ES8704934A1 - Un procedimiento para producir un compuesto analogo a estreptonigrina - Google Patents

Un procedimiento para producir un compuesto analogo a estreptonigrina

Info

Publication number
ES8704934A1
ES8704934A1 ES549715A ES549715A ES8704934A1 ES 8704934 A1 ES8704934 A1 ES 8704934A1 ES 549715 A ES549715 A ES 549715A ES 549715 A ES549715 A ES 549715A ES 8704934 A1 ES8704934 A1 ES 8704934A1
Authority
ES
Spain
Prior art keywords
tumor activity
medicament
preparation
microbiological process
novel substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549715A
Other languages
English (en)
Other versions
ES549715A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of ES549715A0 publication Critical patent/ES549715A0/es
Publication of ES8704934A1 publication Critical patent/ES8704934A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/47—Streptomyces albus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN COMPUESTO ANALOGO A ESTREPTOMICINA, DE FORMULA (I). CONSISTE EN CULTIVAR EL MICROORGANISMO STREPTOMYCES ALBUS O UNO DE SUS MUTANTES, EN UN MEDIO NUTRITIVO SUMERGIDO EN LIQUIDO, QUE CONTIENE FUENTES NUTRITIVAS DE CARBONO Y NITROGENO, ASI COMO SALES INORGANICAS Y ANTIESPUMANTES, A UNA TEMPERATURA COMPRENDIDA ENTRE 20JC Y 35JC, DURANTE 3 A 4 DIAS; RECUPERACION DEL COMPUESTO DEL MEDIO DE CULTIVO MEDIANTE EXTRACCION O ADSORCION; Y PURIFICACION DEL MISMO POR CROMATOGRAFIA EN COLUMNA. ESTE COMPUESTO TIENE APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTITUMORAL.
ES549715A 1984-12-11 1985-12-09 Un procedimiento para producir un compuesto analogo a estreptonigrina Expired ES8704934A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59262317A JPS61139399A (ja) 1984-12-11 1984-12-11 新規抗腫瘍性物質およびその製造方法

Publications (2)

Publication Number Publication Date
ES549715A0 ES549715A0 (es) 1987-04-16
ES8704934A1 true ES8704934A1 (es) 1987-04-16

Family

ID=17374090

Family Applications (1)

Application Number Title Priority Date Filing Date
ES549715A Expired ES8704934A1 (es) 1984-12-11 1985-12-09 Un procedimiento para producir un compuesto analogo a estreptonigrina

Country Status (7)

Country Link
EP (1) EP0185979A1 (es)
JP (1) JPS61139399A (es)
DK (1) DK570185A (es)
ES (1) ES8704934A1 (es)
GR (1) GR852953B (es)
HU (1) HU194940B (es)
PT (1) PT81648B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525611A (en) * 1993-06-04 1996-06-11 Behforouz; Mohammad Lavendamycin analogs and methods of making and using them
US5712289A (en) * 1993-06-04 1998-01-27 Ball State University Quinoline-5,8-diones and methods of using them
CN102993168B (zh) * 2012-09-28 2015-08-26 上海交通大学 链黑菌素类似化合物及其制备方法、用途

Also Published As

Publication number Publication date
DK570185A (da) 1986-06-12
HUT41841A (en) 1987-05-28
GR852953B (es) 1986-04-01
JPS61139399A (ja) 1986-06-26
PT81648B (pt) 1988-02-17
EP0185979A1 (en) 1986-07-02
DK570185D0 (da) 1985-12-10
PT81648A (en) 1986-01-01
ES549715A0 (es) 1987-04-16
HU194940B (en) 1988-03-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203