plaques |
US20090169477A1 (en) * | 2004-12-03 | 2009-07-02 | Michael Panzara | Delaying or preventing onset of multiple sclerosis |
DK1874821T3 (da) | 2005-04-26 | 2013-07-08 | Trion Pharma Gmbh | Kombination af antistoffer med glykokortikoider til behandling af kræft |
US7786266B2 (en) * | 2005-05-12 | 2010-08-31 | Oncotherapy Science, Inc. | Methods for damaging cells using effector function of anti-DSC2 antibody |
BRPI0611285A2 (pt) | 2005-05-20 | 2010-08-31 | Elan Pharm Inc | derivados de imidazolona fenilalanina |
JP2009513783A (ja) * | 2005-10-26 | 2009-04-02 | メディバス エルエルシー | 芳香族二塩基酸含有ポリ(エステルアミド)ポリマーおよび使用の方法 |
US20070106035A1 (en) * | 2005-10-26 | 2007-05-10 | Medivas, Llc | Aromatic di-acid-containing poly (ester amide) polymers and methods of use |
US8017612B2 (en) * | 2006-04-18 | 2011-09-13 | Japan Tobacco Inc. | Piperazine compound and use thereof as a HCV polymerase inhibitor |
US9008378B2 (en) | 2006-12-20 | 2015-04-14 | The Board Of Trustees Of The Leland Stanford Junior University | Arrangement and imaging of biological samples |
EP2198040B1 (fr) * | 2007-08-31 | 2018-08-15 | Case Western Reserve University | Imagerie in vivo de la myéline |
US9040715B2 (en) * | 2008-09-23 | 2015-05-26 | Georgetown University | 1,2-benzisothiazolinone and isoindolinone derivatives |
MX2011010971A (es) * | 2009-04-17 | 2012-01-19 | Biogen Idec Inc | Composiciones y metodos para tratar leucemia mielogena aguda. |
US20120258093A1 (en) * | 2009-08-20 | 2012-10-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy |
SI3202789T1 (sl) | 2010-04-16 | 2020-11-30 | Biogen Ma Inc. | Protitelesa anti-vla 4 |
AU2011280039B2 (en) * | 2010-06-30 | 2014-08-07 | Victoria Link Ltd | Methods and compositions for treatment of multiple sclerosis |
WO2012061074A1 (fr) | 2010-10-25 | 2012-05-10 | Elan Pharmaceuticals, Inc. | Procédés de détermination de différences dans l'activité alpha-4 intégrine par la corrélation de différences des taux de svcam et/ou de smadcam |
MX361929B (es) * | 2010-11-19 | 2018-12-19 | Eisai R&D Man Co Ltd Star | Anticuerpos anti-ligando de quimiocina cc 20 (ccl20) neutralizantes. |
AU2012296543B2 (en) | 2011-08-16 | 2016-08-11 | Georgetown University | Methods of treating bacterial infections with 1,2-benzisothiazolinone and isoindolinone derivatives |
DK3590960T3 (da) | 2012-02-29 | 2023-04-24 | Takeda Pharmaceuticals Co | Igg-stimuleret remyelinisering af perifere nerver |
TWI595007B (zh) | 2012-09-10 | 2017-08-11 | Neotope Biosciences Ltd | 抗mcam抗體及相關使用方法 |
KR20210063443A (ko) * | 2012-10-09 | 2021-06-01 | 바이오젠 엠에이 인코포레이티드 | 탈수초성 질환의 치료를 위한 복합 요법 및 용도 |
AU2014324426A1 (en) | 2013-09-30 | 2016-04-21 | The Regents Of The University Of California | Anti-alphavbeta1 integrin compounds and methods |
WO2015136472A1 (fr) | 2014-03-12 | 2015-09-17 | Prothena Biosciences Limited | Anticorps anti-laminine4 spécifiques contre lg4 -5 |
KR20160127825A (ko) | 2014-03-12 | 2016-11-04 | 프로테나 바이오사이언시즈 리미티드 | 항-mcam 항체 및 관련된 사용 방법 |
KR20170052526A (ko) * | 2014-03-13 | 2017-05-12 | 프로테나 바이오사이언시즈 리미티드 | 다발성 경화증에 대한 병용 치료 |
KR102364840B1 (ko) | 2014-11-05 | 2022-02-18 | 삼성전자주식회사 | 신경세포의 탈수초화와 연관된 질환을 치료하기 위한 약학적 조성물 및 그를 이용하는 방법 |
CN107405331A (zh) * | 2014-12-12 | 2017-11-28 | 联邦科学和工业研究组织 | 使用α9整联蛋白拮抗剂从骨髓干细胞龛迁移和释放HSC |
US10738121B2 (en) | 2015-02-27 | 2020-08-11 | The General Hospital Corporation | Therapeutic use of integrin-binding antibodies |
CA2981371A1 (fr) | 2015-03-10 | 2016-09-15 | The Regents Of The University Of California | Inhibiteurs anti-integrine alphavbeta1 et methodes d'utilisation associees |
CN106316982B (zh) * | 2015-06-30 | 2020-08-14 | 中国人民解放军军事医学科学院毒物药物研究所 | 噻嗪酰胺衍生物及其用途 |
US10947311B2 (en) * | 2015-11-20 | 2021-03-16 | The Board Of Trustees Of The Leland Stanford Junior University | VCAM-1 mediated methods and compositions for treating aging-associated impairments |
KR20210013623A (ko) * | 2018-05-23 | 2021-02-04 | 체에스엘 베링 아게 | Cidp의 치료 |
WO2019236417A1 (fr) | 2018-06-04 | 2019-12-12 | Biogen Ma Inc. | Anticorps anti-vla-4 ayant une fonction effectrice réduite |
WO2020092394A1 (fr) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Dérivés d'imidazopyridine utilisés en tant qu'inhibiteurs de l'intégrine alpha4bêta7 |
CA3115820A1 (fr) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Composes pour l'inhibition de l'integrine .alpha.4.beta.7 |
JP7189369B2 (ja) | 2018-10-30 | 2022-12-13 | ギリアード サイエンシーズ, インコーポレイテッド | アルファ4β7インテグリンの阻害のための化合物 |
JP7192139B2 (ja) | 2018-10-30 | 2022-12-19 | ギリアード サイエンシーズ, インコーポレイテッド | α4β7インテグリン阻害剤としてのキノリン誘導体 |
EP4013499A1 (fr) | 2019-08-14 | 2022-06-22 | Gilead Sciences, Inc. | Composés pour l'inhibition de l'intégrine alpha 4 bêta 7 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998053817A1 (fr) * | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Acide biarylalcanoique utilise en tant qu'inhibiteur de l'adhesion cellulaire |
WO1998053814A1 (fr) * | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Composes d'amide heterocycliques utilises en tant qu'inhibiteurs de l'adhesion cellulaire |
WO1999006437A1 (fr) * | 1997-07-31 | 1999-02-11 | Elan Pharmaceuticals Inc. | Composes dipeptidiques sulfonyles inhibiteurs de l'adhesion des leucocytes induite par vla-4 |
WO2000044408A2 (fr) * | 1999-01-29 | 2000-08-03 | Millennium Pharmaceuticals, Inc. | Methode de traitement des troubles inflammatoires demyelinisants utilisant des agonistes de la fonction ccr1 |
WO2001054690A1 (fr) * | 2000-01-28 | 2001-08-02 | Biogen, Inc. | Compositions pharmaceutiques contenant des composes d'integrine anti-beta 1 et utilisations correspondantes |
WO2002002556A2 (fr) * | 2000-06-30 | 2002-01-10 | Ortho Mcneil Pharmaceutical, Inc. | Derives d'acides amines bicycliques pontes aza utilises comme antagonistes de l'integrine alpha-4 |
US6489300B1 (en) * | 1997-07-31 | 2002-12-03 | Eugene D. Thorsett | Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4 |
US6492421B1 (en) * | 1997-07-31 | 2002-12-10 | Athena Neurosciences, Inc. | Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4 |
Family Cites Families (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
EP0247091B1 (fr) | 1985-11-01 | 1993-09-29 | Xoma Corporation | Assemblage modulaire de genes d'anticorps, anticorps ainsi prepares et utilisation |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
EP0279582A3 (fr) | 1987-02-17 | 1989-10-18 | Pharming B.V. | Séquences d'ADN pour diriger des protéines vers les glandes mammaires afin d'être sécrétées efficacement |
EP0330506A3 (fr) | 1988-02-26 | 1990-06-20 | Dana Farber Cancer Institute | Protéines VLA |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
US6033665A (en) | 1989-09-27 | 2000-03-07 | Elan Pharmaceuticals, Inc. | Compositions and methods for modulating leukocyte adhesion to brain endothelial cells |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
GB9206318D0 (en) | 1992-03-24 | 1992-05-06 | Cambridge Antibody Tech | Binding substances |
US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US6225447B1 (en) | 1991-05-15 | 2001-05-01 | Cambridge Antibody Technology Ltd. | Methods for producing members of specific binding pairs |
DE69230142T2 (de) | 1991-05-15 | 2000-03-09 | Cambridge Antibody Technology Ltd. | Verfahren zur herstellung von spezifischen bindungspaargliedern |
US5858657A (en) | 1992-05-15 | 1999-01-12 | Medical Research Council | Methods for producing members of specific binding pairs |
DK0590058T3 (da) | 1991-06-14 | 2004-03-29 | Genentech Inc | Humaniseret heregulin-antistof |
WO1994004679A1 (fr) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Procede pour fabriquer des anticorps humanises |
US5224539A (en) | 1991-06-14 | 1993-07-06 | Coen Company, Inc. | Cooling system for air heaters and the like |
CA2072249C (fr) | 1991-06-28 | 2003-06-17 | Saiko Hosokawa | Anticorps monoclonal humain liant specifiquement a la surface d'un antigene des membranes des cellules cancereuses |
ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
AU3178993A (en) | 1991-11-25 | 1993-06-28 | Enzon, Inc. | Multivalent antigen-binding proteins |
US5872215A (en) | 1991-12-02 | 1999-02-16 | Medical Research Council | Specific binding members, materials and methods |
ATE463573T1 (de) | 1991-12-02 | 2010-04-15 | Medimmune Ltd | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
US5932214A (en) | 1994-08-11 | 1999-08-03 | Biogen, Inc. | Treatment for inflammatory bowel disease with VLA-4 blockers |
US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
EP0672142B1 (fr) | 1992-12-04 | 2001-02-28 | Medical Research Council | Proteines de liaison multivalentes et multispecifiques, leur fabrication et leur utilisation |
DE69419721T2 (de) | 1993-01-12 | 2000-04-27 | Biogen, Inc. | Rekombinante anti-vla4 antikörpermoleküle |
NZ262615A (en) | 1993-02-09 | 1996-02-27 | Biogen Inc | Treating insulin dependent diabetes (type i) with anti vla4 (very late antigen) antibodies |
US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
US5840299A (en) * | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
JP2001508020A (ja) * | 1994-06-02 | 2001-06-19 | シエーリング アクチエンゲゼルシヤフト | 多発性硬化症治療用のpde iv阻害剤 |
US6060501A (en) * | 1994-06-02 | 2000-05-09 | Schering Aktiengesellschaft | Combined treatment of multiple sclerosis |
US5510332A (en) | 1994-07-07 | 1996-04-23 | Texas Biotechnology Corporation | Process to inhibit binding of the integrin α4 62 1 to VCAM-1 or fibronectin and linear peptides therefor |
DE69530392D1 (de) | 1994-07-11 | 2003-05-22 | Athena Neurosciences Inc | Inhibitoren der leukozytenadhäsion |
US6001809A (en) | 1994-07-11 | 1999-12-14 | Elan Pharmaceuticals, Inc. | Inhibitors of leukocyte adhesion |
AU3559695A (en) | 1994-09-30 | 1996-04-26 | Inex Pharmaceuticals Corp. | Glycosylated protein-liposome conjugates and methods for their preparation |
US6551593B1 (en) | 1995-02-10 | 2003-04-22 | Millennium Pharmaceuticals, Inc. | Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through α 4 β 7 and its ligands and madcam |
US6284473B1 (en) * | 1995-10-02 | 2001-09-04 | Uab Research Foundation | P-cresol sulfate, a component of urinary myelin basic protein-like material, as a correlate of multiple sclerosis status |
DE19541844C1 (de) | 1995-11-09 | 1997-07-24 | Gsf Forschungszentrum Umwelt | Verfahren zur Herstellung von menschlichen Antikörpern und deren Verwendung |
GB9712818D0 (en) | 1996-07-08 | 1997-08-20 | Cambridge Antibody Tech | Labelling and selection of specific binding molecules |
US6306384B1 (en) | 1996-10-01 | 2001-10-23 | E-L Management Corp. | Skin battery cosmetic composition |
IL119989A0 (en) * | 1997-01-10 | 1997-04-15 | Yeda Res & Dev | Pharmaceutical compositions for oral treatment of multiple sclerosis |
NZ502580A (en) * | 1997-07-31 | 2001-06-29 | Elan Pharm Inc | 4-amino-phenylalanine compounds which inhibit leukocyte adhesion mediated by VLA-4 |
US6939855B2 (en) * | 1997-07-31 | 2005-09-06 | Elan Pharmaceuticals, Inc. | Anti-inflammatory compositions and method |
AR016133A1 (es) * | 1997-07-31 | 2001-06-20 | Wyeth Corp | Compuesto de carbamiloxi que inhiben la adhesion de leucocitos mediada por vla-4, compuestos que son prodrogas de dichos compuestos, composicionfarmaceutica, metodo para fijar vla-4 a una muestra biologica, metodo para el tratamiento de una condicion inflamatoria |
US6291453B1 (en) * | 1997-07-31 | 2001-09-18 | Athena Neurosciences, Inc. | 4-amino-phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4 |
US6559127B1 (en) * | 1997-07-31 | 2003-05-06 | Athena Neurosciences, Inc. | Compounds which inhibit leukocyte adhesion mediated by VLA-4 |
US6362341B1 (en) * | 1997-07-31 | 2002-03-26 | Athena Neurosciences, Inc. | Benzyl compounds which inhibit leukocyte adhesion mediated by VLA-4 |
JP2001512134A (ja) | 1997-07-31 | 2001-08-21 | エラン・ファーマシューティカルズ・インコーポレーテッド | Vla−4仲介性白血球付着を阻害する置換フェニルアラニン型化合物 |
US7030114B1 (en) * | 1997-07-31 | 2006-04-18 | Elan Pharmaceuticals, Inc. | Compounds which inhibit leukocyte adhesion mediated by VLA-4 |
US6423688B1 (en) * | 1997-07-31 | 2002-07-23 | Athena Neurosciences, Inc. | Dipeptide and related compounds which inhibit leukocyte adhesion mediated by VLA-4 |
JP2001512138A (ja) * | 1997-07-31 | 2001-08-21 | エラン・ファーマシューティカルズ・インコーポレーテッド | Vla−4が介在する白血球付着を阻害するベンジル化合物 |
US6583139B1 (en) * | 1997-07-31 | 2003-06-24 | Eugene D. Thorsett | Compounds which inhibit leukocyte adhesion mediated by VLA-4 |
US6436904B1 (en) * | 1999-01-25 | 2002-08-20 | Elan Pharmaceuticals, Inc. | Compounds which inhibit leukocyte adhesion mediated by VLA-4 |
JP2002539080A (ja) * | 1999-01-25 | 2002-11-19 | エラン ファーマシューティカルズ,インコーポレイテッド | Vla−4によって媒介される白血球接着を阻害する化合物 |
US6387930B1 (en) * | 1999-05-04 | 2002-05-14 | Schering Corporation | Piperidine derivatives useful as CCR5 antagonists |
ES2415708T3 (es) | 1999-12-16 | 2013-07-26 | Biogen Idec Ma Inc. | Métodos de tratamiento de la lesión isquémica o hemorrágica del sistema nervioso central mediante el uso de antagonistas anti-integrina alfa4 |
BR0015875A (pt) * | 2000-05-10 | 2003-06-24 | Mayo Foundation | Anticorpos igm humano com a capacidade de induzir remielinização, e usos diagnósticos e terapêutico dos mesmos, particularmente no sistema nervoso central |
US6653313B2 (en) * | 2000-08-10 | 2003-11-25 | Warner-Lambert Company Llc | 1,4-dihydropyridine compounds as bradykinin antagonists |
US6753135B2 (en) * | 2000-09-20 | 2004-06-22 | Surromed, Inc. | Biological markers for evaluating therapeutic treatment of inflammatory and autoimmune disorders |
PT1485127E (pt) * | 2002-02-25 | 2011-09-07 | Elan Pharm Inc | Administração de agentes para o tratamento de inflamação |
UY28170A1 (es) | 2003-01-24 | 2004-07-30 | Elan Pharm Inc | Preparacion y tratamiento para las enfermedades desmielinizantes y paralisis mediante la aplicacion de agentes remielinizantes. |
US9501219B2 (en) | 2012-01-25 | 2016-11-22 | Oracle International Corporation | 2D line data cursor |
-
2004
- 2004-01-26 UY UY28170A patent/UY28170A1/es not_active Application Discontinuation
- 2004-01-26 EP EP19152970.0A patent/EP3527228A1/fr not_active Withdrawn
- 2004-01-26 AU AU2004207535A patent/AU2004207535A1/en not_active Abandoned
- 2004-01-26 SK SK5064-2005A patent/SK50642005A3/sk not_active Application Discontinuation
- 2004-01-26 AU AU2004207536A patent/AU2004207536B2/en not_active Expired - Fee Related
- 2004-01-26 JP JP2006502997A patent/JP2006516624A/ja active Pending
- 2004-01-26 EP EP04705270A patent/EP1592387A4/fr not_active Withdrawn
- 2004-01-26 US US10/763,539 patent/US7576101B2/en active Active
- 2004-01-26 WO PCT/US2004/002028 patent/WO2004066931A2/fr active Application Filing
- 2004-01-26 PE PE2004000100A patent/PE20040942A1/es not_active Application Discontinuation
- 2004-01-26 EP EP04705266A patent/EP1592386A4/fr not_active Withdrawn
- 2004-01-26 MX MXPA05007823A patent/MXPA05007823A/es not_active Application Discontinuation
- 2004-01-26 KR KR1020057013695A patent/KR20050114212A/ko active Search and Examination
- 2004-01-26 CA CA002514125A patent/CA2514125A1/fr not_active Abandoned
- 2004-01-26 MX MXPA05007843A patent/MXPA05007843A/es unknown
- 2004-01-26 EP EP11008463A patent/EP2484381A1/fr not_active Withdrawn
- 2004-01-26 WO PCT/US2004/002039 patent/WO2004066932A2/fr active Application Filing
- 2004-01-26 US US10/763,424 patent/US20050069541A1/en not_active Abandoned
- 2004-01-26 RU RU2005126728/15A patent/RU2412721C2/ru active
- 2004-01-26 CA CA002514117A patent/CA2514117A1/fr not_active Abandoned
- 2004-01-26 KR KR1020127024847A patent/KR101260497B1/ko active IP Right Grant
- 2004-01-26 JP JP2006503001A patent/JP2007521249A/ja active Pending
- 2004-01-27 TW TW101146999A patent/TW201311238A/zh unknown
- 2004-01-27 TW TW093101747A patent/TWI428141B/zh not_active IP Right Cessation
-
2005
- 2005-07-19 IL IL169770A patent/IL169770A/en active IP Right Grant
- 2005-08-23 NO NO20053920A patent/NO20053920L/no not_active Application Discontinuation
- 2005-08-24 CO CO05084319A patent/CO5670359A2/es not_active Application Discontinuation
-
2010
- 2010-04-14 AU AU2010201472A patent/AU2010201472A1/en not_active Abandoned
- 2010-08-19 AU AU2010212446A patent/AU2010212446B2/en not_active Expired
-
2011
- 2011-03-22 AU AU2011201262A patent/AU2011201262A1/en not_active Abandoned
- 2011-05-30 JP JP2011121017A patent/JP2011225577A/ja active Pending
-
2013
- 2013-10-07 JP JP2013210543A patent/JP2014040458A/ja active Pending
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998053817A1 (fr) * | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Acide biarylalcanoique utilise en tant qu'inhibiteur de l'adhesion cellulaire |
WO1998053814A1 (fr) * | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Composes d'amide heterocycliques utilises en tant qu'inhibiteurs de l'adhesion cellulaire |
WO1999006437A1 (fr) * | 1997-07-31 | 1999-02-11 | Elan Pharmaceuticals Inc. | Composes dipeptidiques sulfonyles inhibiteurs de l'adhesion des leucocytes induite par vla-4 |
US6489300B1 (en) * | 1997-07-31 | 2002-12-03 | Eugene D. Thorsett | Carbamyloxy compounds which inhibit leukocyte adhesion mediated by VLA-4 |
US6492421B1 (en) * | 1997-07-31 | 2002-12-10 | Athena Neurosciences, Inc. | Substituted phenylalanine type compounds which inhibit leukocyte adhesion mediated by VLA-4 |
WO2000044408A2 (fr) * | 1999-01-29 | 2000-08-03 | Millennium Pharmaceuticals, Inc. | Methode de traitement des troubles inflammatoires demyelinisants utilisant des agonistes de la fonction ccr1 |
WO2001054690A1 (fr) * | 2000-01-28 | 2001-08-02 | Biogen, Inc. | Compositions pharmaceutiques contenant des composes d'integrine anti-beta 1 et utilisations correspondantes |
WO2002002556A2 (fr) * | 2000-06-30 | 2002-01-10 | Ortho Mcneil Pharmaceutical, Inc. | Derives d'acides amines bicycliques pontes aza utilises comme antagonistes de l'integrine alpha-4 |
Non-Patent Citations (2)
Title |
---|
LIN L S ET AL: "Specific and dual antagonists of [alpha]4[beta]1 and [alpha]4[beta]7 integrins", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 12, no. 2, 21 January 2002 (2002-01-21), pages 133 - 136, XP002332347, ISSN: 0960-894X * |
WEILBACH F X ET AL: "DISEASE MODIFYING TREATMENTS FOR MULTIPLE SCLEROSIS WHAT IS ON THE HORIZON?", CNS DRUGS, ADIS INTERNATIONAL, AUCKLAND, NZ, vol. 11, no. 2, February 1999 (1999-02-01), pages 133 - 157, XP001033418, ISSN: 1172-7047 * |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1592387A4 (fr) | Composition permettant de traiter des maladies dues a la demyelinisation et a la paralysie par administration d'agents de remyelinisation | |
IL180600A0 (en) | Compositions and methods of use for treatment of mammalian diseases | |
TWI340640B (en) | Combination, kit and pharmaceutical composition for treatment of parkinson's disease | |
WO2005013892A3 (fr) | Agents therapeutiques contenant du bore et a resistance hydrolytique et procedes pour les utiliser | |
EP1631270A4 (fr) | Methodes et compositions pour distribuer des butanes catecholiques pour assurer le traitement de pathologies | |
PT2359856T (pt) | Formulação de anticorpos humanos para o tratamento de perturbações associadas ao tnf-alfa | |
AU2002329990A1 (en) | Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith | |
EP1567157A4 (fr) | Methodes d'utilisation et compositions recourant a des composes immunomodulatoires pour le traitement et la gestion de syndromes myeloproliferatifs | |
AU2003210428A1 (en) | Phenethanolamine derivatives for treatment of respiratory diseases | |
ZA200707934B (en) | Thereapeutic formulations for the treatment of beta-amyloid related diseases | |
EP1663104A4 (fr) | Compositions therapeutiques a base de porifera destinees au traitement et a la prevention de dermatoses | |
IL175535A0 (en) | Compositions for treatment of neurodegenerative diseases | |
AU2003268531A8 (en) | Materials and methods for treatment of allergic diseases | |
IL176227A0 (en) | Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases | |
EP1560593A4 (fr) | Nouvelle composition et procedes pour le traitement de maladies auto-immunes | |
PL1730144T3 (pl) | Podstawione pochodne 1,4,8-triazaspiro[4.5]dekan-2-onu | |
HK1100812A1 (en) | Composition for the prophylaxis/treatment of hbv infections and hbv- mediated diseases | |
AU2002352533A1 (en) | Methods and compositions for treatment of gastric diseases | |
EP1784173A4 (fr) | Composition pharmaceutique destinee a prevenir et a traiter des maladies osseuses metaboliques, contenant des derives d'alpha-arylmethoxyacrylate | |
AU2002366433A1 (en) | Methods and compositions for treating metabolic bone diseases relating to human endokine alpha | |
EP1709155A4 (fr) | Composes et compositions destines au traitement de maladies dysplasiques, et leurs methodes d'utilisation | |
EP1542664A4 (fr) | Methodes et compositions de traitement de troubles maculaires et retinaux | |
EP1812797A4 (fr) | Compositions et methodes permettant de traiter et de prevenir des maladies hyperproliferatives | |
HK1104800A1 (en) | Method of using and compositions comprising immunomodulatory compounds for the treatment and management of myeloproliferative diseases | |
EP1750740A4 (fr) | Traitement de maladies et troubles associes aux membranes au moyen de compositions contenant des lantibiotiques |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20050805 |
|
AK | Designated contracting states |
Kind code of ref document: A2 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LI LU MC NL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL LT LV MK |
|
PUAK | Availability of information related to the publication of the international search report |
Free format text: ORIGINAL CODE: 0009015 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 31/21 20060101ALI20051221BHEP Ipc: A61K 31/185 20060101ALI20051221BHEP Ipc: A61K 31/16 20060101ALI20051221BHEP Ipc: A61K 31/10 20060101AFI20051221BHEP |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20070510 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 45/06 20060101ALI20070504BHEP Ipc: A61K 31/21 20060101ALI20070504BHEP Ipc: A61K 31/185 20060101ALI20070504BHEP Ipc: A61K 31/16 20060101ALI20070504BHEP Ipc: A61K 31/10 20060101AFI20051221BHEP |
|
17Q | First examination report despatched |
Effective date: 20071024 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20100803 |