CA1087524A - Process of increasing the intravenous compatibility of gamma globulins - Google Patents
Process of increasing the intravenous compatibility of gamma globulinsInfo
- Publication number
- CA1087524A CA1087524A CA271,204A CA271204A CA1087524A CA 1087524 A CA1087524 A CA 1087524A CA 271204 A CA271204 A CA 271204A CA 1087524 A CA1087524 A CA 1087524A
- Authority
- CA
- Canada
- Prior art keywords
- silicates
- process according
- ized
- character
- stratified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108010074605 gamma-Globulins Proteins 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title claims abstract description 28
- 230000008569 process Effects 0.000 title claims abstract description 24
- 238000001990 intravenous administration Methods 0.000 title claims abstract description 4
- 150000004760 silicates Chemical class 0.000 claims abstract description 21
- 238000006243 chemical reaction Methods 0.000 claims abstract description 13
- 239000002002 slurry Substances 0.000 claims abstract description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 5
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 5
- 239000000725 suspension Substances 0.000 claims abstract description 4
- 239000000243 solution Substances 0.000 claims description 14
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 claims description 10
- 229910052901 montmorillonite Inorganic materials 0.000 claims description 10
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 9
- 239000011707 mineral Substances 0.000 claims description 9
- 229910052902 vermiculite Inorganic materials 0.000 claims description 9
- 239000010455 vermiculite Substances 0.000 claims description 9
- 235000019354 vermiculite Nutrition 0.000 claims description 9
- 239000000440 bentonite Substances 0.000 claims description 8
- 229910000278 bentonite Inorganic materials 0.000 claims description 8
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 7
- 239000002244 precipitate Substances 0.000 claims description 7
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims description 6
- 229920001612 Hydroxyethyl starch Polymers 0.000 claims description 5
- 229940050526 hydroxyethylstarch Drugs 0.000 claims description 5
- 108010044091 Globulins Proteins 0.000 claims description 4
- 102000006395 Globulins Human genes 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 claims description 3
- 229920002521 macromolecule Polymers 0.000 claims description 3
- 239000010836 blood and blood product Substances 0.000 claims description 2
- 229940125691 blood product Drugs 0.000 claims description 2
- 238000011084 recovery Methods 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 150000001768 cations Chemical class 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 238000005341 cation exchange Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 description 1
- 102000008100 Human Serum Albumin Human genes 0.000 description 1
- 108091006905 Human Serum Albumin Proteins 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 241001637516 Polygonia c-album Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- HPTYUNKZVDYXLP-UHFFFAOYSA-N aluminum;trihydroxy(trihydroxysilyloxy)silane;hydrate Chemical compound O.[Al].[Al].O[Si](O)(O)O[Si](O)(O)O HPTYUNKZVDYXLP-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000002391 anti-complement effect Effects 0.000 description 1
- 230000003171 anti-complementary effect Effects 0.000 description 1
- 108010008730 anticomplement Proteins 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000008570 general process Effects 0.000 description 1
- 229910052621 halloysite Inorganic materials 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 150000002892 organic cations Chemical class 0.000 description 1
- HCTVWSOKIJULET-LQDWTQKMSA-M phenoxymethylpenicillin potassium Chemical compound [K+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)COC1=CC=CC=C1 HCTVWSOKIJULET-LQDWTQKMSA-M 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 229930195734 saturated hydrocarbon Natural products 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2604759A DE2604759C2 (de) | 1976-02-07 | 1976-02-07 | Verfahren zur Gewinnung von iv-verträglichen Γglobulinen |
| DEP2604759.6 | 1976-02-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1087524A true CA1087524A (en) | 1980-10-14 |
Family
ID=5969262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA271,204A Expired CA1087524A (en) | 1976-02-07 | 1977-02-07 | Process of increasing the intravenous compatibility of gamma globulins |
Country Status (22)
| Country | Link |
|---|---|
| JP (1) | JPS52117414A (cs) |
| AT (1) | AT351672B (cs) |
| AU (1) | AU508852B2 (cs) |
| BE (1) | BE851151R (cs) |
| CA (1) | CA1087524A (cs) |
| CH (1) | CH629669A5 (cs) |
| DD (1) | DD132758A6 (cs) |
| DE (1) | DE2604759C2 (cs) |
| DK (1) | DK151609C (cs) |
| ES (1) | ES455708A2 (cs) |
| FI (1) | FI62624C (cs) |
| FR (1) | FR2340738A2 (cs) |
| GB (1) | GB1577031A (cs) |
| HU (1) | HU177708B (cs) |
| IE (1) | IE44591B1 (cs) |
| IN (1) | IN144987B (cs) |
| MX (1) | MX5356E (cs) |
| NL (1) | NL7700975A (cs) |
| PL (1) | PL104234B3 (cs) |
| SE (1) | SE442707B (cs) |
| YU (1) | YU30577A (cs) |
| ZA (1) | ZA77684B (cs) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2837168A1 (de) * | 1978-08-25 | 1980-03-06 | Blutspendedienst Dt Rote Kreuz | Verfahren zur herstellung einer fuer die intravenoese anwendung geeigneten immunglobulinloesung |
| JPS60222773A (ja) * | 1984-04-19 | 1985-11-07 | Sekisui Chem Co Ltd | ラテツクス試薬の製造方法 |
| DE3483784D1 (de) * | 1984-07-07 | 1991-01-31 | Woelm Pharma Gmbh & Co | Verfahren zur herstellung von gamma-globulin zur intravenoesen anwendung. |
| DE3440444A1 (de) * | 1984-11-06 | 1986-05-07 | Dechema Deutsche Gesellschaft für chemisches Apparatewesen e.V., 6000 Frankfurt | Verfahren zur herstellung grob gekoernter schichtsilikate und deren verwendung als adsorbentien fuer proteine |
| UA64742C2 (uk) * | 1997-12-24 | 2004-03-15 | Альфа Терапевтик Корпорейшн | СПОСІБ ОДЕРЖАННЯ РОЗЧИНУ <font face="Symbol">g</font>-ГЛОБУЛІНУ, ПРИЗНАЧЕНОГО ДЛЯ ВНУТРІШНЬОВЕННОГО ВВЕДЕННЯ, І ПРОДУКТ, ЩО ОДЕРЖУЄТЬСЯ У ЦЕЙ СПОСІБ (ВАРІАНТИ) |
| US10287315B2 (en) | 2014-03-11 | 2019-05-14 | Green Cross Holdings Corporation | Method for purifying immunoglobulin |
| WO2015137531A1 (ko) | 2014-03-11 | 2015-09-17 | 주식회사 녹십자홀딩스 | 면역글로불린의 정제방법 |
| KR101657690B1 (ko) | 2015-06-05 | 2016-09-19 | 주식회사 녹십자홀딩스 | 혈장 유래 b형 간염 사람 면역글로불린 제제의 제조방법 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3449316A (en) * | 1967-03-03 | 1969-06-10 | American Cyanamid Co | Process for the purification of gamma globulin employing bentonite |
| DE2500076C3 (de) * | 1975-01-02 | 1982-11-18 | SCHURA Blutderivate GmbH & Co KG, 4150 Krefeld | Verfahren zur Gewinnung von intravenös-verträglichen Gammaglobulinen |
-
1976
- 1976-02-07 DE DE2604759A patent/DE2604759C2/de not_active Expired
-
1977
- 1977-01-28 FI FI770290A patent/FI62624C/fi not_active IP Right Cessation
- 1977-01-28 IE IE186/77A patent/IE44591B1/en unknown
- 1977-01-31 NL NL7700975A patent/NL7700975A/xx not_active Application Discontinuation
- 1977-01-31 SE SE7700960A patent/SE442707B/xx not_active IP Right Cessation
- 1977-02-03 AU AU21902/77A patent/AU508852B2/en not_active Expired
- 1977-02-04 PL PL1977195821A patent/PL104234B3/pl unknown
- 1977-02-04 AT AT74177A patent/AT351672B/de not_active IP Right Cessation
- 1977-02-04 DD DD7700197241A patent/DD132758A6/xx unknown
- 1977-02-04 MX MX775414U patent/MX5356E/es unknown
- 1977-02-04 DK DK047277A patent/DK151609C/da not_active IP Right Cessation
- 1977-02-04 HU HU77PA1277A patent/HU177708B/hu unknown
- 1977-02-04 YU YU00305/77A patent/YU30577A/xx unknown
- 1977-02-04 BE BE6045865A patent/BE851151R/xx not_active IP Right Cessation
- 1977-02-04 FR FR7703139A patent/FR2340738A2/fr active Granted
- 1977-02-05 IN IN168/CAL/77A patent/IN144987B/en unknown
- 1977-02-07 JP JP1172177A patent/JPS52117414A/ja active Granted
- 1977-02-07 GB GB5017/77A patent/GB1577031A/en not_active Expired
- 1977-02-07 CH CH146277A patent/CH629669A5/de not_active IP Right Cessation
- 1977-02-07 CA CA271,204A patent/CA1087524A/en not_active Expired
- 1977-02-07 ZA ZA770684A patent/ZA77684B/xx unknown
- 1977-02-07 ES ES455708A patent/ES455708A2/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE2604759A1 (de) | 1977-09-29 |
| IN144987B (cs) | 1978-08-05 |
| IE44591B1 (en) | 1982-01-27 |
| ZA77684B (en) | 1977-12-28 |
| AT351672B (de) | 1979-08-10 |
| MX5356E (es) | 1983-06-29 |
| BE851151R (fr) | 1977-08-04 |
| NL7700975A (nl) | 1977-08-09 |
| DE2604759C2 (de) | 1983-06-01 |
| FI62624B (fi) | 1982-10-29 |
| DD132758A6 (de) | 1978-11-01 |
| SE7700960L (sv) | 1977-08-08 |
| DK47277A (da) | 1977-08-07 |
| HU177708B (en) | 1981-12-28 |
| CH629669A5 (en) | 1982-05-14 |
| JPS6231695B2 (cs) | 1987-07-09 |
| DK151609B (da) | 1987-12-21 |
| JPS52117414A (en) | 1977-10-01 |
| PL104234B3 (pl) | 1979-08-31 |
| YU30577A (en) | 1984-04-30 |
| SE442707B (sv) | 1986-01-27 |
| FR2340738B2 (cs) | 1981-07-31 |
| DK151609C (da) | 1988-06-20 |
| GB1577031A (en) | 1980-10-15 |
| AU508852B2 (en) | 1980-04-03 |
| AU2190277A (en) | 1978-08-10 |
| ATA74177A (de) | 1979-01-15 |
| FR2340738A2 (fr) | 1977-09-09 |
| IE44591L (en) | 1977-08-07 |
| FI770290A7 (cs) | 1977-08-08 |
| FI62624C (fi) | 1983-02-10 |
| ES455708A2 (es) | 1978-01-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |