CA2276429C - Compositions for the treatment of ards or irds containing 3-(cyclopropylmethoxy)-n-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide and lung surfactant - Google Patents

Compositions for the treatment of ards or irds containing 3-(cyclopropylmethoxy)-n-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide and lung surfactant Download PDF

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Publication number
CA2276429C
CA2276429C CA002276429A CA2276429A CA2276429C CA 2276429 C CA2276429 C CA 2276429C CA 002276429 A CA002276429 A CA 002276429A CA 2276429 A CA2276429 A CA 2276429A CA 2276429 C CA2276429 C CA 2276429C
Authority
CA
Canada
Prior art keywords
lung surfactant
ards
cyclopropylmethoxy
irds
dichloropyrid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002276429A
Other languages
English (en)
French (fr)
Other versions
CA2276429A1 (en
Inventor
Dietrich Hafner
Klaus Eistetter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Altana Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19705924A external-priority patent/DE19705924A1/de
Application filed by Altana Pharma AG filed Critical Altana Pharma AG
Publication of CA2276429A1 publication Critical patent/CA2276429A1/en
Application granted granted Critical
Publication of CA2276429C publication Critical patent/CA2276429C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Detergent Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002276429A 1997-02-17 1998-02-14 Compositions for the treatment of ards or irds containing 3-(cyclopropylmethoxy)-n-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide and lung surfactant Expired - Lifetime CA2276429C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE19705924A DE19705924A1 (de) 1997-02-17 1997-02-17 Neue Zusammensetzungen
DE19705924.4 1997-02-17
EP97102639 1997-02-19
EP97102639.8 1997-02-19
PCT/EP1998/000847 WO1998035683A1 (en) 1997-02-17 1998-02-14 Compositions for the treatment of ards or irds containing 3-(cyclopropylmethoxy)-n-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide and lung surfactant

Publications (2)

Publication Number Publication Date
CA2276429A1 CA2276429A1 (en) 1998-08-20
CA2276429C true CA2276429C (en) 2007-06-19

Family

ID=26033977

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002276429A Expired - Lifetime CA2276429C (en) 1997-02-17 1998-02-14 Compositions for the treatment of ards or irds containing 3-(cyclopropylmethoxy)-n-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide and lung surfactant

Country Status (25)

Country Link
US (2) US6436970B1 (OSRAM)
EP (1) EP0977577B1 (OSRAM)
JP (1) JP4763104B2 (OSRAM)
KR (1) KR100640025B1 (OSRAM)
CN (1) CN1123345C (OSRAM)
AT (1) ATE336254T1 (OSRAM)
AU (1) AU734122B2 (OSRAM)
BR (1) BR9807399B1 (OSRAM)
CA (1) CA2276429C (OSRAM)
CZ (1) CZ293871B6 (OSRAM)
DE (1) DE69835594T2 (OSRAM)
DK (1) DK0977577T3 (OSRAM)
EA (1) EA001758B1 (OSRAM)
EE (1) EE04094B1 (OSRAM)
ES (1) ES2271990T3 (OSRAM)
HU (1) HU227520B1 (OSRAM)
IL (1) IL130658A (OSRAM)
NO (1) NO323594B1 (OSRAM)
NZ (1) NZ336569A (OSRAM)
PL (1) PL190775B1 (OSRAM)
PT (1) PT977577E (OSRAM)
SI (1) SI0977577T1 (OSRAM)
TR (1) TR199901772T2 (OSRAM)
UA (1) UA50808C2 (OSRAM)
WO (1) WO1998035683A1 (OSRAM)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE04094B1 (et) * 1997-02-17 2003-08-15 Byk Gulden Lomberg Chemische Fabrik Gmbh N-(3,5-dikloro-4-püridinüül)-3-tsüklopropüülmetoksü-4-(difluorometoksü)bensamiidi ja kopsusurfaktanti sisaldavad kompositsioonid ARDS'i või IRDS'i ravimiseks
JP2001081031A (ja) * 1999-08-30 2001-03-27 Schering Ag 溶解性および経口吸収性を改善したベンズアミド誘導体含有製剤
US7053176B1 (en) 1999-09-16 2006-05-30 Altana Pharma Ag Combination of C1-INH and lung surfactant for the treatment of respiratory disorders
DE19957898A1 (de) * 1999-12-01 2001-06-07 Byk Gulden Lomberg Chem Fab Neue Verwendung von Lungensurfactant
CA2407780A1 (en) * 2000-05-25 2001-11-29 Merck Frosst Canada & Co./Merck Frosst Canada & Cie Fluoroalkoxy-substituted benzamide dichloropyridinyl n-oxide pde4 inhibitor
JP4460221B2 (ja) 2001-05-24 2010-05-12 メルク フロスト カナダ リミテツド １−ビアリール−１，８−ナフチリジン−４−オン系ホスホジエステラーゼ−４阻害薬
US20030099601A1 (en) * 2001-11-27 2003-05-29 Gordon Marc S. Inhalation lung surfactant therapy
WO2003053455A1 (en) * 2001-12-12 2003-07-03 Penn State Research Foundation Surfactant prevention of lung complications from cancer chemotherapy
US20030170223A1 (en) * 2002-02-01 2003-09-11 Board Of Trustees Of Michigan State University Pulmonary vasodilator surfactant compositions and method of use
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
US6822114B1 (en) 2002-10-08 2004-11-23 Albemarle Corporation Process for production of fluoroalkoxy-substituted benzamides and their intermediates
WO2004047828A1 (en) * 2002-11-27 2004-06-10 Altana Pharma Ag Synergistic combination compresing roflumilas and (r.r) -formoterol
JP2006508994A (ja) * 2002-11-27 2006-03-16 アルタナ　ファルマ　アクチエンゲゼルシャフト ロフルミラスト及びホルモテロールを含有する新規の相乗組合せ
SI1606261T1 (sl) 2003-03-10 2010-03-31 Nycomed Gmbh Novi postopek za pripravo roflumilasta
CA2529007C (en) * 2003-06-16 2012-03-27 Altana Pharma Ag Composition comprising a pulmonary surfactant and a pde5 inhibitor for the treatment of lung diseases
DE602005019416D1 (de) 2004-08-06 2010-04-01 Nycomed Gmbh Zusammensetzung aus einem pulmonalen surfactant und einem von tnf stammenden peptid
EP2258350B1 (en) * 2005-03-16 2014-12-24 Takeda GmbH Taste masked dosage form containing roflumilast
BRPI0720032A2 (pt) * 2006-12-13 2013-12-17 Gilead Sciences Inc Composto e sais farmaceuticamente aceitáveis dos mesmos, processo, formulação de aerossol, método para a prevenção e tratamento de inflamação pulmonar ou broncoconstrição, e, uso de um composto.
WO2009055788A1 (en) * 2007-10-26 2009-04-30 Aeris Therapeutics, Inc. Pneumoreductive therapy and compositions useful therein
EP3027738B1 (en) * 2013-08-01 2022-03-02 Swedish StromaBio AB Mscs in the treatment of inflammatory pulmonary diseases
CN104800214A (zh) * 2014-01-27 2015-07-29 成都英诺新科技有限公司 一种罗氟司特吸入气雾剂复方及制备方法
RU2728821C1 (ru) * 2020-05-13 2020-07-31 Федеральное государственное бюджетное учреждение науки "Научный центр биомедицинских технологий Федерального медико-биологического агентства" (ФГБУН НЦБМТ ФМБА России) Способ лечения острого респираторного дистресс-синдрома даларгином и легочным сурфактантом

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4223040A (en) * 1974-11-26 1980-09-16 Carroll John M Lauric acid for the prevention and treatment of mycobacterial diseases
JPS5795920A (en) * 1980-12-04 1982-06-15 Teijin Ltd Remedy for respiratory disease
JPS5845299A (ja) * 1981-09-10 1983-03-16 東京田辺製薬株式会社 新規な表面活性物質、その製造法及びそれを含有する呼吸窮迫疾候群治療剤
PT78566B (de) * 1983-05-11 1986-07-17 Byk Gulden Lomberg Chem Fab Pyridazinone ihre herstellung und verwendung pyridazinone enthaltende arzneimittel
US4906476A (en) * 1988-12-14 1990-03-06 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs in lungs
US5006343A (en) * 1988-12-29 1991-04-09 Benson Bradley J Pulmonary administration of pharmaceutically active substances
RU2137754C1 (ru) * 1993-07-02 1999-09-20 Бик Гульден Ломберг Хемише Фабрик ГмбХ Фторалкоксизамещенные бензамиды, способ их получения и фармацевтическая композиция на их основе
US5856196A (en) * 1993-10-25 1999-01-05 Beth Israel Hospital Processes for quantitating phosphoglycerides in a lipid mixture and diagnostic uses therefor
GB9401460D0 (en) 1994-01-26 1994-03-23 Rhone Poulenc Rorer Ltd Compositions of matter
DE4434629C1 (de) * 1994-09-28 1996-06-27 Byk Gulden Lomberg Chem Fab Zusammensetzungen zur Behandlung von IRDS und ARDS
US5531219A (en) * 1994-11-04 1996-07-02 Alliance Pharmaceutical Corp. Use of liquid fluorocarbons to facilitate pulmonary drug delivery
US5698537A (en) * 1996-06-18 1997-12-16 Clarion Pharmaceuticals Inc. Method of lowering the viscosity of mucus
EE04094B1 (et) * 1997-02-17 2003-08-15 Byk Gulden Lomberg Chemische Fabrik Gmbh N-(3,5-dikloro-4-püridinüül)-3-tsüklopropüülmetoksü-4-(difluorometoksü)bensamiidi ja kopsusurfaktanti sisaldavad kompositsioonid ARDS'i või IRDS'i ravimiseks
US6180142B1 (en) * 1998-08-21 2001-01-30 The Regents Of The University Of California Reduction of surfactant inactivation in pulmonary surfactant therapy
KR20020048911A (ko) * 1999-06-29 2002-06-24 엘-테크 코포레이션 화학 필름의 세정 및 건조 방법과 그 장치

Also Published As

Publication number Publication date
EP0977577A1 (en) 2000-02-09
US6436970B1 (en) 2002-08-20
IL130658A (en) 2004-07-25
KR20000071112A (ko) 2000-11-25
AU734122B2 (en) 2001-06-07
HUP0001043A3 (en) 2002-12-28
NZ336569A (en) 2001-04-27
HK1026145A1 (en) 2000-12-08
HU227520B1 (hu) 2011-07-28
JP2001512452A (ja) 2001-08-21
KR100640025B1 (ko) 2006-10-31
DE69835594T2 (de) 2007-08-16
IL130658A0 (en) 2000-06-01
DE69835594D1 (de) 2006-09-28
US6998410B2 (en) 2006-02-14
DK0977577T3 (da) 2006-12-18
EE9900279A (et) 2000-02-15
EA001758B1 (ru) 2001-08-27
AU6497398A (en) 1998-09-08
HUP0001043A2 (hu) 2000-09-28
CZ291499A3 (cs) 2000-02-16
CZ293871B6 (cs) 2004-08-18
NO993875L (no) 1999-08-11
NO993875D0 (no) 1999-08-11
EA199900645A1 (ru) 2000-04-24
CN1123345C (zh) 2003-10-08
PL190775B1 (pl) 2006-01-31
JP4763104B2 (ja) 2011-08-31
CN1248169A (zh) 2000-03-22
US20020132835A1 (en) 2002-09-19
UA50808C2 (uk) 2002-11-15
ATE336254T1 (de) 2006-09-15
EP0977577B1 (en) 2006-08-16
WO1998035683A1 (en) 1998-08-20
PT977577E (pt) 2007-02-28
ES2271990T3 (es) 2007-04-16
PL335134A1 (en) 2000-04-10
CA2276429A1 (en) 1998-08-20
BR9807399A (pt) 2000-03-14
TR199901772T2 (OSRAM) 1999-09-21
BR9807399B1 (pt) 2011-04-19
EE04094B1 (et) 2003-08-15
SI0977577T1 (sl) 2007-02-28
NO323594B1 (no) 2007-06-11

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Effective date: 20180214