CA2028953A1 - Process for the preparation of quinazoline derivatives - Google Patents

Process for the preparation of quinazoline derivatives

Info

Publication number
CA2028953A1
CA2028953A1 CA002028953A CA2028953A CA2028953A1 CA 2028953 A1 CA2028953 A1 CA 2028953A1 CA 002028953 A CA002028953 A CA 002028953A CA 2028953 A CA2028953 A CA 2028953A CA 2028953 A1 CA2028953 A1 CA 2028953A1
Authority
CA
Canada
Prior art keywords
general formula
process according
lower alkyl
reaction
comprises carrying
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002028953A
Other languages
English (en)
French (fr)
Inventor
Jozsef Reiter
Laszlo Pongo
Frigyes Gorgenyi
Marton Fekete
Margit Csorgo
Ilona Sztuhar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egis Gyógyszergyár Zrt
Original Assignee
Egis Gyógyszergyár Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU193089A external-priority patent/HU203333B/hu
Priority claimed from HU193189A external-priority patent/HU203342B/hu
Application filed by Egis Gyógyszergyár Zrt filed Critical Egis Gyógyszergyár Zrt
Publication of CA2028953A1 publication Critical patent/CA2028953A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002028953A 1989-04-21 1990-04-20 Process for the preparation of quinazoline derivatives Abandoned CA2028953A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU1930/89 1989-04-21
HU193089A HU203333B (en) 1989-04-21 1989-04-21 Process for producing n-cyano-carboxamidine derivatives
HU1931/89 1989-04-21
HU193189A HU203342B (en) 1989-04-21 1989-04-21 Process for producing quinazoline deivatives

Publications (1)

Publication Number Publication Date
CA2028953A1 true CA2028953A1 (en) 1990-10-22

Family

ID=26317437

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002028953A Abandoned CA2028953A1 (en) 1989-04-21 1990-04-20 Process for the preparation of quinazoline derivatives
CA2015066A Pending CA2015066A1 (en) 1989-04-21 1990-04-20 Process for the preparation of quinazoline derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2015066A Pending CA2015066A1 (en) 1989-04-21 1990-04-20 Process for the preparation of quinazoline derivatives

Country Status (16)

Country Link
JP (1) JPH02292282A (enExample)
KR (1) KR900016194A (enExample)
AT (1) AT398075B (enExample)
BG (1) BG91821A (enExample)
CA (2) CA2028953A1 (enExample)
CH (1) CH681300A5 (enExample)
DK (1) DK99090A (enExample)
ES (1) ES2019826A6 (enExample)
FI (1) FI902002A7 (enExample)
GB (1) GB2231571B (enExample)
GR (1) GR900100294A (enExample)
IT (1) IT1241128B (enExample)
PL (1) PL162976B1 (enExample)
RU (1) RU1838309C (enExample)
SE (1) SE9001402L (enExample)
YU (1) YU70890A (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2077252C (en) 1992-08-31 2001-04-10 Khashayar Karimian Methods of making ureas and guanidines, and intermediates therefor
ES2096518B1 (es) * 1994-03-28 1997-12-01 Grupo Farmaceutico Almirall S Nuevas anilinas.
WO2008015525A2 (en) * 2006-07-31 2008-02-07 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of alfuzosin hydrochloride
US20100174073A1 (en) 2007-05-04 2010-07-08 Actavis Group Ptc Ehf Process for the preparation of alfuzosin and salts thereof
KR20100044239A (ko) 2007-08-02 2010-04-29 시플라 리미티드 알푸조신 염산염의 제조방법

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4026894A (en) * 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
US4044135A (en) * 1975-10-14 1977-08-23 Abbott Laboratories Antihypertensive agents
GB1591490A (en) * 1977-08-04 1981-06-24 Abbott Lab 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate
US4138561A (en) * 1977-09-30 1979-02-06 Bristol-Myers Company Cyanocarboxamidines and quinazoline process
FI56836C (fi) * 1977-10-25 1980-04-10 Fermion Oy 4-substituerade piperazin-1-(n-aryl-n'-cyano)-karboximidamider som aer mellanprodukter vid framstaellningen av farmakologiskt vaerdefulla 6,7-dimetoxi- eller 6,7,8-trimetoxi-4-amino-2-(4-substituerade-piperazin-1-yl)-kinazoliner
FI57751C (fi) * 1977-10-25 1980-10-10 Fermion Oy Foerfarande foer framstaellning av 6,7-dimetoxi- eller 6,7,8-trimetoxi-4-amino-2-(4-substituerade-piperazin-1-yl)-kinazoliner med blodtryckssaenkande verkan
FR2421888A1 (fr) * 1978-02-06 1979-11-02 Synthelabo Amides d'alkylene-diamines et leur application en therapeutique
FI59800C (fi) * 1979-01-10 1981-10-12 Fermion Oy Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(furo-2-yl)-piperazin-1-yl)-kinazolin
FI67699C (fi) * 1979-01-31 1985-05-10 Orion Yhtymae Oy Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolinhydroklorid med blodtryckssaenkande verkan
EP0146642B1 (de) * 1983-11-22 1988-01-20 LUDWIG HEUMANN & CO GMBH Verfahren zur Herstellung von 4-Amino-6,7-dimethoxy-2-(4-(furo-2-yl)-piperazin-1-yl)-chinazolin und dessen physiologisch annehmbarer Salze

Also Published As

Publication number Publication date
IT1241128B (it) 1993-12-29
KR900016194A (ko) 1990-11-12
PL284860A1 (en) 1991-03-11
RU1838309C (ru) 1993-08-30
GB2231571A (en) 1990-11-21
DK99090D0 (da) 1990-04-20
CA2015066A1 (en) 1990-10-21
PL162976B1 (pl) 1994-01-31
SE9001402L (sv) 1990-10-22
FI902002A7 (fi) 1990-10-22
DK99090A (da) 1990-10-22
CH681300A5 (enExample) 1993-02-26
BG91821A (bg) 1993-12-24
JPH02292282A (ja) 1990-12-03
AT398075B (de) 1994-09-26
GR900100294A (el) 1991-09-27
IT9020092A0 (it) 1990-04-20
FI902002A0 (fi) 1990-04-20
YU70890A (en) 1992-05-28
ATA93190A (de) 1994-01-15
SE9001402D0 (sv) 1990-04-20
ES2019826A6 (es) 1991-07-01
IT9020092A1 (it) 1991-10-20
GB9008941D0 (en) 1990-06-20
GB2231571B (en) 1992-09-16

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Legal Events

Date Code Title Description
FZDE Discontinued