BRPI0519174A2 - cepa recombinante de um microorganismo produtor de Ácido succÍnico, mÉtodo para produzir Ácido succÍnico, molÉcula de dna, plasmÍdeo de dna, e, cÉlula hospedeira - Google Patents
cepa recombinante de um microorganismo produtor de Ácido succÍnico, mÉtodo para produzir Ácido succÍnico, molÉcula de dna, plasmÍdeo de dna, e, cÉlula hospedeiraInfo
- Publication number
- BRPI0519174A2 BRPI0519174A2 BRPI0519174-2A BRPI0519174A BRPI0519174A2 BR PI0519174 A2 BRPI0519174 A2 BR PI0519174A2 BR PI0519174 A BRPI0519174 A BR PI0519174A BR PI0519174 A2 BRPI0519174 A2 BR PI0519174A2
- Authority
- BR
- Brazil
- Prior art keywords
- succinic acid
- producing
- dna
- recombinant
- host cell
- Prior art date
Links
- 244000005700 microbiome Species 0.000 title abstract 8
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 title abstract 8
- 239000001384 succinic acid Substances 0.000 title abstract 3
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000013612 plasmid Substances 0.000 title abstract 2
- 108020004414 DNA Proteins 0.000 title 2
- 102000053602 DNA Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
- 150000007524 organic acids Chemical class 0.000 abstract 2
- 235000005985 organic acids Nutrition 0.000 abstract 2
- 101710155861 Glucose-6-phosphate 1-dehydrogenase Proteins 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 239000004310 lactic acid Substances 0.000 abstract 1
- 235000014655 lactic acid Nutrition 0.000 abstract 1
- -1 pentose phosphate Chemical class 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63944304P | 2004-12-22 | 2004-12-22 | |
| US64714105P | 2005-01-26 | 2005-01-26 | |
| PCT/US2005/045714 WO2006083410A2 (en) | 2004-12-22 | 2005-12-16 | Recombinant microorganisms for increased production of organic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0519174A2 true BRPI0519174A2 (pt) | 2008-12-30 |
Family
ID=36777690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0519174-2A BRPI0519174A2 (pt) | 2004-12-22 | 2005-12-16 | cepa recombinante de um microorganismo produtor de Ácido succÍnico, mÉtodo para produzir Ácido succÍnico, molÉcula de dna, plasmÍdeo de dna, e, cÉlula hospedeira |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US8119377B2 (enExample) |
| EP (2) | EP1838837B1 (enExample) |
| JP (2) | JP5634659B2 (enExample) |
| KR (1) | KR101357015B1 (enExample) |
| CN (1) | CN101128577B (enExample) |
| BR (1) | BRPI0519174A2 (enExample) |
| CA (1) | CA2592449C (enExample) |
| ES (1) | ES2541538T3 (enExample) |
| MX (1) | MX2007007834A (enExample) |
| WO (1) | WO2006083410A2 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008153676A2 (en) * | 2007-05-21 | 2008-12-18 | The Regents Of The University Of California | Pentose phosphate pathway and fermentation enzyme-encoding nucleotide sequences with refined translational kinetics and methods of making same |
| EP2505637B1 (en) * | 2007-08-17 | 2019-10-09 | Basf Se | Novel microbial succinic acid producer |
| CN104818224A (zh) | 2007-11-20 | 2015-08-05 | 帝斯曼知识产权资产管理有限公司 | 在真核细胞中生产琥珀酸 |
| EP2220234B1 (en) | 2007-11-20 | 2012-06-27 | DSM IP Assets B.V. | Dicarboxylic acid production in a recombinant yeast |
| CN104099285A (zh) * | 2008-03-13 | 2014-10-15 | 帝斯曼知识产权资产管理有限公司 | 对能够发酵混合底物的生物的选择 |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| US8431372B2 (en) * | 2009-06-19 | 2013-04-30 | Mbi International | Fermentation method using a magnesium compound containing oxygen |
| JP6116568B2 (ja) † | 2011-08-30 | 2017-04-19 | アカデミッシュ メディッシュ セントラム | インスリン抵抗性を予防および／または処置する方法 |
| US20150017698A1 (en) * | 2012-03-02 | 2015-01-15 | Codexis, Inc. a corporation | Recombinant host cells and processes for producing 1,3-butadiene through a 5-hydroxypent-3-enoate intermediate |
| CA2923794C (en) | 2012-09-09 | 2021-07-27 | Biocheminsights, Inc. | Electrochemical bioreactor module and methods of using the same |
| WO2014055650A1 (en) | 2012-10-02 | 2014-04-10 | The Michigan Biotechnology Institute | Integrated systems and methods for organic acid production |
| EP2904104B1 (en) * | 2012-10-02 | 2018-08-15 | The Michigan Biotechnology Institute | Recombinant microorganisms for producing organic acids |
| CN104178442B (zh) | 2013-05-24 | 2017-10-31 | 中国科学院天津工业生物技术研究所 | 含有突变的lpdA基因的大肠杆菌及其应用 |
| CN104178443B (zh) * | 2013-05-24 | 2017-04-12 | 中国科学院天津工业生物技术研究所 | 生产丁二酸的重组大肠杆菌及其应用 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| KR102384227B1 (ko) | 2015-05-18 | 2022-04-07 | 삼성전자주식회사 | Nadph 생성이 증가된 유전적으로 조작된 효모 세포, 효모 세포 중 nadph 수준을 증가시키는 방법, 상기 효모 세포를 제조하는 방법 및 상기 효모 세포를 이용하여 락테이트를 생산하는 방법 |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| WO2019011948A1 (en) * | 2017-07-11 | 2019-01-17 | Adisseo France S.A.S. | IMPROVED METABOLITE PRODUCTION YEAST |
| KR20220013233A (ko) | 2020-07-24 | 2022-02-04 | 삼성전자주식회사 | 프로모터 영역을 포함하는 분리된 폴리뉴클레오티드, 그를 포함하는 숙주 세포 및 상기 숙주 세포를 이용하여 목적 유전자를 발현시키는 방법 |
| CN113106129A (zh) * | 2020-09-29 | 2021-07-13 | 安徽华恒生物科技股份有限公司 | 一种高转化率的d泛解酸内酯制备方法 |
| CN116333900A (zh) * | 2021-12-15 | 2023-06-27 | 中国科学院大连化学物理研究所 | 一种提高酵母菌株nadph和fadh2供应的方法、工程菌及其应用 |
| WO2025229145A1 (en) | 2024-05-02 | 2025-11-06 | Stichting Amsterdam UMC | Desulfovibrio piger species for prevention or treatment of hepatic steatosis |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5521075A (en) | 1994-12-19 | 1996-05-28 | Michigan Biotechnology Institute | Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants |
| US5504004A (en) | 1994-12-20 | 1996-04-02 | Michigan Biotechnology Institute | Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms |
| US5573931A (en) | 1995-08-28 | 1996-11-12 | Michigan Biotechnology Institute | Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants |
| JP3967812B2 (ja) * | 1998-01-16 | 2007-08-29 | 三菱化学株式会社 | ピルビン酸カルボキシラーゼ遺伝子組み換え菌体による有機酸の製造法 |
| JPH11196887A (ja) * | 1998-01-16 | 1999-07-27 | Mitsubishi Chemical Corp | ホスホエノールピルビン酸カルボキシラーゼ遺伝子組み換え菌体による有機酸の製造法 |
| DK1208205T3 (da) * | 1999-07-23 | 2007-02-05 | Archer Daniels Midland Co | Fremgangsmåder til frembringelse af L-aminosyrer ved hjælp af en forögelse af cellulært NADPH |
| JP2002291477A (ja) * | 2001-03-30 | 2002-10-08 | Mitsubishi Chemicals Corp | フマラーゼをコードするｄｎａ及びその利用 |
| WO2003025006A2 (en) * | 2001-09-21 | 2003-03-27 | Affinium Pharmaceuticals, Inc. | Purified polypeptides involved in co-factor metabolism |
| JP4333088B2 (ja) * | 2002-06-26 | 2009-09-16 | 味の素株式会社 | グルコノバクター属細菌の新規遺伝子及び目的物質の製造法 |
| US7332304B2 (en) * | 2002-07-01 | 2008-02-19 | Arkion Life Sciences Llc | Process and materials for production of glucosamine and N-acetylglucosamine |
| US7163812B2 (en) * | 2003-08-06 | 2007-01-16 | Board Of Trustees Of Michigan State University | Actinobacillus succinogenes shuttle vector and methods of use |
| US7927859B2 (en) * | 2003-08-22 | 2011-04-19 | Rice University | High molar succinate yield bacteria by increasing the intracellular NADH availability |
| WO2005042736A1 (en) | 2003-10-30 | 2005-05-12 | Michaela Slanicka Krieger | Cell culture supplement for the in vitro cultivation of cells and a method for culturing cells |
| JP2005217918A (ja) | 2004-01-30 | 2005-08-11 | Toshiba Corp | 受信装置 |
-
2005
- 2005-12-16 EP EP05857107.6A patent/EP1838837B1/en not_active Expired - Lifetime
- 2005-12-16 JP JP2007548341A patent/JP5634659B2/ja not_active Expired - Fee Related
- 2005-12-16 US US11/722,579 patent/US8119377B2/en active Active
- 2005-12-16 KR KR1020077016510A patent/KR101357015B1/ko not_active Expired - Fee Related
- 2005-12-16 CN CN2005800482427A patent/CN101128577B/zh not_active Expired - Fee Related
- 2005-12-16 WO PCT/US2005/045714 patent/WO2006083410A2/en not_active Ceased
- 2005-12-16 MX MX2007007834A patent/MX2007007834A/es active IP Right Grant
- 2005-12-16 BR BRPI0519174-2A patent/BRPI0519174A2/pt not_active Application Discontinuation
- 2005-12-16 EP EP11178943A patent/EP2460872A1/en not_active Withdrawn
- 2005-12-16 ES ES05857107.6T patent/ES2541538T3/es not_active Expired - Lifetime
- 2005-12-16 CA CA2592449A patent/CA2592449C/en not_active Expired - Lifetime
-
2011
- 2011-10-07 JP JP2011223226A patent/JP5655217B2/ja not_active Expired - Fee Related
- 2011-12-16 US US13/328,894 patent/US8431373B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006083410A2 (en) | 2006-08-10 |
| US8431373B2 (en) | 2013-04-30 |
| MX2007007834A (es) | 2007-09-04 |
| JP2008525026A (ja) | 2008-07-17 |
| KR20070108155A (ko) | 2007-11-08 |
| WO2006083410A3 (en) | 2006-11-23 |
| KR101357015B1 (ko) | 2014-02-03 |
| EP1838837B1 (en) | 2015-04-15 |
| US20080305533A1 (en) | 2008-12-11 |
| EP2460872A1 (en) | 2012-06-06 |
| EP1838837A2 (en) | 2007-10-03 |
| CN101128577B (zh) | 2013-06-19 |
| JP2012034702A (ja) | 2012-02-23 |
| US20120164703A1 (en) | 2012-06-28 |
| CA2592449A1 (en) | 2006-08-10 |
| EP1838837A4 (en) | 2009-01-14 |
| CN101128577A (zh) | 2008-02-20 |
| CA2592449C (en) | 2015-11-24 |
| US8119377B2 (en) | 2012-02-21 |
| JP5655217B2 (ja) | 2015-01-21 |
| ES2541538T3 (es) | 2015-07-21 |
| JP5634659B2 (ja) | 2014-12-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0519174A2 (pt) | cepa recombinante de um microorganismo produtor de Ácido succÍnico, mÉtodo para produzir Ácido succÍnico, molÉcula de dna, plasmÍdeo de dna, e, cÉlula hospedeira | |
| Schievano et al. | Electro-fermentation–merging electrochemistry with fermentation in industrial applications | |
| Brenner | Catalysis in the nitrilase superfamily | |
| Schocke et al. | Thermoacidophilic Sulfolobus species as source for extremozymes and as novel archaeal platform organisms | |
| Choi et al. | Consolidated conversion of protein waste into biofuels and ammonia using Bacillus subtilis | |
| CN106978453B (zh) | 一种利用氨基酸脱氢酶制备l-草铵膦的方法 | |
| UA103335C2 (ru) | Способ изготовления добавки для ферментативного расщепления микотоксинов, добавка и ее применение | |
| MX2009012715A (es) | Variantes de una alfa-amilasa con niveles de produccion mejorados en procesos de fermentacion. | |
| BRPI0814781A8 (pt) | ''proteína, sequência de ácido nucleico, método para a produção de ácido itacônico, vetor, célula hospedeira, e, uso de um ácido cis-aconítico descarboxilase'' | |
| BRPI0910812A2 (pt) | célula de fermentação de açúcar pentose | |
| BR112018011902A2 (pt) | método de fermentação, levedura geneticamente modificada, construto de ácido nucleico, vetor, célula hospedeira, meio de fermentação e utilização da levedura geneticamente modificada | |
| EP3594331A1 (en) | Use of the reductive glycine pathway for generating formatotrophic and autotrophic microorganisms | |
| Luo et al. | Cloning and expression of a novel leucine dehydrogenase: Characterization and L-tert-leucine production | |
| Hess | Thermoacidophilic proteins for biofuel production | |
| Duan et al. | Modular and flexible molecular device for simultaneous cytosine and Adenine base editing at random genomic loci in filamentous fungi | |
| US10053712B2 (en) | Use of enzymes which catalyze pyruvate synthesis from formate and acetyl-CoA and bacteria expressing same | |
| Li et al. | Direct CO2 Transformation to Malate via Bioelectrosynthesis upon Engineered Shewanella oneidensis | |
| ES2683208T3 (es) | Procedimiento para la producción de fructosa | |
| Pateraki et al. | Transcriptional regulation in key metabolic pathways of Actinobacillus succinogenes in the presence of electricity | |
| CN117402803A (zh) | 一种高产d-泛酸的枯草芽孢杆菌基因工程菌、构建方法及应用 | |
| ES2625501T3 (es) | Procedimiento mejorado de producción de enzimas celulolíticas y/o hemicelulolíticas | |
| Ishaq et al. | Recent advances in keratinase production via protein engineering, breeding, and fermentation | |
| Xu et al. | GlnR and PhoP regulate β-glucosidases involved in cellulose digestion in response to nitrogen and phosphate availability | |
| CN103882045B (zh) | 生产丙酮酸的菌株及其构建方法 | |
| WO2014082513A1 (zh) | 脂肪酶及其用途 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06G | Technical and formal requirements: other requirements [chapter 6.7 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |