ES8506351A1 - Un procedimiento para producir un compuesto de antraciclina - Google Patents

Un procedimiento para producir un compuesto de antraciclina

Info

Publication number
ES8506351A1
ES8506351A1 ES529479A ES529479A ES8506351A1 ES 8506351 A1 ES8506351 A1 ES 8506351A1 ES 529479 A ES529479 A ES 529479A ES 529479 A ES529479 A ES 529479A ES 8506351 A1 ES8506351 A1 ES 8506351A1
Authority
ES
Spain
Prior art keywords
medicament
same
production
pharmaceutical composition
composition containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529479A
Other languages
English (en)
Other versions
ES529479A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Priority to PL24890684A priority Critical patent/PL248906A1/xx
Publication of ES529479A0 publication Critical patent/ES529479A0/es
Publication of ES8506351A1 publication Critical patent/ES8506351A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Abstract

PROCEDIMIENTO PARA PRODUCIR UN COMPUESTO ANTRACICLINICO.COMPRENDE CULTIVAR UNA CEPA STERPTOMYCES MG344-HF49 (N.O FERM-P 6605) EN UN MEDIO DE CULTIVO APROPIADO EN CONDICIONES AEROBICAS COMO LIQUIDO SUMERGIDO AEROBICO CONSISTENTE EN FUENTES DE CARBONO NUTRITIVAS, FUENTES DE NITROGENO Y, OPCIONALMENTE, SALES INORGANICAS Y/O AGENTES ANTIESPUMANTES A UNA TEMPERATURA DE 20 A 35JC, TENIENDO DICHA CEPA LA CAPACIDAD DE PRODUCIR EL COMPUESTO ANTRACICLINICO SERIRRUBICINA DE FORMULA (I), Y RECUPERAR DESPUES EL COMPUESTO DE FORMULA (I) DEL MEDIO DE CULTIVO.
ES529479A 1983-02-08 1984-02-06 Un procedimiento para producir un compuesto de antraciclina Expired ES8506351A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PL24890684A PL248906A1 (en) 1983-09-07 1984-07-24 Process for preparing alkyl ester of -l-aspartyl-l-phenyl-alanine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58019341A JPS59148795A (ja) 1983-02-08 1983-02-08 アントラサイクリン化合物、その製造法およびその用途

Publications (2)

Publication Number Publication Date
ES529479A0 ES529479A0 (es) 1985-07-01
ES8506351A1 true ES8506351A1 (es) 1985-07-01

Family

ID=11996694

Family Applications (1)

Application Number Title Priority Date Filing Date
ES529479A Expired ES8506351A1 (es) 1983-02-08 1984-02-06 Un procedimiento para producir un compuesto de antraciclina

Country Status (12)

Country Link
US (1) US4565861A (es)
EP (1) EP0118732B1 (es)
JP (1) JPS59148795A (es)
AT (1) ATE40380T1 (es)
CA (1) CA1207692A (es)
DE (1) DE3476398D1 (es)
DK (1) DK54384A (es)
ES (1) ES8506351A1 (es)
GR (1) GR81412B (es)
IE (1) IE56728B1 (es)
PT (1) PT78072B (es)
ZA (1) ZA84887B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3325957A1 (de) * 1983-07-19 1985-02-07 Hoechst Ag, 6230 Frankfurt Anthracyclin-derivate, ein verfahren zu ihrer herstellung und ihre verwendung als cytostatika
JPS6366194A (ja) * 1986-09-09 1988-03-24 Sanraku Inc 新規なアントラサイクリン抗生物質
US5013549A (en) * 1989-02-16 1991-05-07 Board Of Trustees Operating Michigan State University Production, isolation, and identification of novel antifungal compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6023679B2 (ja) * 1979-07-13 1985-06-08 メルシャン株式会社 ロドマイシン群抗生物質とその製造法
CA1187434A (en) * 1981-08-11 1985-05-21 Akihiro Yoshimoto Anthracycline antibiotics and their preparation method

Also Published As

Publication number Publication date
EP0118732A3 (en) 1986-07-09
GR81412B (es) 1984-12-11
ZA84887B (en) 1984-09-26
IE840280L (en) 1984-08-08
JPS59148795A (ja) 1984-08-25
US4565861A (en) 1986-01-21
DE3476398D1 (en) 1989-03-02
ATE40380T1 (de) 1989-02-15
PT78072A (en) 1984-03-01
EP0118732A2 (en) 1984-09-19
CA1207692A (en) 1986-07-15
DK54384D0 (da) 1984-02-07
EP0118732B1 (en) 1989-01-25
DK54384A (da) 1984-08-09
ES529479A0 (es) 1985-07-01
IE56728B1 (en) 1991-11-20
PT78072B (en) 1986-07-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970203