CA2169719C - Pyrazolo[1,5-a]pyrimidine derivative - Google Patents

Pyrazolo[1,5-a]pyrimidine derivative Download PDF

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Publication number
CA2169719C
CA2169719C CA002169719A CA2169719A CA2169719C CA 2169719 C CA2169719 C CA 2169719C CA 002169719 A CA002169719 A CA 002169719A CA 2169719 A CA2169719 A CA 2169719A CA 2169719 C CA2169719 C CA 2169719C
Authority
CA
Canada
Prior art keywords
phenyl
halogen
hexane
pyrazolo
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002169719A
Other languages
English (en)
French (fr)
Other versions
CA2169719A1 (en
Inventor
Yasuo Shoji
Tsuneo Yasuda
Makoto Inoue
Takashi Okamura
Kinji Hashimoto
Masayuki Ohara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Otsuka Pharmaceutical Factory Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Factory Inc filed Critical Otsuka Pharmaceutical Factory Inc
Publication of CA2169719A1 publication Critical patent/CA2169719A1/en
Application granted granted Critical
Publication of CA2169719C publication Critical patent/CA2169719C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002169719A 1994-06-21 1995-06-05 Pyrazolo[1,5-a]pyrimidine derivative Expired - Fee Related CA2169719C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP13863594 1994-06-21
JP6/138635 1994-06-21
JP5399795 1995-03-14
JP7/53997 1995-03-14
PCT/JP1995/001104 WO1995035298A1 (en) 1994-06-21 1995-06-05 PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE

Publications (2)

Publication Number Publication Date
CA2169719A1 CA2169719A1 (en) 1995-12-28
CA2169719C true CA2169719C (en) 2002-04-16

Family

ID=26394734

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002169719A Expired - Fee Related CA2169719C (en) 1994-06-21 1995-06-05 Pyrazolo[1,5-a]pyrimidine derivative

Country Status (13)

Country Link
US (1) US5707997A (https=)
EP (1) EP0714898B1 (https=)
KR (1) KR100315837B1 (https=)
CN (1) CN1046730C (https=)
AT (1) ATE208776T1 (https=)
AU (1) AU680370B2 (https=)
CA (1) CA2169719C (https=)
DE (1) DE69523864T2 (https=)
DK (1) DK0714898T3 (https=)
ES (1) ES2164153T3 (https=)
PT (1) PT714898E (https=)
TW (1) TW307767B (https=)
WO (1) WO1995035298A1 (https=)

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US6664261B2 (en) 1996-02-07 2003-12-16 Neurocrine Biosciences, Inc. Pyrazolopyrimidines as CRF receptor antagonists
HU229024B1 (en) * 1996-07-24 2013-07-29 Bristol Myers Squibb Pharma Co Azolo-pyridimidines, pharmaceutical compositions containing the same and use thereof
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
US7094782B1 (en) 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
AU731838B2 (en) * 1997-03-14 2001-04-05 Otsuka Pharmaceutical Co., Ltd. Novel pyrimidine derivative
WO2000044754A1 (en) * 1999-01-29 2000-08-03 Sumitomo Chemical Company, Limited Fat accumulation inhibitory agents
AU4203500A (en) 1999-04-06 2000-10-23 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
AU4331500A (en) 1999-04-06 2000-10-23 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
US20020061897A1 (en) 2000-03-30 2002-05-23 Elliott Richard L. Neuropeptide Y antagonists
US6630476B2 (en) 2000-07-07 2003-10-07 Bristol-Myers Squibb Pharma Company Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
CA2465326C (en) * 2001-11-01 2011-03-29 Icagen, Inc. Pyrazolopyrimidines for decreasing ion flow through a voltage-dependent sodium channel
US20040028716A1 (en) * 2002-06-14 2004-02-12 Marks Andrew R. Use of Y-27632 as an agent to prevent restenosis after coronary artery angioplasty/stent implantation
CA2497539A1 (en) 2002-09-04 2004-03-18 Schering Corporation Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
DE60313872T2 (de) 2002-09-04 2008-01-17 Schering Corp. Pyrazoloä1,5-aüpyrimidine als hemmstoffe cyclin-abhängiger kinasen
ES2285164T3 (es) 2002-09-04 2007-11-16 Schering Corporation Pirazolopirimidinas como inhibidores de quinasas dependientes de ciclina.
US8580782B2 (en) 2002-09-04 2013-11-12 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
US8673924B2 (en) 2002-09-04 2014-03-18 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors
US7205308B2 (en) * 2002-09-04 2007-04-17 Schering Corporation Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors
US7161003B1 (en) 2002-09-04 2007-01-09 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
MY141978A (en) 2002-09-04 2010-08-16 Schering Corp Pyrazolopyrimidines as cyclin dependent kinase inhibitors
PL224879B1 (pl) 2002-09-04 2017-02-28 Pharmacopeia Drug Discovery Inc Pirazolo [1,5-a] pirymidynowy związek, jego zastosowanie do wytwarzania leku oraz zawierająca go farmaceutyczna kompozycja
US7196078B2 (en) 2002-09-04 2007-03-27 Schering Corpoartion Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
US7119200B2 (en) * 2002-09-04 2006-10-10 Schering Corporation Pyrazolopyrimidines as cyclin dependent kinase inhibitors
US6949895B2 (en) * 2003-09-03 2005-09-27 Axcelis Technologies, Inc. Unipolar electrostatic quadrupole lens and switching methods for charged beam transport
AR049769A1 (es) * 2004-01-22 2006-09-06 Novartis Ag Derivados de pirazolo(1,5-a)pirimidin 7-il-amina para utilizarse en el tratamiento de enfermedades dependientes de la quinasa de proteina
WO2006040645A1 (en) * 2004-10-11 2006-04-20 Ranbaxy Laboratories Limited N-(3,5-dichloropyridin-4-yl)-2,4,5-alkoxy and 2,3,4-alkoxy benzamide derivatives as pde-iv (phophodiesterase type-iv) inhibitors for the treatment of inflammatory diseases such as asthma
GB0519957D0 (en) 2005-09-30 2005-11-09 Sb Pharmco Inc Chemical compound
TW200639163A (en) 2005-02-04 2006-11-16 Genentech Inc RAF inhibitor compounds and methods
US20080171657A1 (en) * 2005-03-01 2008-07-17 Basf Aktiengesellschaft 5,6-Dialkyl-7-Aminoazolopyrimidines, Their Preparation and Their Use for Controlling Harmful Fungi, and Compositions Comprising These Compounds
WO2006092428A2 (de) * 2005-03-02 2006-09-08 Basf Aktiengesellschaft 2-substituierte 7-amino-azolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel
KR101346902B1 (ko) 2005-07-09 2014-01-02 아스트라제네카 아베 당뇨병 치료에 있어 ｇｌｋ 활성화제로서 사용하기 위한헤테로아릴 벤즈아미드 유도체
JP2009507843A (ja) * 2005-09-09 2009-02-26 シェーリング コーポレイション アザ縮合サイクリン依存性キナーゼ阻害剤
JP5052518B2 (ja) 2005-10-06 2012-10-17 シェーリング コーポレイション プロテインキナーゼインヒビターとしてのピラゾロピリミジン
EP2591675A1 (en) * 2006-11-27 2013-05-15 H. Lundbeck A/S Heteroaryl amide derivatives
WO2008124153A1 (en) * 2007-04-10 2008-10-16 H. Lundbeck A/S Heteroaryl amide analogues as p2x7 antagonists
AR076221A1 (es) 2009-04-09 2011-05-26 Astrazeneca Ab Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad
RU2014120180A (ru) * 2011-10-20 2015-11-27 ГЛЭКСОСМИТКЛАЙН ЭлЭлСи Замещенные бициклические аза-гетероциклы и аналоги в качестве модуляторов сиртуина
JP6073343B2 (ja) 2011-10-20 2017-02-01 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ サーチュイン調節因子としての置換された二環式アザ複素環およびアナログ
AR085073A1 (es) * 2012-01-11 2013-09-11 Richmond Sa Com Ind Y Financiera Lab Compuestos con actividad antibacteriana, un procedimiento para su obtencion y composiciones farmaceuticas que los comprenden
JP2017503772A (ja) * 2013-12-23 2017-02-02 ノージン ビーブイ Ｃｃｒ９阻害剤としてのベンゼンスルホンアミド
WO2015097121A1 (en) 2013-12-23 2015-07-02 Norgine B.V. Compounds useful as ccr9 modulators
WO2015143652A1 (en) * 2014-03-26 2015-10-01 Merck Sharp & Dohme Corp. TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF
US11155560B2 (en) 2018-10-30 2021-10-26 Kronos Bio, Inc. Substituted pyrazolo[1,5-a]pyrimidines for modulating CDK9 activity
CN119661538B (zh) * 2024-11-06 2025-10-17 中国科学院精密测量科学与技术创新研究院 一种吡唑并[3,4-d]嘧啶-4-酮类衍生物及其应用

Family Cites Families (8)

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Publication number Priority date Publication date Assignee Title
US3925385A (en) * 1972-04-20 1975-12-09 Icn Pharmaceuticals 6-Carbethoxy-3,7-disubstitutedpyrazolo{8 1,5a{9 pyrimidines
BE792533A (fr) * 1971-12-09 1973-06-08 Int Chem & Nuclear Corp Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation
JPS6157587A (ja) * 1984-08-29 1986-03-24 Shionogi & Co Ltd 縮合複素環誘導体および抗潰瘍剤
US4950585A (en) * 1987-08-18 1990-08-21 Konica Corporation Coupler for photographic use
JP2585462B2 (ja) * 1989-10-25 1997-02-26 株式会社大塚製薬工場 ピラゾロ［１，５―ａ］ピリミジン誘導体
AU651986B2 (en) * 1991-04-22 1994-08-11 Otsuka Pharmaceutical Factory, Inc. Pyrazolo{1,5-a}pyrimidine derivative and anti-inflammatory containing the same
KR0133372B1 (ko) * 1991-09-06 1998-04-23 고야 다다시 4-아미노(알킬)시클로헥산-1-카르복사미드 화합물 및 그 용도
US5571813A (en) * 1993-06-10 1996-11-05 Beiersdorf-Lilly Gmbh Fused pyrimidine compounds and their use as pharmaceuticals

Also Published As

Publication number Publication date
DE69523864D1 (de) 2001-12-20
US5707997A (en) 1998-01-13
KR100315837B1 (ko) 2002-02-28
ATE208776T1 (de) 2001-11-15
EP0714898A1 (en) 1996-06-05
AU2576595A (en) 1996-01-15
KR960703919A (ko) 1996-08-31
AU680370B2 (en) 1997-07-24
TW307767B (https=) 1997-06-11
PT714898E (pt) 2002-04-29
DK0714898T3 (da) 2002-03-18
EP0714898B1 (en) 2001-11-14
WO1995035298A1 (en) 1995-12-28
CA2169719A1 (en) 1995-12-28
DE69523864T2 (de) 2002-06-13
CN1131948A (zh) 1996-09-25
EP0714898A4 (en) 1997-04-02
CN1046730C (zh) 1999-11-24
ES2164153T3 (es) 2002-02-16

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