CA2006144A1 - Procede microbiologique pour la production d'antibiotiques immunosuppresseurs - Google Patents
Procede microbiologique pour la production d'antibiotiques immunosuppresseursInfo
- Publication number
- CA2006144A1 CA2006144A1 CA2006144A CA2006144A CA2006144A1 CA 2006144 A1 CA2006144 A1 CA 2006144A1 CA 2006144 A CA2006144 A CA 2006144A CA 2006144 A CA2006144 A CA 2006144A CA 2006144 A1 CA2006144 A1 CA 2006144A1
- Authority
- CA
- Canada
- Prior art keywords
- cyclosporine
- complex
- production
- isolating
- antibiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 229940088710 antibiotic agent Drugs 0.000 title abstract 2
- 230000001506 immunosuppresive effect Effects 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 230000007483 microbial process Effects 0.000 title abstract 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 abstract 6
- 108010036949 Cyclosporine Proteins 0.000 abstract 6
- 229960001265 ciclosporin Drugs 0.000 abstract 5
- 229930182912 cyclosporin Natural products 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- 230000003115 biocidal effect Effects 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- 241000233866 Fungi Species 0.000 abstract 2
- 241001149964 Tolypocladium Species 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 2
- 239000011707 mineral Substances 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 235000015097 nutrients Nutrition 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229930105110 Cyclosporin A Natural products 0.000 abstract 1
- 238000010564 aerobic fermentation Methods 0.000 abstract 1
- 230000003570 biosynthesizing effect Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/145—Fungal isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Botany (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU886497A HU201577B (en) | 1988-12-20 | 1988-12-20 | Process for producing cyclosporin antibiotics |
| HU6497/88 | 1988-12-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2006144A1 true CA2006144A1 (fr) | 1990-06-20 |
| CA2006144C CA2006144C (fr) | 1995-02-21 |
Family
ID=10971727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002006144A Expired - Lifetime CA2006144C (fr) | 1988-12-20 | 1989-12-20 | Procede microbiologique pour la production d'antibiotiques immunosuppresseurs |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5156960A (fr) |
| EP (1) | EP0379708B1 (fr) |
| JP (1) | JPH0763356B2 (fr) |
| AT (1) | AT393135B (fr) |
| BG (1) | BG60274B2 (fr) |
| CA (1) | CA2006144C (fr) |
| CZ (1) | CZ283557B6 (fr) |
| DD (1) | DD290356A5 (fr) |
| DE (1) | DE58908740D1 (fr) |
| DK (1) | DK174719B1 (fr) |
| FI (1) | FI92603C (fr) |
| FR (1) | FR2640641B1 (fr) |
| GB (1) | GB2227489B (fr) |
| HU (1) | HU201577B (fr) |
| IT (1) | IT1237799B (fr) |
| LV (2) | LV10102B (fr) |
| NO (1) | NO175873C (fr) |
| PL (1) | PL162959B1 (fr) |
| RU (1) | RU1836425C (fr) |
| SE (1) | SE505442C2 (fr) |
| SK (1) | SK279768B6 (fr) |
| UA (1) | UA13320A (fr) |
| YU (1) | YU47100B (fr) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2101777A1 (fr) * | 1991-01-25 | 1992-07-26 | Toshio Goto | Procede de production de cyclosporine a et/ou de cyclosporine c |
| EP0507968B1 (fr) * | 1991-04-06 | 1995-09-06 | Arzneimittelwerk Dresden Gmbh | Procédé de production par fermentation et isolement de cyclosporine A ainsi que de nouvelles souches productrices de cyclosporine |
| FI92334C (fi) * | 1992-12-30 | 1994-10-25 | Leiras Oy | Menetelmä syklosporiinien tuottamiseksi ja menetelmässä käytettävä uusi Tolypocladium-kanta |
| SI9300303A (en) * | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
| KR100304324B1 (ko) * | 1994-10-13 | 2001-11-22 | 김용규 | 사이클로스포린a의제조방법 |
| KR100341355B1 (ko) * | 1994-10-14 | 2002-10-25 | 주식회사종근당 | 사이클로스포린a의제조방법 |
| KR0126610B1 (ko) * | 1994-10-18 | 1997-12-29 | 김충환 | 고생산 세포융합변이균주에 의한 사이클로스포린 a의 제조방법 |
| EP0725076B1 (fr) * | 1995-02-01 | 2001-06-06 | National Research Development Corporation of India | Procédé de préparation de la cyclosporine A de l'espèce tolypocladium |
| US5854276A (en) * | 1995-06-29 | 1998-12-29 | Fujisawa Pharmaceutical Co., Ltd. | Substance WF16616, process for production thereof, and use thereof |
| DE19611094C2 (de) | 1996-03-21 | 1999-06-17 | Dresden Arzneimittel | Verfahren zur Reinigung von Cyclosporin A und/oder verwandten Cyclosporinen aus einem Cyclosporin-haltigen Rohextrakt unter Anwendung chromatographischer Verfahren mit Kieselgel als Adsorbens |
| US5709797A (en) * | 1996-06-05 | 1998-01-20 | Poli Industria Chimica S.P.A. | Method of isolating cyclosporins |
| US5747330A (en) * | 1996-06-05 | 1998-05-05 | Poli Industria Chimica | Antibiotic producing microbe |
| NZ512599A (en) | 1998-12-30 | 2003-10-31 | Dexcel Ltd | Formulation for cyclosporin administration featuring a hydrophilic solvent and a surfactant with a HLB of less than 5 |
| US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| US7176001B1 (en) | 2000-02-29 | 2007-02-13 | Biocon Limited | Manufacture and purification of cyclosporin A |
| US7696166B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| US7696165B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
| EP2151450A1 (fr) * | 2008-07-29 | 2010-02-10 | Sandoz AG | Procédé de préparation d'oligopeptides cycliques microbiologiques |
| KR101889757B1 (ko) * | 2011-04-28 | 2018-08-20 | 셀진 코포레이션 | 자가 면역 및 염증 질환의 치료 및 관리를 위한 ｐｄｅ4 저해제를 이용한 방법 및 조성물 |
| GB201319791D0 (en) * | 2013-11-08 | 2013-12-25 | Sigmoid Pharma Ltd | Formulations |
| CN117025407B (zh) * | 2023-06-28 | 2024-06-18 | 中国人民解放军海军特色医学中心 | 一株弯颈霉属真菌及其在制备抗辐损伤药物中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4117118A (en) * | 1976-04-09 | 1978-09-26 | Sandoz Ltd. | Organic compounds |
| DE2819094A1 (de) * | 1977-05-10 | 1978-11-23 | Sandoz Ag | Cyclosporin-derivate, ihre verwendung und herstellung |
| US4215199A (en) * | 1978-06-05 | 1980-07-29 | Sandoz Ltd. | Antibiotic production |
| SE448386B (sv) * | 1978-10-18 | 1987-02-16 | Sandoz Ag | Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem |
| US4764503A (en) * | 1986-11-19 | 1988-08-16 | Sandoz Ltd. | Novel cyclosporins |
-
1988
- 1988-12-20 HU HU886497A patent/HU201577B/hu unknown
-
1989
- 1989-12-18 DK DK198906409A patent/DK174719B1/da not_active IP Right Cessation
- 1989-12-19 RU SU4742791A patent/RU1836425C/ru active
- 1989-12-19 SE SE8904262A patent/SE505442C2/sv unknown
- 1989-12-19 UA UA4742791A patent/UA13320A/uk unknown
- 1989-12-20 IT IT22765A patent/IT1237799B/it active IP Right Grant
- 1989-12-20 US US07/454,005 patent/US5156960A/en not_active Expired - Lifetime
- 1989-12-20 CA CA002006144A patent/CA2006144C/fr not_active Expired - Lifetime
- 1989-12-20 CZ CS897225A patent/CZ283557B6/cs not_active IP Right Cessation
- 1989-12-20 DD DD89335977A patent/DD290356A5/de not_active IP Right Cessation
- 1989-12-20 YU YU241589A patent/YU47100B/sh unknown
- 1989-12-20 NO NO895160A patent/NO175873C/no not_active IP Right Cessation
- 1989-12-20 AT AT2891/89A patent/AT393135B/de not_active IP Right Cessation
- 1989-12-20 PL PL28287689A patent/PL162959B1/pl unknown
- 1989-12-20 DE DE58908740T patent/DE58908740D1/de not_active Expired - Lifetime
- 1989-12-20 BG BG90701A patent/BG60274B2/xx unknown
- 1989-12-20 FR FR898916878A patent/FR2640641B1/fr not_active Expired - Lifetime
- 1989-12-20 EP EP89123535A patent/EP0379708B1/fr not_active Expired - Lifetime
- 1989-12-20 GB GB8928715A patent/GB2227489B/en not_active Expired - Lifetime
- 1989-12-20 SK SK7225-89A patent/SK279768B6/sk not_active IP Right Cessation
- 1989-12-20 FI FI896157A patent/FI92603C/fi active IP Right Grant
- 1989-12-20 JP JP1328529A patent/JPH0763356B2/ja not_active Expired - Fee Related
-
1992
- 1992-05-04 LV LVP-92-10A patent/LV10102B/en unknown
-
1993
- 1993-06-28 LV LVP-93-708A patent/LV10500B/lv unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2006144A1 (fr) | Procede microbiologique pour la production d'antibiotiques immunosuppresseurs | |
| Wang et al. | Antimicrobial potentials of endophytic fungi residing in Quercus variabilis and brefeldin A obtained from Cladosporium sp. | |
| CA2152963A1 (fr) | Methode pour l'obtention d'immunosuppresseurs; nouvelle espece microbienne utilisee dans cette methode | |
| AU614760B2 (en) | A new antimicrobial agent, fr 109615 and production thereof | |
| HUT40455A (en) | Process for preparing actagardin monocarboxamide derivatives | |
| CA2361701A1 (fr) | Procede microbien pour la preparation de la pravastatine | |
| HU9903226D0 (en) | Process for producing mycophenolic acid and derivatives thereof | |
| CA2388050A1 (fr) | Caprazamycines antibiotiques et leur procede de production | |
| CA2257254A1 (fr) | Microbe produisant un antibiotique | |
| EP0379395A3 (fr) | Antibiotique L53-18A et sa préparation | |
| YU55601A (sh) | Proces za pripremu antibiotika pseudomonične kiseline a mikrobiološkim metodom | |
| EP0930304A4 (fr) | Procede de production de composes a base de cyclodepsipeptide et nouveau cyclodepsipeptide | |
| CA2085522A1 (fr) | Methode microbienne pour la preparation de trans-4-hydroxy-l-proline | |
| DE3378059D1 (en) | Antitumor antibiotics | |
| ES8706162A1 (es) | Procedimiento de obtencion de antibiotico designado por cl-1577-b4 | |
| EP0765938A3 (fr) | Production fermentative de la vitamine B6 | |
| GB1474129A (en) | Method for the production of d-ribose | |
| EP0282001A3 (en) | Azoxy compounds and process for production thereof | |
| US5279829A (en) | Fungicidal antibiotic from Streptomyces NCIMB 40212 | |
| CA2132869A1 (fr) | Nouvelle substance capable de produire de la rapamycine | |
| SI8912415B (sl) | Mikrobni postopek za proizvodnjo imunosupresivnih antibiotikov | |
| ES8801703A1 (es) | Un nuevo procedimiento para producir el (los) antibiotico (s) macrolido (s) 4s-02930 k-d-e o-h. | |
| BG40969A3 (en) | Method for preparing antibiotic sisomycine | |
| JPH05111388A (ja) | シス−４−ヒドロキシ−ｌ−プロリンの製造法 | |
| Li | Isolation of actinomycetes for antibiotic screening |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed | ||
| MKEC | Expiry (correction) |
Effective date: 20121202 |