CR10957A - Derivados de ciclohexil-amida del acido aril-carboxilico - Google Patents

Derivados de ciclohexil-amida del acido aril-carboxilico

Info

Publication number
CR10957A
CR10957A CR10957A CR10957A CR10957A CR 10957 A CR10957 A CR 10957A CR 10957 A CR10957 A CR 10957A CR 10957 A CR10957 A CR 10957A CR 10957 A CR10957 A CR 10957A
Authority
CR
Costa Rica
Prior art keywords
cyclhexil
aril
carboxilic acid
amida
derivatives
Prior art date
Application number
CR10957A
Other languages
English (en)
Inventor
Rene Hersperger
Philipp Janser
Wolfgang Miltz
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CR10957A publication Critical patent/CR10957A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Un compuesto de la formula (I) o una sal farmaceuticamente aceptable o ester de pro-farmaco del mismo, en donde las variantes R y X se definen en la memoria descriptiva.
CR10957A 2007-02-19 2009-07-24 Derivados de ciclohexil-amida del acido aril-carboxilico CR10957A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07102622 2007-02-19

Publications (1)

Publication Number Publication Date
CR10957A true CR10957A (es) 2009-09-01

Family

ID=38058317

Family Applications (1)

Application Number Title Priority Date Filing Date
CR10957A CR10957A (es) 2007-02-19 2009-07-24 Derivados de ciclohexil-amida del acido aril-carboxilico

Country Status (36)

Country Link
US (1) US8354431B2 (es)
EP (1) EP2125782B1 (es)
JP (1) JP5180234B2 (es)
KR (1) KR101070984B1 (es)
CN (1) CN101605781B (es)
AR (1) AR065369A1 (es)
AT (1) ATE518854T1 (es)
AU (1) AU2008219317B2 (es)
BR (1) BRPI0807625A2 (es)
CA (1) CA2677565C (es)
CL (1) CL2008000497A1 (es)
CR (1) CR10957A (es)
CY (1) CY1111984T1 (es)
DK (1) DK2125782T3 (es)
EA (1) EA017000B1 (es)
EC (1) ECSP099584A (es)
ES (1) ES2371126T3 (es)
GT (1) GT200900226A (es)
HK (1) HK1138836A1 (es)
HN (1) HN2009001607A (es)
HR (1) HRP20110793T1 (es)
IL (1) IL200191A (es)
MA (1) MA31206B1 (es)
MX (1) MX2009008145A (es)
MY (1) MY147487A (es)
NZ (1) NZ578663A (es)
PE (1) PE20081785A1 (es)
PL (1) PL2125782T3 (es)
PT (1) PT2125782E (es)
RS (1) RS51986B (es)
SI (1) SI2125782T1 (es)
TN (1) TN2009000345A1 (es)
TW (1) TW200848038A (es)
UA (1) UA97389C2 (es)
WO (1) WO2008101905A1 (es)
ZA (1) ZA200905160B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8273900B2 (en) 2008-08-07 2012-09-25 Novartis Ag Organic compounds
KR20230124927A (ko) 2020-11-25 2023-08-28 아카제라 메디신즈, 인크. 핵산 전달을 위한 지질 나노입자, 및 관련 사용 방법

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EP0740701B1 (en) 1994-01-13 2006-12-06 The Regents of the University of California Mammalian monocyte chemoattractant protein receptors
DK1482042T3 (da) 1996-03-01 2009-06-15 Euroscreen Sa Aktive og inaktive CC-kemokinreceptorer og nukleinsyremolekyler der koder for receptoren
EP0975749A2 (en) 1996-05-28 2000-02-02 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Cc chemokine receptor 5, antibodies thereto, transgenic animals
US6388055B1 (en) 1996-10-03 2002-05-14 Smithkline Beecham Corporation Mouse CC-CKR5 receptor polypeptide
AR008331A1 (es) 1997-01-23 1999-12-29 Smithkline Beecham Corp Compuestos antagonistas de un receptor de il-8, uso de los mismos para la fabricacion de medicamentos, procedimiento para su obtencion, composicionesfarmaceuticas que los contienen
BR9813691A (pt) * 1997-12-19 2000-10-10 Takeda Chemical Industries Ltd Composição farmacêutica para antagonizar o ccr5, uso do composto ou um sal deste em combinação com um inibidor de protease e/ou um inibidor da transcriptase reversa, e, processo para antagonizar o ccr5.
US6312689B1 (en) 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
WO2000037455A1 (en) 1998-12-21 2000-06-29 Takeda Chemical Industries, Ltd. Benzothiepin-anilide derivatives, their production and their use for antagonizing ccr-5
AU2000227285A1 (en) 2000-01-14 2001-07-24 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Methods of regulating il-12 production by administering ccr5 agonists and antagonists
CA2421842A1 (en) 2000-09-08 2002-03-14 Micromet Ag Antibody and/or chemokine constructs which bind to a chemokine receptor and their use in immunological disorders
CZ2004442A3 (cs) 2001-10-03 2005-03-16 Ucb, S.A. Pyrrolidinonové deriváty
EP1570860A4 (en) 2002-12-13 2009-06-03 Ono Pharmaceutical Co ANTAGONIST AND AGONIST BINDING TO A STRONG BINDING SITE OF THE CHEMOKINE RECEPTOR
US20070270429A1 (en) 2003-05-06 2007-11-22 Shiro Shibayama Function Inhibitor of Effector Cell
GB2423472A (en) 2003-12-11 2006-08-30 Univ Yale Methods and compositions relating to ccr5 antagonist,ifn-&gammed;and il-13 induced inflammation
EP1696919B1 (en) * 2003-12-18 2013-10-02 Incyte Corporation 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors
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EP1746997A4 (en) * 2004-05-11 2010-12-29 Incyte Corp 3- (4-HETEROARYLCYCLOHEXYLAMINE) CYCLOPENTANCARBOXAMIDE AS MODULATORS OF CHEMOKIN RECEPTORS
GB0412468D0 (en) 2004-06-04 2004-07-07 Astrazeneca Ab Chemical compounds
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BRPI0712843A2 (pt) 2006-06-12 2012-07-31 Pfizer Prod Inc antagonista de ccr5 e seus usos
US20080076120A1 (en) 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
KR20090074787A (ko) 2006-10-05 2009-07-07 센토코 오르토 바이오테크 인코포레이티드 섬유증 치료용 ｃｃｒ2 길항제
CL2007002958A1 (es) 2006-10-12 2008-05-09 Epix Delaware Inc Compuestos derivados de heteroaril-carboxamida, antagonistas del receptor de quimioquina; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades tales como rechazo de transplante de organos, artritis reumatoidea, lupus, entr
CN101534824A (zh) 2006-11-17 2009-09-16 艾博特公司 作为化学活素受体拮抗剂的氨基吡咯烷
US20100267765A1 (en) 2007-02-15 2010-10-21 Stephen John Felstead Pharmaceutical Compositions and Methods for CCR5 Antagonists
WO2008134076A1 (en) 2007-04-30 2008-11-06 Progenics Pharmaceuticals, Inc. Methods for reducing viral load in hiv-1-infected patients

Also Published As

Publication number Publication date
CN101605781B (zh) 2014-08-13
EA017000B1 (ru) 2012-09-28
ES2371126T3 (es) 2011-12-27
UA97389C2 (en) 2012-02-10
BRPI0807625A2 (pt) 2014-05-27
JP2010519187A (ja) 2010-06-03
CA2677565C (en) 2014-11-18
EA200901085A1 (ru) 2010-02-26
US20100016361A1 (en) 2010-01-21
MX2009008145A (es) 2009-08-12
JP5180234B2 (ja) 2013-04-10
PL2125782T3 (pl) 2011-12-30
AR065369A1 (es) 2009-06-03
CY1111984T1 (el) 2015-11-04
EP2125782A1 (en) 2009-12-02
WO2008101905A1 (en) 2008-08-28
PE20081785A1 (es) 2009-01-12
HN2009001607A (es) 2011-11-23
NZ578663A (en) 2011-01-28
US8354431B2 (en) 2013-01-15
MY147487A (en) 2012-12-14
RS51986B (en) 2012-02-29
MA31206B1 (fr) 2010-02-01
PT2125782E (pt) 2011-11-17
ECSP099584A (es) 2009-09-29
ATE518854T1 (de) 2011-08-15
DK2125782T3 (da) 2011-11-21
CN101605781A (zh) 2009-12-16
TW200848038A (en) 2008-12-16
HK1138836A1 (en) 2010-09-03
HRP20110793T1 (hr) 2011-11-30
KR20090103943A (ko) 2009-10-01
KR101070984B1 (ko) 2011-10-06
TN2009000345A1 (en) 2010-12-31
AU2008219317A1 (en) 2008-08-28
EP2125782B1 (en) 2011-08-03
SI2125782T1 (sl) 2011-12-30
CA2677565A1 (en) 2008-08-28
IL200191A (en) 2013-12-31
CL2008000497A1 (es) 2008-08-29
ZA200905160B (en) 2010-05-26
GT200900226A (es) 2010-07-02
AU2008219317B2 (en) 2011-09-08
IL200191A0 (en) 2010-04-15

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