CA2252071C - Anti-caries oral compositions - Google Patents
Anti-caries oral compositions Download PDFInfo
- Publication number
- CA2252071C CA2252071C CA002252071A CA2252071A CA2252071C CA 2252071 C CA2252071 C CA 2252071C CA 002252071 A CA002252071 A CA 002252071A CA 2252071 A CA2252071 A CA 2252071A CA 2252071 C CA2252071 C CA 2252071C
- Authority
- CA
- Canada
- Prior art keywords
- arginine
- calcium
- oral composition
- oral
- phytate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 136
- 230000000675 anti-caries Effects 0.000 title description 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims abstract description 126
- 239000004475 Arginine Substances 0.000 claims abstract description 125
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims abstract description 103
- 239000011575 calcium Substances 0.000 claims abstract description 85
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 85
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 78
- 208000002925 dental caries Diseases 0.000 claims abstract description 44
- 238000000034 method Methods 0.000 claims abstract description 40
- 150000001450 anions Chemical class 0.000 claims abstract description 35
- 230000000248 cariostatic effect Effects 0.000 claims abstract description 31
- 210000000214 mouth Anatomy 0.000 claims abstract description 13
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims description 85
- 235000002949 phytic acid Nutrition 0.000 claims description 84
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 42
- RYJDNPSQBGFFSF-WCCKRBBISA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;carbonic acid Chemical compound OC(O)=O.OC(=O)[C@@H](N)CCCNC(N)=N RYJDNPSQBGFFSF-WCCKRBBISA-N 0.000 claims description 23
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 23
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 21
- 229910019142 PO4 Inorganic materials 0.000 claims description 15
- 239000010452 phosphate Substances 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 15
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 13
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 12
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 9
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 9
- 239000005022 packaging material Substances 0.000 claims description 7
- 230000000979 retarding effect Effects 0.000 claims description 7
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical class [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims description 5
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- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 5
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- 238000004519 manufacturing process Methods 0.000 claims description 4
- 235000013305 food Nutrition 0.000 claims description 3
- INAPMGSXUVUWAF-GCVPSNMTSA-N [(2r,3s,5r,6r)-2,3,4,5,6-pentahydroxycyclohexyl] dihydrogen phosphate Chemical class OC1[C@H](O)[C@@H](O)C(OP(O)(O)=O)[C@H](O)[C@@H]1O INAPMGSXUVUWAF-GCVPSNMTSA-N 0.000 claims description 2
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims description 2
- NKWPZUCBCARRDP-UHFFFAOYSA-L calcium bicarbonate Chemical compound [Ca+2].OC([O-])=O.OC([O-])=O NKWPZUCBCARRDP-UHFFFAOYSA-L 0.000 claims description 2
- 229910000020 calcium bicarbonate Inorganic materials 0.000 claims description 2
- 235000015218 chewing gum Nutrition 0.000 claims description 2
- 229940112822 chewing gum Drugs 0.000 claims description 2
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims description 2
- 229940043430 calcium compound Drugs 0.000 claims 4
- 150000001674 calcium compounds Chemical class 0.000 claims 4
- HFNQLYDPNAZRCH-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O.OC(O)=O HFNQLYDPNAZRCH-UHFFFAOYSA-N 0.000 claims 1
- 239000004075 cariostatic agent Substances 0.000 abstract description 19
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- 239000002253 acid Substances 0.000 description 30
- 239000008103 glucose Substances 0.000 description 27
- 238000011534 incubation Methods 0.000 description 27
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- 150000001875 compounds Chemical class 0.000 description 24
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- 239000013049 sediment Substances 0.000 description 19
- 230000007928 solubilization Effects 0.000 description 18
- 238000005063 solubilization Methods 0.000 description 18
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 17
- 229910052698 phosphorus Inorganic materials 0.000 description 17
- 239000011574 phosphorus Substances 0.000 description 17
- 239000000843 powder Substances 0.000 description 14
- 238000004458 analytical method Methods 0.000 description 13
- 230000008569 process Effects 0.000 description 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
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- 230000015572 biosynthetic process Effects 0.000 description 12
- 239000002244 precipitate Substances 0.000 description 12
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 11
- 239000012153 distilled water Substances 0.000 description 11
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- 239000000467 phytic acid Substances 0.000 description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 235000014633 carbohydrates Nutrition 0.000 description 10
- 239000000243 solution Substances 0.000 description 10
- 101710180456 CD-NTase-associated protein 4 Proteins 0.000 description 9
- 102100026548 Caspase-8 Human genes 0.000 description 9
- -1 anion bicarbonate Chemical class 0.000 description 9
- 150000001720 carbohydrates Chemical class 0.000 description 9
- 239000006228 supernatant Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 8
- 210000003296 saliva Anatomy 0.000 description 8
- 208000002064 Dental Plaque Diseases 0.000 description 7
- 150000007513 acids Chemical class 0.000 description 7
- 238000007792 addition Methods 0.000 description 7
- 239000000551 dentifrice Substances 0.000 description 7
- 235000000346 sugar Nutrition 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 102100025971 F-actin-capping protein subunit alpha-2 Human genes 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 239000002585 base Substances 0.000 description 6
- 210000004268 dentin Anatomy 0.000 description 6
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- 238000004448 titration Methods 0.000 description 5
- FENRSEGZMITUEF-ATTCVCFYSA-E [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] FENRSEGZMITUEF-ATTCVCFYSA-E 0.000 description 4
- DIKBFYAXUHHXCS-UHFFFAOYSA-N bromoform Chemical compound BrC(Br)Br DIKBFYAXUHHXCS-UHFFFAOYSA-N 0.000 description 4
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
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- WPEXVRDUEAJUGY-UHFFFAOYSA-B hexacalcium;(2,3,4,5,6-pentaphosphonatooxycyclohexyl) phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])(=O)OC1C(OP([O-])([O-])=O)C(OP([O-])([O-])=O)C(OP([O-])([O-])=O)C(OP([O-])([O-])=O)C1OP([O-])([O-])=O WPEXVRDUEAJUGY-UHFFFAOYSA-B 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Confectionery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/611,206 | 1996-03-05 | ||
| US08/611,206 US5762911A (en) | 1996-03-05 | 1996-03-05 | Anti-caries oral compositions |
| PCT/US1997/005273 WO1997032565A1 (en) | 1996-03-05 | 1997-03-04 | Anti-caries oral compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2252071A1 CA2252071A1 (en) | 1997-09-12 |
| CA2252071C true CA2252071C (en) | 2004-12-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002252071A Expired - Lifetime CA2252071C (en) | 1996-03-05 | 1997-03-04 | Anti-caries oral compositions |
Country Status (14)
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| US (2) | US5762911A (OSRAM) |
| EP (1) | EP0928184B1 (OSRAM) |
| JP (2) | JP3980645B2 (OSRAM) |
| CN (2) | CN1305530C (OSRAM) |
| AT (1) | ATE432685T1 (OSRAM) |
| AU (1) | AU719465B2 (OSRAM) |
| BR (1) | BR9711797B1 (OSRAM) |
| CA (1) | CA2252071C (OSRAM) |
| DE (1) | DE69739440D1 (OSRAM) |
| DK (1) | DK0928184T3 (OSRAM) |
| ES (1) | ES2328301T3 (OSRAM) |
| NZ (1) | NZ332172A (OSRAM) |
| PT (1) | PT928184E (OSRAM) |
| WO (1) | WO1997032565A1 (OSRAM) |
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| US6436370B1 (en) * | 1999-06-23 | 2002-08-20 | The Research Foundation Of State University Of New York | Dental anti-hypersensitivity composition and method |
| WO2002045611A2 (en) * | 2000-12-08 | 2002-06-13 | Brown, Dale, G. | Biofilm therapy process and elements |
| JPWO2004096165A1 (ja) * | 2003-04-30 | 2006-07-13 | アサヒビール株式会社 | エナメル質脱灰抑制素材 |
| DK1635774T4 (da) | 2003-06-23 | 2011-05-30 | Colgate Palmolive Co | Stabile tandplejesammensætninger |
| US8287843B2 (en) | 2003-06-23 | 2012-10-16 | Colgate-Palmolive Company | Antiplaque oral care compositions |
| US20040258629A1 (en) * | 2003-06-23 | 2004-12-23 | Boyd Thomas J. | Antiplaque confectionery dental composition |
| US7198653B2 (en) | 2003-07-31 | 2007-04-03 | Delavau Llc | Calcium carbonate granulation |
| CN102358746A (zh) * | 2005-12-16 | 2012-02-22 | 戴维·坎纳尔 | 表面活性钙磷酸盐 |
| US20070212449A1 (en) * | 2006-03-02 | 2007-09-13 | Shamsuddin Abulkalam M | Reduction of the titratable acidity and the prevention of tooth and other bone degeneration |
| CN101437485A (zh) | 2006-05-09 | 2009-05-20 | 高露洁-棕榄公司 | 口腔护理方案 |
| US20080274065A1 (en) * | 2006-05-09 | 2008-11-06 | Richard Scott Robinson | Oral Care Regimen |
| US9138414B1 (en) | 2006-09-15 | 2015-09-22 | Delavau Llc | Calcium supplement having enhanced absorption |
| US20090155318A1 (en) * | 2006-10-31 | 2009-06-18 | Lee Howard W H | Process to form nano-sized materials, the compositions and uses thereof |
| US20080267891A1 (en) * | 2007-04-30 | 2008-10-30 | Colgate-Palmolive Company | Oral Care Composition To Reduce Or Eliminate Dental Sensitivity |
| US20090053267A1 (en) * | 2007-08-20 | 2009-02-26 | Depierro Karen | Dentifrice composition containing silicone oil beads |
| EP2070422A1 (en) | 2007-12-05 | 2009-06-17 | Südzucker Aktiengesellschaft Mannheim/Ochsenfurt | Confectionery products promoting dental health |
| AR070585A1 (es) * | 2008-02-08 | 2010-04-21 | Colgate Palmolive Co | Cepillo de dientes para cuidado oral |
| TW201002355A (en) * | 2008-02-08 | 2010-01-16 | Colgate Palmolive Co | Cleaning compositions and methods |
| MY155564A (en) * | 2008-02-08 | 2015-10-30 | Colgate Palmolive Co | Arginine salts and their uses for the treatment of illnesses in the oral cavity |
| RU2455001C2 (ru) * | 2008-02-08 | 2012-07-10 | Колгейт-Палмолив Компани | Композиции и способы лечения ксеростомии |
| US9376722B2 (en) * | 2008-02-08 | 2016-06-28 | Colgate-Palmolive Company | Oral care methods and systems |
| CN105380811A (zh) * | 2008-02-08 | 2016-03-09 | 高露洁-棕榄公司 | 擦齿巾 |
| AU2009212333C1 (en) * | 2008-02-08 | 2012-07-19 | Colgate-Palmolive Company | Compositions and devices |
| CN107080702A (zh) * | 2008-02-08 | 2017-08-22 | 高露洁-棕榄公司 | 口腔护理产品及其使用和制备方法 |
| SG191691A1 (en) * | 2008-02-08 | 2013-07-31 | Colgate Palmolive Co | Dental floss |
| US10959967B2 (en) * | 2008-02-08 | 2021-03-30 | Colgate-Palmolive Company | Effervescent compositions |
| US20090202452A1 (en) * | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Oral care regimen |
| BRPI0906451B1 (pt) | 2008-02-08 | 2017-01-24 | Colgate Palmolive Co | método para produzir bicarbonato de arginina |
| AU2012211481B2 (en) * | 2008-02-08 | 2013-08-22 | Colgate-Palmolive Company | Arginine salts and their uses for the treatment of illnesses in the oral cavity |
| PA8774301A1 (es) * | 2008-02-08 | 2009-09-17 | Colgate Palmolive Co | Regimen de cuidado bucal |
| WO2009100279A2 (en) * | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Compositions comprising basic amino acid and soluble carbonate salt |
| AU2015215853B2 (en) * | 2008-02-08 | 2016-11-03 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| RU2481820C2 (ru) * | 2008-02-08 | 2013-05-20 | Колгейт-Палмолив Компани | Средство для ухода за полостью рта и способы его применения и изготовления |
| AU2013200182B2 (en) * | 2008-02-08 | 2015-05-21 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| MX2010005006A (es) * | 2008-02-08 | 2010-05-27 | Colgate Palmolive Co | Producto para el cuidado oral y metodos de uso y fabricacion del mismo. |
| WO2009100260A2 (en) * | 2008-02-08 | 2009-08-13 | Colgate-Palmolive Company | Compositions and methods comprising basic amino acid peptides and proteases |
| CN101938985A (zh) * | 2008-02-08 | 2011-01-05 | 高露洁-棕榄公司 | 组合物和装置 |
| AU2009212325B2 (en) | 2008-02-08 | 2012-11-08 | Colgate-Palmolive Company | Oral care product and methods of use and manufacture thereof |
| AR070356A1 (es) * | 2008-02-08 | 2010-03-31 | Colgate Palmolive Co | Producto para cuidado oral y metodos de uso del mismo |
| CA2711262C (en) * | 2008-02-08 | 2015-06-23 | Colgate-Palmolive Company | Dental composition comprising a basic amino acid for alleviating tooth sensitivity |
| JP5584629B2 (ja) * | 2008-02-08 | 2014-09-03 | コルゲート・パーモリブ・カンパニー | 二構成要素の口腔ケア製品 |
| RU2450554C1 (ru) * | 2008-02-08 | 2012-05-20 | Колгейт-Палмолив Компани | Напиток, включающий аргинин |
| RU2543656C2 (ru) * | 2008-02-08 | 2015-03-10 | Колгейт-Палмолив Компани | Продукт для ухода за полостью рта и способы его применения и производства |
| US20090005320A1 (en) * | 2008-09-02 | 2009-01-01 | Bruce Kneller | Compositions comprising amino acid bicarbonate and methods of use thereof |
| ES2560202T3 (es) * | 2008-11-25 | 2016-02-17 | The Procter & Gamble Company | Composiciones para el cuidado bucal con sílice fundida |
| MX2011011486A (es) | 2009-05-18 | 2011-11-18 | Colgate Palmolive Co | Composiciones orales que contienen compuestos de poliguandino y metodos de preparacion y uso de las mismas. |
| US8741268B2 (en) * | 2009-09-10 | 2014-06-03 | Preventive Technologies, Inc. | Dental prophylactic paste |
| TWI499430B (zh) | 2009-12-17 | 2015-09-11 | Colgate Palmolive Co | 抗侵蝕的牙膏組成物 |
| PH12012501234A1 (en) | 2009-12-18 | 2017-05-12 | Colgate Palmolive Co | Methods for production of arginine bicarbonate at low pressure |
| WO2011075422A1 (en) | 2009-12-18 | 2011-06-23 | Colgate-Palmolive Company | Methods for production of high concentration of arginine bicarbonate solution at high pressue |
| KR101843206B1 (ko) | 2009-12-29 | 2018-03-28 | 더블유.알. 그레이스 앤드 캄파니-콘. | 은폐 막을 형성하기 위한 조성물, 및 이의 제조 및 사용 방법 |
| EP3409324B1 (en) | 2010-01-29 | 2023-11-29 | Colgate-Palmolive Company | Oral care product for sensitive enamel care |
| US8658139B1 (en) | 2010-02-27 | 2014-02-25 | Squigle, Inc. | Prevention and treatment of oral diseases |
| DE102010003280A1 (de) | 2010-03-25 | 2011-02-03 | Henkel Ag & Co. Kgaa | Mund- und Zahnpflege- und -reinigungsmittel mit pflanzlichen Peptiden |
| MX2012013955A (es) | 2010-06-23 | 2013-01-24 | Colgate Palmolive Co | Composiciones terapeuticas bucales. |
| US9717929B2 (en) * | 2010-12-07 | 2017-08-01 | Colgate-Palmolive Company | Dentifrice compositions containing calcium silicate and a basic amino acid |
| US9107838B2 (en) | 2012-04-25 | 2015-08-18 | Therametrics Technologies, Inc. | Fluoride varnish |
| US12146130B2 (en) | 2012-09-04 | 2024-11-19 | Blue Planet Systems Corporation | Carbon sequestration methods and systems, and compositions produced thereby |
| WO2014039578A1 (en) | 2012-09-04 | 2014-03-13 | Blue Planet, Ltd. | Carbon sequestration methods and systems, and compositions produced thereby |
| HK1215162A1 (zh) | 2012-12-06 | 2016-08-19 | Colgate-Palmolive Company | 用於敏感性和牙齿疼痛的口用凝胶 |
| US20140370242A1 (en) | 2013-03-15 | 2014-12-18 | Blue Planet, Ltd. | Highly reflective microcrystalline/amorphous materials, and methods for making and using the same |
| GB2516702B (en) * | 2013-07-19 | 2015-09-02 | Basf Enzymes Llc | Colorimetric Phytic Acid Assay |
| ES2486441B1 (es) * | 2014-04-02 | 2015-06-11 | Universitat De Les Illes Balears | Preparaciones combinadas de acidificantes urinarios e inhibidores de la cristalización y su aplicación para el tratamiento o prevención de la litiasis renal fosfática o inducida por fosfato cálcico |
| AU2014414756B2 (en) | 2014-12-23 | 2018-04-26 | Colgate-Palmolive Company | Oral care compositions |
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| MX2022003754A (es) * | 2019-09-30 | 2022-05-02 | Procter & Gamble | Composiciones para el cuidado bucal que comprenden acido beta de lupulo y fluoruro. |
| WO2021062607A1 (en) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Oral care compositions comprising hops beta acid and amino acid |
| CA3190974A1 (en) | 2020-09-28 | 2022-03-31 | The Proctor & Gamble Company | Array of anticavity oral care compositions |
| BR112023002887A2 (pt) | 2020-09-28 | 2023-04-11 | Procter & Gamble | Composições aquosas que compreendem o complexo lúpulo-metal |
| BR112023002550A2 (pt) | 2020-09-28 | 2023-04-04 | Procter & Gamble | Composição para tratamento bucal compreendendo lúpulo e flavorizante |
| MX2023003550A (es) | 2020-09-28 | 2023-04-21 | Procter & Gamble | Composiciones para el cuidado bucal que comprenden flavonoides prenilados. |
| BR112023019585A2 (pt) | 2021-03-25 | 2024-02-06 | Procter & Gamble | Composições para tratamento bucal que compreendem lúpulo e adoçante |
| WO2022204717A1 (en) | 2021-03-25 | 2022-09-29 | The Procter & Gamble Company | Oral care compositions comprising hops |
| AU2022246246A1 (en) | 2021-03-25 | 2023-09-14 | The Procter & Gamble Company | Edible oral compositions comprising hops |
| CN115572309B (zh) * | 2022-09-20 | 2024-05-03 | 浙江工业大学 | 一种高效阻燃、抗熔滴的环境友好型阻燃剂 |
| AU2024308473A1 (en) | 2023-06-28 | 2025-11-27 | The Procter & Gamble Company | Oral care compositions comprising hops beta acids |
| WO2025006664A2 (en) | 2023-06-28 | 2025-01-02 | The Procter & Gamble Company | Oral care compositions comprising hops beta acids and tin |
| AU2023457960A1 (en) | 2023-06-28 | 2025-11-27 | The Procter & Gamble Company | Oral care compositions comprising hops beta acids |
| US20250120890A1 (en) | 2023-09-14 | 2025-04-17 | The Procter & Gamble Company | Oral Care Compositions Comprising Hops Beta Acids And Tin |
| WO2025080746A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| US20250120897A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| WO2025076709A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| WO2025080747A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| US20250120891A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
| US20250120893A1 (en) | 2023-10-11 | 2025-04-17 | The Procter & Gamble Company | Oral care compositions comprising dicarboxylic acid |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3943241A (en) * | 1971-08-30 | 1976-03-09 | General Mills, Inc. | Cariostatic composition |
| US3932608A (en) * | 1971-08-30 | 1976-01-13 | General Mills, Inc. | Food composition |
| US4064138A (en) * | 1975-11-12 | 1977-12-20 | General Mills, Inc. | Amino acid derivatives |
| ZA773318B (en) * | 1976-06-18 | 1978-04-26 | I Kleinberg | Means and method for improving natural defenses against caries |
| USRE31181E (en) * | 1976-06-18 | 1983-03-15 | Means and method for improving natural defenses against caries | |
| GB1573727A (en) * | 1978-05-19 | 1980-08-28 | Colgate Palmolive Co | Dentifrices |
| US4225579A (en) * | 1979-02-27 | 1980-09-30 | Israel Kleinberg | Means and method for improving defenses against caries |
| JPS5835965B2 (ja) * | 1979-07-31 | 1983-08-05 | ライオン株式会社 | 口腔用組成物 |
| US4367218A (en) * | 1979-09-06 | 1983-01-04 | Jacobson Jerry I | Anti-caries oral rinse |
| US4528181A (en) * | 1984-02-01 | 1985-07-09 | Colgate-Palmolive Company | Dentifrice containing dual sources of fluoride |
| JPS61233612A (ja) * | 1985-04-10 | 1986-10-17 | Kao Corp | チユ−インガム |
| US5370865A (en) * | 1992-05-15 | 1994-12-06 | Kao Corporation | Composition for use in oral cavity |
| CN1094309A (zh) * | 1993-04-27 | 1994-11-02 | 李颖 | 一种矿质吸收因子肽钙及其制剂的制备方法 |
-
1996
- 1996-03-05 US US08/611,206 patent/US5762911A/en not_active Expired - Lifetime
-
1997
- 1997-03-04 EP EP97917135A patent/EP0928184B1/en not_active Expired - Lifetime
- 1997-03-04 WO PCT/US1997/005273 patent/WO1997032565A1/en not_active Ceased
- 1997-03-04 CA CA002252071A patent/CA2252071C/en not_active Expired - Lifetime
- 1997-03-04 AT AT97917135T patent/ATE432685T1/de active
- 1997-03-04 BR BRPI9711797-8A patent/BR9711797B1/pt not_active IP Right Cessation
- 1997-03-04 DE DE69739440T patent/DE69739440D1/de not_active Expired - Lifetime
- 1997-03-04 JP JP53207497A patent/JP3980645B2/ja not_active Expired - Lifetime
- 1997-03-04 NZ NZ332172A patent/NZ332172A/xx not_active IP Right Cessation
- 1997-03-04 DK DK97917135T patent/DK0928184T3/da active
- 1997-03-04 CN CNB2005100727356A patent/CN1305530C/zh not_active Expired - Lifetime
- 1997-03-04 CN CNB971969965A patent/CN1206978C/zh not_active Expired - Lifetime
- 1997-03-04 ES ES97917135T patent/ES2328301T3/es not_active Expired - Lifetime
- 1997-03-04 PT PT97917135T patent/PT928184E/pt unknown
- 1997-03-04 AU AU25563/97A patent/AU719465B2/en not_active Expired
-
1998
- 1998-02-19 US US09/026,132 patent/US6217851B1/en not_active Expired - Lifetime
-
2006
- 2006-06-26 JP JP2006175656A patent/JP2006265268A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| BR9711797B1 (pt) | 2010-12-14 |
| ATE432685T1 (de) | 2009-06-15 |
| ES2328301T3 (es) | 2009-11-11 |
| CA2252071A1 (en) | 1997-09-12 |
| CN1305530C (zh) | 2007-03-21 |
| BR9711797A (pt) | 2000-01-18 |
| US6217851B1 (en) | 2001-04-17 |
| WO1997032565A1 (en) | 1997-09-12 |
| AU719465B2 (en) | 2000-05-11 |
| CN1701815A (zh) | 2005-11-30 |
| JP3980645B2 (ja) | 2007-09-26 |
| DE69739440D1 (de) | 2009-07-16 |
| PT928184E (pt) | 2009-09-09 |
| AU2556397A (en) | 1997-09-22 |
| NZ332172A (en) | 2000-11-24 |
| EP0928184A1 (en) | 1999-07-14 |
| CN1227483A (zh) | 1999-09-01 |
| JP2001504083A (ja) | 2001-03-27 |
| DK0928184T3 (da) | 2009-09-28 |
| EP0928184A4 (en) | 1999-10-20 |
| JP2006265268A (ja) | 2006-10-05 |
| US5762911A (en) | 1998-06-09 |
| CN1206978C (zh) | 2005-06-22 |
| EP0928184B1 (en) | 2009-06-03 |
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