CA2108466C - Hcv genomic sequences for diagnostics and therapeutics - Google Patents

Hcv genomic sequences for diagnostics and therapeutics Download PDF

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Publication number
CA2108466C
CA2108466C CA002108466A CA2108466A CA2108466C CA 2108466 C CA2108466 C CA 2108466C CA 002108466 A CA002108466 A CA 002108466A CA 2108466 A CA2108466 A CA 2108466A CA 2108466 C CA2108466 C CA 2108466C
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CA
Canada
Prior art keywords
nucleic acid
seq
sequence
hcv
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002108466A
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English (en)
French (fr)
Other versions
CA2108466A1 (en
Inventor
Tai-An Cha
Eileen Beall
Bruce Irvine
Janice Kolberg
Michael S. Urdea
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Novartis Vaccines and Diagnostics Inc
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Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24800701&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2108466(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Vaccines and Diagnostics Inc filed Critical Novartis Vaccines and Diagnostics Inc
Publication of CA2108466A1 publication Critical patent/CA2108466A1/en
Application granted granted Critical
Publication of CA2108466C publication Critical patent/CA2108466C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
CA002108466A 1991-05-08 1992-05-08 Hcv genomic sequences for diagnostics and therapeutics Expired - Lifetime CA2108466C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69732691A 1991-05-08 1991-05-08
US697,326 1991-05-08
PCT/US1992/004036 WO1992019743A2 (en) 1991-05-08 1992-05-08 Hcv genomic sequences for diagnostics and therapeutics

Publications (2)

Publication Number Publication Date
CA2108466A1 CA2108466A1 (en) 1992-11-09
CA2108466C true CA2108466C (en) 2007-07-10

Family

ID=24800701

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002108466A Expired - Lifetime CA2108466C (en) 1991-05-08 1992-05-08 Hcv genomic sequences for diagnostics and therapeutics

Country Status (20)

Country Link
EP (2) EP0585398B1 (https=)
JP (7) JPH06508026A (https=)
KR (1) KR100193801B1 (https=)
AT (1) ATE252154T1 (https=)
BG (3) BG62142B1 (https=)
CA (1) CA2108466C (https=)
CZ (2) CZ288720B6 (https=)
DE (1) DE69233234T2 (https=)
DK (1) DK0585398T3 (https=)
ES (1) ES2207633T3 (https=)
FI (1) FI115725B (https=)
HU (1) HU227548B1 (https=)
IE (1) IE921482A1 (https=)
NO (1) NO309532B1 (https=)
PL (2) PL169880B1 (https=)
PT (1) PT100472B (https=)
RO (1) RO117267B1 (https=)
RU (1) RU2155228C2 (https=)
SK (1) SK284205B6 (https=)
WO (1) WO1992019743A2 (https=)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428145A (en) * 1991-08-09 1995-06-27 Immuno Japan, Inc. Non-A, non-B, hepatitis virus genome, polynucleotides, polypeptides, antigen, antibody and detection systems
EP0532167A3 (en) * 1991-08-09 1993-03-31 Immuno Japan Inc. Non-a, non-b hepatitis virus genome, polynucleotides, polypeptides, antigen, antibody and detection systems
EP0532258A2 (en) * 1991-09-09 1993-03-17 Immuno Japan Inc. Oligonucleotides and determination system of HCV genotypes
EP0610436B9 (en) 1991-11-21 2003-03-26 Common Services Agency Hepatitis-c virus testing
US6709828B1 (en) 1992-03-06 2004-03-23 N.V. Innogenetics S.A. Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing them and compositions containing them
US6667387B1 (en) 1996-09-30 2003-12-23 N.V. Innogenetics S.A. HCV core peptides
CA2136764A1 (en) * 1992-05-29 1993-12-09 Ronald L. Marshall Ligase chain reaction starting with rna sequences
WO1994005813A1 (en) * 1992-09-10 1994-03-17 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Compositions and methods for treatment of hepatitis c virus-associated diseases
US6423489B1 (en) * 1992-09-10 2002-07-23 Isis Pharmaceuticals, Inc. Compositions and methods for treatment of Hepatitis C virus-associated diseases
DE69324678T2 (de) 1992-11-27 1999-12-09 Naamloze Vennootschap Innogenetics S.A., Gent Verfahren zur typisierung von hcv-isolaten
US7258977B1 (en) 1992-11-27 2007-08-21 Innogenetics N.V. Process for typing of HCV isolates
JPH06153961A (ja) * 1992-11-27 1994-06-03 Imuno Japan:Kk Ｃ型肝炎ウイルス部分遺伝子、ならびにｃ型肝炎ウイルス遺 伝子の高感度検出法
US7255997B1 (en) 1993-04-27 2007-08-14 N.V. Innogenetics S.A. Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents
EP0984068B1 (en) 1993-04-27 2012-03-28 Innogenetics N.V. Sequences of hepatitis c virus genotypes and their use as therapeutic and diagnostic agents
JPH0775585A (ja) * 1993-06-14 1995-03-20 Immuno Japan:Kk Ｃ型肝炎ウイルス関連オリゴヌクレオチドならびにｃ型肝炎 ウイルス遺伝子型判定方法
US5882852A (en) * 1993-06-29 1999-03-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Hepatitic C virus (HCV) core gene nucleotide sequences and related methods of detecting major and minor genotypes of HCV isolates
US7070790B1 (en) 1993-06-29 2006-07-04 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of the envelope 1 and core genes of isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
US5514539A (en) * 1993-06-29 1996-05-07 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
WO1995011918A1 (en) * 1993-10-29 1995-05-04 Srl, Inc. Antigen peptide compound and immunoassay method
WO1995030746A1 (en) * 1994-05-10 1995-11-16 The General Hospital Corporation Antisense inhibition of hepatitis c virus
JPH10507643A (ja) 1994-10-21 1998-07-28 イノジェネティックス・ナムローゼ・フェンノートシャップ Ｃ型肝炎ウイルス遺伝子型の新規配列、ならびにそれらの予防薬、治療薬および診断薬としての使用
US5851759A (en) * 1996-04-19 1998-12-22 Chiron Corporation Heteroduplex tracking assay (HTA) for genotyping HCV
IT1284847B1 (it) * 1996-06-07 1998-05-22 Sorin Biomedica Diagnostics Sp Procedimento per la rivelazione di acidi nucleici specifici di hcv
JP2002505071A (ja) 1997-11-04 2002-02-19 ロシュ ダイアグノスティックス ゲーエムベーハー 特異的かつ高感度な核酸検出方法
US6680059B2 (en) 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
JP5175417B2 (ja) 2000-08-17 2013-04-03 トリペップ アクチ ボラゲット リバビリンを含むワクチンおよびその使用方法
US6858590B2 (en) 2000-08-17 2005-02-22 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US7022830B2 (en) 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
US6586584B2 (en) 2001-01-29 2003-07-01 Becton, Dickinson And Company Sequences and methods for detection of Hepatitis C virus
US7196183B2 (en) 2001-08-31 2007-03-27 Innogenetics N.V. Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent
US8124747B2 (en) 2003-08-29 2012-02-28 Innogenetics HCV clade and prototype sequences thereof
CA2552949C (en) 2004-01-07 2012-10-02 Third Wave Technologies, Inc. Determination of hepatitis c virus genotype
KR100733186B1 (ko) * 2005-05-31 2007-06-27 재단법인 목암생명공학연구소 Ｈｃｖ 유전자에 특이적인 작은 간섭 ｒｎａ 및 그를유효성분으로 포함하는 ｃ형 간염 치료제
US8071561B2 (en) 2007-08-16 2011-12-06 Chrontech Pharma Ab Immunogen platform

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02500880A (ja) * 1987-11-18 1990-03-29 カイロン　コーポレイション Ｎａｎｂｖの診断用薬およびワクチン
SU1645302A1 (ru) * 1989-01-05 1991-04-30 Московский Научно-Исследовательский Институт Педиатрии И Детской Хирургии Минздрава Рсфср Способ дифференциальной индикации вирусспецифических нуклеотидных последовательностей вируса герпеса простого типа 1 и 2.
KR0185373B1 (ko) * 1989-03-17 1999-05-01 로버트 피. 블랙버언 Hcv 폴리단백질에서 유래되는 hcv 아미노산 서열 부분을 포함하는 폴리펩티드 및 그 사용
GR1001261B (el) * 1989-12-18 1993-06-30 Wellcome Found Ιϊκός παράγων.
WO1991014779A1 (fr) * 1990-03-28 1991-10-03 Mitsui Toatsu Chemicals, Incorporated Diagnostic du virus de l'hepatite
DE69132332T2 (de) * 1990-04-06 2000-11-30 Genelabs Technologies, Inc. Hepatitis c-virus-epitope
EP0933426A1 (en) * 1990-06-25 1999-08-04 The Research Foundation for Microbial Diseases of Osaka University Non-a, non-b hepatitis virus genomic cdna fragments and antigen polypeptides
AU652941B2 (en) * 1990-06-25 1994-09-15 Research Foundation For Microbial Diseases Of Osaka University, The Non-A, Non-B hepatitis virus particles
EP0510952A1 (en) * 1991-04-26 1992-10-28 Immuno Japan Inc. Oligonucleotide primers and their application for high-fidelity detection of non-a, non-b hepatitis virus

Also Published As

Publication number Publication date
AU668355B2 (en) 1996-05-02
JP2003009891A (ja) 2003-01-14
PL169880B1 (pl) 1996-09-30
EP0585398B1 (en) 2003-10-15
SK123293A3 (en) 1994-06-08
FI115725B (fi) 2005-06-30
HU227548B1 (en) 2011-08-29
NO934019D0 (no) 1993-11-05
NO934019L (no) 1993-11-05
WO1992019743A3 (en) 1993-11-25
CZ288720B6 (cs) 2001-08-15
BG98200A (bg) 1995-01-31
BG101876A (en) 1998-11-30
KR100193801B1 (ko) 1999-06-15
EP1394256A3 (en) 2008-03-12
FI934937A0 (fi) 1993-11-08
FI934937L (fi) 1994-01-05
BG62142B1 (bg) 1999-03-31
IE921482A1 (en) 1992-11-18
PL170151B1 (pl) 1996-10-31
CZ288722B6 (cs) 2001-08-15
JP2003024090A (ja) 2003-01-28
DE69233234D1 (de) 2003-12-04
CZ237793A3 (en) 1994-04-13
BG64627B1 (bg) 2005-09-30
JP2008178416A (ja) 2008-08-07
JP2003009893A (ja) 2003-01-14
EP0585398A1 (en) 1994-03-09
NO309532B1 (no) 2001-02-12
CZ121096A3 (en) 1996-08-14
CA2108466A1 (en) 1992-11-09
WO1992019743A2 (en) 1992-11-12
DK0585398T3 (da) 2004-02-02
JP2003009892A (ja) 2003-01-14
DE69233234T2 (de) 2004-08-05
HU9303166D0 (en) 1994-03-28
HUT69609A (en) 1995-09-28
EP1394256A2 (en) 2004-03-03
JPH06508026A (ja) 1994-09-14
RU2155228C2 (ru) 2000-08-27
PT100472A (pt) 1993-08-31
JP2004290204A (ja) 2004-10-21
SK284205B6 (sk) 2004-10-05
ES2207633T3 (es) 2004-06-01
RO117267B1 (ro) 2001-12-28
AU2155892A (en) 1992-12-21
ATE252154T1 (de) 2003-11-15
PT100472B (pt) 1999-08-31

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