WO2005097787A3 - Derives de benzothiazoles capables de moduler l’activite des cdk et leur utilisation comme agents anticancereux - Google Patents

Derives de benzothiazoles capables de moduler l’activite des cdk et leur utilisation comme agents anticancereux Download PDF

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Publication number
WO2005097787A3
WO2005097787A3 PCT/FR2005/000761 FR2005000761W WO2005097787A3 WO 2005097787 A3 WO2005097787 A3 WO 2005097787A3 FR 2005000761 W FR2005000761 W FR 2005000761W WO 2005097787 A3 WO2005097787 A3 WO 2005097787A3
Authority
WO
WIPO (PCT)
Prior art keywords
medicaments
novel
benzothiazoles
novel benzothiazoles
compounds
Prior art date
Application number
PCT/FR2005/000761
Other languages
English (en)
Other versions
WO2005097787A2 (fr
Inventor
Stephanie Deprets
Anke Steinmetz
Odile Angouillant-Boniface
Daniel Bezard
Jidong Zhang
Yannick Benedetti
Francois Clerc
Original Assignee
Aventis Pharma Sa
Stephanie Deprets
Anke Steinmetz
Odile Angouillant-Boniface
Daniel Bezard
Jidong Zhang
Yannick Benedetti
Francois Clerc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa, Stephanie Deprets, Anke Steinmetz, Odile Angouillant-Boniface, Daniel Bezard, Jidong Zhang, Yannick Benedetti, Francois Clerc filed Critical Aventis Pharma Sa
Priority to CA002560683A priority Critical patent/CA2560683A1/fr
Priority to EP05744302A priority patent/EP1745044A2/fr
Priority to AU2005232012A priority patent/AU2005232012A1/en
Priority to BRPI0508182-3A priority patent/BRPI0508182A/pt
Priority to JP2007505593A priority patent/JP2007530644A/ja
Publication of WO2005097787A2 publication Critical patent/WO2005097787A2/fr
Publication of WO2005097787A3 publication Critical patent/WO2005097787A3/fr
Priority to IL178259A priority patent/IL178259A0/en
Priority to US11/536,757 priority patent/US7632952B2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

La présente invention concerne des dérivés des benzothiazoles de formule (I), les compositions les contenant, et leur utilisation comme inhibiteurs de CDK pour le traitement du cancer.
PCT/FR2005/000761 2004-04-01 2005-03-30 Derives de benzothiazoles capables de moduler l’activite des cdk et leur utilisation comme agents anticancereux WO2005097787A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002560683A CA2560683A1 (fr) 2004-04-01 2005-03-30 Derives de benzothiazoles capables de moduler l'activite des cdk et leur utilisation comme agents anticancereux
EP05744302A EP1745044A2 (fr) 2004-04-01 2005-03-30 Derives de benzothiazoles capables de moduler l'activité des cdk et leur utilisation comme agents anticancereux
AU2005232012A AU2005232012A1 (en) 2004-04-01 2005-03-30 Novel benzothiazoles and the use thereof as medicaments
BRPI0508182-3A BRPI0508182A (pt) 2004-04-01 2005-03-30 benzotiazóis e sua utilização como medicamentos
JP2007505593A JP2007530644A (ja) 2004-04-01 2005-03-30 新規ベンゾチアゾール及びその医薬としての使用
IL178259A IL178259A0 (en) 2004-04-01 2006-09-21 Novel benzothiazoles and the use thereof as medicaments
US11/536,757 US7632952B2 (en) 2004-04-01 2006-09-29 Benzothiazoles and the use thereof as medicaments

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0403421 2004-04-01
FR0403421A FR2868421B1 (fr) 2004-04-01 2004-04-01 Nouveaux benzothiazoles et leur utilisation comme medicaments

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/536,757 Continuation US7632952B2 (en) 2004-04-01 2006-09-29 Benzothiazoles and the use thereof as medicaments

Publications (2)

Publication Number Publication Date
WO2005097787A2 WO2005097787A2 (fr) 2005-10-20
WO2005097787A3 true WO2005097787A3 (fr) 2006-01-26

Family

ID=34946087

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2005/000761 WO2005097787A2 (fr) 2004-04-01 2005-03-30 Derives de benzothiazoles capables de moduler l’activite des cdk et leur utilisation comme agents anticancereux

Country Status (12)

Country Link
US (1) US7632952B2 (fr)
EP (1) EP1745044A2 (fr)
JP (1) JP2007530644A (fr)
KR (1) KR20070007885A (fr)
CN (1) CN1950369A (fr)
AU (1) AU2005232012A1 (fr)
BR (1) BRPI0508182A (fr)
CA (1) CA2560683A1 (fr)
FR (1) FR2868421B1 (fr)
IL (1) IL178259A0 (fr)
SG (1) SG151306A1 (fr)
WO (1) WO2005097787A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006017275A1 (fr) 2004-07-13 2006-02-16 The University Of Tennessee Research Foundation Composition adhésive pour le support d’agents thérapeutiques comme vecteur d’enduits appliqués sur des implants vasculaires
FR2891273B1 (fr) * 2005-09-27 2007-11-23 Aventis Pharma Sa NOUVEAUX DERIVES BENZIMIDAZOLES ET BENZOTHIAZOLES, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE NOTAMMENT COMME INHIBITEURS DE CMet
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
US20070112589A1 (en) * 2005-11-17 2007-05-17 Searete Llc, A Limited Liability Corporation Of The State Of Delaware User interface for providing assistance related to health
US20100120717A1 (en) 2006-10-09 2010-05-13 Brown Jason W Kinase inhibitors
EP2223925A1 (fr) * 2006-10-09 2010-09-01 Takeda Pharmaceutical Company Limited Inhibiteurs de kinase
FR2922550B1 (fr) 2007-10-19 2009-11-27 Sanofi Aventis Nouveaux derives de 6-aryl/heteroalkyloxy benzothiazole et benzimidazole, application comme medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de cmet
CN102391207B (zh) * 2011-07-26 2014-04-09 贵州大学 N-(2-(取代苯并噻唑-2-氨基甲酰基)-苯基)-苯甲酰胺及其制备方法和用途
CA2889981A1 (fr) 2012-10-29 2014-05-08 Ariste Medical, Inc. Compositions de revetement polymere et produits revetus
GB2528421B (en) 2014-04-22 2016-12-14 Ariste Medical Inc Methods and processes for application of drug delivery polymeric coatings

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024035A1 (fr) * 1997-11-10 1999-05-20 Bristol-Myers Squibb Company Composes de benzothiazole utilises comme inhibiteurs de la proteine tyrosine-kinase
WO2000026202A1 (fr) * 1998-10-30 2000-05-11 Pharmacia & Upjohn S.P.A. Derives 2-amino-thiazole, leur procede de preparation et leur utilisation en tant qu'agents antitumoraux
WO2001057008A1 (fr) * 2000-02-07 2001-08-09 Abbott Gesellschaft Mit Beschrankter Haftung & Company Kommanditgesellschaft Derives de 2-benzothiazolyle uree et leur utilisation en tant qu'inhibiteurs de proteine kinase

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2541752A1 (de) 1975-09-19 1977-03-24 Hoechst Ag Anthelminthisch wirksame 2-carbalkoxyamino-5(6)-phenyl-sulfonyloxy- benzimidazole und verfahren zu ihrer herstellung
DE3247615A1 (de) 1982-12-23 1984-07-05 Hoechst Ag, 6230 Frankfurt Substituierte phenylsulfonyloxybenzimidazolcarbaminate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
GB9216298D0 (en) 1991-08-15 1992-09-16 Ici Plc Piperidine derivatives
GB9900752D0 (en) 1999-01-15 1999-03-03 Angiogene Pharm Ltd Benzimidazole vascular damaging agents
US20050038022A1 (en) 2001-03-26 2005-02-17 Unisearch Limited Method for treatment of cancer and compositions for use therein
EP1298125A1 (fr) 2001-09-26 2003-04-02 Aventis Pharma S.A. Benzimidazoles substitués et leur usage comme traitement du cancer
EP1388341A1 (fr) * 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Dérivés héteroaromatiques acylamino substitués et leur utilisation en tant que medicaments
FR2891273B1 (fr) 2005-09-27 2007-11-23 Aventis Pharma Sa NOUVEAUX DERIVES BENZIMIDAZOLES ET BENZOTHIAZOLES, LEUR PREPARATION ET LEUR UTILISATION PHARMACEUTIQUE NOTAMMENT COMME INHIBITEURS DE CMet

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999024035A1 (fr) * 1997-11-10 1999-05-20 Bristol-Myers Squibb Company Composes de benzothiazole utilises comme inhibiteurs de la proteine tyrosine-kinase
WO2000026202A1 (fr) * 1998-10-30 2000-05-11 Pharmacia & Upjohn S.P.A. Derives 2-amino-thiazole, leur procede de preparation et leur utilisation en tant qu'agents antitumoraux
WO2001057008A1 (fr) * 2000-02-07 2001-08-09 Abbott Gesellschaft Mit Beschrankter Haftung & Company Kommanditgesellschaft Derives de 2-benzothiazolyle uree et leur utilisation en tant qu'inhibiteurs de proteine kinase

Also Published As

Publication number Publication date
US20070093488A1 (en) 2007-04-26
KR20070007885A (ko) 2007-01-16
EP1745044A2 (fr) 2007-01-24
CN1950369A (zh) 2007-04-18
SG151306A1 (en) 2009-04-30
FR2868421B1 (fr) 2008-08-01
IL178259A0 (en) 2006-12-31
BRPI0508182A (pt) 2007-08-07
FR2868421A1 (fr) 2005-10-07
AU2005232012A1 (en) 2005-10-20
JP2007530644A (ja) 2007-11-01
US7632952B2 (en) 2009-12-15
WO2005097787A2 (fr) 2005-10-20
CA2560683A1 (fr) 2005-10-20

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