ES2009188A6 - Metodo y aparato de analisis diferencial de componentes multiples utilizando tecnicas de difusion de luz. - Google Patents

Metodo y aparato de analisis diferencial de componentes multiples utilizando tecnicas de difusion de luz.

Info

Publication number
ES2009188A6
ES2009188A6 ES8800748A ES8800748A ES2009188A6 ES 2009188 A6 ES2009188 A6 ES 2009188A6 ES 8800748 A ES8800748 A ES 8800748A ES 8800748 A ES8800748 A ES 8800748A ES 2009188 A6 ES2009188 A6 ES 2009188A6
Authority
ES
Spain
Prior art keywords
leukocytes
analyzing apparatus
light scatter
apparatus utilizing
utilizing light
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8800748A
Other languages
English (en)
Inventor
Carlos M Rodriguez
Wallace H Coulter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Coulter Electronics Inc
Original Assignee
Coulter Electronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coulter Electronics Inc filed Critical Coulter Electronics Inc
Publication of ES2009188A6 publication Critical patent/ES2009188A6/es
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/01—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
    • G01N2015/016—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1019—Associating Coulter-counter and optical flow cytometer [OFC]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1024—Counting particles by non-optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
    • G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
    • G01N2015/139—Measuring the ratio of AC/DC impedances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G01N2015/1413—Hydrodynamic focussing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1477—Multiparameters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N2021/4704—Angular selective
    • G01N2021/4711—Multiangle measurement

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

METODO Y APARATO DE ANALISIS DE PARTICULAS PARA DIFERENCIACION DE CELULAS BLANCAS DE LA SANGRE (LEUCOCITOS) MEDIANTE MEDICIONES OPTICAS Y ELECTRONICAS, SIN USAR COLORANTES, EN UNA CORRIENTE DE LEUCOCITOS EN CIRCULACION. UNA CORRIENTE DE LEUCOCITOS CONCENTRADA HIDRODINAMICAMENTE, EN ESTADO ORIGINAL, SE HACE PASAR EN Y A TRAVES DE UN HAZ (20) DE ENERGIA RADIANTE EN UNA CUBA DE CIRCULACION (10), CON LO CUAL EL HAZ DE ENERGIA ES DISPERSADO DE MANERA ESPECIAL POR LAS DIFERENTES SUB-POBLACIONES DE LEUCOCITOS. LA LUZ DISPERSADA CHOCA CON UN MEDIO DE CAPTACION DE LUZ (24) DISPUESTO EN POSICION ADYACENTE A LA CUBA DE CIRCULACION. PARA LA DETECCION DE EOSINOFOLOS, LA LUZ DISPERSADA SE RECOGE EN POSICIONES ANGULARES COMPRENDIDAS ENTRE 10G Y 70G RESPECTO AL EJE (26) DEL HAZ (20). LAS OTRAS SUBPOBLACIONES DE LEUCOCITOS SE DIFERENCIAN RESPECTO A LOS EOSINOFILOS Y LAS UNAS RESPECTO A LAS OTRAS MEDIANTE MEDICIONES OPTICAS Y/O ELECTRONICAS, QUE INCLUYEN ESPECIALMENTE EL PRINCIPIO DE COULTER PARA ANALISIS DEPARTICULAS.
ES8800748A 1987-03-13 1988-03-11 Metodo y aparato de analisis diferencial de componentes multiples utilizando tecnicas de difusion de luz. Expired ES2009188A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2544287A 1987-03-13 1987-03-13
US12995487A 1987-12-04 1987-12-04

Publications (1)

Publication Number Publication Date
ES2009188A6 true ES2009188A6 (es) 1989-09-01

Family

ID=26699741

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8800748A Expired ES2009188A6 (es) 1987-03-13 1988-03-11 Metodo y aparato de analisis diferencial de componentes multiples utilizando tecnicas de difusion de luz.

Country Status (11)

Country Link
US (1) US5125737A (es)
EP (1) EP0311655B1 (es)
JP (1) JP2505873B2 (es)
KR (1) KR970007077B1 (es)
CN (1) CN1014742B (es)
AU (2) AU602207B2 (es)
CA (1) CA1315125C (es)
DE (1) DE3852270T2 (es)
ES (1) ES2009188A6 (es)
IL (1) IL85671A (es)
WO (1) WO1988007198A1 (es)

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EP0311655A1 (en) 1989-04-19
JP2505873B2 (ja) 1996-06-12
DE3852270T2 (de) 1995-04-06
KR890700829A (ko) 1989-04-27
CN1014742B (zh) 1991-11-13
AU632393B2 (en) 1992-12-24
EP0311655B1 (en) 1994-11-30
IL85671A0 (en) 1988-08-31
AU602207B2 (en) 1990-10-04
JPH01502533A (ja) 1989-08-31
US5125737A (en) 1992-06-30
AU1497088A (en) 1988-10-10
KR970007077B1 (ko) 1997-05-02
CN1031422A (zh) 1989-03-01
IL85671A (en) 1995-12-31
EP0311655A4 (en) 1990-09-05
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AU6848390A (en) 1991-03-14
CA1315125C (en) 1993-03-30

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