ES8706162A1 - Procedimiento de obtencion de antibiotico designado por cl-1577-b4 - Google Patents

Procedimiento de obtencion de antibiotico designado por cl-1577-b4

Info

Publication number
ES8706162A1
ES8706162A1 ES553051A ES553051A ES8706162A1 ES 8706162 A1 ES8706162 A1 ES 8706162A1 ES 553051 A ES553051 A ES 553051A ES 553051 A ES553051 A ES 553051A ES 8706162 A1 ES8706162 A1 ES 8706162A1
Authority
ES
Spain
Prior art keywords
compound
activity against
gram
cell line
leukemia cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES553051A
Other languages
English (en)
Other versions
ES553051A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Publication of ES8706162A1 publication Critical patent/ES8706162A1/es
Publication of ES553051A0 publication Critical patent/ES553051A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

PROCEDIMIENTO PARA OBTENER ANTIBIOTICOS CL-1577-B4. COMPRENDE LAS ETAPAS DE: CULTIVAR UNA CEPA PURIFICADA DE ACTINOMICETOS IDENTIFICADA POR ATCC 39363, EN CONDICIONES AEROBICAS, EN UN MEDIO QUE COMPRENDE FUENTES ASIMILABLES DE CARBONO, NITROGENO Y AZUFRE, HASTA QUE SE OBTIENE UNA CANTIDAD SUFICIENTE DEL COMPUESTO CL-1577A O CL-1577B; AISLAR EL COMPUESTO CL=1577A O CL-1577B EN DICHO MEDIO; Y SOLVOLIZAR EL COMPUESTO CL-1577A O CL-1577B PARA PRODUCIR ASI EL COMPUESTO ANTIBIOTICO DESEADO CL-1577B4; EFECTUANDOSE LA ETAPA DE SOLVOLISIS CON EL EMPLEO DE ACIDO CLORHIDRICO METANOLICO ANHIDRO. TIENE APLICACIONES FARMACEUTICAS POR SU ACTIVIDAD CONTRA BACTERIAS GRAM-POSITIVAS Y GRAM-NEGATIVAS.
ES553051A 1985-03-15 1986-03-14 Procedimiento de obtencion de antibiotico designado por cl-1577-b4 Expired ES8706162A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/712,294 US4594248A (en) 1985-03-15 1985-03-15 CL-1577-B4 compound, its production and use

Publications (2)

Publication Number Publication Date
ES8706162A1 true ES8706162A1 (es) 1987-05-16
ES553051A0 ES553051A0 (es) 1987-05-16

Family

ID=24861526

Family Applications (1)

Application Number Title Priority Date Filing Date
ES553051A Expired ES8706162A1 (es) 1985-03-15 1986-03-14 Procedimiento de obtencion de antibiotico designado por cl-1577-b4

Country Status (10)

Country Link
US (2) US4594248A (es)
EP (1) EP0194784B1 (es)
JP (1) JPH0689012B2 (es)
AT (1) ATE72565T1 (es)
AU (1) AU589943B2 (es)
CA (1) CA1253820A (es)
DE (1) DE3683860D1 (es)
DK (1) DK116286A (es)
ES (1) ES8706162A1 (es)
ZA (1) ZA861052B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4539203A (en) * 1984-11-13 1985-09-03 Warner-Lambert Company CL-1577D And CL-1577E antibiotic/antitumor compounds, their production and use
US4921700A (en) * 1985-08-27 1990-05-01 Bristol-Myers Company BBM-1675c and d antitumor antibiotics
US4939244A (en) * 1987-01-30 1990-07-03 American Cyanamid Company Pseudoaglycones of LL-E33288 antibiotics
US4837206A (en) * 1987-04-29 1989-06-06 Bristol-Myers Company Esperamicin derivatives
US4916065A (en) * 1988-06-10 1990-04-10 Bristol-Myers Company BU-3420T Antitumor antibiotic
US4952572A (en) * 1988-06-10 1990-08-28 Bristol-Myers Company BU-3420T antifungal antibiotic
US5086045A (en) * 1989-03-15 1992-02-04 Bristol-Myers Squibb Company Antitumor antibiotic
US5028536A (en) * 1989-03-15 1991-07-02 Bristol-Myers Squibb Company Antitumor antibiotic BMY-41339
US5116845A (en) * 1990-05-04 1992-05-26 Bristol-Myers Company BU-3420T antitumor antibiotic
US6676967B1 (en) 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4335108A (en) * 1980-08-25 1982-06-15 The Upjohn Company Paulomycin A and B and preparation thereof
US4530835A (en) * 1983-07-08 1985-07-23 Warner-Lambert Company CL-1577 Antibiotic compounds and their production
US4539203A (en) * 1984-11-13 1985-09-03 Warner-Lambert Company CL-1577D And CL-1577E antibiotic/antitumor compounds, their production and use

Also Published As

Publication number Publication date
EP0194784A2 (en) 1986-09-17
JPH0689012B2 (ja) 1994-11-09
AU5337386A (en) 1986-09-18
EP0194784B1 (en) 1992-02-12
EP0194784A3 (en) 1987-12-09
ES553051A0 (es) 1987-05-16
DK116286D0 (da) 1986-03-13
ATE72565T1 (de) 1992-02-15
DK116286A (da) 1986-09-16
ZA861052B (en) 1987-09-30
CA1253820A (en) 1989-05-09
US4594248A (en) 1986-06-10
JPS61216692A (ja) 1986-09-26
AU589943B2 (en) 1989-10-26
US4661353A (en) 1987-04-28
DE3683860D1 (de) 1992-03-26

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970612