BRPI0919876A8 - Composto, composição farmacêutica, uso de um composto, e, método para intensificar a qualidade do sono, para tratar insônia, e para tratar ou controlar obesidade em um paciente mamífero que necessita do mesmo. - Google Patents
Composto, composição farmacêutica, uso de um composto, e, método para intensificar a qualidade do sono, para tratar insônia, e para tratar ou controlar obesidade em um paciente mamífero que necessita do mesmo.Info
- Publication number
- BRPI0919876A8 BRPI0919876A8 BRPI0919876A BRPI0919876A BRPI0919876A8 BR PI0919876 A8 BRPI0919876 A8 BR PI0919876A8 BR PI0919876 A BRPI0919876 A BR PI0919876A BR PI0919876 A BRPI0919876 A BR PI0919876A BR PI0919876 A8 BRPI0919876 A8 BR PI0919876A8
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- treatment
- pharmaceutical composition
- need
- mammalian patient
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 208000008589 Obesity Diseases 0.000 title 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 title 1
- 230000002708 enhancing effect Effects 0.000 title 1
- 206010022437 insomnia Diseases 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 235000020824 obesity Nutrition 0.000 title 1
- 108050000742 Orexin Receptor Proteins 0.000 abstract 2
- 102000008834 Orexin receptor Human genes 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 229940123730 Orexin receptor antagonist Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- VFQXVTODMYMSMJ-UHFFFAOYSA-N isonicotinamide Chemical class NC(=O)C1=CC=NC=C1 VFQXVTODMYMSMJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19778908P | 2008-10-30 | 2008-10-30 | |
| US18057409P | 2009-05-22 | 2009-05-22 | |
| PCT/US2009/061987 WO2010051236A1 (en) | 2008-10-30 | 2009-10-26 | Isonicotinamide orexin receptor antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI0919876A2 BRPI0919876A2 (pt) | 2015-08-18 |
| BRPI0919876A8 true BRPI0919876A8 (pt) | 2016-02-10 |
Family
ID=41348271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0919876A BRPI0919876A8 (pt) | 2008-10-30 | 2009-10-26 | Composto, composição farmacêutica, uso de um composto, e, método para intensificar a qualidade do sono, para tratar insônia, e para tratar ou controlar obesidade em um paciente mamífero que necessita do mesmo. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8592457B2 (enExample) |
| EP (1) | EP2350010B1 (enExample) |
| JP (1) | JP5635991B2 (enExample) |
| KR (1) | KR101320245B1 (enExample) |
| CN (1) | CN102272103B (enExample) |
| AU (1) | AU2009308980B2 (enExample) |
| BR (1) | BRPI0919876A8 (enExample) |
| CA (1) | CA2741644C (enExample) |
| CL (1) | CL2011000976A1 (enExample) |
| CO (1) | CO6361994A2 (enExample) |
| CR (1) | CR20110228A (enExample) |
| DO (1) | DOP2011000120A (enExample) |
| EA (1) | EA201170624A1 (enExample) |
| EC (1) | ECSP11011019A (enExample) |
| IL (1) | IL212436A0 (enExample) |
| MA (1) | MA32804B1 (enExample) |
| MX (1) | MX2011004551A (enExample) |
| NI (1) | NI201100084A (enExample) |
| NZ (1) | NZ592544A (enExample) |
| PE (1) | PE20110852A1 (enExample) |
| TN (1) | TN2011000171A1 (enExample) |
| WO (1) | WO2010051236A1 (enExample) |
| ZA (1) | ZA201103156B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2010535769A (ja) | 2007-08-09 | 2010-11-25 | メルク・シャープ・エンド・ドーム・コーポレイション | ピリジンカルボキサミドオレキシン受容体アンタゴニスト |
| AR072899A1 (es) | 2008-08-07 | 2010-09-29 | Merck Sharp & Dohme | Derivados de terpiridina-carboxamida antagonistas de receptores de orexina, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del insomnio y la obesidad. |
| EP2349262B1 (en) | 2008-10-30 | 2014-06-25 | Merck Sharp & Dohme Corp. | 2,5-disubstituted phenyl carboxamide orexin receptor antagonists |
| US8703770B2 (en) | 2008-10-30 | 2014-04-22 | Merck Sharp & Dohme Corp. | Pyridazine carboxamide orexin receptor antagonists |
| WO2011050202A1 (en) | 2009-10-23 | 2011-04-28 | Janssen Pharmaceutica Nv | Fused heterocyclic compounds as orexin receptor modulators |
| MX2012004753A (es) | 2009-10-23 | 2012-09-07 | Janssen Pharmaceutica Nv | Octahidropirrolo[3,4-c]pirrolos disustituidos como moduladores del receptor de orexina. |
| WO2011050200A1 (en) | 2009-10-23 | 2011-04-28 | Janssen Pharmaceutica Nv | Fused heterocyclic compounds as orexin receptor modulators |
| CN103380130B (zh) * | 2011-02-18 | 2015-06-17 | 埃科特莱茵药品有限公司 | 用作为食欲素拮抗剂的新颖的吡唑和咪唑衍生物 |
| US9586962B2 (en) | 2011-04-20 | 2017-03-07 | Janssen Pharmaceutica Nv | Disubstituted octahydropyrrolo [3,4-C] pyrroles as orexin receptor modulators |
| AR088352A1 (es) * | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
| US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
| RU2014136339A (ru) | 2012-02-07 | 2016-03-27 | Иолас Терапьютикс, Инк. | Замещенные пролины/пиперидины как антагонисты орексиновых рецепторов |
| WO2013187466A1 (ja) * | 2012-06-15 | 2013-12-19 | 大正製薬株式会社 | 分岐鎖アルキルヘテロ芳香環誘導体 |
| DK2862860T3 (en) * | 2012-06-15 | 2017-01-30 | Taisho Pharmaceutical Co Ltd | 1,3-oxazolidine or 1,3-oxazinan compounds as orexin receptor antagonists |
| JP5907310B2 (ja) * | 2013-12-13 | 2016-04-26 | 大正製薬株式会社 | オキサジナン化合物の結晶形及びその製造方法 |
| JP5930010B2 (ja) * | 2013-12-13 | 2016-06-08 | 大正製薬株式会社 | ヘテロ芳香環メチル環状アミン誘導体を含有する医薬 |
| EP2915811A1 (en) * | 2014-03-04 | 2015-09-09 | Centre Régional de Lutte contre le Cancer - Centre François Baclesse | MCL-1 modulating compounds for cancer treatment |
| EP3180332B1 (en) | 2014-08-13 | 2021-10-27 | Eolas Therapeutics Inc. | Difluoropyrrolidines as orexin receptor modulators |
| US10011595B2 (en) | 2014-12-19 | 2018-07-03 | Merck Sharp & Dohme Corp. | Ethyldiamine orexin receptor antagonists |
| WO2016101118A1 (en) * | 2014-12-23 | 2016-06-30 | Merck Sharp & Dohme Corp. | Amidoethyl azole orexin receptor antagonists |
| EP3340971B1 (en) * | 2015-08-24 | 2024-03-13 | Zogenix International Limited | Methods of treating lennox-gastaut syndrome using fenfluramine |
| WO2017088759A1 (en) | 2015-11-23 | 2017-06-01 | Sunshine Lake Pharma Co., Ltd. | OCTAHYDROPYRROLO [3, 4-c] PYRROLE DERIVATIVES AND USES THEREOF |
| KR102738491B1 (ko) | 2016-02-12 | 2024-12-03 | 아스트라제네카 아베 | 오렉신 수용체 조정제로서의 할로-치환된 피페리딘 |
| RS63296B1 (sr) | 2016-03-10 | 2022-07-29 | Janssen Pharmaceutica Nv | Metode lečenja depresije korišćenjem antagonista receptora oreksin-2 |
| GB201702174D0 (en) | 2017-02-09 | 2017-03-29 | Benevolentai Bio Ltd | Orexin receptor antagonists |
| GB201707499D0 (en) | 2017-05-10 | 2017-06-21 | Benevolentai Bio Ltd | Orexin receptor antagonists |
| GB201707504D0 (en) | 2017-05-10 | 2017-06-21 | Benevolentai Bio Ltd | Orexin receptor antagonists |
| CN109280027A (zh) * | 2018-12-13 | 2019-01-29 | 康化（上海）新药研发有限公司 | 一种5,6-二甲氧基-2-吡啶甲酸的合成方法 |
| CN116600803A (zh) * | 2020-11-02 | 2023-08-15 | 默沙东有限责任公司 | 大环脲食欲素受体激动剂 |
| CA3215210A1 (en) * | 2021-04-26 | 2022-11-03 | Younggi Choi | Substituted amide macrocyclic compounds with orexin-2 receptor agonist activity |
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-
2009
- 2009-10-26 MX MX2011004551A patent/MX2011004551A/es active IP Right Grant
- 2009-10-26 EA EA201170624A patent/EA201170624A1/ru unknown
- 2009-10-26 PE PE2011000959A patent/PE20110852A1/es not_active Application Discontinuation
- 2009-10-26 JP JP2011534650A patent/JP5635991B2/ja not_active Expired - Fee Related
- 2009-10-26 BR BRPI0919876A patent/BRPI0919876A8/pt not_active IP Right Cessation
- 2009-10-26 NZ NZ592544A patent/NZ592544A/xx not_active IP Right Cessation
- 2009-10-26 CA CA2741644A patent/CA2741644C/en not_active Expired - Fee Related
- 2009-10-26 CN CN200980153418.3A patent/CN102272103B/zh not_active Expired - Fee Related
- 2009-10-26 EP EP09741173.0A patent/EP2350010B1/en active Active
- 2009-10-26 KR KR1020117009859A patent/KR101320245B1/ko not_active Expired - Fee Related
- 2009-10-26 US US13/124,568 patent/US8592457B2/en active Active
- 2009-10-26 AU AU2009308980A patent/AU2009308980B2/en not_active Ceased
- 2009-10-26 WO PCT/US2009/061987 patent/WO2010051236A1/en not_active Ceased
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2011
- 2011-04-12 TN TN2011000171A patent/TN2011000171A1/fr unknown
- 2011-04-17 IL IL212436A patent/IL212436A0/en unknown
- 2011-04-29 CL CL2011000976A patent/CL2011000976A1/es unknown
- 2011-04-29 ZA ZA2011/03156A patent/ZA201103156B/en unknown
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- 2011-04-29 EC EC2011011019A patent/ECSP11011019A/es unknown
- 2011-04-29 DO DO2011000120A patent/DOP2011000120A/es unknown
- 2011-04-29 CR CR20110228A patent/CR20110228A/es unknown
- 2011-05-12 CO CO11058578A patent/CO6361994A2/es not_active Application Discontinuation
- 2011-05-19 MA MA33859A patent/MA32804B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP5635991B2 (ja) | 2014-12-03 |
| CR20110228A (es) | 2011-06-24 |
| US20110201591A1 (en) | 2011-08-18 |
| EA201170624A1 (ru) | 2011-12-30 |
| CA2741644A1 (en) | 2010-05-06 |
| WO2010051236A1 (en) | 2010-05-06 |
| EP2350010B1 (en) | 2014-03-26 |
| ZA201103156B (en) | 2012-01-25 |
| IL212436A0 (en) | 2011-06-30 |
| KR20110071101A (ko) | 2011-06-28 |
| JP2012507538A (ja) | 2012-03-29 |
| CN102272103A (zh) | 2011-12-07 |
| EP2350010A1 (en) | 2011-08-03 |
| BRPI0919876A2 (pt) | 2015-08-18 |
| CL2011000976A1 (es) | 2012-02-24 |
| MA32804B1 (fr) | 2011-11-01 |
| CN102272103B (zh) | 2015-10-21 |
| NZ592544A (en) | 2013-01-25 |
| DOP2011000120A (es) | 2011-10-15 |
| KR101320245B1 (ko) | 2013-10-30 |
| CA2741644C (en) | 2013-05-07 |
| PE20110852A1 (es) | 2011-11-25 |
| TN2011000171A1 (en) | 2012-12-17 |
| ECSP11011019A (es) | 2011-05-31 |
| CO6361994A2 (es) | 2012-01-20 |
| AU2009308980B2 (en) | 2013-02-28 |
| NI201100084A (es) | 2011-11-03 |
| AU2009308980A1 (en) | 2010-05-06 |
| US8592457B2 (en) | 2013-11-26 |
| MX2011004551A (es) | 2011-05-25 |
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