CA1088059A - Piperazinyl et homopiperazinyl quinazolines - Google Patents

Piperazinyl et homopiperazinyl quinazolines

Info

Publication number
CA1088059A
CA1088059A CA314,027A CA314027A CA1088059A CA 1088059 A CA1088059 A CA 1088059A CA 314027 A CA314027 A CA 314027A CA 1088059 A CA1088059 A CA 1088059A
Authority
CA
Canada
Prior art keywords
formula
benzodioxan
chloroform
vacuo
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA314,027A
Other languages
English (en)
Inventor
Simon F. Campbell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp
Original Assignee
Pfizer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp filed Critical Pfizer Corp
Application granted granted Critical
Publication of CA1088059A publication Critical patent/CA1088059A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CA314,027A 1977-11-05 1978-10-24 Piperazinyl et homopiperazinyl quinazolines Expired CA1088059A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IE46128/77 1977-11-05
GB4612877 1977-11-05
GB46128/77 1977-11-05

Publications (1)

Publication Number Publication Date
CA1088059A true CA1088059A (fr) 1980-10-21

Family

ID=10439957

Family Applications (1)

Application Number Title Priority Date Filing Date
CA314,027A Expired CA1088059A (fr) 1977-11-05 1978-10-24 Piperazinyl et homopiperazinyl quinazolines

Country Status (36)

Country Link
JP (1) JPS5498792A (fr)
AR (2) AR219562A1 (fr)
AT (1) AT365186B (fr)
AU (1) AU509329B2 (fr)
BE (1) BE871771A (fr)
CA (1) CA1088059A (fr)
CH (1) CH643255A5 (fr)
CS (2) CS207671B2 (fr)
DD (1) DD139850A5 (fr)
DE (1) DE2847623C2 (fr)
DK (1) DK154082C (fr)
EG (1) EG13594A (fr)
ES (2) ES474805A1 (fr)
FI (1) FI64366C (fr)
FR (1) FR2407929A1 (fr)
GR (1) GR81514B (fr)
HK (1) HK94284A (fr)
HU (1) HU176306B (fr)
IE (1) IE47888B1 (fr)
IL (1) IL55857A (fr)
IN (1) IN148828B (fr)
IT (1) IT1100919B (fr)
KE (1) KE3350A (fr)
LU (2) LU80470A1 (fr)
MY (1) MY8500286A (fr)
NL (2) NL174549C (fr)
NO (1) NO150158C (fr)
NZ (1) NZ188813A (fr)
PH (1) PH13966A (fr)
PL (2) PL119419B1 (fr)
PT (1) PT68735A (fr)
SE (1) SE437518B (fr)
SU (1) SU816403A3 (fr)
UA (1) UA8324A1 (fr)
YU (2) YU40204B (fr)
ZA (1) ZA786184B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986002644A1 (fr) * 1984-11-01 1986-05-09 Takeda Chemical Industries, Ltd. Derives de 1,5-benzoxathiepines et leur procede de preparation
WO1985002617A1 (fr) * 1983-12-14 1985-06-20 Takeda Chemical Industries. Ltd. Derives de 1,5-benzoxathiepine et leur procede de preparation
WO1985004658A1 (fr) * 1984-04-04 1985-10-24 Takeda Chemical Industries, Ltd. Derives de 1,5 benzoxathiepine et leur preparation
EP0849265A1 (fr) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Nouvelle forme polymorphique de mésylate de doxazosin (forme II)
EP0849264A1 (fr) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Nouvelle forme polymorphique de mésylate de doxazosin (forme I)
DK0849266T3 (da) * 1996-12-20 2007-06-04 Heumann Pcs Gmbh Hidtil ukendt polymorf form af doxazosin-mesylat (form III)
TW448155B (en) * 1999-03-29 2001-08-01 Dev Center Biotechnology Method for producing amide compounds and quinazolin derivatives
EP1403263B1 (fr) * 2002-09-27 2005-06-22 Council of Scientific and Industrial Research Procédé pour la préparation de la N-(2,3-dihydrobenzo[1,4]dioxin-2-carbonyl)piperazine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3635979A (en) * 1969-09-29 1972-01-18 Pfizer Certain 6- and/or 7-alkoxy-substituted-2 4-bis(disubstituted amino) quinazolines
US3669968A (en) * 1970-05-21 1972-06-13 Pfizer Trialkoxy quinazolines

Also Published As

Publication number Publication date
FR2407929A1 (fr) 1979-06-01
NO150158B (no) 1984-05-21
IT1100919B (it) 1985-09-28
NO150158C (no) 1984-08-29
JPS5498792A (en) 1979-08-03
MY8500286A (en) 1985-12-31
AU4132278A (en) 1979-05-17
PL210681A1 (fr) 1979-11-05
EG13594A (en) 1982-03-31
ES480121A0 (es) 1980-07-16
AU509329B2 (en) 1980-05-08
DK154082C (da) 1989-02-27
ATA784378A (de) 1981-05-15
CS354491A3 (en) 1992-06-17
AR223015A1 (es) 1981-07-15
KE3350A (en) 1983-12-16
IE47888B1 (en) 1984-07-11
IE782179L (en) 1979-05-05
PH13966A (en) 1980-11-12
SE437518B (sv) 1985-03-04
DD139850A5 (de) 1980-01-23
YU38683A (en) 1983-06-30
NL930062I1 (nl) 1993-09-01
YU255378A (en) 1983-06-30
IL55857A0 (en) 1979-01-31
FI783347A (fi) 1979-05-06
LU88331I2 (fr) 1994-05-04
DE2847623A1 (de) 1979-05-23
DE2847623C2 (de) 1983-06-01
NL930062I2 (nl) 1993-11-16
NZ188813A (en) 1980-10-08
ES8308559A1 (es) 1980-07-16
FI64366B (fi) 1983-07-29
HK94284A (en) 1984-12-07
FR2407929B1 (fr) 1981-02-27
IL55857A (en) 1982-07-30
LU80470A1 (fr) 1980-06-05
SU816403A3 (ru) 1981-03-23
IN148828B (fr) 1981-06-27
NL7810909A (nl) 1979-05-08
JPS5625233B2 (fr) 1981-06-11
DK428678A (da) 1979-05-06
DK154082B (da) 1988-10-10
CS207671B2 (en) 1981-08-31
NL174549C (nl) 1984-07-02
NO783705L (no) 1979-05-08
NL174549B (nl) 1984-02-01
PL119586B1 (en) 1982-01-30
YU40419B (en) 1985-12-31
ZA786184B (en) 1979-10-31
HU176306B (en) 1981-01-28
BE871771A (fr) 1979-05-03
SE7811382L (sv) 1979-05-06
CH643255A5 (en) 1984-05-30
PT68735A (en) 1978-12-01
GR81514B (fr) 1984-12-11
FI64366C (fi) 1983-11-10
PL119419B1 (en) 1981-12-31
IT7829434A0 (it) 1978-11-03
ES474805A1 (es) 1980-01-16
AR219562A1 (es) 1980-08-29
UA8324A1 (uk) 1996-03-29
AT365186B (de) 1981-12-28
YU40204B (en) 1985-08-31

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