CA1174679A - Process for the preparation of 2,4-diamino-5-(3',4', 5'-trimethoxy-benzyl)-pyrimidine - Google Patents

Process for the preparation of 2,4-diamino-5-(3',4', 5'-trimethoxy-benzyl)-pyrimidine

Info

Publication number
CA1174679A
CA1174679A CA000406060A CA406060A CA1174679A CA 1174679 A CA1174679 A CA 1174679A CA 000406060 A CA000406060 A CA 000406060A CA 406060 A CA406060 A CA 406060A CA 1174679 A CA1174679 A CA 1174679A
Authority
CA
Canada
Prior art keywords
general formula
trimethoxy
compound
benzyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000406060A
Other languages
English (en)
French (fr)
Inventor
Ivan Beck
Zoltan Takacs
Istvan Simonyi
Andras Dietz
Imre Biro
Laszlo Ladanyi
Elemer Jakfalvi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Egyt Gyogyszervegyeszeti Gyar
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Application granted granted Critical
Publication of CA1174679A publication Critical patent/CA1174679A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CA000406060A 1981-06-26 1982-06-25 Process for the preparation of 2,4-diamino-5-(3',4', 5'-trimethoxy-benzyl)-pyrimidine Expired CA1174679A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU811869A HU187370B (en) 1981-06-26 1981-06-26 Improved process for producing 2,4-diamino-5-bracket-3-comma above, 4-comma above,5-comma above-trimethoxy-benzyl-bracket closed-pyrimidine
HU1869/81 1981-06-26

Publications (1)

Publication Number Publication Date
CA1174679A true CA1174679A (en) 1984-09-18

Family

ID=10956594

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000406060A Expired CA1174679A (en) 1981-06-26 1982-06-25 Process for the preparation of 2,4-diamino-5-(3',4', 5'-trimethoxy-benzyl)-pyrimidine

Country Status (21)

Country Link
JP (1) JPS5838266A (fi)
AT (1) AT387961B (fi)
AU (1) AU547823B2 (fi)
BE (1) BE893611A (fi)
CA (1) CA1174679A (fi)
CH (1) CH648834A5 (fi)
CS (1) CS244908B2 (fi)
DD (1) DD202703A5 (fi)
DK (1) DK155434C (fi)
ES (1) ES8304949A1 (fi)
FI (1) FI76790C (fi)
FR (1) FR2508450B1 (fi)
GB (1) GB2104508B (fi)
GR (1) GR76159B (fi)
HU (1) HU187370B (fi)
IE (1) IE53466B1 (fi)
IL (1) IL66132A (fi)
IT (1) IT1190889B (fi)
SE (1) SE451133B (fi)
SU (1) SU1145929A3 (fi)
YU (1) YU42774B (fi)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2602507B1 (fr) * 1986-08-08 1989-06-09 Sanofi Pharma Procede de preparation de diamino-2,4 benzyl-5 pyrimidines

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB743221A (en) * 1953-05-26 1956-01-11 Wellcome Found Improvements in or relating to the manufacture of acrylonitriles
DE1303727B (de) * 1959-09-03 1976-02-05 Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London Alpha-Arylidensubstituierte Propioni-Irile
NL122146C (fi) * 1960-09-02
US4033962A (en) * 1975-06-26 1977-07-05 Hoffman-La Roche Inc. 2,4-Diamino-pyrimidine derivatives and processes
DE2635765C3 (de) * 1976-08-09 1979-02-08 Ludwig Heumann & Co Gmbh, 8500 Nuernberg Verfahren zur Herstellung von 2,4-EMamino-5-(3',4'r5'-trimethoxybenzyl)-pyrimidin
US4115650A (en) * 1976-11-17 1978-09-19 Hoffmann-La Roche Inc. Process for preparing 2,4-diamino-5-(substituted benzyl)-pyrimidines
DE2730467A1 (de) * 1977-07-06 1979-01-18 Basf Ag Benzylpyrimidine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
ATA244982A (de) 1988-09-15
FI76790B (fi) 1988-08-31
IE821520L (en) 1982-12-26
FI76790C (fi) 1988-12-12
GB2104508B (en) 1985-01-16
YU42774B (en) 1988-12-31
SE8203914L (sv) 1982-12-27
BE893611A (fr) 1982-12-23
CS471782A2 (en) 1985-09-17
DK288082A (da) 1982-12-27
DK155434B (da) 1989-04-10
JPS5838266A (ja) 1983-03-05
AU8534682A (en) 1983-01-06
GB2104508A (en) 1983-03-09
CH648834A5 (de) 1985-04-15
IL66132A0 (en) 1982-09-30
IT8222035A0 (it) 1982-06-24
SU1145929A3 (ru) 1985-03-15
AT387961B (de) 1989-04-10
HU187370B (en) 1985-12-28
AU547823B2 (en) 1985-11-07
DK155434C (da) 1989-09-18
ES513482A0 (es) 1983-04-01
SE451133B (sv) 1987-09-07
IE53466B1 (en) 1988-11-23
IT1190889B (it) 1988-02-24
FR2508450A1 (fr) 1982-12-31
ES8304949A1 (es) 1983-04-01
FR2508450B1 (fr) 1986-01-03
CS244908B2 (en) 1986-08-14
YU138582A (en) 1984-10-31
FI822268L (fi) 1982-12-27
FI822268A0 (fi) 1982-06-24
GR76159B (fi) 1984-08-03
DD202703A5 (de) 1983-09-28
IL66132A (en) 1985-04-30
SE8203914D0 (sv) 1982-06-23

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Legal Events

Date Code Title Description
MKEC Expiry (correction)
MKEX Expiry