ES8601918A1 - Procedimiento para la preparacion de 6-aril-3 (2h)piridazinonas - Google Patents

Procedimiento para la preparacion de 6-aril-3 (2h)piridazinonas

Info

Publication number
ES8601918A1
ES8601918A1 ES532337A ES532337A ES8601918A1 ES 8601918 A1 ES8601918 A1 ES 8601918A1 ES 532337 A ES532337 A ES 532337A ES 532337 A ES532337 A ES 532337A ES 8601918 A1 ES8601918 A1 ES 8601918A1
Authority
ES
Spain
Prior art keywords
pyridazinones
preparation
medicines containing
pyridazinone
methoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532337A
Other languages
English (en)
Other versions
ES532337A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Publication of ES8601918A1 publication Critical patent/ES8601918A1/es
Publication of ES532337A0 publication Critical patent/ES532337A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/18—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE 6-ARIL-3-2HPIRIDAZINONAS, DE FORMULA GENERAL (I), EN LA QUE UNO DE LOS SUSTITUYENTES R1 O R2 SIGNIFICA UN GRUPO METOXI Y EL OTRO SIGNIFICA UN GRUPO ALCOXI DE 2 A 5 ATOMOS DE CARBONO O UN GRUPO ALQUENILOXI DE 3 A 5 ATOMOS DE CARBONO; Y X SIGNIFICA UN ATOMO DE OXIGENO O UN ATOMO DE AZUFRE, Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR CON HIDRAZINA UN ACIDO ACRILICO DE FORMULA GENERAL (II), EN LA QUE R1 Y R2 TIENEN LOS SIGNIFICADOS YA MENCIONADOS. EN CASO DESEADO SE TRANSFORMA LA PIRIDAZINONA DE FORMULA GENERAL (I), EN LA QUE X ES OXIGENO, EN UNA PIRIDAZINONA DE FORMULA GENERAL (I), EN LA QUE X ES AZUFRE O EN LA SAL CORRESPONDIENTE. DE APLICACION EN MEDICINA COMO AGENTE BRONCOESPASMOLITICO O CARDIOTONICO.
ES532337A 1983-05-11 1984-05-09 Procedimiento para la preparacion de 6-aril-3 (2h)piridazinonas Granted ES532337A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH258183 1983-05-11

Publications (2)

Publication Number Publication Date
ES8601918A1 true ES8601918A1 (es) 1985-12-01
ES532337A0 ES532337A0 (es) 1985-12-01

Family

ID=4237009

Family Applications (1)

Application Number Title Priority Date Filing Date
ES532337A Granted ES532337A0 (es) 1983-05-11 1984-05-09 Procedimiento para la preparacion de 6-aril-3 (2h)piridazinonas

Country Status (15)

Country Link
US (1) US4707481A (es)
EP (1) EP0125636B1 (es)
JP (1) JPS60501258A (es)
AT (1) ATE26266T1 (es)
AU (1) AU560607B2 (es)
CA (1) CA1247100A (es)
DE (2) DE3462890D1 (es)
DK (1) DK156655C (es)
ES (1) ES532337A0 (es)
GR (1) GR82072B (es)
IL (1) IL71788A (es)
NZ (1) NZ208107A (es)
PT (1) PT78566B (es)
WO (1) WO1984004521A1 (es)
ZA (1) ZA843520B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK159431C (da) * 1984-05-10 1991-03-18 Byk Gulden Lomberg Chem Fab 6-phenyl-3(2h)-pyridazinoner, fremgangsmaade til fremstilling deraf, laegemidler indeholdende disse samt anvendelse af forbindelserne til fremstilling af laegemidler
IL79280A (en) * 1985-07-05 1990-07-12 Smith Kline French Lab 4-(6-oxo-dihydro or tetrahydropyridazin-3-yl)benzene derivatives,their preparation and pharmaceutical compositions containing them
DE3827362A1 (de) * 1988-08-12 1990-02-15 Basf Ag Pulvrige, hydrophile theophyllinformulierung und verfahren zur ihrer herstellung
CA2065364A1 (en) * 1989-04-17 1990-10-18 Hermann Amschler Arylpyridazines, their manufacture, use and medicaments containing them
ATE168101T1 (de) * 1990-10-16 1998-07-15 Byk Gulden Lomberg Chem Fab Arylpyridazinone
EP0581805A1 (de) * 1991-04-26 1994-02-09 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue pyridazine
WO1993000903A1 (de) * 1991-07-05 1993-01-21 Byk Gulden Lomberg Chemische Fabrik Gmbh Verwendung substituierter pyridazine gegen dermatosen
CZ141795A3 (en) * 1992-12-02 1995-11-15 Pfizer 4-substituted catechol diethers as such and for treating diseases and pharmaceutical preparations based thereon
US5814651A (en) * 1992-12-02 1998-09-29 Pfizer Inc. Catechol diethers as selective PDEIV inhibitors
DE19514568A1 (de) * 1995-04-20 1996-10-24 Merck Patent Gmbh Arylalkyl-pyridazinone
EA001758B1 (ru) * 1997-02-17 2001-08-27 Бык Гульден Ломберг Хемише Фабрик Гмбх Композиции для лечения респираторного дистресс-синдрома взрослых или респираторного дистресс-синдрома новорожденных, содержащие 3-(циклопропилметокси)-n-(3,5-дихлор-4-пиридинил)-4-(дифторметокси)бензамид и легочное поверхностно-активное вещество
US7437192B2 (en) * 2005-04-05 2008-10-14 Pacesetter, Inc. System and method for detecting heart failure and pulmonary edema based on ventricular end-diastolic pressure using an implantable medical device
CN101668732A (zh) * 2007-04-02 2010-03-10 同一世界健康研究院 Cftr抑制剂化合物及其用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT343125B (de) * 1976-03-24 1978-05-10 Chemie Linz Ag Verfahren zur herstellung von 3-phenylpyridazon- (6)
JPS6037101B2 (ja) * 1977-03-09 1985-08-24 三共株式会社 フエニルピリダジノン誘導体の製法
US4397854A (en) * 1981-05-14 1983-08-09 Warner-Lambert Company Substituted 6-phenyl-3(2H)-pyridazinones useful as cardiotonic agents
JPS588015A (ja) * 1981-07-06 1983-01-18 Mitsubishi Chem Ind Ltd 強心剤

Also Published As

Publication number Publication date
GR82072B (es) 1984-12-13
DK12485D0 (da) 1985-01-10
PT78566B (de) 1986-07-17
DK156655B (da) 1989-09-18
AU2961784A (en) 1984-12-04
DK156655C (da) 1990-02-05
DK12485A (da) 1985-01-10
ES532337A0 (es) 1985-12-01
AU560607B2 (en) 1987-04-09
PT78566A (de) 1984-06-01
DE3462890D1 (en) 1987-05-07
DE3417391A1 (de) 1984-11-15
IL71788A0 (en) 1984-09-30
ATE26266T1 (de) 1987-04-15
EP0125636B1 (de) 1987-04-01
NZ208107A (en) 1986-12-05
ZA843520B (en) 1984-12-24
US4707481A (en) 1987-11-17
JPS60501258A (ja) 1985-08-08
CA1247100A (en) 1988-12-20
EP0125636A1 (de) 1984-11-21
WO1984004521A1 (fr) 1984-11-22
IL71788A (en) 1987-09-16

Similar Documents

Publication Publication Date Title
ES8601918A1 (es) Procedimiento para la preparacion de 6-aril-3 (2h)piridazinonas
DE59109027D1 (en) Arylpyridazinone
ATE47844T1 (de) Pyridazinone, ihre herstellung und verwendung, pyridazinone enthaltende arzeimittel.
DE3471655D1 (en) 6-(acylaminoaryl)-3(2h)-pyridazinone derivatives, their preparation and use
MY102117A (en) Naphthquinone derivatives
ES8603459A1 (es) Un procedimiento para la preparacion de nuevos derivados de quinazolina e isoquinolina.
GB1392475A (en) Hydrazino-pyrimido-pyridazine derivative
ES8506306A1 (es) Procedimiento para preparar 6-(tien-2-il)-3(2h)-piridazinonas sustituidas
GB2180535B (en) Gamma-carbolines
ES8801828A1 (es) Procedimiento para preparar piridazinonas alquil-substituidas
EP0310313A3 (en) Anti-arrhythmic agent
GB1194598A (en) Benzofuran Derivatives
GB1420533A (en) Pyridine derivatives having juvenile hormone activity
JPS539321A (en) Agri-horticultural fungicide
ATE12388T1 (de) Verfahren zur herstellung von 3-chloro-6-(2hydroxy-phenyl)pyridazinen.
ES8405408A1 (es) Procedimiento para la obtencion de derivados de benzoxazina sustituidos
GB1342598A (en) Pyrazines
HK33385A (en) 3-hydroxy-1,4-benzodiazepine-2-ones, process for the preparation thereof and compositions containing them
JPS57188574A (en) Pyridazinone derivative

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303