CA2071811C - Improved meningococcal polysaccharide conjugate vaccine - Google Patents

Improved meningococcal polysaccharide conjugate vaccine Download PDF

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Publication number
CA2071811C
CA2071811C CA002071811A CA2071811A CA2071811C CA 2071811 C CA2071811 C CA 2071811C CA 002071811 A CA002071811 A CA 002071811A CA 2071811 A CA2071811 A CA 2071811A CA 2071811 C CA2071811 C CA 2071811C
Authority
CA
Canada
Prior art keywords
group
polysaccharide
conjugate
protein
gbmp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002071811A
Other languages
English (en)
French (fr)
Other versions
CA2071811A1 (en
Inventor
Harold J. Jennings
Francis Michon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Council of Canada
Original Assignee
National Research Council of Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Council of Canada filed Critical National Research Council of Canada
Publication of CA2071811A1 publication Critical patent/CA2071811A1/en
Application granted granted Critical
Publication of CA2071811C publication Critical patent/CA2071811C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1228Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K16/1232Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/025Enterobacteriales, e.g. Enterobacter
    • A61K39/0258Escherichia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/095Neisseria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1217Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6037Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CA002071811A 1989-12-14 1990-12-13 Improved meningococcal polysaccharide conjugate vaccine Expired - Fee Related CA2071811C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44819589A 1989-12-14 1989-12-14
US448,195 1989-12-14
PCT/CA1990/000437 WO1991008772A1 (en) 1989-12-14 1990-12-13 Improved meningococcal polysaccharide conjugate vaccine

Publications (2)

Publication Number Publication Date
CA2071811A1 CA2071811A1 (en) 1991-06-15
CA2071811C true CA2071811C (en) 2003-11-04

Family

ID=23779371

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002071811A Expired - Fee Related CA2071811C (en) 1989-12-14 1990-12-13 Improved meningococcal polysaccharide conjugate vaccine

Country Status (30)

Country Link
US (3) US5576002A (US06724976-20040420-M00002.png)
EP (1) EP0504202B1 (US06724976-20040420-M00002.png)
JP (1) JP2637845B2 (US06724976-20040420-M00002.png)
KR (1) KR0158436B1 (US06724976-20040420-M00002.png)
CN (4) CN1049223C (US06724976-20040420-M00002.png)
AR (1) AR243934A1 (US06724976-20040420-M00002.png)
AT (1) ATE121947T1 (US06724976-20040420-M00002.png)
AU (1) AU641715B2 (US06724976-20040420-M00002.png)
BR (1) BR9007917A (US06724976-20040420-M00002.png)
CA (1) CA2071811C (US06724976-20040420-M00002.png)
CZ (1) CZ283530B6 (US06724976-20040420-M00002.png)
DE (1) DE69019164T2 (US06724976-20040420-M00002.png)
DK (1) DK0504202T3 (US06724976-20040420-M00002.png)
ES (1) ES2071288T3 (US06724976-20040420-M00002.png)
FI (2) FI104539B (US06724976-20040420-M00002.png)
HR (1) HRP920872A2 (US06724976-20040420-M00002.png)
HU (2) HU9201966D0 (US06724976-20040420-M00002.png)
IE (1) IE68414B1 (US06724976-20040420-M00002.png)
IL (1) IL96676A (US06724976-20040420-M00002.png)
IN (1) IN171747B (US06724976-20040420-M00002.png)
NO (2) NO305275B1 (US06724976-20040420-M00002.png)
NZ (1) NZ236471A (US06724976-20040420-M00002.png)
PH (1) PH30305A (US06724976-20040420-M00002.png)
PL (2) PL166659B1 (US06724976-20040420-M00002.png)
RO (1) RO111416B1 (US06724976-20040420-M00002.png)
RU (1) RU2105568C1 (US06724976-20040420-M00002.png)
SI (1) SI20008B (US06724976-20040420-M00002.png)
WO (1) WO1991008772A1 (US06724976-20040420-M00002.png)
YU (1) YU24391A (US06724976-20040420-M00002.png)
ZA (1) ZA9010065B (US06724976-20040420-M00002.png)

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RO111416B1 (ro) * 1989-12-14 1996-10-31 Ca Nat Research Council Polizaharide modificate de neisseria meningitidis si e coli, combinatii antigenice si metoda de imunizare
CA2145397C (en) * 1992-09-24 2007-10-30 Harold J. Jennings Group b streptococcus type ii and type v polysaccharide-protein conjugate vaccines
US6153406A (en) * 1993-07-23 2000-11-28 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane protein P2 from Haemophilus influenzae type B
US5439808A (en) * 1993-07-23 1995-08-08 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
US5700787A (en) * 1994-09-02 1997-12-23 Brigham & Women's Hospital, Inc. Capsular polysaccharide immunomodulator
US5679654A (en) * 1994-09-02 1997-10-21 Brigham & Women's Hospital, Inc. Capsular polysaccharide immunomodulator
US5747287A (en) * 1995-04-28 1998-05-05 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
DK1090642T3 (da) * 1995-06-07 2008-09-22 Glaxosmithkline Biolog Sa Vacciner omfattende et polysaccharidantigen-bæreprotein-konjugat og frit bæreprotein
US6284884B1 (en) 1995-06-07 2001-09-04 North American Vaccine, Inc. Antigenic group B streptococcus type II and type III polysaccharide fragments having a 2,5-anhydro-D-mannose terminal structure and conjugate vaccine thereof
US5811102A (en) 1995-06-07 1998-09-22 National Research Council Of Canada Modified meningococcal polysaccharide conjugate vaccines
ZA97248B (en) * 1996-01-18 1997-07-18 Rohm & Haas Method for identifying and quantifying polymers utilizing immunoassay techniques
CA2264585C (en) 1996-08-27 2005-06-14 Chiron Corporation Monoclonal antibodies that define unique meningococcal b epitopes and their use in the preparation of vaccine compositions
DK0939647T4 (da) 1996-08-27 2006-10-23 Novartis Vaccines & Diagnostic Neisseria Meningitidis-serogruppe B-glycokonjugat og fremgangsmåde til anvendelse deraf
US6426074B1 (en) 1997-03-19 2002-07-30 The Brigham And Women's Hospital Inc. Group B Streptococcus vaccine
JP2002506448A (ja) 1997-06-24 2002-02-26 カイロン コーポレイション 抗髄膜炎菌ワクチン組成物を使用して成体を免疫する方法
AU9120898A (en) * 1997-08-27 1999-03-16 Chiron Corporation Molecular mimetics of meningococcal b epitopes
ES2346022T3 (es) 1997-12-23 2010-10-07 Baxter Healthcare S.A. Procedimiento para la extraccion y el aislamiento de polisacaridos capsulares bacterianos para su uso como vacunas o ligandos a proteinas como vacunas de conjugados.
DE69941574D1 (de) * 1998-08-19 2009-12-03 Baxter Healthcare Sa Immunogenes beta-propionamido-gebundenes polysaccharid-protein konjugat geeignet als impfstoff und hergestellt bei verwendung von n-acryloyliertem polysaccharid
US6436653B1 (en) 1998-12-15 2002-08-20 Exiqon A/S Method for introduction of reporter groups into bacterial lipopolysaccharide-derived carbohydrates and the subsequent coupling of such derivatives onto solid surfaces
US7083777B1 (en) * 1999-04-02 2006-08-01 The Brigham And Women's Hospital, Inc. Immunomodulating polymers
US6518037B2 (en) * 1999-11-12 2003-02-11 University Of Iowa Research Foundation Two-component system that controls bacterial membrane synthesis
GB9928196D0 (en) * 1999-11-29 2000-01-26 Chiron Spa Combinations of B, C and other antigens
SV2003000753A (es) 2000-12-05 2003-06-16 Brigham & Womens Hospital Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico
JP2004529643A (ja) 2001-04-17 2004-09-30 カイロン コーポレイション 機能活性抗体を誘発する髄膜炎菌性bエピトープの分子模倣物
GB0115176D0 (en) * 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
GB0121591D0 (en) * 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
AR045702A1 (es) 2001-10-03 2005-11-09 Chiron Corp Composiciones de adyuvantes.
ES2616180T3 (es) * 2002-03-26 2017-06-09 Glaxosmithkline Biologicals Sa Sacáridos modificados con estabilidad mejorada en agua para su uso como medicamento
US20040219160A1 (en) * 2003-03-31 2004-11-04 The Brigham And Women's Hospital, Inc. Zwitterionic immunomodulators for the treatment of asthma and allergy
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
JP4566194B2 (ja) * 2003-08-12 2010-10-20 リポクセン テクノロジーズ リミテッド タンパク質の誘導体化及び結合のためのシアル酸誘導体
US8148335B2 (en) 2004-06-23 2012-04-03 Children's Hospital & Research Center Oakland De-N-acetyl sialic acid antigens, antibodies thereto, and methods of use in cancer therapy
MXPA06015107A (es) 2004-06-23 2007-03-26 Childrens Hosp & Res Ct Oak Derivados de polisacaridos y sus usos en la induccion de una respuesta inmune.
GB0428394D0 (en) * 2004-12-24 2005-02-02 Chiron Srl Saccharide conjugate vaccines
KR20130122810A (ko) 2005-06-27 2013-11-08 글락소스미스클라인 바이오로지칼즈 에스.에이. 백신 제조 방법
WO2007092451A2 (en) 2006-02-06 2007-08-16 The Brigham And Women's Hospital, Inc. Zwitterionic polysaccharides for promotion of immune system maturation and health
GB0611914D0 (en) 2006-06-15 2006-07-26 Teti Giuseppe Peptides that mimic non-human cross-reactive protective epitopes of the group Bmeningococcal capsulsar polysaccharide
EP1872791A1 (en) * 2006-06-30 2008-01-02 Institut Pasteur Use of bacterial polysaccharides for biofilm inhibition
AU2008265767B2 (en) * 2007-06-20 2014-11-13 Pfizer Ireland Pharmaceuticals Modified polysaccharides for conjugate vaccines
ES2664753T3 (es) 2007-12-07 2018-04-23 Glaxosmithkline Biologicals Sa Composiciones de inducción de respuestas inmunes
US9050283B2 (en) 2009-01-16 2015-06-09 University Of Maryland, Baltimore Broad spectrum vaccine against non-typhoidal Salmonella
WO2013009945A1 (en) 2011-07-12 2013-01-17 The Brigham And Women's Hospital, Inc. Lipid-containing psa compositions, methods of isolation and methods of use thereof
EP2752403A1 (de) * 2013-01-08 2014-07-09 Sika Technology AG Amin für emissionsarme Epoxidharz-Produkte
JP6918365B2 (ja) 2015-08-19 2021-08-11 プレジデント アンド フェローズ オブ ハーバード カレッジ 脂質化psa組成物および方法
WO2018014012A1 (en) 2016-07-15 2018-01-18 President And Fellows Of Harvard College Glycolipid compositions and methods of use
SG11201906519RA (en) * 2017-01-31 2019-08-27 Pfizer Neisseria meningitidis compositions and methods thereof

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US4356170A (en) * 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
US4673574A (en) * 1981-08-31 1987-06-16 Anderson Porter W Immunogenic conjugates
US4619828A (en) * 1982-07-06 1986-10-28 Connaught Laboratories, Inc. Polysaccharide exotoxoid conjugate vaccines
US4496538A (en) * 1982-07-06 1985-01-29 Connaught Laboratories, Inc. Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine
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RO111416B1 (ro) * 1989-12-14 1996-10-31 Ca Nat Research Council Polizaharide modificate de neisseria meningitidis si e coli, combinatii antigenice si metoda de imunizare

Also Published As

Publication number Publication date
US5576002A (en) 1996-11-19
IE68414B1 (en) 1996-06-12
NZ236471A (en) 1992-10-28
NO922316D0 (no) 1992-06-12
FI104539B (fi) 2000-02-29
CZ628490A3 (en) 1997-12-17
KR0158436B1 (ko) 1998-12-01
AU641715B2 (en) 1993-09-30
CN1072506C (zh) 2001-10-10
DK0504202T3 (da) 1995-10-02
CN1100428A (zh) 1995-03-22
NO305275B1 (no) 1999-05-03
NO973311L (no) 1992-08-14
CN1096516A (zh) 1994-12-21
PH30305A (en) 1997-02-20
RU2105568C1 (ru) 1998-02-27
IL96676A (en) 1996-09-12
US5683699A (en) 1997-11-04
NO307835B1 (no) 2000-06-05
HU9201966D0 (en) 1992-10-28
PL288271A1 (en) 1991-12-16
SI20008A (sl) 2000-02-29
HUT64480A (en) 1994-01-28
CN1036504C (zh) 1997-11-26
JP2637845B2 (ja) 1997-08-06
YU24391A (sh) 1995-12-04
RO111416B1 (ro) 1996-10-31
FI19991917A (fi) 1999-09-09
HRP920872A2 (en) 1997-06-30
CN1036522C (zh) 1997-11-26
CA2071811A1 (en) 1991-06-15
CN1055541A (zh) 1991-10-23
FI922737A0 (fi) 1992-06-12
CZ283530B6 (cs) 1998-04-15
IE904513A1 (en) 1991-06-19
US5902586A (en) 1999-05-11
AR243934A1 (es) 1993-09-30
WO1991008772A1 (en) 1991-06-27
EP0504202B1 (en) 1995-05-03
NO922316L (no) 1992-08-14
DE69019164D1 (de) 1995-06-08
IL96676A0 (en) 1991-09-16
NO973311D0 (no) 1997-07-17
SI20008B (en) 2001-02-28
CN1100656A (zh) 1995-03-29
ATE121947T1 (de) 1995-05-15
ZA9010065B (en) 1992-02-26
PL166659B1 (pl) 1995-06-30
JPH05505392A (ja) 1993-08-12
IN171747B (US06724976-20040420-M00002.png) 1992-12-26
PL166035B1 (pl) 1995-03-31
EP0504202A1 (en) 1992-09-23
HU218146B (hu) 2000-06-28
ES2071288T3 (es) 1995-06-16
BR9007917A (pt) 1992-10-20
CN1049223C (zh) 2000-02-09
DE69019164T2 (de) 1995-09-07
AU6898791A (en) 1991-07-18

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