CA1132904A - Process for the recovery of heparin - Google Patents
Process for the recovery of heparinInfo
- Publication number
- CA1132904A CA1132904A CA319,121A CA319121A CA1132904A CA 1132904 A CA1132904 A CA 1132904A CA 319121 A CA319121 A CA 319121A CA 1132904 A CA1132904 A CA 1132904A
- Authority
- CA
- Canada
- Prior art keywords
- heparin
- sodium chloride
- chloride solution
- solution
- intestinal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229920000669 heparin Polymers 0.000 title claims abstract description 53
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title claims abstract description 45
- 229960002897 heparin Drugs 0.000 title claims abstract description 45
- 238000000034 method Methods 0.000 title claims abstract description 24
- 238000011084 recovery Methods 0.000 title description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 74
- 239000000243 solution Substances 0.000 claims abstract description 46
- 239000011780 sodium chloride Substances 0.000 claims abstract description 37
- 239000012267 brine Substances 0.000 claims abstract description 17
- 241001465754 Metazoa Species 0.000 claims abstract description 15
- 210000000936 intestine Anatomy 0.000 claims abstract description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 12
- 238000011282 treatment Methods 0.000 claims abstract description 8
- 239000007787 solid Substances 0.000 claims abstract description 3
- 150000003839 salts Chemical class 0.000 claims description 2
- 230000000968 intestinal effect Effects 0.000 abstract description 20
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 abstract description 15
- 210000003097 mucus Anatomy 0.000 abstract description 10
- 241001494479 Pecora Species 0.000 abstract description 4
- 241000283690 Bos taurus Species 0.000 abstract description 3
- 241000282887 Suidae Species 0.000 abstract description 3
- 239000003146 anticoagulant agent Substances 0.000 abstract description 2
- 229940127219 anticoagulant drug Drugs 0.000 abstract description 2
- 239000006227 byproduct Substances 0.000 abstract description 2
- 210000004185 liver Anatomy 0.000 abstract description 2
- 210000004072 lung Anatomy 0.000 abstract description 2
- 235000002639 sodium chloride Nutrition 0.000 description 27
- 229960002668 sodium chloride Drugs 0.000 description 26
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 239000002244 precipitate Substances 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- 238000005406 washing Methods 0.000 description 6
- 238000001035 drying Methods 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000000875 corresponding effect Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000010828 elution Methods 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000010626 work up procedure Methods 0.000 description 2
- 108091006522 Anion exchangers Proteins 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000003957 anion exchange resin Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 159000000009 barium salts Chemical class 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 238000010908 decantation Methods 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- -1 sodium chlor- Chemical class 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2800943A DE2800943C2 (de) | 1978-01-06 | 1978-01-06 | Verwendung von Darm-Salzlake zur Gewinnung von reinem Heparin |
| DEP2800943.0 | 1978-01-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1132904A true CA1132904A (en) | 1982-10-05 |
Family
ID=6029250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA319,121A Expired CA1132904A (en) | 1978-01-06 | 1979-01-04 | Process for the recovery of heparin |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS5943042B2 (en, 2012) |
| AR (1) | AR220734A1 (en, 2012) |
| AT (1) | AT365073B (en, 2012) |
| AU (1) | AU526459B2 (en, 2012) |
| BE (1) | BE873327A (en, 2012) |
| BR (1) | BR7900056A (en, 2012) |
| CA (1) | CA1132904A (en, 2012) |
| CH (1) | CH638818A5 (en, 2012) |
| CS (1) | CS216189B2 (en, 2012) |
| DD (1) | DD141311A5 (en, 2012) |
| DE (1) | DE2800943C2 (en, 2012) |
| DK (1) | DK163063C (en, 2012) |
| ES (1) | ES476623A1 (en, 2012) |
| FI (1) | FI65073C (en, 2012) |
| FR (1) | FR2414055A1 (en, 2012) |
| GB (1) | GB2012790B (en, 2012) |
| GR (1) | GR72952B (en, 2012) |
| HU (1) | HU179594B (en, 2012) |
| IT (1) | IT1109918B (en, 2012) |
| LU (1) | LU80755A1 (en, 2012) |
| NL (1) | NL187070C (en, 2012) |
| PL (1) | PL117279B3 (en, 2012) |
| RO (1) | RO78606A (en, 2012) |
| SE (1) | SE439109B (en, 2012) |
| YU (1) | YU301878A (en, 2012) |
| ZA (1) | ZA787305B (en, 2012) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3265781D1 (en) * | 1981-05-21 | 1985-10-03 | Akzo Nv | New anti-thromboticum based on polysacharides, method for its preparation and pharmaceutical compositions |
| CN103601821B (zh) * | 2013-11-15 | 2016-01-06 | 重庆三腾食品有限公司 | 一种酶解加工方法及对应肝素钠加工方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1156938B (de) * | 1957-09-23 | 1963-11-07 | Upjohn Company Eine Ges Nach D | Verfahren zur Gewinnung von Heparin |
| GB889010A (en) * | 1957-11-06 | 1962-02-07 | Crinos Industria Farmaco | A new heparin-like compound |
| DE2660052A1 (de) * | 1976-11-12 | 1979-01-25 | Schering Ag | Verfahren zur herstellung von heparin |
| DE2652272C2 (de) * | 1976-11-12 | 1979-02-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von Heparin |
-
1978
- 1978-01-06 DE DE2800943A patent/DE2800943C2/de not_active Expired
- 1978-12-19 FI FI783904A patent/FI65073C/fi not_active IP Right Cessation
- 1978-12-21 YU YU03018/78A patent/YU301878A/xx unknown
- 1978-12-27 DK DK582878A patent/DK163063C/da not_active IP Right Cessation
- 1978-12-27 ZA ZA00787305A patent/ZA787305B/xx unknown
- 1978-12-27 RO RO7896066A patent/RO78606A/ro unknown
- 1978-12-28 NL NLAANVRAGE7812621,A patent/NL187070C/xx not_active IP Right Cessation
- 1978-12-28 JP JP53161328A patent/JPS5943042B2/ja not_active Expired
-
1979
- 1979-01-03 LU LU80755A patent/LU80755A1/de unknown
- 1979-01-04 SE SE7900077A patent/SE439109B/sv not_active IP Right Cessation
- 1979-01-04 CS CS79133A patent/CS216189B2/cs unknown
- 1979-01-04 AT AT0006879A patent/AT365073B/de not_active IP Right Cessation
- 1979-01-04 PL PL1979212596A patent/PL117279B3/pl unknown
- 1979-01-04 CA CA319,121A patent/CA1132904A/en not_active Expired
- 1979-01-05 GR GR58030A patent/GR72952B/el unknown
- 1979-01-05 ES ES476623A patent/ES476623A1/es not_active Expired
- 1979-01-05 GB GB79457A patent/GB2012790B/en not_active Expired
- 1979-01-05 BR BR7900056A patent/BR7900056A/pt unknown
- 1979-01-05 BE BE0/192777A patent/BE873327A/xx not_active IP Right Cessation
- 1979-01-05 IT IT19085/79A patent/IT1109918B/it active
- 1979-01-05 CH CH10279A patent/CH638818A5/de not_active IP Right Cessation
- 1979-01-05 HU HU79SCHE667A patent/HU179594B/hu unknown
- 1979-01-05 AR AR275072A patent/AR220734A1/es active
- 1979-01-05 DD DD79210359A patent/DD141311A5/de unknown
- 1979-01-08 FR FR7900295A patent/FR2414055A1/fr active Granted
- 1979-01-08 AU AU43181/79A patent/AU526459B2/en not_active Ceased
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |