GB1345494A - Preparation of n-1-ethyl-a-pyrrolidyl-methyl-2-methoxy-5- sulphonamido-benzamide - Google Patents
Preparation of n-1-ethyl-a-pyrrolidyl-methyl-2-methoxy-5- sulphonamido-benzamideInfo
- Publication number
- GB1345494A GB1345494A GB4087072A GB4087072A GB1345494A GB 1345494 A GB1345494 A GB 1345494A GB 4087072 A GB4087072 A GB 4087072A GB 4087072 A GB4087072 A GB 4087072A GB 1345494 A GB1345494 A GB 1345494A
- Authority
- GB
- United Kingdom
- Prior art keywords
- ethyl
- methoxy
- pyrrolidylmethyl
- phosphoramide
- sulphonamido
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 1 - ethyl Chemical group 0.000 abstract 3
- DMSZORWOGDLWGN-UHFFFAOYSA-N ctk1a3526 Chemical compound NP(N)(N)=O DMSZORWOGDLWGN-UHFFFAOYSA-N 0.000 abstract 2
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 abstract 2
- UNRBEYYLYRXYCG-UHFFFAOYSA-N (1-ethylpyrrolidin-2-yl)methanamine Chemical compound CCN1CCCC1CN UNRBEYYLYRXYCG-UHFFFAOYSA-N 0.000 abstract 1
- SQAILWDRVDGLGY-UHFFFAOYSA-N 2-methoxy-5-sulfamoylbenzoic acid Chemical compound COC1=CC=C(S(N)(=O)=O)C=C1C(O)=O SQAILWDRVDGLGY-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
Abstract
1345494 N - (1 - ethyl - alpha - pyrrolidylmethyl) - 2 - methoxy - 5 - sulphonamidobenzamide and a phosphoramide FRATMANN AG 4 Sept 1972 [13 June 1972] 40870/72 Headings C2C and C2P The invention comprises a process for preparing N - (1 - ethyl - α - pyrrolidylmethyl) - 2- methoxy - 5 - sulfonamidobenzamide by reacting N - ethyl - α - aminomethyl - pyrrolidine with phosphorus oxychloride to give N,N<SP>1</SP>,N<SP>11</SP>- (1 - ethyl - α - pyrrolidylmethyl) - phosphoramide and reacting the N,N<SP>1</SP>,N<SP>11</SP>-(1-ethyl-α-pyrrolidylmethyl)-phosphoramide with 2-methoxy-5-sulfonamidobenzoic acid. The phosphoramide may be isolated as a mixture of di- and tri-hydrochlorides.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH881372A CH562790A5 (en) | 1972-06-13 | 1972-06-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1345494A true GB1345494A (en) | 1974-01-30 |
Family
ID=4345021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4087072A Expired GB1345494A (en) | 1972-06-13 | 1972-09-04 | Preparation of n-1-ethyl-a-pyrrolidyl-methyl-2-methoxy-5- sulphonamido-benzamide |
Country Status (31)
| Country | Link |
|---|---|
| JP (1) | JPS565733B2 (en) |
| AR (1) | AR193288A1 (en) |
| AT (1) | AT316536B (en) |
| AU (1) | AU464143B2 (en) |
| BE (1) | BE787180A (en) |
| BG (1) | BG20575A3 (en) |
| CA (1) | CA976554A (en) |
| CH (1) | CH562790A5 (en) |
| CS (1) | CS181712B2 (en) |
| DD (1) | DD100249A5 (en) |
| DE (1) | DE2246799A1 (en) |
| EG (1) | EG10796A (en) |
| ES (1) | ES407141A1 (en) |
| FI (1) | FI59243C (en) |
| FR (1) | FR2187782B1 (en) |
| GB (1) | GB1345494A (en) |
| HU (1) | HU165916B (en) |
| IE (1) | IE36719B1 (en) |
| IL (1) | IL40503A (en) |
| IT (1) | IT1034031B (en) |
| LU (1) | LU65860A1 (en) |
| MC (1) | MC938A1 (en) |
| NL (1) | NL7213128A (en) |
| NO (1) | NO140347C (en) |
| OA (1) | OA04167A (en) |
| PL (1) | PL83580B1 (en) |
| RO (1) | RO60562A (en) |
| SE (1) | SE385695B (en) |
| YU (1) | YU35119B (en) |
| ZA (1) | ZA726084B (en) |
| ZM (1) | ZM15172A1 (en) |
-
0
- BE BE787180D patent/BE787180A/en not_active IP Right Cessation
-
1971
- 1971-08-24 AR AR243725A patent/AR193288A1/en active
-
1972
- 1972-06-13 CH CH881372A patent/CH562790A5/xx not_active IP Right Cessation
- 1972-08-07 LU LU65860A patent/LU65860A1/xx unknown
- 1972-08-22 MC MC1007A patent/MC938A1/en unknown
- 1972-08-30 IT IT28620/72A patent/IT1034031B/en active
- 1972-08-31 FR FR7230990A patent/FR2187782B1/fr not_active Expired
- 1972-09-02 OA OA54681A patent/OA04167A/en unknown
- 1972-09-04 GB GB4087072A patent/GB1345494A/en not_active Expired
- 1972-09-06 ZA ZA726084A patent/ZA726084B/en unknown
- 1972-09-07 AU AU46416/72A patent/AU464143B2/en not_active Expired
- 1972-09-12 SE SE7211723A patent/SE385695B/en unknown
- 1972-09-12 NO NO3232/72A patent/NO140347C/en unknown
- 1972-09-14 CA CA151,723A patent/CA976554A/en not_active Expired
- 1972-09-15 CS CS7200006345A patent/CS181712B2/en unknown
- 1972-09-15 FI FI2549/72A patent/FI59243C/en active
- 1972-09-18 HU HUEA921A patent/HU165916B/hu unknown
- 1972-09-19 ZM ZM151/72*UA patent/ZM15172A1/en unknown
- 1972-09-19 IE IE1280/72A patent/IE36719B1/en unknown
- 1972-09-20 PL PL1972157841A patent/PL83580B1/pl unknown
- 1972-09-21 AT AT812672A patent/AT316536B/en not_active IP Right Cessation
- 1972-09-23 DE DE19722246799 patent/DE2246799A1/en active Pending
- 1972-09-25 YU YU2421/72A patent/YU35119B/en unknown
- 1972-09-28 NL NL7213128A patent/NL7213128A/xx unknown
- 1972-09-29 DD DD165950A patent/DD100249A5/xx unknown
- 1972-09-29 ES ES407141A patent/ES407141A1/en not_active Expired
- 1972-09-30 RO RO72382A patent/RO60562A/ro unknown
- 1972-10-04 IL IL40503A patent/IL40503A/en unknown
- 1972-10-12 BG BG21603A patent/BG20575A3/xx unknown
- 1972-12-28 EG EG547/72A patent/EG10796A/en active
-
1973
- 1973-02-01 JP JP1332573A patent/JPS565733B2/ja not_active Expired
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |