CA2118121C - Methods and compositions for the treatment of diseases with interferon while reducing side effects - Google Patents
Methods and compositions for the treatment of diseases with interferon while reducing side effects Download PDFInfo
- Publication number
- CA2118121C CA2118121C CA002118121A CA2118121A CA2118121C CA 2118121 C CA2118121 C CA 2118121C CA 002118121 A CA002118121 A CA 002118121A CA 2118121 A CA2118121 A CA 2118121A CA 2118121 C CA2118121 C CA 2118121C
- Authority
- CA
- Canada
- Prior art keywords
- hepatitis
- use according
- human leukocyte
- effective amount
- therapeutically effective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000006992 Interferon-alpha Human genes 0.000 claims abstract 19
- 108010047761 Interferon-alpha Proteins 0.000 claims abstract 19
- 201000010099 disease Diseases 0.000 claims 14
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 14
- 231100000419 toxicity Toxicity 0.000 claims 14
- 230000001988 toxicity Effects 0.000 claims 14
- 230000003612 virological effect Effects 0.000 claims 14
- 208000005176 Hepatitis C Diseases 0.000 claims 8
- 208000005331 Hepatitis D Diseases 0.000 claims 8
- 208000037262 Hepatitis delta Diseases 0.000 claims 8
- 208000005252 hepatitis A Diseases 0.000 claims 8
- 208000002672 hepatitis B Diseases 0.000 claims 8
- 208000029570 hepatitis D virus infection Diseases 0.000 claims 8
- 230000008520 organization Effects 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 4
- 108091029865 Exogenous DNA Proteins 0.000 claims 2
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims 2
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims 2
- 206010019233 Headaches Diseases 0.000 claims 2
- 206010028813 Nausea Diseases 0.000 claims 2
- 206010037660 Pyrexia Diseases 0.000 claims 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 2
- 208000022531 anorexia Diseases 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 229940127089 cytotoxic agent Drugs 0.000 claims 2
- 206010061428 decreased appetite Diseases 0.000 claims 2
- 231100000869 headache Toxicity 0.000 claims 2
- 206010022437 insomnia Diseases 0.000 claims 2
- 238000007918 intramuscular administration Methods 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 230000008693 nausea Effects 0.000 claims 2
- 230000009465 prokaryotic expression Effects 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 238000000034 method Methods 0.000 abstract description 2
- 102000014150 Interferons Human genes 0.000 abstract 1
- 108010050904 Interferons Proteins 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 208000035269 cancer or benign tumor Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229940079322 interferon Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/868,916 US5372808A (en) | 1990-10-17 | 1992-04-15 | Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect |
| US07/868,916 | 1992-04-15 | ||
| PCT/US1993/004471 WO1993021229A1 (en) | 1992-04-15 | 1993-04-14 | Methods and compositions for the treatment of diseases with interferon while reducing side effects |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2118121A1 CA2118121A1 (en) | 1993-10-28 |
| CA2118121C true CA2118121C (en) | 2005-08-02 |
Family
ID=25352556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002118121A Expired - Lifetime CA2118121C (en) | 1992-04-15 | 1993-04-14 | Methods and compositions for the treatment of diseases with interferon while reducing side effects |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5372808A (OSRAM) |
| EP (3) | EP0641359A4 (OSRAM) |
| JP (2) | JPH07505894A (OSRAM) |
| KR (1) | KR950701350A (OSRAM) |
| CN (1) | CN1098103C (OSRAM) |
| AT (1) | ATE254926T1 (OSRAM) |
| AU (1) | AU683214B2 (OSRAM) |
| CA (1) | CA2118121C (OSRAM) |
| CZ (1) | CZ247194A3 (OSRAM) |
| DE (1) | DE69333321T3 (OSRAM) |
| DK (1) | DK0911033T4 (OSRAM) |
| ES (1) | ES2210864T5 (OSRAM) |
| HU (1) | HU227310B1 (OSRAM) |
| IL (1) | IL105366A (OSRAM) |
| MX (1) | MX9302160A (OSRAM) |
| NO (1) | NO318643B1 (OSRAM) |
| NZ (1) | NZ252871A (OSRAM) |
| PT (1) | PT911033E (OSRAM) |
| RO (1) | RO115700B1 (OSRAM) |
| RU (1) | RU2128056C1 (OSRAM) |
| SG (1) | SG52443A1 (OSRAM) |
| SK (1) | SK284712B6 (OSRAM) |
| TW (1) | TW265265B (OSRAM) |
| UA (1) | UA44223C2 (OSRAM) |
| WO (1) | WO1993021229A1 (OSRAM) |
| ZA (1) | ZA932641B (OSRAM) |
Families Citing this family (111)
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|---|---|---|---|---|
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| US5906816A (en) * | 1995-03-16 | 1999-05-25 | University Of Florida | Method for treatment of autoimmune diseases |
| US6372206B1 (en) * | 1989-03-02 | 2002-04-16 | University Of Florida | Orally-administered interferon-TAU compositions and methods |
| US5372808A (en) † | 1990-10-17 | 1994-12-13 | Amgen Inc. | Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect |
| US5676942A (en) * | 1992-02-10 | 1997-10-14 | Interferon Sciences, Inc. | Composition containing human alpha interferon species proteins and method for use thereof |
| KR100223255B1 (ko) * | 1992-02-10 | 1999-10-15 | 더글라스 테스타 | 개량된 알파 인터페론 조성물 및 인간 말초혈 백혈구로 부터의 제조 방법 |
| US5789551A (en) * | 1993-06-11 | 1998-08-04 | Pestka Biomedical Laboratories, Inc. | Human leukocyte interferon Hu-IFN-α001 |
| US6001589A (en) * | 1993-06-11 | 1999-12-14 | Pbl Biomedical Laboratories, Inc. | Method of identifying proteins modified by disease states related thereto |
| WO1995015177A2 (en) * | 1993-12-02 | 1995-06-08 | President And Fellows Of Harvard College | Improved efficacy of alpha-helical cytokines |
| WO1995021629A1 (en) * | 1994-02-08 | 1995-08-17 | Amgen Inc. | Oral delivery of chemically modified proteins |
| US20030053982A1 (en) * | 1994-09-26 | 2003-03-20 | Kinstler Olaf B. | N-terminally chemically modified protein compositions and methods |
| US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| IL116730A0 (en) * | 1995-01-13 | 1996-05-14 | Amgen Inc | Chemically modified interferon |
| JP3104257B2 (ja) * | 1995-08-30 | 2000-10-30 | 東レ株式会社 | 心疾患治療剤 |
| US5908621A (en) * | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| EP0858343B1 (en) | 1995-11-02 | 2004-03-31 | Schering Corporation | Continuous low-dose cytokine infusion therapy |
| US5739313A (en) * | 1995-11-13 | 1998-04-14 | Regents Of The University Of Minnesota | Radionuclide labeling of vitamin B12 and coenzymes thereof |
| US20030026779A1 (en) * | 1999-10-15 | 2003-02-06 | Liming Yu | Treatment of tumors and viral infections with a hybrid conjugate of interferon and an immunoglobulin Fc |
| US5980884A (en) * | 1996-02-05 | 1999-11-09 | Amgen, Inc. | Methods for retreatment of patients afflicted with Hepatitis C using consensus interferon |
| US5831062A (en) * | 1996-05-09 | 1998-11-03 | Amgen Inc. | Use of the human interferon consensus gene for gene therapy |
| AUPN976596A0 (en) * | 1996-05-09 | 1996-05-30 | Pharma Pacific Pty Ltd | Stimulation of host defence mechanisms |
| WO1997041884A1 (en) | 1996-05-09 | 1997-11-13 | Pharma Pacific Pty. Ltd. | Method of treatment |
| US20030190307A1 (en) * | 1996-12-24 | 2003-10-09 | Biogen, Inc. | Stable liquid interferon formulations |
| US6017876A (en) | 1997-08-15 | 2000-01-25 | Amgen Inc. | Chemical modification of granulocyte-colony stimulating factor (G-CSF) bioactivity |
| US6013253A (en) * | 1997-08-15 | 2000-01-11 | Amgen, Inc. | Treatment of multiple sclerosis using consensus interferon and IL-1 receptor antagonist |
| US6541033B1 (en) | 1998-06-30 | 2003-04-01 | Amgen Inc. | Thermosensitive biodegradable hydrogels for sustained delivery of leptin |
| US6432398B1 (en) * | 1998-09-29 | 2002-08-13 | W. Robert Fleischmann | Methods of treating diseased cells |
| US6420339B1 (en) | 1998-10-14 | 2002-07-16 | Amgen Inc. | Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility |
| US6451346B1 (en) * | 1998-12-23 | 2002-09-17 | Amgen Inc | Biodegradable pH/thermosensitive hydrogels for sustained delivery of biologically active agents |
| US6245740B1 (en) | 1998-12-23 | 2001-06-12 | Amgen Inc. | Polyol:oil suspensions for the sustained release of proteins |
| RU2140285C1 (ru) * | 1999-01-25 | 1999-10-27 | Гапонюк Петр Яковлевич | Противовирусное средство - капли в нос "гриппферон" |
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| PL3290428T3 (pl) | 2010-03-31 | 2022-02-07 | Gilead Pharmasset Llc | Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES8302778A1 (es) † | 1980-11-10 | 1983-02-01 | Genentech Inc | Un procedimiento para producir un polipeptido antiviral. |
| US6936694B1 (en) * | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| SE8502430L (sv) † | 1985-05-15 | 1986-11-16 | Kabivitrum Ab | En cdna-molekyl som kodar for expressionen av en polypeptid av typen interferon alfa, en bakteriell eller celluler verd transformerad med en sadan molekyl och en polypeptid som uppvisar interferonaktivetet framstelld me |
| ATE78262T1 (de) † | 1985-06-11 | 1992-08-15 | Ciba Geigy Ag | Hybrid-interferone. |
| ES2128348T3 (es) * | 1990-10-17 | 1999-05-16 | Amgen Inc | Obtencion de composiciones para el tratamiento de alteraciones de la proliferacion celular. |
| US5372808A (en) † | 1990-10-17 | 1994-12-13 | Amgen Inc. | Methods and compositions for the treatment of diseases with consensus interferon while reducing side effect |
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1992
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