ATE208776T1 - Pyrazolo(1,5-a) pyrimidin-derivate - Google Patents
Pyrazolo(1,5-a) pyrimidin-derivateInfo
- Publication number
- ATE208776T1 ATE208776T1 AT95920260T AT95920260T ATE208776T1 AT E208776 T1 ATE208776 T1 AT E208776T1 AT 95920260 T AT95920260 T AT 95920260T AT 95920260 T AT95920260 T AT 95920260T AT E208776 T1 ATE208776 T1 AT E208776T1
- Authority
- AT
- Austria
- Prior art keywords
- halogen
- alkyl
- phenyl
- substituted
- hydrogen
- Prior art date
Links
- LDIJKUBTLZTFRG-UHFFFAOYSA-N pyrazolo[1,5-a]pyrimidine Chemical class N1=CC=CN2N=CC=C21 LDIJKUBTLZTFRG-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000001544 thienyl group Chemical group 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000002541 furyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000000951 phenoxy group Chemical class [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- -1 phenylthio-substituted phenyl Chemical group 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000004076 pyridyl group Chemical class 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13863594 | 1994-06-21 | ||
| JP5399795 | 1995-03-14 | ||
| PCT/JP1995/001104 WO1995035298A1 (en) | 1994-06-21 | 1995-06-05 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE208776T1 true ATE208776T1 (de) | 2001-11-15 |
Family
ID=26394734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95920260T ATE208776T1 (de) | 1994-06-21 | 1995-06-05 | Pyrazolo(1,5-a) pyrimidin-derivate |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5707997A (https=) |
| EP (1) | EP0714898B1 (https=) |
| KR (1) | KR100315837B1 (https=) |
| CN (1) | CN1046730C (https=) |
| AT (1) | ATE208776T1 (https=) |
| AU (1) | AU680370B2 (https=) |
| CA (1) | CA2169719C (https=) |
| DE (1) | DE69523864T2 (https=) |
| DK (1) | DK0714898T3 (https=) |
| ES (1) | ES2164153T3 (https=) |
| PT (1) | PT714898E (https=) |
| TW (1) | TW307767B (https=) |
| WO (1) | WO1995035298A1 (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843951A (en) * | 1995-09-28 | 1998-12-01 | Otsuka Pharmaceutical Factory Inc. | Analgesic composition of pyrazolo(1,5-A) pyrimidines |
| US6664261B2 (en) | 1996-02-07 | 2003-12-16 | Neurocrine Biosciences, Inc. | Pyrazolopyrimidines as CRF receptor antagonists |
| HU229024B1 (en) * | 1996-07-24 | 2013-07-29 | Bristol Myers Squibb Pharma Co | Azolo-pyridimidines, pharmaceutical compositions containing the same and use thereof |
| US6191131B1 (en) | 1997-07-23 | 2001-02-20 | Dupont Pharmaceuticals Company | Azolo triazines and pyrimidines |
| US6060478A (en) * | 1996-07-24 | 2000-05-09 | Dupont Pharmaceuticals | Azolo triazines and pyrimidines |
| US6313124B1 (en) | 1997-07-23 | 2001-11-06 | Dupont Pharmaceuticals Company | Tetrazine bicyclic compounds |
| US7094782B1 (en) | 1996-07-24 | 2006-08-22 | Bristol-Myers Squibb Company | Azolo triazines and pyrimidines |
| US6124289A (en) * | 1996-07-24 | 2000-09-26 | Dupont Pharmaceuticals Co. | Azolo triazines and pyrimidines |
| AU731838B2 (en) * | 1997-03-14 | 2001-04-05 | Otsuka Pharmaceutical Co., Ltd. | Novel pyrimidine derivative |
| WO2000044754A1 (en) * | 1999-01-29 | 2000-08-03 | Sumitomo Chemical Company, Limited | Fat accumulation inhibitory agents |
| AU4203500A (en) | 1999-04-06 | 2000-10-23 | Du Pont Pharmaceuticals Company | Pyrazolopyrimidines as crf antagonists |
| AU4331500A (en) | 1999-04-06 | 2000-10-23 | Du Pont Pharmaceuticals Company | Pyrazolotriazines as crf antagonists |
| US20020061897A1 (en) | 2000-03-30 | 2002-05-23 | Elliott Richard L. | Neuropeptide Y antagonists |
| US6630476B2 (en) | 2000-07-07 | 2003-10-07 | Bristol-Myers Squibb Pharma Company | Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists |
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| CA2465326C (en) * | 2001-11-01 | 2011-03-29 | Icagen, Inc. | Pyrazolopyrimidines for decreasing ion flow through a voltage-dependent sodium channel |
| US20040028716A1 (en) * | 2002-06-14 | 2004-02-12 | Marks Andrew R. | Use of Y-27632 as an agent to prevent restenosis after coronary artery angioplasty/stent implantation |
| CA2497539A1 (en) | 2002-09-04 | 2004-03-18 | Schering Corporation | Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| DE60313872T2 (de) | 2002-09-04 | 2008-01-17 | Schering Corp. | Pyrazoloä1,5-aüpyrimidine als hemmstoffe cyclin-abhängiger kinasen |
| ES2285164T3 (es) | 2002-09-04 | 2007-11-16 | Schering Corporation | Pirazolopirimidinas como inhibidores de quinasas dependientes de ciclina. |
| US8580782B2 (en) | 2002-09-04 | 2013-11-12 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
| US8673924B2 (en) | 2002-09-04 | 2014-03-18 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors |
| US7205308B2 (en) * | 2002-09-04 | 2007-04-17 | Schering Corporation | Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US7161003B1 (en) | 2002-09-04 | 2007-01-09 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| MY141978A (en) | 2002-09-04 | 2010-08-16 | Schering Corp | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| PL224879B1 (pl) | 2002-09-04 | 2017-02-28 | Pharmacopeia Drug Discovery Inc | Pirazolo [1,5-a] pirymidynowy związek, jego zastosowanie do wytwarzania leku oraz zawierająca go farmaceutyczna kompozycja |
| US7196078B2 (en) | 2002-09-04 | 2007-03-27 | Schering Corpoartion | Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US7119200B2 (en) * | 2002-09-04 | 2006-10-10 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US6949895B2 (en) * | 2003-09-03 | 2005-09-27 | Axcelis Technologies, Inc. | Unipolar electrostatic quadrupole lens and switching methods for charged beam transport |
| AR049769A1 (es) * | 2004-01-22 | 2006-09-06 | Novartis Ag | Derivados de pirazolo(1,5-a)pirimidin 7-il-amina para utilizarse en el tratamiento de enfermedades dependientes de la quinasa de proteina |
| WO2006040645A1 (en) * | 2004-10-11 | 2006-04-20 | Ranbaxy Laboratories Limited | N-(3,5-dichloropyridin-4-yl)-2,4,5-alkoxy and 2,3,4-alkoxy benzamide derivatives as pde-iv (phophodiesterase type-iv) inhibitors for the treatment of inflammatory diseases such as asthma |
| GB0519957D0 (en) | 2005-09-30 | 2005-11-09 | Sb Pharmco Inc | Chemical compound |
| TW200639163A (en) | 2005-02-04 | 2006-11-16 | Genentech Inc | RAF inhibitor compounds and methods |
| US20080171657A1 (en) * | 2005-03-01 | 2008-07-17 | Basf Aktiengesellschaft | 5,6-Dialkyl-7-Aminoazolopyrimidines, Their Preparation and Their Use for Controlling Harmful Fungi, and Compositions Comprising These Compounds |
| WO2006092428A2 (de) * | 2005-03-02 | 2006-09-08 | Basf Aktiengesellschaft | 2-substituierte 7-amino-azolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel |
| KR101346902B1 (ko) | 2005-07-09 | 2014-01-02 | 아스트라제네카 아베 | 당뇨병 치료에 있어 ｇｌｋ 활성화제로서 사용하기 위한헤테로아릴 벤즈아미드 유도체 |
| JP2009507843A (ja) * | 2005-09-09 | 2009-02-26 | シェーリング コーポレイション | アザ縮合サイクリン依存性キナーゼ阻害剤 |
| JP5052518B2 (ja) | 2005-10-06 | 2012-10-17 | シェーリング コーポレイション | プロテインキナーゼインヒビターとしてのピラゾロピリミジン |
| EP2591675A1 (en) * | 2006-11-27 | 2013-05-15 | H. Lundbeck A/S | Heteroaryl amide derivatives |
| WO2008124153A1 (en) * | 2007-04-10 | 2008-10-16 | H. Lundbeck A/S | Heteroaryl amide analogues as p2x7 antagonists |
| AR076221A1 (es) | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad |
| RU2014120180A (ru) * | 2011-10-20 | 2015-11-27 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Замещенные бициклические аза-гетероциклы и аналоги в качестве модуляторов сиртуина |
| JP6073343B2 (ja) | 2011-10-20 | 2017-02-01 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ | サーチュイン調節因子としての置換された二環式アザ複素環およびアナログ |
| AR085073A1 (es) * | 2012-01-11 | 2013-09-11 | Richmond Sa Com Ind Y Financiera Lab | Compuestos con actividad antibacteriana, un procedimiento para su obtencion y composiciones farmaceuticas que los comprenden |
| JP2017503772A (ja) * | 2013-12-23 | 2017-02-02 | ノージン ビーブイ | Ｃｃｒ９阻害剤としてのベンゼンスルホンアミド |
| WO2015097121A1 (en) | 2013-12-23 | 2015-07-02 | Norgine B.V. | Compounds useful as ccr9 modulators |
| WO2015143652A1 (en) * | 2014-03-26 | 2015-10-01 | Merck Sharp & Dohme Corp. | TrkA KINASE INHIBITORS,COMPOSITIONS AND METHODS THEREOF |
| US11155560B2 (en) | 2018-10-30 | 2021-10-26 | Kronos Bio, Inc. | Substituted pyrazolo[1,5-a]pyrimidines for modulating CDK9 activity |
| CN119661538B (zh) * | 2024-11-06 | 2025-10-17 | 中国科学院精密测量科学与技术创新研究院 | 一种吡唑并[3,4-d]嘧啶-4-酮类衍生物及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3925385A (en) * | 1972-04-20 | 1975-12-09 | Icn Pharmaceuticals | 6-Carbethoxy-3,7-disubstitutedpyrazolo{8 1,5a{9 pyrimidines |
| BE792533A (fr) * | 1971-12-09 | 1973-06-08 | Int Chem & Nuclear Corp | Nouvelles pyrazolo (1,5a) pyrimidines et leur procede de preparation |
| JPS6157587A (ja) * | 1984-08-29 | 1986-03-24 | Shionogi & Co Ltd | 縮合複素環誘導体および抗潰瘍剤 |
| US4950585A (en) * | 1987-08-18 | 1990-08-21 | Konica Corporation | Coupler for photographic use |
| JP2585462B2 (ja) * | 1989-10-25 | 1997-02-26 | 株式会社大塚製薬工場 | ピラゾロ［１，５―ａ］ピリミジン誘導体 |
| AU651986B2 (en) * | 1991-04-22 | 1994-08-11 | Otsuka Pharmaceutical Factory, Inc. | Pyrazolo{1,5-a}pyrimidine derivative and anti-inflammatory containing the same |
| KR0133372B1 (ko) * | 1991-09-06 | 1998-04-23 | 고야 다다시 | 4-아미노(알킬)시클로헥산-1-카르복사미드 화합물 및 그 용도 |
| US5571813A (en) * | 1993-06-10 | 1996-11-05 | Beiersdorf-Lilly Gmbh | Fused pyrimidine compounds and their use as pharmaceuticals |
-
1995
- 1995-06-05 WO PCT/JP1995/001104 patent/WO1995035298A1/ja not_active Ceased
- 1995-06-05 ES ES95920260T patent/ES2164153T3/es not_active Expired - Lifetime
- 1995-06-05 PT PT95920260T patent/PT714898E/pt unknown
- 1995-06-05 US US08/602,824 patent/US5707997A/en not_active Expired - Lifetime
- 1995-06-05 AU AU25765/95A patent/AU680370B2/en not_active Ceased
- 1995-06-05 DK DK95920260T patent/DK0714898T3/da active
- 1995-06-05 DE DE69523864T patent/DE69523864T2/de not_active Expired - Fee Related
- 1995-06-05 CA CA002169719A patent/CA2169719C/en not_active Expired - Fee Related
- 1995-06-05 KR KR1019960700854A patent/KR100315837B1/ko not_active Expired - Fee Related
- 1995-06-05 AT AT95920260T patent/ATE208776T1/de not_active IP Right Cessation
- 1995-06-05 CN CN95190760A patent/CN1046730C/zh not_active Expired - Fee Related
- 1995-06-05 EP EP95920260A patent/EP0714898B1/en not_active Expired - Lifetime
- 1995-06-16 TW TW084106201A patent/TW307767B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| DE69523864D1 (de) | 2001-12-20 |
| US5707997A (en) | 1998-01-13 |
| KR100315837B1 (ko) | 2002-02-28 |
| CA2169719C (en) | 2002-04-16 |
| EP0714898A1 (en) | 1996-06-05 |
| AU2576595A (en) | 1996-01-15 |
| KR960703919A (ko) | 1996-08-31 |
| AU680370B2 (en) | 1997-07-24 |
| TW307767B (https=) | 1997-06-11 |
| PT714898E (pt) | 2002-04-29 |
| DK0714898T3 (da) | 2002-03-18 |
| EP0714898B1 (en) | 2001-11-14 |
| WO1995035298A1 (en) | 1995-12-28 |
| CA2169719A1 (en) | 1995-12-28 |
| DE69523864T2 (de) | 2002-06-13 |
| CN1131948A (zh) | 1996-09-25 |
| EP0714898A4 (en) | 1997-04-02 |
| CN1046730C (zh) | 1999-11-24 |
| ES2164153T3 (es) | 2002-02-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE208776T1 (de) | Pyrazolo(1,5-a) pyrimidin-derivate | |
| EP0955293A4 (en) | NEW UREA DERIVATIVES | |
| EP0945452A4 (en) | SUGAR COMPOSITIONS, GELLING AGENTS, GELLING AGENT COMPOSITIONS, METHODS OF PREPARING SAME, AND GEL COMPOSITIONS | |
| FI906204A0 (fi) | Menetelmä farmaseuttisesti vaikuttavien peptidiyhdisteiden valmistamiseksi | |
| EP0731106A4 (en) | Novel peptide derivative | |
| LV10608A (lv) | N-acetonilbenzamidi un to pielietojums par fungicidiem | |
| DE3851073D1 (de) | Herbizide substituierte cyclische Dione. | |
| EP0365364A3 (en) | 2-azetidinone derivatives | |
| BR9608040A (pt) | Composto pentacíclico | |
| ES2063300T3 (es) | Derivado de acido aminobencensulfonico. | |
| NO901926D0 (no) | Arylimidazoler med pesticid virkning, deres fremstilling og anvendelse. | |
| MY141488A (en) | Hydroximic acid derivatives, processes for their preparation, and compositions comprising them | |
| NO971384D0 (no) | Pyrimidinylpyrazol-derivat | |
| EP1431299A4 (en) | IMIDAZO (1,2-a) PYRIMIDINE AND FUNGICIDE COMPOSITIONS THEREOF | |
| ES2169220T3 (es) | Derivados de vitamina d3 con sustituyentes en la posicion 2. | |
| ATE383860T1 (de) | Chinazolinderivate und -arzneimittel | |
| AU5387990A (en) | Thiazole derivatives | |
| EP0335979A4 (en) | Thienopyrimidine derivatives | |
| PT852226E (pt) | Derivados de pirimidina | |
| AU5034690A (en) | Carboxylimino benzothiazole derivatives | |
| DE69614102D1 (de) | Pyrazol[1,5-a]pyrimidin derivate | |
| WO1996022286A3 (en) | Arthropodicidal oxazines and thiazines | |
| AU2661800A (en) | Azadioxacycloalkenes and their use for combating harmful fungi and animal pests |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |