WO2010055119A3 - Pharmaceutical composition comprising pimobendan - Google Patents
Pharmaceutical composition comprising pimobendan Download PDFInfo
- Publication number
- WO2010055119A3 WO2010055119A3 PCT/EP2009/065106 EP2009065106W WO2010055119A3 WO 2010055119 A3 WO2010055119 A3 WO 2010055119A3 EP 2009065106 W EP2009065106 W EP 2009065106W WO 2010055119 A3 WO2010055119 A3 WO 2010055119A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pimobendan
- pharmaceutical composition
- disclosed
- storage stability
- oral pharmaceutical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
An oral pharmaceutical composition comprising Pimobendan and improvements for storage stability and dissolution performance is disclosed.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08169298 | 2008-11-17 | ||
| EP08169298.0 | 2008-11-17 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2010055119A2 WO2010055119A2 (en) | 2010-05-20 |
| WO2010055119A3 true WO2010055119A3 (en) | 2010-08-05 |
Family
ID=40433918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2009/065106 WO2010055119A2 (en) | 2008-11-17 | 2009-11-13 | Pharmaceutical composition comprising pimobendan |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2010055119A2 (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1579862A1 (en) | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure |
| US8980894B2 (en) | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
| EP1920785A1 (en) | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
| AU2012357795B2 (en) | 2011-12-21 | 2017-04-06 | Elanco Tiergesundheit Ag | New combination |
| EP2825159B1 (en) | 2012-03-15 | 2022-06-22 | Boehringer Ingelheim Vetmedica GmbH | Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof |
| ES2860526T3 (en) * | 2013-07-19 | 2021-10-05 | Boehringer Ingelheim Vetmedica Gmbh | Preserved Etherified Cyclodextrin Derivatives Containing A Liquid Aqueous Pharmaceutical Composition |
| KR102308973B1 (en) | 2013-12-04 | 2021-10-08 | 베링거잉겔하임베트메디카게엠베하 | Improved pharmaceutical compositions of pimobendan |
| AU2016369367B2 (en) * | 2015-12-17 | 2021-12-02 | Ceva Sante Animale | Pharmaceutical composition comprising pimobendan |
| US10449195B2 (en) | 2016-03-29 | 2019-10-22 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical formulation of palbociclib and a preparation method thereof |
| US10537570B2 (en) | 2016-04-06 | 2020-01-21 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease |
| CN114306245A (en) | 2020-09-29 | 2022-04-12 | 深圳市药欣生物科技有限公司 | Pharmaceutical composition of amorphous solid dispersion and preparation method thereof |
| WO2024126434A1 (en) | 2022-12-15 | 2024-06-20 | Boehringer Ingelheim Vetmedica Gmbh | Solid dispersions comprising amorphous pimobendan and one or more stabilizing polymers |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0439030A2 (en) * | 1990-01-20 | 1991-07-31 | Dr. Karl Thomae GmbH | Oral dosage forms containing pimobendan |
| WO2005084647A1 (en) * | 2004-03-08 | 2005-09-15 | Boehringer Ingelheim Vetmedica Gmbh | Pharmaceutical composition comprising pimobendan |
| JP2006028130A (en) * | 2004-07-21 | 2006-02-02 | Toa Eiyo Ltd | Pimopendan preparation for oral administration |
| JP2006056880A (en) * | 2004-07-21 | 2006-03-02 | Toa Eiyo Ltd | Oral pharmaceutical preparation of pimobendan |
| JP2007191419A (en) * | 2006-01-19 | 2007-08-02 | Toa Eiyo Ltd | Pimobendan preparation for oral administration |
| EP1818047A2 (en) * | 2002-03-07 | 2007-08-15 | Boehringer Ingelheim Pharma GmbH & Co. KG | Oral administration form for difficulty soluble basic active ingredients |
-
2009
- 2009-11-13 WO PCT/EP2009/065106 patent/WO2010055119A2/en active Application Filing
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0439030A2 (en) * | 1990-01-20 | 1991-07-31 | Dr. Karl Thomae GmbH | Oral dosage forms containing pimobendan |
| EP1818047A2 (en) * | 2002-03-07 | 2007-08-15 | Boehringer Ingelheim Pharma GmbH & Co. KG | Oral administration form for difficulty soluble basic active ingredients |
| WO2005084647A1 (en) * | 2004-03-08 | 2005-09-15 | Boehringer Ingelheim Vetmedica Gmbh | Pharmaceutical composition comprising pimobendan |
| JP2006028130A (en) * | 2004-07-21 | 2006-02-02 | Toa Eiyo Ltd | Pimopendan preparation for oral administration |
| JP2006056880A (en) * | 2004-07-21 | 2006-03-02 | Toa Eiyo Ltd | Oral pharmaceutical preparation of pimobendan |
| JP2007191419A (en) * | 2006-01-19 | 2007-08-02 | Toa Eiyo Ltd | Pimobendan preparation for oral administration |
Non-Patent Citations (3)
| Title |
|---|
| DATABASE WPI Week 200613, Derwent World Patents Index; AN 2006-121993, XP002520487 * |
| DATABASE WPI Week 200619, Derwent World Patents Index; AN 2006-178263, XP002520486 * |
| DATABASE WPI Week 200767, Derwent World Patents Index; AN 2007-712118, XP002520087 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010055119A2 (en) | 2010-05-20 |
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