CL2011000976A1 - Compuestos derivados de isonicotinamida y carboxamida, antagonistas de los receptores de orexina; composicion farmaceutica que los comprende; y su uso para la prevencion de un trastorno del sueno. - Google Patents
Compuestos derivados de isonicotinamida y carboxamida, antagonistas de los receptores de orexina; composicion farmaceutica que los comprende; y su uso para la prevencion de un trastorno del sueno.Info
- Publication number
- CL2011000976A1 CL2011000976A1 CL2011000976A CL2011000976A CL2011000976A1 CL 2011000976 A1 CL2011000976 A1 CL 2011000976A1 CL 2011000976 A CL2011000976 A CL 2011000976A CL 2011000976 A CL2011000976 A CL 2011000976A CL 2011000976 A1 CL2011000976 A1 CL 2011000976A1
- Authority
- CL
- Chile
- Prior art keywords
- isonicotinamide
- carboxamide
- prevention
- pharmaceutical composition
- receptor antagonists
- Prior art date
Links
- 229940123730 Orexin receptor antagonist Drugs 0.000 title abstract 2
- 150000003857 carboxamides Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- VFQXVTODMYMSMJ-UHFFFAOYSA-N isonicotinamide Chemical compound NC(=O)C1=CC=NC=C1 VFQXVTODMYMSMJ-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 208000019116 sleep disease Diseases 0.000 title abstract 2
- 208000020685 sleep-wake disease Diseases 0.000 title abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19778908P | 2008-10-30 | 2008-10-30 | |
| US18057409P | 2009-05-22 | 2009-05-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2011000976A1 true CL2011000976A1 (es) | 2012-02-24 |
Family
ID=41348271
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2011000976A CL2011000976A1 (es) | 2008-10-30 | 2011-04-29 | Compuestos derivados de isonicotinamida y carboxamida, antagonistas de los receptores de orexina; composicion farmaceutica que los comprende; y su uso para la prevencion de un trastorno del sueno. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US8592457B2 (enExample) |
| EP (1) | EP2350010B1 (enExample) |
| JP (1) | JP5635991B2 (enExample) |
| KR (1) | KR101320245B1 (enExample) |
| CN (1) | CN102272103B (enExample) |
| AU (1) | AU2009308980B2 (enExample) |
| BR (1) | BRPI0919876A8 (enExample) |
| CA (1) | CA2741644C (enExample) |
| CL (1) | CL2011000976A1 (enExample) |
| CO (1) | CO6361994A2 (enExample) |
| CR (1) | CR20110228A (enExample) |
| DO (1) | DOP2011000120A (enExample) |
| EA (1) | EA201170624A1 (enExample) |
| EC (1) | ECSP11011019A (enExample) |
| IL (1) | IL212436A0 (enExample) |
| MA (1) | MA32804B1 (enExample) |
| MX (1) | MX2011004551A (enExample) |
| NI (1) | NI201100084A (enExample) |
| NZ (1) | NZ592544A (enExample) |
| PE (1) | PE20110852A1 (enExample) |
| TN (1) | TN2011000171A1 (enExample) |
| WO (1) | WO2010051236A1 (enExample) |
| ZA (1) | ZA201103156B (enExample) |
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| CA2695621A1 (en) | 2007-08-09 | 2009-02-12 | Merck Sharp & Dohme Corp. | Pyridine carboxamide orexin receptor antagonists |
| AR072899A1 (es) | 2008-08-07 | 2010-09-29 | Merck Sharp & Dohme | Derivados de terpiridina-carboxamida antagonistas de receptores de orexina, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del insomnio y la obesidad. |
| EP2349262B1 (en) | 2008-10-30 | 2014-06-25 | Merck Sharp & Dohme Corp. | 2,5-disubstituted phenyl carboxamide orexin receptor antagonists |
| EP2349267B1 (en) | 2008-10-30 | 2014-06-25 | Merck Sharp & Dohme Corp. | Pyridazine carboxamide orexin receptor antagonists |
| ME03452B (me) | 2009-10-23 | 2020-01-20 | Janssen Pharmaceutica Nv | Disupstituisani oktahi-dropirolo[3,4-c]piroli kao modulatori oreksin receptora |
| EP2491034B1 (en) | 2009-10-23 | 2013-12-18 | Janssen Pharmaceutica, N.V. | Fused heterocyclic compounds as orexin receptor modulators |
| EP2491031B1 (en) | 2009-10-23 | 2013-08-07 | Janssen Pharmaceutica N.V. | Fused heterocyclic compounds as orexin receptor modulators |
| ES2541531T3 (es) * | 2011-02-18 | 2015-07-21 | Actelion Pharmaceuticals Ltd. | Nuevos derivados de pirazol e imidazol útiles como antagonistas de orexina |
| WO2012145581A1 (en) | 2011-04-20 | 2012-10-26 | Janssen Pharmaceutica Nv | Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators |
| AR088352A1 (es) * | 2011-10-19 | 2014-05-28 | Merck Sharp & Dohme | Antagonistas del receptor de 2-piridiloxi-4-nitrilo orexina |
| US9440982B2 (en) | 2012-02-07 | 2016-09-13 | Eolas Therapeutics, Inc. | Substituted prolines/piperidines as orexin receptor antagonists |
| JP6346862B2 (ja) | 2012-02-07 | 2018-06-20 | エオラス セラピューティクス， インコーポレイテッド | オレキシンレセプターアンタゴニストとしての置換プロリン／ピペリジン |
| ES2613663T3 (es) * | 2012-06-15 | 2017-05-25 | Taisho Pharmaceutical Co., Ltd. | Compuestos de 1,3-oxazolidina o 1,3-oxazinano como antagonistas del receptor de orexina |
| KR20150023390A (ko) * | 2012-06-15 | 2015-03-05 | 다이쇼 세이야꾸 가부시끼가이샤 | 분지쇄 알킬 헤테로 방향환 유도체 |
| JP5907310B2 (ja) * | 2013-12-13 | 2016-04-26 | 大正製薬株式会社 | オキサジナン化合物の結晶形及びその製造方法 |
| JP5930010B2 (ja) * | 2013-12-13 | 2016-06-08 | 大正製薬株式会社 | ヘテロ芳香環メチル環状アミン誘導体を含有する医薬 |
| EP2915811A1 (en) * | 2014-03-04 | 2015-09-09 | Centre Régional de Lutte contre le Cancer - Centre François Baclesse | MCL-1 modulating compounds for cancer treatment |
| TW201613902A (en) | 2014-08-13 | 2016-04-16 | Eolas Therapeutics Inc | Difluoropyrrolidines as orexin receptor modulators |
| WO2016100161A1 (en) * | 2014-12-19 | 2016-06-23 | Merck Sharp & Dohme Corp. | Ethyldiamine orexin receptor antagonists |
| WO2016101118A1 (en) * | 2014-12-23 | 2016-06-30 | Merck Sharp & Dohme Corp. | Amidoethyl azole orexin receptor antagonists |
| KR102615486B1 (ko) * | 2015-08-24 | 2023-12-19 | 조게닉스 인터내셔널 리미티드 | 펜플루라민을 사용하여 레녹스-가스토 증후군을 치료하는 방법 |
| US10370380B2 (en) | 2015-11-23 | 2019-08-06 | Sunshine Lake Pharma Co., Ltd. | Octahydropyrrolo[3,4-c]pyrrole derivatives and uses thereof |
| US10894789B2 (en) | 2016-02-12 | 2021-01-19 | Astrazeneca Ab | Halo-substituted piperidines as orexin receptor modulators |
| KR20230116948A (ko) | 2016-03-10 | 2023-08-04 | 얀센 파마슈티카 엔.브이. | 오렉신-2 수용체 길항제를 사용한 우울증의 치료 방법 |
| GB201702174D0 (en) | 2017-02-09 | 2017-03-29 | Benevolentai Bio Ltd | Orexin receptor antagonists |
| GB201707499D0 (en) | 2017-05-10 | 2017-06-21 | Benevolentai Bio Ltd | Orexin receptor antagonists |
| GB201707504D0 (en) | 2017-05-10 | 2017-06-21 | Benevolentai Bio Ltd | Orexin receptor antagonists |
| CN109280027A (zh) * | 2018-12-13 | 2019-01-29 | 康化（上海）新药研发有限公司 | 一种5,6-二甲氧基-2-吡啶甲酸的合成方法 |
| WO2022094012A1 (en) | 2020-11-02 | 2022-05-05 | Merck Sharp & Dohme Corp. | Macrocyclic urea orexin receptor agonists |
| WO2022232025A1 (en) * | 2021-04-26 | 2022-11-03 | Alkermes, Inc. | Substituted amide macrocyclic compounds with orexin-2 receptor agonist activity |
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- 2009-10-26 MX MX2011004551A patent/MX2011004551A/es active IP Right Grant
- 2009-10-26 EP EP09741173.0A patent/EP2350010B1/en active Active
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- 2009-10-26 WO PCT/US2009/061987 patent/WO2010051236A1/en not_active Ceased
- 2009-10-26 CN CN200980153418.3A patent/CN102272103B/zh not_active Expired - Fee Related
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- 2009-10-26 KR KR1020117009859A patent/KR101320245B1/ko not_active Expired - Fee Related
- 2009-10-26 AU AU2009308980A patent/AU2009308980B2/en not_active Ceased
- 2009-10-26 EA EA201170624A patent/EA201170624A1/ru unknown
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- 2009-10-26 US US13/124,568 patent/US8592457B2/en active Active
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2350010B1 (en) | 2014-03-26 |
| BRPI0919876A2 (pt) | 2015-08-18 |
| CN102272103A (zh) | 2011-12-07 |
| DOP2011000120A (es) | 2011-10-15 |
| NZ592544A (en) | 2013-01-25 |
| US20110201591A1 (en) | 2011-08-18 |
| WO2010051236A1 (en) | 2010-05-06 |
| PE20110852A1 (es) | 2011-11-25 |
| NI201100084A (es) | 2011-11-03 |
| AU2009308980A1 (en) | 2010-05-06 |
| CR20110228A (es) | 2011-06-24 |
| MA32804B1 (fr) | 2011-11-01 |
| CN102272103B (zh) | 2015-10-21 |
| KR101320245B1 (ko) | 2013-10-30 |
| EP2350010A1 (en) | 2011-08-03 |
| KR20110071101A (ko) | 2011-06-28 |
| JP2012507538A (ja) | 2012-03-29 |
| ECSP11011019A (es) | 2011-05-31 |
| EA201170624A1 (ru) | 2011-12-30 |
| CA2741644A1 (en) | 2010-05-06 |
| CO6361994A2 (es) | 2012-01-20 |
| BRPI0919876A8 (pt) | 2016-02-10 |
| IL212436A0 (en) | 2011-06-30 |
| TN2011000171A1 (en) | 2012-12-17 |
| AU2009308980B2 (en) | 2013-02-28 |
| US8592457B2 (en) | 2013-11-26 |
| JP5635991B2 (ja) | 2014-12-03 |
| CA2741644C (en) | 2013-05-07 |
| ZA201103156B (en) | 2012-01-25 |
| MX2011004551A (es) | 2011-05-25 |
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