BRPI0708366A2 - compostos quìmicos de natureza peptìdica, composição farmacêutica, composição veterinária e uso de compostos quìmicos - Google Patents
compostos quìmicos de natureza peptìdica, composição farmacêutica, composição veterinária e uso de compostos quìmicos Download PDFInfo
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- BRPI0708366A2 BRPI0708366A2 BRPI0708366-1A BRPI0708366A BRPI0708366A2 BR PI0708366 A2 BRPI0708366 A2 BR PI0708366A2 BR PI0708366 A BRPI0708366 A BR PI0708366A BR PI0708366 A2 BRPI0708366 A2 BR PI0708366A2
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- ghrelin
- peptide
- chemical compounds
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- growth hormone
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU20060050A CU23558A1 (es) | 2006-02-28 | 2006-02-28 | Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento |
| CU2006-0050 | 2006-02-28 | ||
| PCT/CU2007/000007 WO2007098716A1 (es) | 2006-02-28 | 2007-02-28 | Compuestos analogos a los secretagogos peptidicos de la hormona de crecimiento y preparaciones que los contienen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0708366A2 true BRPI0708366A2 (pt) | 2011-05-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0708366-1A BRPI0708366A2 (pt) | 2006-02-28 | 2007-02-28 | compostos quìmicos de natureza peptìdica, composição farmacêutica, composição veterinária e uso de compostos quìmicos |
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| US (1) | US8367620B2 (enExample) |
| EP (1) | EP1997827B1 (enExample) |
| JP (1) | JP5183496B2 (enExample) |
| KR (1) | KR101409277B1 (enExample) |
| CN (1) | CN101432294B (enExample) |
| AR (1) | AR059646A1 (enExample) |
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| CA (1) | CA2637593C (enExample) |
| CL (2) | CL2007000528A1 (enExample) |
| CU (1) | CU23558A1 (enExample) |
| ES (1) | ES2441441T3 (enExample) |
| MX (1) | MX2008011142A (enExample) |
| MY (1) | MY184130A (enExample) |
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| RU (1) | RU2416618C2 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2010052828A1 (ja) * | 2008-11-06 | 2010-05-14 | 国立大学法人名古屋大学 | 非虚血性心筋障害に対する医薬 |
| CU24473B1 (es) * | 2016-11-01 | 2020-02-04 | Centro De Ingenieria Genetica Y Biotecnologia Biocubafarma | Composición vacunal que comprende un péptido secretagogo de la hormona de crecimiento como adyuvante vacunal |
| RU2734835C1 (ru) * | 2020-02-11 | 2020-10-23 | Федеральное государственное бюджетное учреждение науки Лимнологический институт Сибирского отделение Российской академии наук (ЛИН СО РАН) | Способ повышения жизнестойкости эмбрионов рыб в аквакультуре |
Family Cites Families (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3239345A (en) | 1965-02-15 | 1966-03-08 | Estrogenic compounds and animal growth promoters | |
| US4411890A (en) | 1981-04-14 | 1983-10-25 | Beckman Instruments, Inc. | Synthetic peptides having pituitary growth hormone releasing activity |
| US4036979A (en) | 1974-01-25 | 1977-07-19 | American Cyanamid Company | Compositions containing 4,5,6,7-tetrahydrobenz[b]thien-4-yl-ureas or derivatives and methods of enhancing growth rate |
| ATE122357T1 (de) | 1988-01-28 | 1995-05-15 | Polygen Holding Corp | Polypeptide mit hormonwachstumsbefreiender wirkung. |
| JPH03502326A (ja) | 1988-01-28 | 1991-05-30 | ポリゲン ホールディング コーポレイション | 成長ホルモン放出活性を有するポリペプチド化合物類 |
| JP2670680B2 (ja) | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | 生理活性物質含有ポリ乳酸系微小球およびその製造法 |
| WO1992007578A1 (en) | 1990-10-25 | 1992-05-14 | Genentech, Inc. | Use of protective agents against reactive oxygen species |
| US5663146A (en) | 1991-08-22 | 1997-09-02 | Administrators Of The Tulane Educational Fund | Polypeptide analogues having growth hormone releasing activity |
| WO1994011012A1 (en) | 1992-11-06 | 1994-05-26 | Merck & Co., Inc. | Substituted dipeptide analogs promote release of growth hormone |
| US5726319A (en) | 1992-11-06 | 1998-03-10 | Merck & Co., Inc. | Biphenyl substituted dipeptide analogs promote release of growth hormone |
| US5578593A (en) | 1992-12-11 | 1996-11-26 | Merck & Co., Inc. | Spiro piperidines and homologs promote release of growth hormone |
| NZ258412A (en) | 1992-12-11 | 1997-01-29 | Merck & Co Inc | Spiro-fused piperidine derivatives and pharmaceutical compositions |
| JPH09504525A (ja) | 1993-10-19 | 1997-05-06 | メルク エンド カンパニー インコーポレーテッド | ビスホスホン酸塩類と成長ホルモン分泌促進薬との併用剤 |
| US5492916A (en) | 1993-12-23 | 1996-02-20 | Merck & Co., Inc. | Di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
| KR960705808A (ko) | 1993-11-09 | 1996-11-08 | 조셉 에프. 디프리마 | 성장 호르몬의 방출을 촉진시키는 피페리딘, 피롤리딘 및 헥사하이드로-1H-아제핀(Piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone) |
| US5494919A (en) | 1993-11-09 | 1996-02-27 | Merck & Co., Inc. | 2-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
| EP0730578A4 (en) | 1993-11-24 | 1997-10-08 | Merck & Co Inc | COMPOUNDS CONTAINING INDOLYL GROUPS AND THE USE THEREOF TO PROMOTE THE RELEASE OF GROWTH HORMONES |
| US5721251A (en) | 1993-12-10 | 1998-02-24 | Merck & Co., Inc. | Piperidine, pyrrolidine and hexahydro-1H-azepines promote release of growth hormone |
| CA2179597A1 (en) | 1993-12-23 | 1995-06-29 | Nils Langeland Johansen | Compounds with growth hormone releasing properties |
| US5721250A (en) | 1993-12-23 | 1998-02-24 | Merck & Co. Inc. | Di-and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone |
| AU683121B2 (en) | 1993-12-23 | 1997-10-30 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US5777112A (en) | 1994-06-13 | 1998-07-07 | Merck & Co., Inc | Piperazine compounds promote release of growth hormone |
| US5783582A (en) | 1994-07-20 | 1998-07-21 | Merck & Co., Inc. | Piperidines and hexahydro-1H-azepines spiro substituted at the 4-position promote release of growth hormone |
| US5798337A (en) | 1994-11-16 | 1998-08-25 | Genentech, Inc. | Low molecular weight peptidomimetic growth hormone secretagogues |
| AU4495996A (en) | 1995-01-25 | 1996-08-14 | Nippon Chemiphar Co. Ltd. | Dihydrophenazine derivatives |
| CZ238197A3 (en) | 1995-01-27 | 1997-12-17 | Novo Nordisk As | Growth hormone formation stimulating compounds |
| WO1996024587A1 (en) | 1995-02-09 | 1996-08-15 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| WO1996024580A1 (en) | 1995-02-09 | 1996-08-15 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US5559128A (en) | 1995-04-18 | 1996-09-24 | Merck & Co., Inc. | 3-substituted piperidines promote release of growth hormone |
| WO1996033189A1 (en) | 1995-04-19 | 1996-10-24 | Merck & Co., Inc. | Process for the preparation of spiroindolines |
| WO1996035713A1 (en) | 1995-05-08 | 1996-11-14 | Pfizer, Inc. | Dipeptides which promote release of growth hormone |
| FI974368A0 (fi) | 1995-05-29 | 1997-11-28 | Pfizer | Kasvuhormonin vapautumista edistäviä dipeptidejä |
| IL122371A0 (en) | 1995-06-22 | 1998-06-15 | Novo Nordisk As | Compounds with growth hormone releasing properties |
| EP0761220A1 (en) | 1995-08-21 | 1997-03-12 | Eli Lilly And Company | 2-Acylaminopropanamides as growth hormone secretagogues |
| CA2203424A1 (en) | 1995-08-21 | 1997-02-27 | Eli Lilly And Company | 2-acylaminopropanamines as growth hormone secretagogues |
| EP0766966A3 (en) | 1995-09-08 | 2001-02-28 | Eli Lilly And Company | Method of treating insulin resistance |
| WO1997011697A1 (en) | 1995-09-26 | 1997-04-03 | Merck & Co., Inc. | 3-spirolactam, 3-spiroamino, 3-spirolactone and 3-spirobenzopyran piperidines and pyrrolidines promote release of growth hormone |
| JPH11513989A (ja) | 1995-10-27 | 1999-11-30 | メルク エンド カンパニー インコーポレーテッド | 成長ホルモン分泌促進薬の湿式造粒製剤 |
| EP0863900A1 (en) | 1995-10-27 | 1998-09-16 | Merck & Co., Inc. | Process for the preparation of a growth hormone secretagogue |
| US5767124A (en) | 1995-10-27 | 1998-06-16 | Merck & Co., Inc. | Polymorphic forms of a growth hormone secretagogue |
| US5723616A (en) | 1995-10-27 | 1998-03-03 | Merck & Co., Inc. | Process for the preparation of a growth hormone secretagogue |
| DE69633637T2 (de) | 1995-12-13 | 2006-03-09 | Merck & Co., Inc. | Wachstumshormonsekretionsförderer rezeptorfamilie |
| JP3798024B2 (ja) | 1995-12-13 | 2006-07-19 | メルク エンド カンパニー インコーポレーテッド | 成長ホルモン分泌促進物質レセプターアッセイ |
| WO1997022367A1 (en) | 1995-12-20 | 1997-06-26 | Merck & Co., Inc. | Radiolabeled growth hormone secretagogue |
| IT1277113B1 (it) | 1995-12-20 | 1997-11-04 | Romano Deghenghi | Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita |
| AU715856B2 (en) | 1995-12-22 | 2000-02-10 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| TW432073B (en) | 1995-12-28 | 2001-05-01 | Pfizer | Pyrazolopyridine compounds |
| AU2334097A (en) | 1996-03-21 | 1997-10-10 | Merck & Co., Inc. | 4-spiroindoline piperidines promote release of growth hormone |
| AU2722297A (en) | 1996-04-03 | 1997-10-22 | Merck & Co., Inc. | Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone |
| SE9601397D0 (sv) | 1996-04-12 | 1996-04-12 | Pharmacia Ab | Use of growth hormone |
| WO1997040071A1 (en) | 1996-04-19 | 1997-10-30 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| US5919777A (en) | 1996-04-24 | 1999-07-06 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| HUP9902668A3 (en) | 1996-04-24 | 2000-07-28 | Novo Nordisk As | Piperazine derivatives, pharmaceutical compositions containing them and their use |
| AU711884B2 (en) | 1996-05-07 | 1999-10-21 | Merck & Co., Inc. | Enhancement of sleep with a growth hormone secretagogue |
| AU2931997A (en) | 1996-05-07 | 1997-11-26 | Merck & Co., Inc. | Treatment of mood disorders with a growth hormone secretagogue |
| WO1997043278A1 (en) | 1996-05-14 | 1997-11-20 | Novo Nordisk A/S | Somatostatin agonists and antagonists |
| WO1997044042A1 (en) | 1996-05-22 | 1997-11-27 | Arch Development Corporation | Sleep quality improvement using a growth hormone secretagogue |
| CZ383298A3 (cs) | 1996-05-31 | 1999-07-14 | Novo Nordisk A/S | Cyklická (koherentní) léčba osteoporózy komponentou růstového hormonu a činidlem antiresopčně působícím na kost |
| JP4425992B2 (ja) | 1996-07-22 | 2010-03-03 | サファイア セラピューティクス，インコーポレイティド | 成長ホルモン放出特性を有する化合物 |
| WO1998010653A1 (en) | 1996-09-13 | 1998-03-19 | Merck & Co., Inc. | Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone |
| WO1998018815A1 (en) | 1996-10-25 | 1998-05-07 | Merck & Co., Inc. | Convergent process for the preparation of a growth hormone secretagogue |
| SE9703929D0 (sv) | 1996-11-22 | 1997-10-28 | Pharmacia & Upjohn Ab | Therapeutical use and method |
| AU6747498A (en) | 1997-04-11 | 1998-11-11 | Sumitomo Pharmaceuticals Company, Limited | Benzene derivatives |
| WO1998051687A1 (en) | 1997-05-14 | 1998-11-19 | Fujisawa Pharmaceutical Co., Ltd. | Piperidino derivatives which promote growth hormone release |
| US5861149A (en) | 1997-06-04 | 1999-01-19 | Polyheal Ltd. | Methods for wound treatment |
| EP1005484A1 (en) | 1997-06-20 | 2000-06-07 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| ATE356139T1 (de) | 1997-06-25 | 2007-03-15 | Pfizer | Dipeptidderivate zur förderung der sekretion von wachstumshormon |
| UA53716C2 (uk) | 1997-06-25 | 2003-02-17 | Пфайзер Продактс Інк. | Тартратна сіль заміщеного дипептиду, спосіб її одержання, проміжні сполуки та спосіб їх одержання, фармацевтична композиція (варіанти), спосіб підвищення рівнів ендогенного гормону росту та спосіб лікування або профілактики захворювань (варіанти) |
| UA64751C2 (uk) | 1997-06-25 | 2004-03-15 | Пфайзер Продактс Інк. | Спосіб лікування інсулінової толерантності речовинами, які посилюють секрецію гормону росту (варіанти) та фармацевтична композиція (варіанти) |
| ZA987383B (en) | 1997-08-19 | 2000-02-17 | Lilly Co Eli | Treatment of congestive heart failure with growth hormone secretagogues. |
| CN1213036C (zh) | 1997-08-22 | 2005-08-03 | 科研制药株式会社 | 新的酰胺类衍生物 |
| WO1999036431A1 (en) | 1998-01-16 | 1999-07-22 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| WO1999039730A1 (en) | 1998-02-09 | 1999-08-12 | Kaken Pharmaceutical Co., Ltd. | Oral preparations containing peptides promoting the secretion of growth hormone |
| ZA991572B (en) | 1998-03-03 | 1999-09-03 | Novo Nordisk As | New salt forms of (2E)-5-amino-5-methylhex-2-enoic acid N-methyl-N-((1R)-1-(N-methyl-N-((1R)-1-(methylcarbamoyl)-2-phenylethyl)carbamoy L)-2-(2-naphthyl)ethyl)amide. |
| CA2329881C (en) | 1998-05-11 | 2010-03-16 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| EP1093463A1 (en) | 1998-06-09 | 2001-04-25 | Novo Nordisk A/S | A method for preparing a compound with growth hormone releasing properties |
| KR20010052817A (ko) | 1998-06-16 | 2001-06-25 | 실버스타인 아써 에이. | 근골격 무름을 치료하기 위한 선택적인 에스트로겐 수용체조절제 및 성장 호르몬 분비촉진제의 치료적 혼합물 |
| AR018869A1 (es) | 1998-06-16 | 2001-12-12 | Pfizer Prod Inc | Composicion farmaceutica, su uso para la preparacion de medicamentos y estuche que la contiene |
| RU2298547C2 (ru) | 1998-06-30 | 2007-05-10 | Ново Нордиск А/С | Соединения и фармацевтическая композиция, обладающие свойствами высвобождения гормона роста, способ стимуляции выделения гормона роста из гипофиза млекопитающего |
| US6576656B1 (en) | 1998-08-20 | 2003-06-10 | Sumitomo Pharmaceuticals Co., Ltd. | Oxindole derivative |
| US6358951B1 (en) | 1998-08-21 | 2002-03-19 | Pfizer Inc. | Growth hormone secretagogues |
| EP1258250B1 (en) | 1999-12-28 | 2005-09-14 | Kaken Pharmaceutical Co., Ltd. | Nerve protective drugs |
| EP1353683A4 (en) | 2000-05-30 | 2004-05-12 | Merck & Co Inc | ANALOGS BY GHRELIN |
| EP1159964B1 (en) | 2000-05-31 | 2009-10-28 | Pfizer Products Inc. | Use of growth hormone secretagogues for stimulating gastrointestinal motility |
| CA2407659C (en) | 2000-06-13 | 2010-11-09 | Zentaris Ag | Growth hormone secretagogues |
| EP1297839A4 (en) | 2000-06-23 | 2005-12-07 | Kaken Pharma Co Ltd | PREVENTIVA OR THERAPEUTIC AGAINST HEART FAILURE |
| ITMI20011445A1 (it) | 2001-07-06 | 2003-01-06 | Europ Geie | Analoghi della cortistantina capaci di legarsi selettivamente ai recettori dei secretagoghi dell'ormone della crescita |
| CU23043A1 (es) | 2001-12-20 | 2005-05-20 | Ct Ingenieria Genetica Biotech | Composicion farmaceutica que contiene factor de crecimiento epidrmico (egf) para la prevencion de la amputacion de pie diabetico. |
| US7476653B2 (en) | 2003-06-18 | 2009-01-13 | Tranzyme Pharma, Inc. | Macrocyclic modulators of the ghrelin receptor |
| WO2005039625A1 (en) | 2003-10-28 | 2005-05-06 | Rheoscience A/S | Growth hormone secretagogue receptor agonists |
| CA2544602A1 (en) | 2003-11-04 | 2005-05-26 | Elixir Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
| WO2005048916A2 (en) | 2003-11-20 | 2005-06-02 | Biovitrum Ab | Tetrahydrospiro-beta-carboline-1,3 '-pyrrolidine derivatives and their use in ghsr-related disorders |
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- 2007-02-27 CL CL2007000528A patent/CL2007000528A1/es unknown
- 2007-02-27 AR ARP070100806A patent/AR059646A1/es not_active Application Discontinuation
- 2007-02-28 ES ES07711101.1T patent/ES2441441T3/es active Active
- 2007-02-28 US US12/281,085 patent/US8367620B2/en not_active Expired - Fee Related
- 2007-02-28 EP EP07711101.1A patent/EP1997827B1/en not_active Not-in-force
- 2007-02-28 WO PCT/CU2007/000007 patent/WO2007098716A1/es not_active Ceased
- 2007-02-28 CN CN2007800153594A patent/CN101432294B/zh not_active Expired - Fee Related
- 2007-02-28 BR BRPI0708366-1A patent/BRPI0708366A2/pt not_active IP Right Cessation
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Also Published As
| Publication number | Publication date |
|---|---|
| CN101432294A (zh) | 2009-05-13 |
| US8367620B2 (en) | 2013-02-05 |
| JP5183496B2 (ja) | 2013-04-17 |
| ES2441441T3 (es) | 2014-02-04 |
| ZA200807162B (en) | 2009-06-24 |
| EP1997827A1 (en) | 2008-12-03 |
| WO2007098716A1 (es) | 2007-09-07 |
| US20100055118A1 (en) | 2010-03-04 |
| NO20084118L (no) | 2008-09-29 |
| JP2009528303A (ja) | 2009-08-06 |
| MX2008011142A (es) | 2008-09-08 |
| AU2007219569A1 (en) | 2007-09-07 |
| AR059646A1 (es) | 2008-04-16 |
| KR20080110763A (ko) | 2008-12-19 |
| CL2016001648A1 (es) | 2017-02-24 |
| RU2416618C2 (ru) | 2011-04-20 |
| CA2637593A1 (en) | 2007-09-07 |
| KR101409277B1 (ko) | 2014-06-24 |
| EP1997827B1 (en) | 2013-10-09 |
| RU2008138569A (ru) | 2010-04-10 |
| AU2007219569B2 (en) | 2012-03-15 |
| MY184130A (en) | 2021-03-19 |
| CA2637593C (en) | 2015-04-14 |
| CU23558A1 (es) | 2010-07-20 |
| CN101432294B (zh) | 2013-09-11 |
| CL2007000528A1 (es) | 2008-01-18 |
| WO2007098716A8 (es) | 2008-12-18 |
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