WO2009069643A1 - 3-{5-[4-(シクロペンチルオキシ)-2-ヒドロキシベンゾイル]-2-[(3-ヒドロキシ-1,2-ベンズイソオキサゾール-6-イル)メトキシ]フェニル}プロピオン酸またはその塩を含有する固体分散体またはその組成物 - Google Patents
3-{5-[4-(シクロペンチルオキシ)-2-ヒドロキシベンゾイル]-2-[(3-ヒドロキシ-1,2-ベンズイソオキサゾール-6-イル)メトキシ]フェニル}プロピオン酸またはその塩を含有する固体分散体またはその組成物 Download PDFInfo
- Publication number
- WO2009069643A1 WO2009069643A1 PCT/JP2008/071425 JP2008071425W WO2009069643A1 WO 2009069643 A1 WO2009069643 A1 WO 2009069643A1 JP 2008071425 W JP2008071425 W JP 2008071425W WO 2009069643 A1 WO2009069643 A1 WO 2009069643A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- solid dispersion
- composition
- benzisoxazol
- hydroxybenzoyl
- cyclopentyloxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
3-{5-[4-(シクロペンチルオキシ)-2-ヒドロキシベンゾイル]-2-[(3-ヒドロキシ-1,2-ベンズイソオキサゾール6-イル)メトキシ]フェニル}プロピオン酸またはその塩、およびポリビニルピロリドンを含有する固体分散体またはその組成物は、中性領域でのT-5224の溶解性を改善、維持し、消化管吸収を向上させた経口用医薬組成物として有用である。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009543823A JP5615554B2 (ja) | 2007-11-27 | 2008-11-26 | 3−{5−[4−(シクロペンチルオキシ)−2−ヒドロキシベンゾイル]−2−[(3−ヒドロキシ−1,2−ベンズイソオキサゾール−6−イル)メトキシ]フェニル}プロピオン酸またはその塩を含有する固体分散体の組成物 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007305851 | 2007-11-27 | ||
JP2007-305851 | 2007-11-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009069643A1 true WO2009069643A1 (ja) | 2009-06-04 |
Family
ID=40678538
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/071425 WO2009069643A1 (ja) | 2007-11-27 | 2008-11-26 | 3-{5-[4-(シクロペンチルオキシ)-2-ヒドロキシベンゾイル]-2-[(3-ヒドロキシ-1,2-ベンズイソオキサゾール-6-イル)メトキシ]フェニル}プロピオン酸またはその塩を含有する固体分散体またはその組成物 |
Country Status (2)
Country | Link |
---|---|
JP (1) | JP5615554B2 (ja) |
WO (1) | WO2009069643A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017175792A1 (ja) * | 2016-04-06 | 2017-10-12 | アステラス製薬株式会社 | 速溶出性三次元造形物、速溶出性三次元造形物用フィラメント及び速溶出性三次元造形物用材料 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55129221A (en) * | 1979-03-29 | 1980-10-06 | Kaken Pharmaceut Co Ltd | Preparation of oral preparation containing hardly soluble medicine |
JPS5942313A (ja) * | 1982-09-01 | 1984-03-08 | Teijin Ltd | ポリビニルポリピロリドンを用いた製剤 |
JPS60190723A (ja) * | 1984-03-09 | 1985-09-28 | Yamanouchi Pharmaceut Co Ltd | 難溶性薬物の溶解速度向上方法 |
WO2003042150A1 (fr) * | 2001-11-16 | 2003-05-22 | Toyama Chemical Co., Ltd. | Nouveaux derives de benzophenone ou sels de ceux-ci |
-
2008
- 2008-11-26 WO PCT/JP2008/071425 patent/WO2009069643A1/ja active Application Filing
- 2008-11-26 JP JP2009543823A patent/JP5615554B2/ja active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55129221A (en) * | 1979-03-29 | 1980-10-06 | Kaken Pharmaceut Co Ltd | Preparation of oral preparation containing hardly soluble medicine |
JPS5942313A (ja) * | 1982-09-01 | 1984-03-08 | Teijin Ltd | ポリビニルポリピロリドンを用いた製剤 |
JPS60190723A (ja) * | 1984-03-09 | 1985-09-28 | Yamanouchi Pharmaceut Co Ltd | 難溶性薬物の溶解速度向上方法 |
WO2003042150A1 (fr) * | 2001-11-16 | 2003-05-22 | Toyama Chemical Co., Ltd. | Nouveaux derives de benzophenone ou sels de ceux-ci |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2017175792A1 (ja) * | 2016-04-06 | 2017-10-12 | アステラス製薬株式会社 | 速溶出性三次元造形物、速溶出性三次元造形物用フィラメント及び速溶出性三次元造形物用材料 |
JPWO2017175792A1 (ja) * | 2016-04-06 | 2019-02-14 | アステラス製薬株式会社 | 速溶出性三次元造形物、速溶出性三次元造形物用フィラメント及び速溶出性三次元造形物用材料 |
Also Published As
Publication number | Publication date |
---|---|
JP5615554B2 (ja) | 2014-10-29 |
JPWO2009069643A1 (ja) | 2011-04-14 |
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