BRPI0617085A2 - método para obter uma célula-tronco mesenquimal (msc), célula ou linhagem celular, método para derivar uma cultura celular a partir de uma célula-tronco embrionária, método para tratamento de uma doença, uso de uma célula-tronco mesenquimal, linhagem diferenciada, composição farmacêutica, método para condicionar um meio de cultura celular, meio condicionado e uso do mesmo, mpetodo para obterum polipeptídeo, método para obtar uma cultura celular, cultura celular, célula-tronco mesenquimal, linhagem de célula-tronco mesenquimal ou uma célula mesenquimal diferenciada - Google Patents

método para obter uma célula-tronco mesenquimal (msc), célula ou linhagem celular, método para derivar uma cultura celular a partir de uma célula-tronco embrionária, método para tratamento de uma doença, uso de uma célula-tronco mesenquimal, linhagem diferenciada, composição farmacêutica, método para condicionar um meio de cultura celular, meio condicionado e uso do mesmo, mpetodo para obterum polipeptídeo, método para obtar uma cultura celular, cultura celular, célula-tronco mesenquimal, linhagem de célula-tronco mesenquimal ou uma célula mesenquimal diferenciada

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Publication number
BRPI0617085A2
BRPI0617085A2 BRPI0617085A BRPI0617085A BRPI0617085A2 BR PI0617085 A2 BRPI0617085 A2 BR PI0617085A2 BR PI0617085 A BRPI0617085 A BR PI0617085A BR PI0617085 A BRPI0617085 A BR PI0617085A BR PI0617085 A2 BRPI0617085 A2 BR PI0617085A2
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BR
Brazil
Prior art keywords
cell
mesenchymal stem
stem cell
obtaining
cell culture
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Application number
BRPI0617085A
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English (en)
Inventor
Elias Lye
Sai Kiang Lim
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Publication of BRPI0617085A2 publication Critical patent/BRPI0617085A2/pt

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    • C12N2502/13Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
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    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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BRPI0617085A 2005-09-02 2006-08-15 método para obter uma célula-tronco mesenquimal (msc), célula ou linhagem celular, método para derivar uma cultura celular a partir de uma célula-tronco embrionária, método para tratamento de uma doença, uso de uma célula-tronco mesenquimal, linhagem diferenciada, composição farmacêutica, método para condicionar um meio de cultura celular, meio condicionado e uso do mesmo, mpetodo para obterum polipeptídeo, método para obtar uma cultura celular, cultura celular, célula-tronco mesenquimal, linhagem de célula-tronco mesenquimal ou uma célula mesenquimal diferenciada BRPI0617085A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71399205P 2005-09-02 2005-09-02
PCT/SG2006/000232 WO2007027156A1 (en) 2005-09-02 2006-08-15 Method of deriving mesenchymal stem cells

Publications (1)

Publication Number Publication Date
BRPI0617085A2 true BRPI0617085A2 (pt) 2016-11-08

Family

ID=37075090

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0617085A BRPI0617085A2 (pt) 2005-09-02 2006-08-15 método para obter uma célula-tronco mesenquimal (msc), célula ou linhagem celular, método para derivar uma cultura celular a partir de uma célula-tronco embrionária, método para tratamento de uma doença, uso de uma célula-tronco mesenquimal, linhagem diferenciada, composição farmacêutica, método para condicionar um meio de cultura celular, meio condicionado e uso do mesmo, mpetodo para obterum polipeptídeo, método para obtar uma cultura celular, cultura celular, célula-tronco mesenquimal, linhagem de célula-tronco mesenquimal ou uma célula mesenquimal diferenciada
BRPI0617084-6A BRPI0617084A2 (pt) 2005-09-02 2006-08-15 método, linhagem de célula progenitora, célula diferenciada e método para gerar uma célula diferenciada de uma célula-tronco (es) embrionária

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BRPI0617084-6A BRPI0617084A2 (pt) 2005-09-02 2006-08-15 método, linhagem de célula progenitora, célula diferenciada e método para gerar uma célula diferenciada de uma célula-tronco (es) embrionária

Country Status (9)

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US (6) US20080199849A1 (pt)
EP (2) EP1937801A1 (pt)
JP (2) JP2009506769A (pt)
KR (2) KR20080056181A (pt)
CN (2) CN101341244A (pt)
AU (2) AU2006285468A1 (pt)
BR (2) BRPI0617085A2 (pt)
IL (2) IL189878A0 (pt)
WO (2) WO2007027157A1 (pt)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
PL1888123T3 (pl) 2005-06-08 2013-06-28 Janssen Biotech Inc Terapia komórkowa chorób degeneracyjnych oka
CN102660495A (zh) 2006-04-14 2012-09-12 先进细胞技术公司 血管瘤集落形成细胞
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
US8628964B2 (en) * 2006-10-11 2014-01-14 Drexel University Fetal pulmonary cells and uses thereof
CN101743306A (zh) 2007-03-23 2010-06-16 威斯康星校友研究基金会 体细胞重编程
US20100184212A1 (en) * 2007-05-30 2010-07-22 Steven Stice Human embryonic stem cell derived mesoderm-like epithelium transitions to mesenchymal progenitor cells
WO2008151390A1 (en) * 2007-06-15 2008-12-18 Australian Stem Cell Centre Ltd Differentiation of human embryonic stem cells
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
EP2185693B1 (en) 2007-07-31 2019-07-03 Lifescan, Inc. Differentiation of human embryonic stem cells
AU2008298816B2 (en) 2007-09-11 2013-09-26 Sapporo Medical University Cell growth method and pharmaceutical preparation for tissue repair and regeneration
US20110236971A2 (en) * 2007-09-25 2011-09-29 Maksym Vodyanyk Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions
EP2229434B1 (en) 2007-11-27 2011-09-07 Lifescan, Inc. Differentiation of human embryonic stem cells
US8512696B2 (en) * 2007-11-30 2013-08-20 Autologous, Llc Methods of isolating non-senescent cardiac stem cells and uses thereof
CA2959401C (en) 2008-02-21 2021-12-07 Centocor Ortho Biotech Inc. Methods, surface modified plates and compositions for cell attachment, cultivation and detachment
KR101077042B1 (ko) * 2008-03-28 2011-10-26 경희대학교 산학협력단 중배엽 줄기세포의 증식을 촉진하기 위한 cd45+ 세포 또는 cd45+ 세포 배양액의 용도
JP5429755B2 (ja) * 2008-04-18 2014-02-26 国立大学法人名古屋大学 間葉系幹細胞およびその生産方法
US8623648B2 (en) 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
US7939322B2 (en) 2008-04-24 2011-05-10 Centocor Ortho Biotech Inc. Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm
CA2763548C (en) 2008-05-27 2019-01-15 Energesis Pharmaceuticals, Inc. Brown adipocyte progenitors in human skeletal muscle
EP2310492B1 (en) 2008-06-30 2015-07-22 Janssen Biotech, Inc. Differentiation of pluripotent stem cells
WO2010040262A1 (zh) * 2008-10-10 2010-04-15 深圳市嘉天源生物科技有限公司 分离动物胚胎间质性干细胞并提取其分泌物的方法
CA2742268C (en) 2008-10-31 2020-02-18 Centocor Ortho Biotech Inc. Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
US9012218B2 (en) 2008-10-31 2015-04-21 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
AU2009316583B2 (en) 2008-11-20 2016-04-21 Janssen Biotech, Inc. Methods and compositions for cell attachment and cultivation on planar substrates
RU2555538C2 (ru) 2008-11-20 2015-07-10 Сентокор Орто Байотек Инк. Культура плюрипотентных стволовых клеток на микроносителях
US8790638B2 (en) * 2009-02-04 2014-07-29 Stemedica Cell Technologies, Inc. Compositions of stem cells and stem cell factors and methods for their use and manufacture
KR101032271B1 (ko) * 2009-05-25 2011-05-06 (주)미래생명공학연구소 피부세포 재생용 조성물, 그 제조 방법, 피부세포 재생 방법 및 화장료 조성물
EP2436775A4 (en) * 2009-05-26 2013-11-13 Takeda Pharmaceutical SCREENING METHOD FOR REGENERATIVE MEDICINE
GB2485113B (en) 2009-07-20 2016-12-28 Janssen Biotech Inc Differentiation of human embryonic stem cells into cells of the pancreatic endoderm lineage
CN102482640B (zh) 2009-07-20 2015-03-11 詹森生物科技公司 人胚胎干细胞的分化
BR112012001480A2 (pt) 2009-07-20 2015-09-01 Janssen Biotech Inc Diferenciação de células-tronco embriônicas humanas
SG10201403202XA (en) * 2009-07-23 2014-08-28 Agency Science Tech & Res Pre-natal mesenchymal stem cells
EP2496711B1 (en) 2009-11-02 2016-02-17 Agency For Science, Technology And Research Methods for monitoring cellular states and for immortalizing mesenchymal stem cells
RU2664864C1 (ru) 2009-12-23 2018-08-23 Янссен Байотек, Инк. Способы увеличения экспрессии ngn3 и nkx6.1 в эндокринных клетках поджелудочной железы
US9150833B2 (en) 2009-12-23 2015-10-06 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
US20110206647A1 (en) * 2010-02-25 2011-08-25 Abt Holding Company Modulation of Angiogenesis
WO2011109279A2 (en) 2010-03-01 2011-09-09 Centocor Ortho Biotech Inc. Methods for purifying cells derived from pluripotent stem cells
CN102884176B (zh) 2010-05-12 2017-09-05 詹森生物科技公司 人胚胎干细胞的分化
ES2712709T3 (es) * 2010-07-20 2019-05-14 Univ Southern California Células madre mesenquimales de médula ósea con telomerasa de alta actividad, métodos de producción de las mismas y productos farmacéuticos y métodos de tratamiento basados en las mismas
RU2673946C1 (ru) 2010-08-31 2018-12-03 Янссен Байотек, Инк. Дифференцирование плюрипотентных стволовых клеток
PL2611910T3 (pl) 2010-08-31 2018-06-29 Janssen Biotech, Inc Różnicowanie ludzkich embrionalnych komórek macierzystych
PL2611909T3 (pl) 2010-08-31 2018-05-30 Janssen Biotech, Inc Zróżnicowanie ludzkich embrionalnych komórek macierzystych
US20120087933A1 (en) 2010-10-08 2012-04-12 Samson Tom Enhanced msc preparations
US20130309209A1 (en) * 2010-10-22 2013-11-21 Center For Regenerative Medicine Of Barcelona Formation of hematopoietic progenitor cells from mesenchymal stem cells
CN109432126B (zh) 2011-03-11 2022-06-14 儿童医学中心公司 与间充质干细胞外来体相关的方法和组合物
JP2014519854A (ja) * 2011-06-23 2014-08-21 ザ チルドレンズ ホスピタル オブ フィラデルフィア ヒト多能性幹細胞から生じる自己複製する内胚葉前駆細胞株とその使用方法
WO2013008803A1 (ja) * 2011-07-11 2013-01-17 国立大学法人 熊本大学 発酵能を有する細菌を用いた多能性細胞の製造方法
WO2013071050A1 (en) 2011-11-10 2013-05-16 Energesis Pharmaceuticals, Inc. Brown adipocyte progenitors in human skeletal muscle
JP6344821B2 (ja) * 2011-11-21 2018-06-20 ユニバーシティ・ヘルス・ネットワーク 造血前駆体の集団および造血前駆体のための幹細胞を富化する方法
EP2785734B1 (en) 2011-11-30 2017-11-01 Agency For Science, Technology And Research Gm1 ganglioside to annexin v microparticle polypeptide ratio for biological monitoring
BR112014015417A8 (pt) 2011-12-22 2017-07-04 Janssen Biotech Inc diferenciação de células-tronco embrionárias humanas em células positivas de insulina hormonal únicas
AU2013230020B2 (en) 2012-03-07 2018-08-09 Janssen Biotech, Inc. Defined media for expansion and maintenance of pluripotent stem cells
KR101422559B1 (ko) * 2012-03-09 2014-07-24 창원대학교 산학협력단 지방유래 줄기세포 배양액, 이의 제조방법, 및 이를 포함하는 발모촉진용 조성물
CN104334719B (zh) 2012-06-08 2018-02-13 詹森生物科技公司 人胚胎干细胞向胰腺内分泌细胞的分化
CN104487568B (zh) * 2012-07-11 2017-08-15 爱姆斯坦生物技术公司 人胚胎干细胞衍生的间充质样干细胞、方法及其应用
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
RU2018116647A (ru) 2012-12-31 2018-10-24 Янссен Байотек, Инк. Культивация эмбриональных стволовых клеток человека в воздушно-жидкостной зоне взаимодействия с целью их дифференцировки в панкреатические эндокринные клетки
MX2015008619A (es) 2012-12-31 2016-01-12 Janssen Biotech Inc Suspension y agrupamiento de celulas humanas pluripotentes para la diferenciacion a celulas endocrinas pancreaticas.
MX2015008578A (es) 2012-12-31 2015-09-07 Janssen Biotech Inc Diferenciacion de celulas madre embrionarias humanas en celulas endocrinas pancreaticas mediante el uso de relugadores de hb9.
CN103509753B (zh) * 2013-08-12 2016-06-15 中国科学院广州生物医药与健康研究院 一种人体造血干细胞分化培养方法
TWI486447B (zh) * 2013-09-05 2015-06-01 Buddhist Tzu Chi Medical Foundation 人類間質幹細胞體外快速增生之佐劑、體外快速擴增人類間質幹細胞之方法、體外快速擴增人類間質幹細胞以獲取生長因子的方法及其用途
RU2694311C2 (ru) 2014-05-16 2019-07-11 Янссен Байотек, Инк. Применение малых молекул для увеличения экспрессии mafa в панкреатических эндокринных клетках
CN113817672A (zh) 2014-05-18 2021-12-21 儿童医学中心公司 涉及外排体的方法和组合物
WO2016139340A1 (en) * 2015-03-04 2016-09-09 Mesoblast International Sàrl Cell culture method for mesenchymal stem cells
CN105624104B (zh) * 2015-06-01 2018-10-12 中国医学科学院血液病医院(血液学研究所) 一种提高人间充质干细胞功能的细胞处理方法
WO2017160986A1 (en) * 2016-03-16 2017-09-21 Cell Medicine, Inc. Mesenchymal stem cells with enhanced efficacy
MA45479A (fr) 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
CN106085953A (zh) * 2016-07-19 2016-11-09 安徽惠恩生物科技股份有限公司 一种临床级脐带间质细胞提取制备方法
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
KR20200029475A (ko) * 2017-07-16 2020-03-18 라모트 앳 텔-아비브 유니버시티 리미티드 인간 구강 점막 줄기세포 분비체
US20200345781A1 (en) * 2017-11-09 2020-11-05 Sapporo Medical University Medicine for tissue regeneration, and preparation method therefor
US11285177B2 (en) 2018-01-03 2022-03-29 Globus Medical, Inc. Allografts containing viable cells and methods thereof
CN108570447A (zh) * 2018-01-26 2018-09-25 皓昇莱生物制药有限公司 一种筛选分化hPSCs向MSCs的方法
CN109943525B (zh) * 2019-03-15 2021-07-30 中科睿极(深圳)医学科技有限公司 无血清、无动物源成分、组分明确的培养基及其应用
JP6712740B1 (ja) * 2019-03-25 2020-06-24 学校法人東海大学 Tie2陽性幹/前駆細胞を含む細胞集団の培養方法およびその利用
KR102280509B1 (ko) * 2020-09-04 2021-07-22 건국대학교 글로컬산학협력단 전분화능 줄기세포 기반 자가면역성 및 염증성 피부질환 예방 또는 치료용 조성물 및 이의 제조방법
CN112430626A (zh) * 2020-11-27 2021-03-02 成都康景生物科技有限公司 一种基因修饰的脐间充质干细胞、制备方法及应用
CN116836920B (zh) * 2023-08-21 2024-05-24 广东横琴粤澳深度合作区齐美国际干细胞医院有限公司 一种无血清培养基及其制备间充质干细胞的方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE286118T1 (de) 1998-03-13 2005-01-15 Osiris Therapeutics Inc Anwendungen für humane nicht autologe, mesenchymale stammzellen
US20030082152A1 (en) * 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
KR100870508B1 (ko) 1999-03-10 2008-11-25 유니버시티 오브 피츠버그 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 지방 유래 간세포 및 격자
US7005252B1 (en) * 2000-03-09 2006-02-28 Wisconsin Alumni Research Foundation Serum free cultivation of primate embryonic stem cells
US7439064B2 (en) * 2000-03-09 2008-10-21 Wicell Research Institute, Inc. Cultivation of human embryonic stem cells in the absence of feeder cells or without conditioned medium
US7011828B2 (en) 2000-03-14 2006-03-14 Es Cell International Pte. Ltd. Implanting neural progenitor cells derived for human embryonic stem cells
GB2379447B (en) * 2000-05-17 2004-12-29 Geron Corp Neural progenitor cell populations
WO2002026941A2 (en) * 2000-09-29 2002-04-04 Kooy Derek V D Primitive neural stem cells and method for differentiation of stem cells to neural cells
GB2392674B (en) 2001-07-06 2005-08-10 Geron Corp Mesenchymal cells and osteoblasts from human embryonic stem cell
US20050148034A1 (en) * 2002-04-12 2005-07-07 Hariri Robert J. Methods for identification of modulators of angiogenesis, compounds discovered thereby, and methods of treatment using the compounds
AU2003231358A1 (en) 2002-04-17 2003-10-27 Otsuka Pharmaceutical Co., Ltd. METHOD OF FORMING PANCREATIC Beta CELLS FROM MESENCHYMAL CELLS
US20040052771A1 (en) * 2002-07-12 2004-03-18 Lim Sai Kiang Hemangioblast progenitor cells
JP3762975B2 (ja) * 2003-03-18 2006-04-05 学校法人慶應義塾 単球由来多能性細胞momc
JPWO2005024004A1 (ja) * 2003-08-27 2006-11-02 株式会社レノメディクス研究所 間葉系幹細胞の肝細胞への分化方法及び人工ヒト肝臓細胞
JP2005304443A (ja) * 2004-04-26 2005-11-04 Institute Of Physical & Chemical Research 前駆間葉系幹細胞
US7592176B2 (en) * 2004-05-07 2009-09-22 Wisconsin Alumni Research Foundation Method of forming mesenchymal stem cells from embryonic stem cells

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