BR0214177A - Derivado de benzofenona, agente preventivo ou terapêutico para uma doença em que está envolvida expressão excessiva de ap-1, e, inibidor de ap-1 - Google Patents

Derivado de benzofenona, agente preventivo ou terapêutico para uma doença em que está envolvida expressão excessiva de ap-1, e, inibidor de ap-1

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Publication number
BR0214177A
BR0214177A BR0214177-9A BR0214177A BR0214177A BR 0214177 A BR0214177 A BR 0214177A BR 0214177 A BR0214177 A BR 0214177A BR 0214177 A BR0214177 A BR 0214177A
Authority
BR
Brazil
Prior art keywords
preventive
inhibitor
therapeutic agent
disease
benzophenone derivative
Prior art date
Application number
BR0214177-9A
Other languages
English (en)
Inventor
Hisaaki Chaki
Hironori Kotsubo
Tadashi Tanaka
Yukihiko Aikawa
Shuichi Hirono
Shunichi Shiozawa
Original Assignee
Toyama Chemical Co Ltd
Suichi Hirono
Shunichi Shiozawa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co Ltd, Suichi Hirono, Shunichi Shiozawa filed Critical Toyama Chemical Co Ltd
Publication of BR0214177A publication Critical patent/BR0214177A/pt

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    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • C07C205/34—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups bound to carbon atoms of six-membered aromatic rings and etherified hydroxy groups bound to acyclic carbon atoms of the carbon skeleton
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    • C07C217/76—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and etherified hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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    • C07C259/10—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of six-membered aromatic rings
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Abstract

"DERIVADO DE BENZOFENONA, AGENTE PREVENTIVO OU TERAPêUTICO PARA UMA DOENçA EM QUE ESTá ENVOLVIDA EXPRESSãO EXCESSIVA DE AP-1, E, INIBIDOR DE AP-1". Por apresentarem um efeito anti-artrítico, inibindo fratura óssea induzida por artrite e por apresentarem alta segurança, derivados de benzofenona representados pela fórmula geral a seguir, ou sais dos mesmos, são remédios para artrite com dinâmicas favoráveis in vivo: em que R^ 1^ representa, por exemplo, um heterociclo opcionalmente substituído, fenila substituído, etc; Z representa alquileno, etc; R^ 2^ representa carboxila opcionalmente bloqueado com alquila, etc; R^ 3^ representa um grupo hidroxila opcionalmente bloqueado; R^ 4^ representa cicloalquilóxi opcionalmente substituído; e R^ 5^ representa hidrogênio, etc. Adicionalmente, estes compostos apresentam um efeito inibidor sobre atividade de AP-1, o que os torna úteis como preventivos e remédios para doenças em que a superexpressão de AP-1 participa.
BR0214177-9A 2001-11-16 2002-11-13 Derivado de benzofenona, agente preventivo ou terapêutico para uma doença em que está envolvida expressão excessiva de ap-1, e, inibidor de ap-1 BR0214177A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001351217 2001-11-16
JP2002209382 2002-07-18
PCT/JP2002/011846 WO2003042150A1 (fr) 2001-11-16 2002-11-13 Nouveaux derives de benzophenone ou sels de ceux-ci

Publications (1)

Publication Number Publication Date
BR0214177A true BR0214177A (pt) 2004-09-14

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BR0214177-9A BR0214177A (pt) 2001-11-16 2002-11-13 Derivado de benzofenona, agente preventivo ou terapêutico para uma doença em que está envolvida expressão excessiva de ap-1, e, inibidor de ap-1

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KR (1) KR100947253B1 (pt)
CN (1) CN1602291B (pt)
AU (1) AU2002349777B2 (pt)
BR (1) BR0214177A (pt)
CA (1) CA2467261C (pt)
CY (1) CY1113657T1 (pt)
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NZ (1) NZ532810A (pt)
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PT (1) PT1445249E (pt)
RO (1) RO123430B1 (pt)
WO (1) WO2003042150A1 (pt)
ZA (1) ZA200403373B (pt)

Families Citing this family (29)

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US7615538B2 (en) * 1993-10-29 2009-11-10 Shunichi Shiozawa Method for therapy of rheumatoid arthritis
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