CA2204478C - Analogues fluores de la vitamine d3 - Google Patents
Analogues fluores de la vitamine d3 Download PDFInfo
- Publication number
- CA2204478C CA2204478C CA002204478A CA2204478A CA2204478C CA 2204478 C CA2204478 C CA 2204478C CA 002204478 A CA002204478 A CA 002204478A CA 2204478 A CA2204478 A CA 2204478A CA 2204478 C CA2204478 C CA 2204478C
- Authority
- CA
- Canada
- Prior art keywords
- formula
- compound
- trifluoro
- hydroxy
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 C[C@@](C([C@@]1(C)CCC2)=CC[C@@]1C2=O)C#CC(C)(**)C(F)(F)F Chemical compound C[C@@](C([C@@]1(C)CCC2)=CC[C@@]1C2=O)C#CC(C)(**)C(F)(F)F 0.000 description 6
- KTVCEQMQNZDRNN-HDOQBGNKSA-N C[C@@H](C([C@@]1(C)CCC2)=CC[C@H]1/C2=C/C=C(/C[C@H](CC1)O)\C1=C)C#CC(C)(C(F)(F)F)O Chemical compound C[C@@H](C([C@@]1(C)CCC2)=CC[C@H]1/C2=C/C=C(/C[C@H](CC1)O)\C1=C)C#CC(C)(C(F)(F)F)O KTVCEQMQNZDRNN-HDOQBGNKSA-N 0.000 description 1
- FUCMCVQJTCSEFF-ZOYZDBQRSA-N C[C@H](CC#CC(C)C(F)(F)F)C([C@@]1(C)CCC2)=CC[C@H]1/C2=C/C=C(/C[C@H](C[C@@H]1F)O)\C1=C Chemical compound C[C@H](CC#CC(C)C(F)(F)F)C([C@@]1(C)CCC2)=CC[C@H]1/C2=C/C=C(/C[C@H](C[C@@H]1F)O)\C1=C FUCMCVQJTCSEFF-ZOYZDBQRSA-N 0.000 description 1
- KHPFWJJVYHYJAZ-ZOYZDBQRSA-N C[C@H](CC#CC(C)C(F)(F)F)C([C@@]1(C)CCC2)=CC[C@H]1/C2=C/C=C(/C[C@H](C[C@@H]1O)O)\C1=C Chemical compound C[C@H](CC#CC(C)C(F)(F)F)C([C@@]1(C)CCC2)=CC[C@H]1/C2=C/C=C(/C[C@H](C[C@@H]1O)O)\C1=C KHPFWJJVYHYJAZ-ZOYZDBQRSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Nutrition Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1818796P | 1996-05-23 | 1996-05-23 | |
| US60/018,187 | 1996-05-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2204478A1 CA2204478A1 (fr) | 1997-11-23 |
| CA2204478C true CA2204478C (fr) | 2006-11-21 |
Family
ID=21786696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002204478A Expired - Fee Related CA2204478C (fr) | 1996-05-23 | 1997-05-05 | Analogues fluores de la vitamine d3 |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US5888994A (fr) |
| EP (1) | EP0808831B1 (fr) |
| JP (1) | JP2858571B2 (fr) |
| KR (1) | KR100237523B1 (fr) |
| CN (1) | CN1081184C (fr) |
| AR (1) | AR007240A1 (fr) |
| AT (1) | ATE195514T1 (fr) |
| AU (1) | AU720098B2 (fr) |
| BR (1) | BR9703373A (fr) |
| CA (1) | CA2204478C (fr) |
| CO (1) | CO4840512A1 (fr) |
| CZ (1) | CZ157997A3 (fr) |
| DE (1) | DE69702812T2 (fr) |
| DK (1) | DK0808831T3 (fr) |
| ES (1) | ES2150719T3 (fr) |
| GR (1) | GR3034832T3 (fr) |
| HR (1) | HRP970274A2 (fr) |
| HU (1) | HUP9700927A3 (fr) |
| IL (1) | IL120842A0 (fr) |
| MA (1) | MA24345A1 (fr) |
| NO (1) | NO971934L (fr) |
| NZ (1) | NZ314838A (fr) |
| PL (1) | PL320131A1 (fr) |
| PT (1) | PT808831E (fr) |
| SG (1) | SG50831A1 (fr) |
| TR (1) | TR199700418A3 (fr) |
| TW (1) | TW374762B (fr) |
| UY (1) | UY24563A1 (fr) |
| YU (1) | YU19997A (fr) |
| ZA (1) | ZA974334B (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO971934L (no) * | 1996-05-23 | 1997-11-24 | Hoffmann La Roche | Flourinerte vitamin D3 -analoger |
| EP0981514B1 (fr) * | 1997-05-16 | 2006-04-05 | Woman & Infants Hospital | Composes de 3-epi-vitamine d2 et utilisations desdits composes |
| CA2289209C (fr) | 1997-05-16 | 2006-07-25 | Women & Infants Hospital | Composes de vitamine d3 a ether cyclique et composes de 1.alpha.(oh) 3-epi-vitamine d3, et utilisation desdits composes |
| AU1022999A (en) * | 1997-09-08 | 1999-03-29 | F. Hoffmann-La Roche Ag | 1,3-dihydroxy-20,20-dialkyl-vitamin d3 analogs |
| WO2000051554A2 (fr) * | 1999-03-05 | 2000-09-08 | Johns Hopkins University | Regulation de l'aspect de la peau et composition contenant un compose d'analogue de vitamine d3 fluore |
| US7148211B2 (en) * | 2002-09-18 | 2006-12-12 | Genzyme Corporation | Formulation for lipophilic agents |
| US20080293647A1 (en) | 2004-11-12 | 2008-11-27 | Luciano Adorini | Combined Use Of Vitamin D Derivatives And Anti-Proliferative Agents For Treating Bladder Cancer |
| HUE029572T2 (en) | 2006-02-03 | 2017-03-28 | Opko Renal Llc | Treatment of Vitamin D Insufficiency and Deficiency with 25-Hydroxy-D2 and 25-Hydroxy-D3 |
| US8329677B2 (en) | 2006-06-21 | 2012-12-11 | Cytochroma, Inc. | Method of treating and preventing secondary hyperparathyroidism |
| KR101495578B1 (ko) | 2007-04-25 | 2015-02-25 | 사이토크로마 인코포레이티드 | 비타민 ｄ 부족 및 결핍의 치료 방법 |
| EP3542792B1 (fr) | 2007-04-25 | 2023-06-28 | EirGen Pharma Ltd. | Libération contrôlée de 25-hydroxyvitamine d |
| LT2552484T (lt) | 2010-03-29 | 2020-04-27 | Opko Ireland Global Holdings, Ltd. | Būdai ir kompozicijos, skirti paratiroidų lygiams sumažinti |
| WO2012065050A1 (fr) | 2010-11-12 | 2012-05-18 | Wisconsin Alumni Research Foundation | Analogues 22-haloacétoxy-homoprégnacalciférol et leurs utilisations |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 ｄ 방출 제형 |
| CN114681468A (zh) | 2014-08-07 | 2022-07-01 | 欧普科爱尔兰环球控股有限公司 | 利用25-羟基维生素d的辅助疗法 |
| TW202214257A (zh) | 2016-03-28 | 2022-04-16 | 愛爾蘭商歐科愛爾蘭全球控股股份有限公司 | 維生素d治療之方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5039671A (en) * | 1984-12-19 | 1991-08-13 | Hoffmann-La Roche Inc. | Trifluorinated-1α,25S-dihydroxy vitamin D3 compounds |
| US5145846A (en) * | 1988-01-20 | 1992-09-08 | Hoffmann-La Roche Inc. | Vitamin D3 analogs |
| US4804502A (en) * | 1988-01-20 | 1989-02-14 | Hoffmann-La Roche Inc. | Vitamin D compounds |
| GB9007236D0 (en) * | 1990-03-30 | 1990-05-30 | Leo Pharm Prod Ltd | Chemical compounds |
| GB9017890D0 (en) * | 1990-08-15 | 1990-09-26 | Leo Pharm Prod Ltd | Chemical compounds i |
| US5206230A (en) * | 1991-06-05 | 1993-04-27 | Daikin Industries, Ltd. | Fluorine-containing vitamin D3 analogues and pharmaceutical composition containing the same |
| US5210237A (en) * | 1991-08-27 | 1993-05-11 | Daikin Industries, Ltd. | Vitamin d3 analogues |
| US5200536A (en) * | 1992-02-10 | 1993-04-06 | Daikin Industries Ltd. | Fluorine-containing vitamin D3 analogues |
| GB9206648D0 (en) * | 1992-03-26 | 1992-05-06 | Leo Pharm Prod Ltd | Chemical compounds |
| DE69304279T2 (de) * | 1992-05-20 | 1997-02-20 | Hoffmann La Roche | Fluorierte Analoge Vitamins D3 |
| CA2096105A1 (fr) * | 1992-10-07 | 1994-04-08 | Enrico Giuseppe Baggiolini (Deceased) | Analogues fluores de vitamine d3 |
| TW267161B (fr) * | 1992-11-20 | 1996-01-01 | Hoffmann La Roche | |
| US5428029A (en) * | 1993-11-24 | 1995-06-27 | Hoffmann-La Roche Inc. | Vitamin D3 fluorinated analogs |
| US5384314B1 (en) * | 1994-03-11 | 1997-08-05 | Hoffmann La Roche | 1alpha-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol |
| NO971934L (no) * | 1996-05-23 | 1997-11-24 | Hoffmann La Roche | Flourinerte vitamin D3 -analoger |
-
1997
- 1997-04-25 NO NO971934A patent/NO971934L/no unknown
- 1997-04-28 TW TW086105570A patent/TW374762B/zh active
- 1997-05-05 CA CA002204478A patent/CA2204478C/fr not_active Expired - Fee Related
- 1997-05-12 SG SG1997001491A patent/SG50831A1/en unknown
- 1997-05-14 EP EP97107848A patent/EP0808831B1/fr not_active Expired - Lifetime
- 1997-05-14 AT AT97107848T patent/ATE195514T1/de not_active IP Right Cessation
- 1997-05-14 DE DE69702812T patent/DE69702812T2/de not_active Expired - Fee Related
- 1997-05-14 ES ES97107848T patent/ES2150719T3/es not_active Expired - Lifetime
- 1997-05-14 DK DK97107848T patent/DK0808831T3/da active
- 1997-05-14 PT PT97107848T patent/PT808831E/pt unknown
- 1997-05-16 NZ NZ314838A patent/NZ314838A/en unknown
- 1997-05-16 IL IL12084297A patent/IL120842A0/xx unknown
- 1997-05-16 US US08/857,883 patent/US5888994A/en not_active Expired - Fee Related
- 1997-05-19 ZA ZA9704334A patent/ZA974334B/xx unknown
- 1997-05-20 JP JP9129238A patent/JP2858571B2/ja not_active Expired - Fee Related
- 1997-05-20 HR HR60/018,187A patent/HRP970274A2/xx not_active Application Discontinuation
- 1997-05-20 YU YU19997A patent/YU19997A/sh unknown
- 1997-05-21 CO CO97027698A patent/CO4840512A1/es unknown
- 1997-05-21 AR ARP970102157A patent/AR007240A1/es active IP Right Grant
- 1997-05-21 HU HU9700927A patent/HUP9700927A3/hu unknown
- 1997-05-21 MA MA24629A patent/MA24345A1/fr unknown
- 1997-05-22 UY UY24563A patent/UY24563A1/es not_active Application Discontinuation
- 1997-05-22 CZ CZ971579A patent/CZ157997A3/cs unknown
- 1997-05-22 KR KR1019970019921A patent/KR100237523B1/ko not_active IP Right Cessation
- 1997-05-22 AU AU23572/97A patent/AU720098B2/en not_active Ceased
- 1997-05-22 PL PL97320131A patent/PL320131A1/xx unknown
- 1997-05-23 CN CN97111050A patent/CN1081184C/zh not_active Expired - Fee Related
- 1997-05-23 BR BR9703373A patent/BR9703373A/pt not_active Application Discontinuation
- 1997-05-23 TR TR97/00418A patent/TR199700418A3/tr unknown
-
2000
- 2000-11-13 GR GR20000402519T patent/GR3034832T3/el not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |