CA1032927A - Procede de preparation de nouveaux haptenes derives de l'estrone - Google Patents

Procede de preparation de nouveaux haptenes derives de l'estrone

Info

Publication number
CA1032927A
CA1032927A CA202,616A CA202616A CA1032927A CA 1032927 A CA1032927 A CA 1032927A CA 202616 A CA202616 A CA 202616A CA 1032927 A CA1032927 A CA 1032927A
Authority
CA
Canada
Prior art keywords
formule
composé
que
groupement
représente
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA202,616A
Other languages
English (en)
Other versions
CA202616S (en
Inventor
Vesperto Torelli
Andre Pierdet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Application granted granted Critical
Publication of CA1032927A publication Critical patent/CA1032927A/fr
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/823—Immunogenic carrier or carrier per se

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PRECIS DE LA DIVULGATION:

La présente invention concerne les composés répondant à la formule I:
(I) Dans laquelle X représente un atome d'oxygène ou le groupe , Y représente un atome d'hydrogène ou le groupe OH et soit R1 repré-sente un groupe-(CH2) a CO2H, a étant un nombre entier égal à
2n + 3, n étant égal à 0, 1 ou 2 et R2 représente un groupe , soit R1 représente un atome d'hydrogène et R2 représente un radical , b étant un nombre entier variant de 3 à
18 ou bien R2 représente un groupe =NZ-(CH2)c CO2H, Z représen-tant un atome d'oxygène ou un groupe -NHCONH-, c étant un nombre entier variant de 1 à 8, ainsi que la préparation des composés de formule I. Les composés de formule I trouvent leur applica-tion dans la fabrication d'anticorps.
CA202,616A 1973-06-18 1974-06-17 Procede de preparation de nouveaux haptenes derives de l'estrone Expired CA1032927A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7322114A FR2235949B1 (fr) 1973-06-18 1973-06-18

Publications (1)

Publication Number Publication Date
CA1032927A true CA1032927A (fr) 1978-06-13

Family

ID=9121104

Family Applications (1)

Application Number Title Priority Date Filing Date
CA202,616A Expired CA1032927A (fr) 1973-06-18 1974-06-17 Procede de preparation de nouveaux haptenes derives de l'estrone

Country Status (16)

Country Link
US (1) US3922292A (fr)
JP (4) JPS5827280B2 (fr)
AT (1) AT343295B (fr)
BE (1) BE816457A (fr)
BR (1) BR7404979D0 (fr)
CA (1) CA1032927A (fr)
DE (1) DE2429040C2 (fr)
DK (1) DK322274A (fr)
ES (3) ES427318A1 (fr)
FR (1) FR2235949B1 (fr)
GB (2) GB1478356A (fr)
IE (1) IE41524B1 (fr)
LU (1) LU70329A1 (fr)
NL (1) NL7408041A (fr)
SE (1) SE402461B (fr)
ZA (1) ZA743841B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2277821A1 (fr) * 1974-07-10 1976-02-06 Roussel Uclaf Nouveaux haptenes derives de la progesterone, leur procede de preparation et leur application a la fabrication d'antigenes
FR2377418A1 (fr) * 1977-01-13 1978-08-11 Roussel Uclaf Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments
FR2377417A1 (fr) * 1977-01-13 1978-08-11 Roussel Uclaf Nouveaux derives steroides substitues en 11b, ainsi que leur procede de preparation
FR2377419A1 (fr) * 1977-01-13 1978-08-11 Roussel Uclaf Nouveaux derives steroides 11b-substitues 1,3,5 (10) trieniques, leur procede de preparation et leur application comme medicament
NL7701384A (nl) * 1977-02-10 1978-08-14 Akzo Nv Werkwijze voor het bereiden van nieuwe steroiden van de oestraanreeks.
GB8327256D0 (en) * 1983-10-12 1983-11-16 Ici Plc Steroid derivatives
CA1285866C (fr) 1984-10-19 1991-07-09 Akiko Kubodera Dosage immunologique du sulfate de 3-oestriol
FR2643638B1 (fr) * 1989-02-24 1991-06-14 Roussel Uclaf Nouveaux 19-nor steroides ayant en position 11beta une chaine carbonee comportant une fonction amide ou carbamate, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant
FR2665901B2 (fr) * 1989-02-24 1994-07-29 Roussel Uclaf Nouveaux 19-nor sterouides ayant en position 11beta une chaine carbonee comportant une fonction amide, leur preparation, leur application comme medicaments.
DK0471612T3 (da) * 1990-08-14 1999-02-22 Hoechst Marion Roussel Inc Nye 19-nor steroider med carbonkæde omfattende en amidgruppe i 11-beta-stillingen, fremgangsmåde til deres fremstilling, de
JPH059418U (ja) * 1991-07-12 1993-02-09 広島アルミニウム工業株式会社 電磁コンロ用発熱器
JPH07297707A (ja) * 1994-04-27 1995-11-10 Nec Corp 位相同期発振回路
JP2000511404A (ja) 1996-04-09 2000-09-05 ビー・テイー・ジー・インターナシヨナル・リミテツド 神経精神、免疫又は内分泌障害を治療するための７α置換ステロイドの使用
WO2006015081A2 (fr) * 2004-07-27 2006-02-09 Sicor, Inc. Procede de preparation de 19-norsteroides 7$g(a)-alkyles
US7910755B2 (en) * 2004-09-29 2011-03-22 Harbor Biosciences, Inc. Stem cell expansion and uses

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3211756A (en) * 1963-07-23 1965-10-12 Searle & Co 3-hydroxyimino-17alpha-(lower alkyl)-5alpha-androstan-17beta-ols and the optionally substituted 3-acyloxyimino and 3-alkoxyimino derivatives corresponding
DE1668682A1 (de) * 1967-03-14 1971-09-23 Searle & Co Gegebenenfalls in 17-Stellung alkylierte 11,13ss-Dialkylgona-1,3,5(10)-trien-3,17ss-diole und deren Ester

Also Published As

Publication number Publication date
GB1478357A (en) 1977-06-29
ES427318A1 (es) 1976-09-16
SE7407108L (fr) 1974-12-19
FR2235949B1 (fr) 1978-03-17
ES448013A1 (es) 1977-07-01
FR2235949A1 (fr) 1975-01-31
JPS5036451A (fr) 1975-04-05
ES448012A1 (es) 1977-07-01
SE402461B (sv) 1978-07-03
JPS6241719B2 (fr) 1987-09-04
JPS5890600A (ja) 1983-05-30
JPS5890597A (ja) 1983-05-30
LU70329A1 (fr) 1975-03-06
IE41524B1 (en) 1980-01-30
IE41524L (en) 1974-12-18
BR7404979D0 (pt) 1975-01-21
NL7408041A (fr) 1974-12-20
BE816457A (fr) 1974-12-17
DE2429040A1 (de) 1975-01-09
GB1478356A (en) 1977-06-29
JPS5838440B2 (ja) 1983-08-23
DK322274A (fr) 1975-02-10
US3922292A (en) 1975-11-25
JPS601200A (ja) 1985-01-07
JPS5827280B2 (ja) 1983-06-08
JPS5934200B2 (ja) 1984-08-21
ATA504374A (de) 1977-09-15
AT343295B (de) 1978-05-26
AU7014874A (en) 1975-12-18
DE2429040C2 (de) 1985-10-31
ZA743841B (en) 1976-01-28

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