BRPI0808442A2 - Composições de àcido nucleico de filamento duplo fechado - Google Patents
Composições de àcido nucleico de filamento duplo fechado Download PDFInfo
- Publication number
- BRPI0808442A2 BRPI0808442A2 BRPI0808442-4A BRPI0808442A BRPI0808442A2 BR PI0808442 A2 BRPI0808442 A2 BR PI0808442A2 BR PI0808442 A BRPI0808442 A BR PI0808442A BR PI0808442 A2 BRPI0808442 A2 BR PI0808442A2
- Authority
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- Prior art keywords
- formula
- nucleoside
- integer
- analog
- inosine
- Prior art date
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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Landscapes
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| US95027107P | 2007-07-17 | 2007-07-17 | |
| US60/950,271 | 2007-07-17 | ||
| PCT/CA2008/000473 WO2008106803A1 (en) | 2007-03-07 | 2008-03-07 | Double-stranded locked nucleic acid compositions |
Publications (1)
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| BRPI0808442A2 true BRPI0808442A2 (pt) | 2014-08-05 |
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| EP (1) | EP2125853A1 (https=) |
| JP (1) | JP2010519915A (https=) |
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| GB0228540D0 (en) * | 2002-12-06 | 2003-01-15 | Glaxo Group Ltd | Novel compositions |
| WO2009149470A1 (en) | 2008-06-06 | 2009-12-10 | Aurora Biofuels, Inc. | Vcp-based vectors for algal cell transformation |
| WO2009155489A2 (en) | 2008-06-19 | 2009-12-23 | Variation Biotechnologies, Inc. | Compositions and methods for treating influenza |
| SG10201605780QA (en) | 2009-03-19 | 2016-09-29 | Emd Millipore Corp | Removal of microorganisms from fluid samples using nanofiber filtration media |
| US20110097418A1 (en) * | 2009-05-29 | 2011-04-28 | Variation Biotechnologies, Inc. | Compositions and methods for treating influenza |
| US8865468B2 (en) | 2009-10-19 | 2014-10-21 | Aurora Algae, Inc. | Homologous recombination in an algal nuclear genome |
| US9029137B2 (en) | 2009-06-08 | 2015-05-12 | Aurora Algae, Inc. | ACP promoter |
| US8809046B2 (en) | 2011-04-28 | 2014-08-19 | Aurora Algae, Inc. | Algal elongases |
| US9907746B2 (en) | 2009-07-06 | 2018-03-06 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
| AU2010270722B2 (en) | 2009-07-06 | 2015-06-04 | Variation Biotechnologies, Inc. | Methods for preparing vesicles and formulations produced therefrom |
| US8709765B2 (en) | 2009-07-20 | 2014-04-29 | Aurora Algae, Inc. | Manipulation of an alternative respiratory pathway in photo-autotrophs |
| EP2482824B1 (en) | 2009-10-02 | 2016-11-30 | The Trustees of Columbia University in the City of New York | Piscine reovirus immunogenic compositions |
| US8846388B2 (en) * | 2009-10-16 | 2014-09-30 | Zoetis Llc | Infectious clones of torque teno virus |
| CA2802721C (en) * | 2010-06-25 | 2015-08-18 | Idera Pharmaceuticals, Inc. | Novel agonists of toll-like receptor 3 and methods of their use |
| MX342138B (es) | 2010-07-06 | 2016-09-14 | Variation Biotechnologies Inc | Composiciones y metodos para el tratamiento de influenza. |
| ES2774949T3 (es) | 2010-08-10 | 2020-07-23 | Emd Millipore Corp | Método para la eliminación de retrovirus |
| BR112013015797B1 (pt) | 2010-12-23 | 2021-08-31 | Shell Internationale Research Maatschappij B.V. | Organismo microbiano e método de produzir um derivado de acil-coa graxo |
| CA2862864C (en) | 2011-01-13 | 2018-12-11 | Variation Biotechnologies Inc. | Compositions and methods for treating viral infections |
| CA2862871C (en) | 2011-01-13 | 2020-09-22 | Variation Biotechnologies Inc. | Methods for preparing vesicles and formulations produced therefrom |
| US8722359B2 (en) | 2011-01-21 | 2014-05-13 | Aurora Algae, Inc. | Genes for enhanced lipid metabolism for accumulation of lipids |
| CN105413480B (zh) | 2011-04-01 | 2019-03-29 | Emd密理博公司 | 含有纳米纤维的复合材料结构 |
| MX2013012565A (es) | 2011-04-28 | 2013-11-21 | Aurora Algae Inc | Desaturasas de algas. |
| EP2794630A4 (en) | 2011-12-22 | 2015-04-01 | Alios Biopharma Inc | SUBSTITUTED PHOSPHORTHIOAT NUCLEOTIDE ANALOGUE |
| US20140356399A1 (en) | 2012-01-12 | 2014-12-04 | Variation Biotechnologies, Inc. | Compositions and methods for treating viral infections |
| US20150079077A1 (en) | 2012-01-27 | 2015-03-19 | Variation Biotechnologies, Inc. | Methods and compositions for therapeutic agents |
| WO2013142124A1 (en) | 2012-03-21 | 2013-09-26 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
| US9157101B2 (en) * | 2012-12-21 | 2015-10-13 | Algenol Biotech LLC | Cyanobacterium sp. for production of compounds |
| AR095882A1 (es) | 2013-04-22 | 2015-11-18 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9 |
| US9994831B2 (en) | 2013-12-12 | 2018-06-12 | The Regents Of The University Of California | Methods and compositions for modifying a single stranded target nucleic acid |
| JP6568545B2 (ja) | 2014-06-26 | 2019-08-28 | イー・エム・デイー・ミリポア・コーポレイシヨン | 増強された汚れ保持容量を有するフィルタ構造 |
| WO2016061131A1 (en) | 2014-10-14 | 2016-04-21 | The J. David Gladstone Institutes | Compositions and methods for reactivating latent immunodeficiency virus |
| MX2017008289A (es) | 2014-12-23 | 2017-10-02 | Algenol Biotech LLC | Metodos para aumentar la estabilidad de la produccion de compuestos en celulas huesped microbianas. |
| EP3283202B1 (en) | 2015-04-17 | 2025-10-01 | EMD Millipore Corporation | Method of purifying a biological materia of interest in a sample using nanofiber ultrafiltration membranes operated in tangential flow filtration mode |
| EP3303634B1 (en) | 2015-06-03 | 2023-08-30 | The Regents of The University of California | Cas9 variants and methods of use thereof |
| US10138489B2 (en) | 2016-10-20 | 2018-11-27 | Algenol Biotech LLC | Cyanobacterial strains capable of utilizing phosphite |
| EP3655142B1 (en) | 2017-07-21 | 2026-02-25 | Merck Millipore Ltd | Non-woven fiber membranes |
| WO2019066571A2 (ko) | 2017-09-28 | 2019-04-04 | 연세대학교 산학협력단 | 골수유래 면역반응 억제세포의 제조방법, 이에 의해 제조된 골수유래 면역반응 억제세포 및 그 용도 |
| AU2019264232A1 (en) * | 2018-05-04 | 2020-11-12 | Tollys | TLR3 ligands that activate both epithelial and myeloid cells |
| US12275964B2 (en) | 2018-08-22 | 2025-04-15 | The Regents Of The University Of California | Variant type V CRISPR/Cas effector polypeptides and methods of use thereof |
| CA3117730A1 (en) | 2018-11-09 | 2020-05-14 | Inari Agriculture, Inc. | Rna-guided nucleases and dna binding proteins |
| CA3130789A1 (en) | 2019-03-07 | 2020-09-10 | The Regents Of The University Of California | Crispr-cas effector polypeptides and methods of use thereof |
| KR102256001B1 (ko) * | 2019-07-02 | 2021-05-26 | 주식회사 엔에이백신연구소 | 신규한 리보핵산 및 이를 기반으로 하는 약제학적 조성물 |
| JP2022543735A (ja) * | 2019-07-02 | 2022-10-14 | エヌエー ヴァクシン インスティテュート | 新規のリボ核酸、及びそれを基にする薬剤学的組成物 |
| WO2022036255A1 (en) * | 2020-08-14 | 2022-02-17 | Allen Institute | Artificial expression constructs for modulating gene expression in striatal neurons |
| JP2024517181A (ja) | 2021-04-28 | 2024-04-19 | ウエヌイグレックオ・ファーマ | 組合せ治療としてｆｘｒアゴニストを使用するｔｌｒ３アゴニストの効果の強い増強 |
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| US3692899A (en) * | 1969-12-17 | 1972-09-19 | Us Health Education & Welfare | Inhibition of transplanted tumor growth by polyinosinic-polycytidylic acid in mice |
| US3952097A (en) * | 1974-09-27 | 1976-04-20 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid |
| US4024241A (en) * | 1974-09-27 | 1977-05-17 | The United States Of America As Represented By The Secretary Of Health, Education And Welfare | Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid |
| US4349538A (en) * | 1979-12-07 | 1982-09-14 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid |
| ATE509102T1 (de) * | 1994-07-15 | 2011-05-15 | Univ Iowa Res Found | Immunomodulatorische oligonukleotide |
| US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US7157089B1 (en) * | 1996-11-26 | 2007-01-02 | Stressgen Biotechnologies Corporation | Immune responses using compositions containing stress proteins |
| JP3756313B2 (ja) * | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| CA2203843C (en) * | 1997-04-28 | 2013-07-23 | Her Majesty The Queen, In Right Of Canada, As Represented By The Ministe R Of National Defence | Liposome-encapsulated poly iclc |
| US6794499B2 (en) * | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| US6083482A (en) * | 1999-05-11 | 2000-07-04 | Icn Pharmaceuticals, Inc. | Conformationally locked nucleosides and oligonucleotides |
| AT410173B (de) * | 2000-06-08 | 2003-02-25 | Cistem Biotechnologies Gmbh | Antigene zusammensetzung |
| EP1474432A1 (en) * | 2002-02-04 | 2004-11-10 | Biomira Inc. | Immunostimulatory, covalently lipidated oligonucleotides |
| EP1778186B1 (en) * | 2002-07-03 | 2011-11-30 | Oncovir, Inc. | Method for preparation of poly-iclc and uses thereof |
| GB0228540D0 (en) * | 2002-12-06 | 2003-01-15 | Glaxo Group Ltd | Novel compositions |
| EP2508608A1 (en) * | 2003-06-09 | 2012-10-10 | Alnylam Pharmaceuticals Inc. | Method of treating neurodegenerative disease |
| CA2587676A1 (en) * | 2004-11-19 | 2006-05-26 | Institut Gustave Roussy | Improved treatment of cancer by double-stranded rna |
| US7834064B2 (en) * | 2005-01-03 | 2010-11-16 | Andres Mario Salazar | Clinical method for the immunomodulatory and vaccine adjuvant use of poly-ICLC and other dsRNAs |
| CA2626977A1 (en) * | 2005-10-27 | 2007-05-03 | Rosetta Inpharmatics Llc | Nucleic acid amplification using non-random primers |
| EP2202239A1 (en) * | 2005-11-01 | 2010-06-30 | Alnylam Pharmaceuticals Inc. | RNAI inhibition of influenza virus replication |
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- 2008-03-07 MX MX2009009530A patent/MX2009009530A/es not_active Application Discontinuation
- 2008-03-07 WO PCT/CA2008/000473 patent/WO2008106803A1/en not_active Ceased
- 2008-03-07 EP EP08733577A patent/EP2125853A1/en not_active Withdrawn
- 2008-03-07 CA CA002680060A patent/CA2680060A1/en not_active Abandoned
- 2008-03-07 US US12/044,895 patent/US20090041809A1/en not_active Abandoned
- 2008-03-07 CN CN200880014144A patent/CN101687900A/zh active Pending
- 2008-03-07 JP JP2009552038A patent/JP2010519915A/ja not_active Abandoned
- 2008-03-07 AU AU2008222523A patent/AU2008222523A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2009009530A (es) | 2010-05-19 |
| KR20100051041A (ko) | 2010-05-14 |
| CA2680060A1 (en) | 2008-09-12 |
| JP2010519915A (ja) | 2010-06-10 |
| AU2008222523A1 (en) | 2008-09-12 |
| EP2125853A1 (en) | 2009-12-02 |
| US20090041809A1 (en) | 2009-02-12 |
| WO2008106803A1 (en) | 2008-09-12 |
| CN101687900A (zh) | 2010-03-31 |
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