KR101357015B1 - 유기산의 증가된 생성을 위한 재조합 미생물 - Google Patents

유기산의 증가된 생성을 위한 재조합 미생물 Download PDF

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KR101357015B1
KR101357015B1 KR1020077016510A KR20077016510A KR101357015B1 KR 101357015 B1 KR101357015 B1 KR 101357015B1 KR 1020077016510 A KR1020077016510 A KR 1020077016510A KR 20077016510 A KR20077016510 A KR 20077016510A KR 101357015 B1 KR101357015 B1 KR 101357015B1
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microorganism
zwf
recombinant
transformed
succinic acid
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KR20070108155A (ko
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지안 이
수잔 클레프
마이클 브이. 구틀러
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더 미시간 바이오테크노로지 인스티튜트
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020077016510A 2004-12-22 2005-12-16 유기산의 증가된 생성을 위한 재조합 미생물 Expired - Fee Related KR101357015B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US63944304P 2004-12-22 2004-12-22
US60/639,443 2004-12-22
US64714105P 2005-01-26 2005-01-26
US60/647,141 2005-01-26
PCT/US2005/045714 WO2006083410A2 (en) 2004-12-22 2005-12-16 Recombinant microorganisms for increased production of organic acids

Publications (2)

Publication Number Publication Date
KR20070108155A KR20070108155A (ko) 2007-11-08
KR101357015B1 true KR101357015B1 (ko) 2014-02-03

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KR1020077016510A Expired - Fee Related KR101357015B1 (ko) 2004-12-22 2005-12-16 유기산의 증가된 생성을 위한 재조합 미생물

Country Status (10)

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US (2) US8119377B2 (enExample)
EP (2) EP1838837B1 (enExample)
JP (2) JP5634659B2 (enExample)
KR (1) KR101357015B1 (enExample)
CN (1) CN101128577B (enExample)
BR (1) BRPI0519174A2 (enExample)
CA (1) CA2592449C (enExample)
ES (1) ES2541538T3 (enExample)
MX (1) MX2007007834A (enExample)
WO (1) WO2006083410A2 (enExample)

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WO2008153676A2 (en) * 2007-05-21 2008-12-18 The Regents Of The University Of California Pentose phosphate pathway and fermentation enzyme-encoding nucleotide sequences with refined translational kinetics and methods of making same
EP2505637B1 (en) * 2007-08-17 2019-10-09 Basf Se Novel microbial succinic acid producer
CN104818224A (zh) 2007-11-20 2015-08-05 帝斯曼知识产权资产管理有限公司 在真核细胞中生产琥珀酸
EP2220234B1 (en) 2007-11-20 2012-06-27 DSM IP Assets B.V. Dicarboxylic acid production in a recombinant yeast
CN104099285A (zh) * 2008-03-13 2014-10-15 帝斯曼知识产权资产管理有限公司 对能够发酵混合底物的生物的选择
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
US8431372B2 (en) * 2009-06-19 2013-04-30 Mbi International Fermentation method using a magnesium compound containing oxygen
JP6116568B2 (ja) † 2011-08-30 2017-04-19 アカデミッシュ メディッシュ セントラム インスリン抵抗性を予防および／または処置する方法
US20150017698A1 (en) * 2012-03-02 2015-01-15 Codexis, Inc. a corporation Recombinant host cells and processes for producing 1,3-butadiene through a 5-hydroxypent-3-enoate intermediate
CA2923794C (en) 2012-09-09 2021-07-27 Biocheminsights, Inc. Electrochemical bioreactor module and methods of using the same
WO2014055650A1 (en) 2012-10-02 2014-04-10 The Michigan Biotechnology Institute Integrated systems and methods for organic acid production
EP2904104B1 (en) * 2012-10-02 2018-08-15 The Michigan Biotechnology Institute Recombinant microorganisms for producing organic acids
CN104178442B (zh) 2013-05-24 2017-10-31 中国科学院天津工业生物技术研究所 含有突变的lpdA基因的大肠杆菌及其应用
CN104178443B (zh) * 2013-05-24 2017-04-12 中国科学院天津工业生物技术研究所 生产丁二酸的重组大肠杆菌及其应用
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
KR102384227B1 (ko) 2015-05-18 2022-04-07 삼성전자주식회사 Nadph 생성이 증가된 유전적으로 조작된 효모 세포, 효모 세포 중 nadph 수준을 증가시키는 방법, 상기 효모 세포를 제조하는 방법 및 상기 효모 세포를 이용하여 락테이트를 생산하는 방법
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
WO2019011948A1 (en) * 2017-07-11 2019-01-17 Adisseo France S.A.S. IMPROVED METABOLITE PRODUCTION YEAST
KR20220013233A (ko) 2020-07-24 2022-02-04 삼성전자주식회사 프로모터 영역을 포함하는 분리된 폴리뉴클레오티드, 그를 포함하는 숙주 세포 및 상기 숙주 세포를 이용하여 목적 유전자를 발현시키는 방법
CN113106129A (zh) * 2020-09-29 2021-07-13 安徽华恒生物科技股份有限公司 一种高转化率的d泛解酸内酯制备方法
CN116333900A (zh) * 2021-12-15 2023-06-27 中国科学院大连化学物理研究所 一种提高酵母菌株nadph和fadh2供应的方法、工程菌及其应用
WO2025229145A1 (en) 2024-05-02 2025-11-06 Stichting Amsterdam UMC Desulfovibrio piger species for prevention or treatment of hepatic steatosis

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WO2004003175A2 (en) * 2002-07-01 2004-01-08 Arkion Life Sciences Llc Process and materials for production of glucosamine and n-acetylglucosamine

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US5504004A (en) 1994-12-20 1996-04-02 Michigan Biotechnology Institute Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms
US5573931A (en) 1995-08-28 1996-11-12 Michigan Biotechnology Institute Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants
JP3967812B2 (ja) * 1998-01-16 2007-08-29 三菱化学株式会社 ピルビン酸カルボキシラーゼ遺伝子組み換え菌体による有機酸の製造法
JPH11196887A (ja) * 1998-01-16 1999-07-27 Mitsubishi Chemical Corp ホスホエノールピルビン酸カルボキシラーゼ遺伝子組み換え菌体による有機酸の製造法
DK1208205T3 (da) * 1999-07-23 2007-02-05 Archer Daniels Midland Co Fremgangsmåder til frembringelse af L-aminosyrer ved hjælp af en forögelse af cellulært NADPH
JP2002291477A (ja) * 2001-03-30 2002-10-08 Mitsubishi Chemicals Corp フマラーゼをコードするｄｎａ及びその利用
WO2003025006A2 (en) * 2001-09-21 2003-03-27 Affinium Pharmaceuticals, Inc. Purified polypeptides involved in co-factor metabolism
JP4333088B2 (ja) * 2002-06-26 2009-09-16 味の素株式会社 グルコノバクター属細菌の新規遺伝子及び目的物質の製造法
US7163812B2 (en) * 2003-08-06 2007-01-16 Board Of Trustees Of Michigan State University Actinobacillus succinogenes shuttle vector and methods of use
US7927859B2 (en) * 2003-08-22 2011-04-19 Rice University High molar succinate yield bacteria by increasing the intracellular NADH availability
WO2005042736A1 (en) 2003-10-30 2005-05-12 Michaela Slanicka Krieger Cell culture supplement for the in vitro cultivation of cells and a method for culturing cells
JP2005217918A (ja) 2004-01-30 2005-08-11 Toshiba Corp 受信装置

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Publication number Priority date Publication date Assignee Title
WO2004003175A2 (en) * 2002-07-01 2004-01-08 Arkion Life Sciences Llc Process and materials for production of glucosamine and n-acetylglucosamine

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Publication number Publication date
WO2006083410A2 (en) 2006-08-10
US8431373B2 (en) 2013-04-30
MX2007007834A (es) 2007-09-04
JP2008525026A (ja) 2008-07-17
KR20070108155A (ko) 2007-11-08
WO2006083410A3 (en) 2006-11-23
BRPI0519174A2 (pt) 2008-12-30
EP1838837B1 (en) 2015-04-15
US20080305533A1 (en) 2008-12-11
EP2460872A1 (en) 2012-06-06
EP1838837A2 (en) 2007-10-03
CN101128577B (zh) 2013-06-19
JP2012034702A (ja) 2012-02-23
US20120164703A1 (en) 2012-06-28
CA2592449A1 (en) 2006-08-10
EP1838837A4 (en) 2009-01-14
CN101128577A (zh) 2008-02-20
CA2592449C (en) 2015-11-24
US8119377B2 (en) 2012-02-21
JP5655217B2 (ja) 2015-01-21
ES2541538T3 (es) 2015-07-21
JP5634659B2 (ja) 2014-12-03

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