BRPI0518928A2 - suspensço oftÁlmica aquosa de rebamipide cristalino - Google Patents
suspensço oftÁlmica aquosa de rebamipide cristalinoInfo
- Publication number
- BRPI0518928A2 BRPI0518928A2 BRPI0518928-4A BRPI0518928A BRPI0518928A2 BR PI0518928 A2 BRPI0518928 A2 BR PI0518928A2 BR PI0518928 A BRPI0518928 A BR PI0518928A BR PI0518928 A2 BRPI0518928 A2 BR PI0518928A2
- Authority
- BR
- Brazil
- Prior art keywords
- rebamipide
- aqueous
- crystalline
- suspension
- aqueous ophthalmic
- Prior art date
Links
- ALLWOAVDORUJLA-UHFFFAOYSA-N Rebamipida Chemical compound C=1C(=O)NC2=CC=CC=C2C=1CC(C(=O)O)NC(=O)C1=CC=C(Cl)C=C1 ALLWOAVDORUJLA-UHFFFAOYSA-N 0.000 title abstract 5
- 229950004535 rebamipide Drugs 0.000 title abstract 4
- 229940100654 ophthalmic suspension Drugs 0.000 title abstract 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- 208000003556 Dry Eye Syndromes Diseases 0.000 abstract 1
- 206010013774 Dry eye Diseases 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 239000011260 aqueous acid Substances 0.000 abstract 1
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 229940023490 ophthalmic product Drugs 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 229920003169 water-soluble polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Ophthalmology & Optometry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004330140 | 2004-11-15 | ||
| PCT/JP2005/021178 WO2006052018A1 (en) | 2004-11-15 | 2005-11-11 | Aqueous ophthalmic suspension of crystalline rebamipide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0518928A2 true BRPI0518928A2 (pt) | 2008-12-16 |
Family
ID=36336674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0518928-4A BRPI0518928A2 (pt) | 2004-11-15 | 2005-11-11 | suspensço oftÁlmica aquosa de rebamipide cristalino |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9211254B2 (enExample) |
| EP (1) | EP1812000A4 (enExample) |
| JP (3) | JP4934587B2 (enExample) |
| KR (1) | KR101271959B1 (enExample) |
| CN (1) | CN100594901C (enExample) |
| AR (2) | AR052779A1 (enExample) |
| AU (1) | AU2005302908B2 (enExample) |
| BR (1) | BRPI0518928A2 (enExample) |
| CA (1) | CA2584017C (enExample) |
| MX (1) | MX2007005782A (enExample) |
| MY (1) | MY152867A (enExample) |
| RU (1) | RU2398585C2 (enExample) |
| SG (1) | SG156692A1 (enExample) |
| TW (1) | TWI363626B (enExample) |
| WO (1) | WO2006052018A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200808375A (en) * | 2006-05-12 | 2008-02-16 | Otsuka Pharma Co Ltd | Hydrogel suspension and manufacturing process thereof |
| TWI415629B (zh) * | 2006-10-26 | 2013-11-21 | Otsuka Pharma Co Ltd | 含有瑞巴匹特之水性醫藥懸浮物及其製造方法 |
| WO2008074853A1 (en) * | 2006-12-21 | 2008-06-26 | Novartis Ag | Ophthalmic rebamipide solution |
| CA2725487A1 (en) * | 2008-06-19 | 2009-12-23 | Otsuka Pharmaceutical Co., Ltd. | A pharmaceutical composition |
| US20100247666A1 (en) * | 2009-03-24 | 2010-09-30 | Macleod Steven K | Method for Preparing Suspensions of Low-Solubility Materials |
| US9775802B2 (en) | 2009-03-24 | 2017-10-03 | Bausch & Lomb Incorporated | Method for preparing suspensions of low-solubility materials |
| AR085527A1 (es) | 2011-03-24 | 2013-10-09 | Otsuka Pharma Co Ltd | Una composicon farmaceutica para tratar una enfermedad en la cavidad oral que comprende rebamipida |
| TW201322982A (zh) * | 2011-11-01 | 2013-06-16 | Otsuka Pharma Co Ltd | 用於治療前眼疾病之藥劑，該藥劑包含瑞巴派特及眼淚保持劑 |
| SA113340675B1 (ar) * | 2012-06-26 | 2015-08-16 | استيش. كو.، ليمتد | أدوية ريباميبايد تحضيرية جديدة، طريقة تحضيرها واستخدامها |
| KR101692578B1 (ko) | 2013-04-18 | 2017-01-03 | 삼진제약주식회사 | 레바미피드 또는 이의 전구체를 포함하는 안구건조증의 예방 또는 치료를 위한 경구용 약제학적 조성물 |
| WO2014184243A1 (en) * | 2013-05-16 | 2014-11-20 | Universiteit Antwerpen | Thermolabile drug release formulation |
| TWI697337B (zh) | 2013-08-07 | 2020-07-01 | 學校法人近畿大學 | 奈米粒子或奈米粒子組成物之製造方法，及支架或球囊導管之製造方法 |
| CN104586762A (zh) * | 2014-04-11 | 2015-05-06 | 广州仁恒医药科技有限公司 | 含有瑞巴派特的药物组合物及其制备方法 |
| JP6854587B2 (ja) * | 2015-04-17 | 2021-04-07 | ロート製薬株式会社 | 医薬製剤 |
| KR101718733B1 (ko) * | 2015-08-21 | 2017-03-22 | 국제약품 주식회사 | 레바미피드의 가용화 방법 및 이에 의해 제조된 안구건조증 치료용 액제 |
| KR102307958B1 (ko) | 2015-10-01 | 2021-10-05 | 삼진제약주식회사 | 레바미피드를 함유하는 신규한 점안 조성물 및 이의 제조방법 |
| KR20170039347A (ko) | 2015-10-01 | 2017-04-11 | 삼진제약주식회사 | 레바미피드를 함유하는 신규한 점안 조성물 및 이의 제조방법 |
| JP6732441B2 (ja) * | 2015-12-11 | 2020-07-29 | ロート製薬株式会社 | 局所粘膜適用水性組成物 |
| KR101840256B1 (ko) * | 2017-09-21 | 2018-03-21 | 대우제약 주식회사 | 레바미피드를 함유하는 새로운 안구건조증 치료용 점안 조성물 및 이의 가용화 및 안정화 방법 |
| KR101923519B1 (ko) | 2018-06-26 | 2019-02-27 | 대우제약 주식회사 | 레바미피드를 함유하는 안구 건조증 치료용 수용성 다회용 점안제 조성물 및 이의 가용화 및 안정화 방법 |
| KR20200019451A (ko) | 2018-08-14 | 2020-02-24 | 대우제약 주식회사 | 레바미피드를 함유하는 안구 건조증 치료용 수용성 다회용 점안제 조성물 및 이의 가용화 및 안정화 방법 |
| WO2021199813A1 (ja) * | 2020-03-31 | 2021-10-07 | 参天製薬株式会社 | レバミピドまたはその塩および高分子を含有する水性懸濁液 |
| KR102615076B1 (ko) * | 2021-07-14 | 2023-12-19 | 대우제약 주식회사 | 안정한 레바미피드 점안제의 대용량 제조 방법 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS50121414A (enExample) | 1974-02-18 | 1975-09-23 | ||
| JPS55139319A (en) | 1979-04-13 | 1980-10-31 | Furointo Sangyo Kk | Activation of drug soluble in alkali and acid |
| AU650889B2 (en) | 1991-03-27 | 1994-07-07 | Senju Pharmaceutical Co., Ltd. | Process for preparing aqueous suspension |
| JP2808378B2 (ja) * | 1991-03-27 | 1998-10-08 | 武田薬品工業株式会社 | 水性懸濁液剤の製造法 |
| US5665331A (en) | 1995-01-10 | 1997-09-09 | Nanosystems L.L.C. | Co-microprecipitation of nanoparticulate pharmaceutical agents with crystal growth modifiers |
| US5662883A (en) | 1995-01-10 | 1997-09-02 | Nanosystems L.L.C. | Microprecipitation of micro-nanoparticulate pharmaceutical agents |
| US5560932A (en) | 1995-01-10 | 1996-10-01 | Nano Systems L.L.C. | Microprecipitation of nanoparticulate pharmaceutical agents |
| US5716642A (en) | 1995-01-10 | 1998-02-10 | Nano Systems L.L.C. | Microprecipitation of nanoparticulate pharmaceutical agents using surface active material derived from similar pharmaceutical agents |
| AR004214A1 (es) * | 1995-10-12 | 1998-11-04 | Otsuka Pharma Co Ltd | Una preparación de gotas oftálmicas para la cura de enfermedades oftálmicas |
| JP3093661B2 (ja) * | 1995-10-12 | 2000-10-03 | 大塚製薬株式会社 | 眼疾患治療剤 |
| JPH09301855A (ja) * | 1996-05-13 | 1997-11-25 | Fuairudo Kk | 健康用部材 |
| ES2284202T3 (es) | 1997-05-14 | 2007-11-01 | Senju Pharmaceutical Co., Ltd. | Preparaciones acuosas en suspension con excelente redispersabilidad. |
| JP3402195B2 (ja) * | 1997-05-14 | 2003-04-28 | 千寿製薬株式会社 | 再分散性の良い水性懸濁液剤 |
| GB9810859D0 (en) * | 1998-05-20 | 1998-07-22 | Zeneca Ltd | Crystallisation process |
| CN100350977C (zh) * | 2001-06-14 | 2007-11-28 | 大塚制药株式会社 | 药物组合物 |
-
2005
- 2005-10-26 TW TW094137417A patent/TWI363626B/zh not_active IP Right Cessation
- 2005-10-27 AR ARP050104503A patent/AR052779A1/es not_active Application Discontinuation
- 2005-10-28 MY MYPI20055098 patent/MY152867A/en unknown
- 2005-11-11 BR BRPI0518928-4A patent/BRPI0518928A2/pt not_active IP Right Cessation
- 2005-11-11 MX MX2007005782A patent/MX2007005782A/es active IP Right Grant
- 2005-11-11 RU RU2007122392/15A patent/RU2398585C2/ru not_active IP Right Cessation
- 2005-11-11 CN CN200580038786A patent/CN100594901C/zh not_active Expired - Fee Related
- 2005-11-11 WO PCT/JP2005/021178 patent/WO2006052018A1/en not_active Ceased
- 2005-11-11 US US11/667,313 patent/US9211254B2/en not_active Expired - Fee Related
- 2005-11-11 CA CA2584017A patent/CA2584017C/en not_active Expired - Fee Related
- 2005-11-11 SG SG200907285-1A patent/SG156692A1/en unknown
- 2005-11-11 EP EP05806737A patent/EP1812000A4/en not_active Withdrawn
- 2005-11-11 AU AU2005302908A patent/AU2005302908B2/en not_active Ceased
- 2005-11-11 JP JP2007522862A patent/JP4934587B2/ja not_active Expired - Fee Related
- 2005-11-11 KR KR1020077013372A patent/KR101271959B1/ko not_active Expired - Fee Related
-
2011
- 2011-12-27 JP JP2011286557A patent/JP2012092139A/ja active Pending
-
2014
- 2014-01-06 JP JP2014000138A patent/JP2014077012A/ja active Pending
-
2015
- 2015-10-19 US US14/887,222 patent/US9533052B2/en not_active Expired - Fee Related
-
2017
- 2017-07-05 AR ARP170101857A patent/AR108955A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2584017A1 (en) | 2006-05-18 |
| AU2005302908B2 (en) | 2011-03-31 |
| TW200621252A (en) | 2006-07-01 |
| HK1112718A1 (zh) | 2008-09-12 |
| WO2006052018A1 (en) | 2006-05-18 |
| SG156692A1 (en) | 2009-11-26 |
| RU2007122392A (ru) | 2008-12-20 |
| AR052779A1 (es) | 2007-04-04 |
| US20160101183A1 (en) | 2016-04-14 |
| AU2005302908A1 (en) | 2006-05-18 |
| KR101271959B1 (ko) | 2013-06-10 |
| JP2012092139A (ja) | 2012-05-17 |
| US9533052B2 (en) | 2017-01-03 |
| CN100594901C (zh) | 2010-03-24 |
| CA2584017C (en) | 2013-08-27 |
| JP2008519759A (ja) | 2008-06-12 |
| US9211254B2 (en) | 2015-12-15 |
| MY152867A (en) | 2014-11-28 |
| EP1812000A1 (en) | 2007-08-01 |
| JP4934587B2 (ja) | 2012-05-16 |
| KR20070092965A (ko) | 2007-09-14 |
| EP1812000A4 (en) | 2012-08-08 |
| CN101056636A (zh) | 2007-10-17 |
| US20070287729A1 (en) | 2007-12-13 |
| TWI363626B (en) | 2012-05-11 |
| AR108955A2 (es) | 2018-10-10 |
| MX2007005782A (es) | 2007-07-19 |
| JP2014077012A (ja) | 2014-05-01 |
| RU2398585C2 (ru) | 2010-09-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
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