BRPI0718029A2 - Derivados de imidazo(1,2-b)piridazina e pirazolo(1,5-a)pirimidina e seu uso como inibidores da proteína cinase - Google Patents

Info

Publication number

BRPI0718029A2

BRPI0718029A2 BRPI0718029-2A BRPI0718029A BRPI0718029A2 BR PI0718029 A2 BRPI0718029 A2 BR PI0718029A2 BR PI0718029 A BRPI0718029 A BR PI0718029A BR PI0718029 A2 BRPI0718029 A2 BR PI0718029A2

Authority

BR

Brazil

Prior art keywords

formula

compound

compound according

phenyl

substituted

Prior art date

2006-11-06

Links

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• CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title description 4
• 239000003909 protein kinase inhibitor Substances 0.000 title description 4
• 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title description 3
• VTVRXITWWZGKHV-UHFFFAOYSA-N imidazo[1,2-b]pyridazine Chemical compound N1=CC=CC2=NC=CN21 VTVRXITWWZGKHV-UHFFFAOYSA-N 0.000 title description 3
• 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title description 2
• 150000001875 compounds Chemical class 0.000 claims description 260
• -1 substituted Chemical class 0.000 claims description 111
• 239000000203 mixture Substances 0.000 claims description 43
• 108010017121 Proto-Oncogene Proteins c-pim-1 Proteins 0.000 claims description 37
• 102000004433 Proto-Oncogene Proteins c-pim-1 Human genes 0.000 claims description 37
• 125000001424 substituent group Chemical group 0.000 claims description 37
• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 36
• 238000000034 method Methods 0.000 claims description 35
• 125000000217 alkyl group Chemical group 0.000 claims description 33
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• 108060006633 protein kinase Proteins 0.000 claims description 28
• 150000003839 salts Chemical class 0.000 claims description 28
• 201000010099 disease Diseases 0.000 claims description 25
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 23
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 19
• 230000001404 mediated effect Effects 0.000 claims description 17
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• 125000003545 alkoxy group Chemical group 0.000 claims description 9
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 9
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 8
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• 239000001257 hydrogen Substances 0.000 claims description 7
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• BXDOEKDAMOWUSS-LBPRGKRZSA-N (2s)-1-[3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-yl]oxybutan-2-amine Chemical compound N12N=C(OC[C@@H](N)CC)C=CC2=NC=C1C1=CC=CC(OC(F)(F)F)=C1 BXDOEKDAMOWUSS-LBPRGKRZSA-N 0.000 claims 2
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• DCLWNTIANRACSB-UHFFFAOYSA-N imidazo[1,2-b]pyridazin-6-amine Chemical compound N1=C(N)C=CC2=NC=CN21 DCLWNTIANRACSB-UHFFFAOYSA-N 0.000 claims 2
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