CA1244412A - Mitomycin analogs - Google Patents

Mitomycin analogs

Info

Publication number
CA1244412A
CA1244412A CA000398102A CA398102A CA1244412A CA 1244412 A CA1244412 A CA 1244412A CA 000398102 A CA000398102 A CA 000398102A CA 398102 A CA398102 A CA 398102A CA 1244412 A CA1244412 A CA 1244412A
Authority
CA
Canada
Prior art keywords
lower alkyl
methoxy
indole
hexahydro
azirino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000398102A
Other languages
English (en)
French (fr)
Inventor
William A. Remers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University Patents Inc
Original Assignee
University Patents Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Patents Inc filed Critical University Patents Inc
Application granted granted Critical
Publication of CA1244412A publication Critical patent/CA1244412A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA000398102A 1981-05-15 1982-03-11 Mitomycin analogs Expired CA1244412A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26418781A 1981-05-15 1981-05-15
US264,187 1981-05-15

Publications (1)

Publication Number Publication Date
CA1244412A true CA1244412A (en) 1988-11-08

Family

ID=23004963

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000398102A Expired CA1244412A (en) 1981-05-15 1982-03-11 Mitomycin analogs

Country Status (27)

Country Link
JP (1) JPS57188590A (ja)
KR (1) KR890000935B1 (ja)
AT (1) AT375943B (ja)
AU (1) AU559686B2 (ja)
BE (1) BE893162A (ja)
CA (1) CA1244412A (ja)
CH (1) CH655116A5 (ja)
DE (1) DE3217769A1 (ja)
DK (1) DK161078C (ja)
ES (1) ES511874A0 (ja)
FI (1) FI78100C (ja)
FR (1) FR2505839B1 (ja)
GB (1) GB2106096B (ja)
GR (1) GR76033B (ja)
HU (1) HU186510B (ja)
IE (1) IE52956B1 (ja)
IL (1) IL64998A0 (ja)
IT (1) IT1156453B (ja)
LU (1) LU84144A1 (ja)
NL (1) NL8200839A (ja)
NO (1) NO158743C (ja)
NZ (1) NZ199617A (ja)
PH (1) PH20358A (ja)
PT (1) PT74895B (ja)
SE (1) SE450895B (ja)
YU (1) YU44819B (ja)
ZA (1) ZA82923B (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA833967B (en) * 1982-06-04 1984-02-29 Bristol Myers Co Amidines
EP0116208B1 (en) * 1982-12-07 1988-03-30 Kyowa Hakko Kogyo Co., Ltd. Mitomycin analogues
NZ206932A (en) * 1983-02-07 1987-08-31 University Patents Inc Certain 6-(heterocyclyl or amino) mitosanes and pharmaceutical compositions
US4803212A (en) * 1983-04-11 1989-02-07 Bristol-Myers Company Amino disulfides
US4642352A (en) * 1983-12-23 1987-02-10 Bristol-Myers Company Acylamino mitosanes
JPS60255789A (ja) * 1984-06-01 1985-12-17 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体，その製造法および抗腫瘍剤
FR2571373A1 (fr) * 1984-10-09 1986-04-11 Bristol Myers Co Procede de preparation de derives n7-substitues de la mitomycine c
EP0197799B1 (en) * 1985-04-10 1990-09-12 Kyowa Hakko Kogyo Kabushiki Kaisha Pharmacologically active mitomycin derivatives
US5023253A (en) * 1987-12-21 1991-06-11 University Patents, Inc. 6-substituted mitomycin analogs
EP2768805B1 (en) 2011-10-20 2020-03-25 Oryzon Genomics, S.A. (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL129868C (ja) * 1963-06-07
US3420846A (en) * 1964-08-25 1969-01-07 Kyowa Hakko Kogyo Kk 7-substituted mitomycin a
US3332944A (en) * 1964-11-02 1967-07-25 American Cyanamid Co Antibiotic derivatives of mitomycins a, b, c and porfiromycin
JPS5439098A (en) * 1977-08-31 1979-03-24 Kyowa Hakko Kogyo Co Ltd Mitomycin c derivatives
US4268676A (en) * 1979-12-05 1981-05-19 University Patents, Inc. Mitomycin analogs
JPS5686184A (en) * 1979-12-17 1981-07-13 Kyowa Hakko Kogyo Co Ltd Novel mitomycin c derivative

Also Published As

Publication number Publication date
PT74895A (en) 1982-06-01
NO158743C (no) 1988-10-26
NO158743B (no) 1988-07-18
FI821241L (fi) 1982-11-16
IT1156453B (it) 1987-02-04
ATA184482A (de) 1984-02-15
ES8303417A1 (es) 1983-02-01
KR890000935B1 (ko) 1989-04-14
GB2106096B (en) 1985-12-04
IE820431L (en) 1982-11-15
IE52956B1 (en) 1988-04-27
IT8267321A0 (it) 1982-03-15
ZA82923B (en) 1983-01-26
DK161078C (da) 1991-11-11
GB2106096A (en) 1983-04-07
HU186510B (en) 1985-08-28
IL64998A0 (en) 1982-04-30
NO821598L (no) 1982-11-16
FR2505839A1 (fr) 1982-11-19
PH20358A (en) 1986-12-04
GR76033B (ja) 1984-08-03
ES511874A0 (es) 1983-02-01
FI78100C (fi) 1989-06-12
FI78100B (fi) 1989-02-28
YU97282A (en) 1985-04-30
NL8200839A (nl) 1982-12-01
JPS57188590A (en) 1982-11-19
BE893162A (fr) 1982-08-30
DK219182A (da) 1982-11-16
DK161078B (da) 1991-05-27
AT375943B (de) 1984-09-25
AU8268282A (en) 1983-11-17
DE3217769A1 (de) 1982-12-09
FR2505839B1 (fr) 1985-11-08
SE450895B (sv) 1987-08-10
LU84144A1 (fr) 1982-09-13
AU559686B2 (en) 1987-03-19
CH655116A5 (de) 1986-03-27
KR830009102A (ko) 1983-12-17
SE8203035L (sv) 1982-11-16
YU44819B (en) 1991-02-28
FI821241A0 (fi) 1982-04-07
NZ199617A (en) 1985-08-30
PT74895B (en) 1984-08-02

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Legal Events

Date Code Title Description
MKEX Expiry