CA1315125C - Appareil d'analyse differentielle multi-pieces a diffusion - Google Patents
Appareil d'analyse differentielle multi-pieces a diffusionInfo
- Publication number
- CA1315125C CA1315125C CA000561233A CA561233A CA1315125C CA 1315125 C CA1315125 C CA 1315125C CA 000561233 A CA000561233 A CA 000561233A CA 561233 A CA561233 A CA 561233A CA 1315125 C CA1315125 C CA 1315125C
- Authority
- CA
- Canada
- Prior art keywords
- light
- signal
- differentiating
- cell
- white blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000034 method Methods 0.000 title claims abstract description 80
- 210000004027 cell Anatomy 0.000 claims abstract description 144
- 210000000265 leukocyte Anatomy 0.000 claims abstract description 86
- 210000003979 eosinophil Anatomy 0.000 claims abstract description 52
- 230000004069 differentiation Effects 0.000 claims abstract description 14
- 238000001514 detection method Methods 0.000 claims abstract description 3
- 210000004698 lymphocyte Anatomy 0.000 claims description 64
- 210000000440 neutrophil Anatomy 0.000 claims description 58
- 210000003651 basophil Anatomy 0.000 claims description 50
- 210000001616 monocyte Anatomy 0.000 claims description 48
- 210000004369 blood Anatomy 0.000 claims description 36
- 239000008280 blood Substances 0.000 claims description 36
- 238000012545 processing Methods 0.000 claims description 34
- 239000012530 fluid Substances 0.000 claims description 19
- 210000000601 blood cell Anatomy 0.000 claims description 15
- 238000010276 construction Methods 0.000 claims description 5
- 230000002708 enhancing effect Effects 0.000 claims description 3
- 239000006194 liquid suspension Substances 0.000 claims description 3
- 230000004044 response Effects 0.000 claims description 3
- 230000003750 conditioning effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 abstract description 50
- 238000005259 measurement Methods 0.000 abstract description 20
- 230000003287 optical effect Effects 0.000 abstract description 16
- 238000004458 analytical method Methods 0.000 abstract description 10
- 239000000975 dye Substances 0.000 abstract 1
- 208000034628 Celiac artery compression syndrome Diseases 0.000 description 34
- BBWBEZAMXFGUGK-UHFFFAOYSA-N bis(dodecylsulfanyl)-methylarsane Chemical compound CCCCCCCCCCCCS[As](C)SCCCCCCCCCCCC BBWBEZAMXFGUGK-UHFFFAOYSA-N 0.000 description 34
- 238000000569 multi-angle light scattering Methods 0.000 description 34
- 239000011159 matrix material Substances 0.000 description 19
- 239000000523 sample Substances 0.000 description 17
- 238000000926 separation method Methods 0.000 description 13
- 230000002159 abnormal effect Effects 0.000 description 8
- 238000002156 mixing Methods 0.000 description 8
- 239000003153 chemical reaction reagent Substances 0.000 description 7
- 210000003714 granulocyte Anatomy 0.000 description 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 7
- 238000010586 diagram Methods 0.000 description 6
- 239000007788 liquid Substances 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- 230000005684 electric field Effects 0.000 description 5
- 230000002934 lysing effect Effects 0.000 description 5
- 230000000712 assembly Effects 0.000 description 4
- 238000000429 assembly Methods 0.000 description 4
- 230000000875 corresponding effect Effects 0.000 description 4
- 230000008878 coupling Effects 0.000 description 4
- 238000010168 coupling process Methods 0.000 description 4
- 238000005859 coupling reaction Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000010453 quartz Substances 0.000 description 4
- 238000010791 quenching Methods 0.000 description 4
- 238000010186 staining Methods 0.000 description 4
- 238000000149 argon plasma sintering Methods 0.000 description 3
- 230000000093 cytochemical effect Effects 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- CPBQJMYROZQQJC-UHFFFAOYSA-N helium neon Chemical compound [He].[Ne] CPBQJMYROZQQJC-UHFFFAOYSA-N 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000007493 shaping process Methods 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- 238000005452 bending Methods 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 239000005350 fused silica glass Substances 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000004513 sizing Methods 0.000 description 2
- 238000001374 small-angle light scattering Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229920002307 Dextran Polymers 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 239000003570 air Substances 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 238000005282 brightening Methods 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 238000000684 flow cytometry Methods 0.000 description 1
- -1 for example Substances 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 238000002847 impedance measurement Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000000207 lymphocyte subset Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229920012128 methyl methacrylate acrylonitrile butadiene styrene Polymers 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 229910052594 sapphire Inorganic materials 0.000 description 1
- 239000010980 sapphire Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000012780 transparent material Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
- G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
- G01N2015/016—White blood cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1019—Associating Coulter-counter and optical flow cytometer [OFC]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1024—Counting particles by non-optical means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
- G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
- G01N2015/139—Measuring the ratio of AC/DC impedances
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
- G01N2015/1413—Hydrodynamic focussing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1477—Multiparameters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N2021/4704—Angular selective
- G01N2021/4711—Multiangle measurement
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2544287A | 1987-03-13 | 1987-03-13 | |
| US07/025,442 | 1987-03-13 | ||
| US12995487A | 1987-12-04 | 1987-12-04 | |
| US07/129,954 | 1987-12-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1315125C true CA1315125C (fr) | 1993-03-30 |
Family
ID=26699741
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000561233A Expired - Fee Related CA1315125C (fr) | 1987-03-13 | 1988-03-11 | Appareil d'analyse differentielle multi-pieces a diffusion |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5125737A (fr) |
| EP (1) | EP0311655B1 (fr) |
| JP (1) | JP2505873B2 (fr) |
| KR (1) | KR970007077B1 (fr) |
| CN (1) | CN1014742B (fr) |
| AU (2) | AU602207B2 (fr) |
| CA (1) | CA1315125C (fr) |
| DE (1) | DE3852270T2 (fr) |
| ES (1) | ES2009188A6 (fr) |
| IL (1) | IL85671A (fr) |
| WO (1) | WO1988007198A1 (fr) |
Families Citing this family (160)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2096530A1 (fr) * | 1990-11-23 | 1992-05-24 | Thomas Russell | Methode et appareil pour l'identification des cellules microscopiques faisant appel a des techniques de diffusion de la lumiere |
| US5247188A (en) * | 1992-01-23 | 1993-09-21 | High Yield Technology | Concentrator funnel for vacuum line particle monitors |
| US6509192B1 (en) * | 1992-02-24 | 2003-01-21 | Coulter International Corp. | Quality control method |
| US5371585A (en) * | 1992-11-10 | 1994-12-06 | Pacific Scientific Company | Particle detecting instrument with sapphire detecting cell defining a rectangular flow path |
| DE69434942T2 (de) * | 1993-02-25 | 2007-11-29 | Abbott Laboratories, Abbott Park | Mehrzweckreagenzsystem zur schnellen lysierung von vollblutproben |
| US5534999A (en) * | 1993-03-05 | 1996-07-09 | Shinmikuni Kikai Ltd. | Monitoring sub-micron particles |
| EP0698211B1 (fr) * | 1993-05-14 | 2003-04-02 | Coulter International Corporation | Procede et appareil d'analyse de reticulocytes utilisant des techniques de dispersion de la lumiere |
| US5576185A (en) | 1994-04-15 | 1996-11-19 | Coulter Corporation | Method of positive or negative selection of a population or subpopulation of a sample utilizing particles and gravity sedimentation |
| JP3355038B2 (ja) * | 1994-08-03 | 2002-12-09 | シスメックス株式会社 | 白血球分類方法 |
| JP3375203B2 (ja) | 1994-08-08 | 2003-02-10 | シスメックス株式会社 | 細胞分析装置 |
| US5559037A (en) * | 1994-12-15 | 1996-09-24 | Abbott Laboratories | Method for rapid and simultaneous analysis of nucleated red blood cells |
| US5879900A (en) * | 1994-12-15 | 1999-03-09 | Abbott Laboratories | Method for simultaneous analysis of cell viability, nucleated red blood cells and white blood cell differentials |
| US5882933A (en) * | 1995-06-08 | 1999-03-16 | Coulter International Corp. | Method for determination of leukocytes and hemoglobin concentration in blood |
| US5843608A (en) * | 1995-06-08 | 1998-12-01 | Coulter International Corp. | Reagent and method for differential determination of leukocytes in blood |
| US5686308A (en) * | 1995-06-08 | 1997-11-11 | Coulter Corporation | Reagent and method for differential determination of leukocytes in blood |
| US5786224A (en) * | 1995-06-29 | 1998-07-28 | Coulter Corporation | Reagent and method for differential determination of leukocytes in blood |
| US5817518A (en) * | 1995-12-18 | 1998-10-06 | Coulter International Corp. | Reagent and method for differential determination of leukocytes in blood |
| US5686309A (en) * | 1996-01-19 | 1997-11-11 | Coulter International Corp. | Method and apparatus for determination of hemoglobin content of individual red blood cells |
| JP4136017B2 (ja) * | 1996-09-19 | 2008-08-20 | シスメックス株式会社 | 粒子分析装置 |
| US6175227B1 (en) | 1997-07-03 | 2001-01-16 | Coulter International Corp. | Potential-sensing method and apparatus for sensing and characterizing particles by the Coulter principle |
| US5945293A (en) * | 1997-10-09 | 1999-08-31 | Coulter International Corp. | Protein-colloidal metal-aminodextran coated particle and methods of preparation and use |
| US5874310A (en) * | 1997-11-21 | 1999-02-23 | Coulter International Corp. | Method for differentiation of nucleated red blood cells |
| US5874311A (en) * | 1997-11-21 | 1999-02-23 | Coulter International Corp. | Method for differentiation of reticulocytes in blood |
| US5917584A (en) * | 1997-11-21 | 1999-06-29 | Coulter International Corp. | Method for differentiation of nucleated red blood cells |
| US6149867A (en) | 1997-12-31 | 2000-11-21 | Xy, Inc. | Sheath fluids and collection systems for sex-specific cytometer sorting of sperm |
| CA2322202C (fr) * | 1998-03-10 | 2010-11-30 | Large Scale Proteomics Corporation | Detection et caracterisation des micro-organismes |
| FR2779296B1 (fr) * | 1998-06-02 | 2000-08-18 | France Telecom | Dispositif pour l'emission ou la reception d'un signal crypte par chaos deterministe |
| JP4101994B2 (ja) * | 1999-01-21 | 2008-06-18 | シスメックス株式会社 | 粒子分析装置および自動粒子分析方法 |
| US6228652B1 (en) * | 1999-02-16 | 2001-05-08 | Coulter International Corp. | Method and apparatus for analyzing cells in a whole blood sample |
| US6323632B1 (en) * | 1999-08-13 | 2001-11-27 | Coulter International Corp. | Solid state RF oscillator-detector for flow cytometer |
| US6507400B1 (en) | 1999-02-27 | 2003-01-14 | Mwi, Inc. | Optical system for multi-part differential particle discrimination and an apparatus using the same |
| JP3817091B2 (ja) * | 1999-07-02 | 2006-08-30 | テルモ株式会社 | 細胞数測定装置 |
| US6232125B1 (en) | 1999-08-09 | 2001-05-15 | Coulter International Corp. | Method and apparatus for differentiating and enumerating leukocytes |
| US6646742B1 (en) | 2000-02-19 | 2003-11-11 | Mwi, Inc. | Optical device and method for multi-angle laser light scatter |
| EP2258172B1 (fr) | 2000-05-09 | 2017-04-19 | Xy, Llc | Cytométre de flux pour différencier des populations de spermatozoïdes portant un chromosome X et un chromosome Y |
| US6597438B1 (en) * | 2000-08-02 | 2003-07-22 | Honeywell International Inc. | Portable flow cytometry |
| US7130046B2 (en) * | 2004-09-27 | 2006-10-31 | Honeywell International Inc. | Data frame selection for cytometer analysis |
| US6784981B1 (en) | 2000-06-02 | 2004-08-31 | Idexx Laboratories, Inc. | Flow cytometry-based hematology system |
| US20060263888A1 (en) * | 2000-06-02 | 2006-11-23 | Honeywell International Inc. | Differential white blood count on a disposable card |
| US7283223B2 (en) * | 2002-08-21 | 2007-10-16 | Honeywell International Inc. | Cytometer having telecentric optics |
| JP4708605B2 (ja) * | 2000-07-24 | 2011-06-22 | シスメックス株式会社 | 粒子分析装置とその粒子分画方法 |
| US8354647B2 (en) * | 2000-11-08 | 2013-01-15 | University Of North Florida | Photoelectric chemical sensor and sensing method utilizing interfacial photo-voltages |
| CA2822983C (fr) | 2000-11-29 | 2017-05-09 | Xy, Llc | Systeme de dissociation de spermatozoides congeles-decongeles porteurs d'un chromosome x de ceux porteurs d'un chromosome y |
| US20030048433A1 (en) * | 2001-06-01 | 2003-03-13 | Jean-Marie Desjonqueres | Cytometer signal processing system and method |
| US6472215B1 (en) | 2001-07-27 | 2002-10-29 | Coulter International Corp. | Method of analyzing nucleated red blood cells in a blood sample |
| JP2005506525A (ja) * | 2001-07-27 | 2005-03-03 | ベックマン コールター，インコーポレーテッド | 有核赤血球の計測法の方法 |
| US6916658B2 (en) * | 2001-07-27 | 2005-07-12 | Beckman Coulter, Inc. | Method for measurement of immature granulocytes |
| US6774995B2 (en) | 2001-08-03 | 2004-08-10 | Pointsource Technologies, Llc | Identification of particles in fluid |
| US6519033B1 (en) | 2001-11-19 | 2003-02-11 | Point Source Technologies, Llc | Identification of particles in fluid |
| AUPR846501A0 (en) * | 2001-10-26 | 2001-11-15 | Btf Pty Ltd | A cytometer |
| WO2003040703A1 (fr) * | 2001-11-02 | 2003-05-15 | Pointsource Technologies, Llc. | Detection de diffusion de lumiere |
| US6590652B2 (en) | 2001-11-02 | 2003-07-08 | Pointsource Technologies, Inc. | Flow through light scattering device |
| US6573992B1 (en) | 2001-11-13 | 2003-06-03 | Pointsource Technologies, Llc | Plano convex fluid carrier for scattering correction |
| US6628386B2 (en) | 2001-12-12 | 2003-09-30 | Pointsource Technologies, Llc | Particle detection beam |
| US7057724B1 (en) | 2002-03-21 | 2006-06-06 | Institute Of Critical Care Medicine | Particulate info to field units |
| US6930769B1 (en) | 2002-03-21 | 2005-08-16 | Pointsource Technologies, Llc | Optical sensor module tester |
| US6972424B1 (en) | 2002-04-16 | 2005-12-06 | Pointsource Technologies, Llc | High detection rate particle identifier |
| US6710874B2 (en) * | 2002-07-05 | 2004-03-23 | Rashid Mavliev | Method and apparatus for detecting individual particles in a flowable sample |
| US6743634B2 (en) * | 2002-08-23 | 2004-06-01 | Coulter International Corp. | Method and apparatus for differentiating blood cells using back-scatter |
| US6798508B2 (en) * | 2002-08-23 | 2004-09-28 | Coulter International Corp. | Fiber optic apparatus for detecting light scatter to differentiate blood cells and the like |
| US7169548B2 (en) | 2002-09-13 | 2007-01-30 | Xy, Inc. | Sperm cell processing and preservation systems |
| US7053783B2 (en) * | 2002-12-18 | 2006-05-30 | Biovigilant Systems, Inc. | Pathogen detector system and method |
| US8323984B2 (en) * | 2002-12-19 | 2012-12-04 | Beckman Coulter, Inc. | Method and apparatus for mixing blood samples for cell analysis |
| DK2305171T3 (da) | 2003-03-28 | 2022-03-21 | Inguran Llc | Apparat og fremgangsmåder til tilvejebringelse af kønssorteret dyresæd |
| US7092078B2 (en) * | 2003-03-31 | 2006-08-15 | Nihon Kohden Corporation | Flow cytometer for classifying leukocytes and method for determining detection angle range of the same |
| US6819421B1 (en) | 2003-04-11 | 2004-11-16 | Point Source Technologies, Llc | Detection of new species of particles |
| DE10341520A1 (de) * | 2003-09-09 | 2005-04-07 | Schupp, Wolfgang, Dr. | Verfahren und Vorrichtung zur Durchführung einer Lichtstreuung |
| US7198953B2 (en) * | 2003-10-12 | 2007-04-03 | Beckman Coulter, Inc. | Method of using a reference control composition for measurement of nucleated red blood cells |
| US7195919B2 (en) * | 2003-12-19 | 2007-03-27 | Beckman Coulter, Inc. | Hematology controls for reticulocytes and nucleated red blood cells |
| US7208319B2 (en) * | 2004-02-10 | 2007-04-24 | Beckman Coulter, Inc. | Method of measurement of nucleated red blood cells |
| JP4911601B2 (ja) * | 2004-02-10 | 2012-04-04 | ベックマン コールター， インコーポレイテッド | 有核赤血球細胞の計測方法 |
| US9297737B2 (en) * | 2004-03-06 | 2016-03-29 | Michael Trainer | Methods and apparatus for determining characteristics of particles |
| US8634072B2 (en) * | 2004-03-06 | 2014-01-21 | Michael Trainer | Methods and apparatus for determining characteristics of particles |
| US10620105B2 (en) * | 2004-03-06 | 2020-04-14 | Michael Trainer | Methods and apparatus for determining characteristics of particles from scattered light |
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- 1988-03-04 KR KR1019880701385A patent/KR970007077B1/ko not_active IP Right Cessation
- 1988-03-08 IL IL8567188A patent/IL85671A/en not_active IP Right Cessation
- 1988-03-11 CA CA000561233A patent/CA1315125C/fr not_active Expired - Fee Related
- 1988-03-11 ES ES8800748A patent/ES2009188A6/es not_active Expired
- 1988-03-12 CN CN88101232A patent/CN1014742B/zh not_active Expired
- 1988-03-14 DE DE3852270T patent/DE3852270T2/de not_active Expired - Lifetime
- 1988-03-14 WO PCT/US1988/000753 patent/WO1988007198A1/fr active IP Right Grant
- 1988-03-14 JP JP63502800A patent/JP2505873B2/ja not_active Expired - Lifetime
- 1988-03-14 EP EP88903074A patent/EP0311655B1/fr not_active Expired - Lifetime
- 1988-03-14 AU AU14970/88A patent/AU602207B2/en not_active Expired
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1990
- 1990-02-13 US US07/479,199 patent/US5125737A/en not_active Expired - Lifetime
- 1990-12-21 AU AU68483/90A patent/AU632393B2/en not_active Expired
Also Published As
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|---|---|
| AU6848390A (en) | 1991-03-14 |
| US5125737A (en) | 1992-06-30 |
| EP0311655A1 (fr) | 1989-04-19 |
| JPH01502533A (ja) | 1989-08-31 |
| EP0311655A4 (en) | 1990-09-05 |
| CN1014742B (zh) | 1991-11-13 |
| CN1031422A (zh) | 1989-03-01 |
| AU1497088A (en) | 1988-10-10 |
| WO1988007198A1 (fr) | 1988-09-22 |
| IL85671A0 (en) | 1988-08-31 |
| EP0311655B1 (fr) | 1994-11-30 |
| DE3852270D1 (de) | 1995-01-12 |
| IL85671A (en) | 1995-12-31 |
| ES2009188A6 (es) | 1989-09-01 |
| KR890700829A (ko) | 1989-04-27 |
| DE3852270T2 (de) | 1995-04-06 |
| AU632393B2 (en) | 1992-12-24 |
| KR970007077B1 (ko) | 1997-05-02 |
| JP2505873B2 (ja) | 1996-06-12 |
| AU602207B2 (en) | 1990-10-04 |
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