CL2008000497A1 - Compuestos derivados de ciclohexil-amida del acido aril-carboxilico, antagonistas del receptor de quimiocina 2 y 5; proceso de preparacion de dichos compuestos; composicion farmaceutica; y uso del compuesto para el tratamiento de una enfermedad o con - Google Patents
Compuestos derivados de ciclohexil-amida del acido aril-carboxilico, antagonistas del receptor de quimiocina 2 y 5; proceso de preparacion de dichos compuestos; composicion farmaceutica; y uso del compuesto para el tratamiento de una enfermedad o conInfo
- Publication number
- CL2008000497A1 CL2008000497A1 CL200800497A CL2008000497A CL2008000497A1 CL 2008000497 A1 CL2008000497 A1 CL 2008000497A1 CL 200800497 A CL200800497 A CL 200800497A CL 2008000497 A CL2008000497 A CL 2008000497A CL 2008000497 A1 CL2008000497 A1 CL 2008000497A1
- Authority
- CL
- Chile
- Prior art keywords
- compounds
- cyclhexil
- chemiokin
- amida
- aril
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07102622 | 2007-02-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2008000497A1 true CL2008000497A1 (es) | 2008-08-29 |
Family
ID=38058317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL200800497A CL2008000497A1 (es) | 2007-02-19 | 2008-02-18 | Compuestos derivados de ciclohexil-amida del acido aril-carboxilico, antagonistas del receptor de quimiocina 2 y 5; proceso de preparacion de dichos compuestos; composicion farmaceutica; y uso del compuesto para el tratamiento de una enfermedad o con |
Country Status (36)
Country | Link |
---|---|
US (1) | US8354431B2 (es) |
EP (1) | EP2125782B1 (es) |
JP (1) | JP5180234B2 (es) |
KR (1) | KR101070984B1 (es) |
CN (1) | CN101605781B (es) |
AR (1) | AR065369A1 (es) |
AT (1) | ATE518854T1 (es) |
AU (1) | AU2008219317B2 (es) |
BR (1) | BRPI0807625A2 (es) |
CA (1) | CA2677565C (es) |
CL (1) | CL2008000497A1 (es) |
CR (1) | CR10957A (es) |
CY (1) | CY1111984T1 (es) |
DK (1) | DK2125782T3 (es) |
EA (1) | EA017000B1 (es) |
EC (1) | ECSP099584A (es) |
ES (1) | ES2371126T3 (es) |
GT (1) | GT200900226A (es) |
HK (1) | HK1138836A1 (es) |
HN (1) | HN2009001607A (es) |
HR (1) | HRP20110793T1 (es) |
IL (1) | IL200191A (es) |
MA (1) | MA31206B1 (es) |
MX (1) | MX2009008145A (es) |
MY (1) | MY147487A (es) |
NZ (1) | NZ578663A (es) |
PE (1) | PE20081785A1 (es) |
PL (1) | PL2125782T3 (es) |
PT (1) | PT2125782E (es) |
RS (1) | RS51986B (es) |
SI (1) | SI2125782T1 (es) |
TN (1) | TN2009000345A1 (es) |
TW (1) | TW200848038A (es) |
UA (1) | UA97389C2 (es) |
WO (1) | WO2008101905A1 (es) |
ZA (1) | ZA200905160B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8273900B2 (en) | 2008-08-07 | 2012-09-25 | Novartis Ag | Organic compounds |
AU2021385572A1 (en) | 2020-11-25 | 2023-06-22 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids, and related methods of use |
US12064479B2 (en) | 2022-05-25 | 2024-08-20 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids and methods of use thereof |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1679395A (en) | 1994-01-13 | 1995-08-01 | Regents Of The University Of California, The | Mammalian monocyte chemoattractant protein receptors |
ATE280826T1 (de) | 1996-03-01 | 2004-11-15 | Euroscreen Sa | Cc-chemokinzeptor c-c ckr-5, dessen derivate und verwendungen |
WO1997045543A2 (en) | 1996-05-28 | 1997-12-04 | The Government Of The United States Of America, As Represented By The Secretary Of Health And Human Services, National Institutes Of Health | Cc chemokine receptor 5, antibodies thereto, transgenic animals |
US6388055B1 (en) | 1996-10-03 | 2002-05-14 | Smithkline Beecham Corporation | Mouse CC-CKR5 receptor polypeptide |
AR008331A1 (es) | 1997-01-23 | 1999-12-29 | Smithkline Beecham Corp | Compuestos antagonistas de un receptor de il-8, uso de los mismos para la fabricacion de medicamentos, procedimiento para su obtencion, composicionesfarmaceuticas que los contienen |
CN1282243A (zh) | 1997-12-19 | 2001-01-31 | 武田药品工业株式会社 | 用于拮抗ccr5的含n-酰苯胺衍生物的药物组合物 |
US6312689B1 (en) | 1998-07-23 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Anti-CCR2 antibodies and methods of use therefor |
EP1140896A1 (en) | 1998-12-21 | 2001-10-10 | Takeda Chemical Industries, Ltd. | Benzothiepin-anilide derivatives, their production and their use for antagonizing ccr-5 |
WO2001051077A1 (en) | 2000-01-14 | 2001-07-19 | The Government Of The United States Of Americarep Resented By The Secretary, Department Of Health And Human Services | Methods of regulating il-12 production by administering ccr5 agonists and antagonists |
EP1317284A2 (en) | 2000-09-08 | 2003-06-11 | Micromet AG | Antibody and/or chemokine constructs which bind to a chemokine receptor and their use in immunological disorders |
HUP0402503A2 (hu) | 2001-10-03 | 2005-03-29 | Ucb, S.A. | Pirrolidinonszármazékok és a vegyületeket tartalmazó gyógyászati készítmények |
WO2004054616A1 (ja) | 2002-12-13 | 2004-07-01 | Ono Pharmaceutical Co., Ltd. | ケモカイン受容体の強結合部位に結合するアンタゴニストおよびアゴニスト |
JPWO2004098638A1 (ja) | 2003-05-06 | 2006-07-13 | 小野薬品工業株式会社 | エフェクター細胞機能阻害剤 |
GB2423472A (en) | 2003-12-11 | 2006-08-30 | Univ Yale | Methods and compositions relating to ccr5 antagonist,ifn-&gammed;and il-13 induced inflammation |
KR100859027B1 (ko) * | 2003-12-18 | 2008-09-17 | 인사이트 코포레이션 | 케모킨 수용체의 조절제로서의3-사이클로알킬아미노피롤리딘 유도체 |
GB0403038D0 (en) * | 2004-02-11 | 2004-03-17 | Novartis Ag | Organic compounds |
US7435831B2 (en) | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
CN1950085A (zh) | 2004-05-11 | 2007-04-18 | 因赛特公司 | 作为趋化因子受体调节剂的3-(4-杂芳基环己基氨基)环戊烷羧酰胺 |
GB0412468D0 (en) | 2004-06-04 | 2004-07-07 | Astrazeneca Ab | Chemical compounds |
US20070149557A1 (en) | 2005-11-21 | 2007-06-28 | Amgen Inc. | CXCR3 antagonists |
GB0525957D0 (en) | 2005-12-21 | 2006-02-01 | Astrazeneca Ab | Methods |
WO2007144720A2 (en) | 2006-06-12 | 2007-12-21 | Pfizer Products Inc. | Ccr5 antagonist for enhancing immune reconstitution and treating opportunistic infection in hiv patients |
US20080076120A1 (en) | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
AU2007319660A1 (en) | 2006-10-05 | 2008-05-22 | Centocor Ortho Biotech Inc. | CCR2 antagonists for treatment of fibrosis |
WO2008045564A2 (en) | 2006-10-12 | 2008-04-17 | Epix Delaware, Inc. | Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor |
EP2099454A4 (en) | 2006-11-17 | 2010-11-10 | Abbott Lab | AMINOPYRROLIDINES AS CHEMOKINE RECEPTOR ANTAGONISTS |
JP2010519216A (ja) | 2007-02-15 | 2010-06-03 | ファイザー・リミテッド | Ccr5拮抗薬のための医薬組成物および方法 |
EP2150817A4 (en) | 2007-04-30 | 2011-09-07 | Progenics Pharm Inc | PROCEDURE FOR REDUCING VIRUS LOAD IN HIV-1 INFECTED PATIENTS |
-
2008
- 2008-02-15 PE PE2008000326A patent/PE20081785A1/es not_active Application Discontinuation
- 2008-02-15 AR ARP080100655A patent/AR065369A1/es not_active Application Discontinuation
- 2008-02-18 EA EA200901085A patent/EA017000B1/ru not_active IP Right Cessation
- 2008-02-18 PT PT08709083T patent/PT2125782E/pt unknown
- 2008-02-18 KR KR1020097017079A patent/KR101070984B1/ko not_active IP Right Cessation
- 2008-02-18 DK DK08709083.3T patent/DK2125782T3/da active
- 2008-02-18 JP JP2009549430A patent/JP5180234B2/ja not_active Expired - Fee Related
- 2008-02-18 CA CA2677565A patent/CA2677565C/en not_active Expired - Fee Related
- 2008-02-18 WO PCT/EP2008/051951 patent/WO2008101905A1/en active Application Filing
- 2008-02-18 CN CN200880004192.6A patent/CN101605781B/zh not_active Expired - Fee Related
- 2008-02-18 RS RS20110474A patent/RS51986B/en unknown
- 2008-02-18 TW TW097105608A patent/TW200848038A/zh unknown
- 2008-02-18 PL PL08709083T patent/PL2125782T3/pl unknown
- 2008-02-18 ES ES08709083T patent/ES2371126T3/es active Active
- 2008-02-18 MX MX2009008145A patent/MX2009008145A/es active IP Right Grant
- 2008-02-18 US US12/527,469 patent/US8354431B2/en not_active Expired - Fee Related
- 2008-02-18 CL CL200800497A patent/CL2008000497A1/es unknown
- 2008-02-18 UA UAA200908589A patent/UA97389C2/ru unknown
- 2008-02-18 BR BRPI0807625-1A patent/BRPI0807625A2/pt not_active IP Right Cessation
- 2008-02-18 SI SI200830417T patent/SI2125782T1/sl unknown
- 2008-02-18 MY MYPI20093281A patent/MY147487A/en unknown
- 2008-02-18 NZ NZ578663A patent/NZ578663A/en not_active IP Right Cessation
- 2008-02-18 AT AT08709083T patent/ATE518854T1/de active
- 2008-02-18 AU AU2008219317A patent/AU2008219317B2/en not_active Ceased
- 2008-02-18 EP EP08709083A patent/EP2125782B1/en active Active
-
2009
- 2009-07-23 ZA ZA200905160A patent/ZA200905160B/xx unknown
- 2009-07-24 CR CR10957A patent/CR10957A/es not_active Application Discontinuation
- 2009-07-30 IL IL200191A patent/IL200191A/en not_active IP Right Cessation
- 2009-08-12 GT GT200900226A patent/GT200900226A/es unknown
- 2009-08-17 TN TNP2009000345A patent/TN2009000345A1/fr unknown
- 2009-08-17 EC EC2009009584A patent/ECSP099584A/es unknown
- 2009-08-18 HN HN2009001607A patent/HN2009001607A/es unknown
- 2009-08-31 MA MA32193A patent/MA31206B1/fr unknown
-
2010
- 2010-06-01 HK HK10105350.1A patent/HK1138836A1/xx not_active IP Right Cessation
-
2011
- 2011-10-28 HR HR20110793T patent/HRP20110793T1/hr unknown
- 2011-11-02 CY CY20111101048T patent/CY1111984T1/el unknown
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