MA38488A1 - Formes de sel de (s)-quinuclidin-3-yl (2-(2-(4-fluorophényl)thiazol-4-yl)propan-2-yl)carbamate - Google Patents
Formes de sel de (s)-quinuclidin-3-yl (2-(2-(4-fluorophényl)thiazol-4-yl)propan-2-yl)carbamateInfo
- Publication number
- MA38488A1 MA38488A1 MA38488A MA38488A MA38488A1 MA 38488 A1 MA38488 A1 MA 38488A1 MA 38488 A MA38488 A MA 38488A MA 38488 A MA38488 A MA 38488A MA 38488 A1 MA38488 A1 MA 38488A1
- Authority
- MA
- Morocco
- Prior art keywords
- quinuclidin
- thiazol
- propan
- fluorophenyl
- forms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La présente invention concerne de nouvelles formes de sels de (s)-quinuclidin-3-yl (2-(2-(4-fluorophényl)thiazol-4-yl)propan-2-yl)carbamate utiles en tant qu'un inhibiteur de synthase de glucosylcéramide (gcs) et pour le traitement de maladies métaboliques telles que les maladies lysosomales, soit seul, soit en association avec une thérapie de remplacement enzymatique, et pour le traitement du cancer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361791706P | 2013-03-15 | 2013-03-15 | |
PCT/US2014/027081 WO2014152215A1 (fr) | 2013-03-15 | 2014-03-14 | Formes de sel de (s)-quinuclidin-3-yl (2-(2-(4-fluorophényl)thiazol-4-yl)propan-2-yl)carbamate |
Publications (1)
Publication Number | Publication Date |
---|---|
MA38488A1 true MA38488A1 (fr) | 2017-10-31 |
Family
ID=50543351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA38488A MA38488A1 (fr) | 2013-03-15 | 2014-03-14 | Formes de sel de (s)-quinuclidin-3-yl (2-(2-(4-fluorophényl)thiazol-4-yl)propan-2-yl)carbamate |
Country Status (34)
Country | Link |
---|---|
US (1) | US9518049B2 (fr) |
EP (1) | EP2970250B1 (fr) |
JP (1) | JP6438455B2 (fr) |
KR (1) | KR102302064B1 (fr) |
CN (1) | CN105189490A (fr) |
AR (1) | AR095435A1 (fr) |
AU (1) | AU2014240028B2 (fr) |
BR (1) | BR112015022907B1 (fr) |
CA (1) | CA2906691A1 (fr) |
CL (1) | CL2015002701A1 (fr) |
DK (1) | DK2970250T3 (fr) |
EA (1) | EA037527B1 (fr) |
ES (1) | ES2872326T3 (fr) |
HK (1) | HK1214821A1 (fr) |
HR (1) | HRP20210692T1 (fr) |
HU (1) | HUE054349T2 (fr) |
IL (1) | IL241229B (fr) |
JO (1) | JO3713B1 (fr) |
LT (1) | LT2970250T (fr) |
MA (1) | MA38488A1 (fr) |
MX (1) | MX370178B (fr) |
MY (1) | MY181766A (fr) |
PH (1) | PH12015502021A1 (fr) |
PL (1) | PL2970250T3 (fr) |
PT (1) | PT2970250T (fr) |
RS (1) | RS61852B1 (fr) |
SA (1) | SA515361078B1 (fr) |
SG (1) | SG11201507054YA (fr) |
SI (1) | SI2970250T1 (fr) |
TN (1) | TN2015000427A1 (fr) |
TW (1) | TWI713438B (fr) |
UY (1) | UY35439A (fr) |
WO (1) | WO2014152215A1 (fr) |
ZA (1) | ZA201506602B (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG10201804952QA (en) * | 2013-12-11 | 2018-07-30 | Genzyme Corp | Glucosylceramide synthase inhibitors |
US10519157B2 (en) * | 2018-02-09 | 2019-12-31 | X-Cutag Therapeutics, Inc. | Deuterated compounds for treating Fabry, Gaucher, Parkinson's and related diseases and conditions, and compositions and methods thereof |
JP2022519131A (ja) | 2019-02-04 | 2022-03-18 | ジェンザイム・コーポレーション | グルコシルセラミドシンターゼ(gcs)阻害剤を使用した繊毛病の処置 |
AU2021215396A1 (en) * | 2020-02-03 | 2022-09-29 | Genzyme Corporation | Methods for treating neurological symptoms associated with lysosomal storage diseases |
AU2021311131A1 (en) | 2020-07-24 | 2023-03-23 | Genzyme Corporation | Pharmaceutical compositions comprising venglustat |
WO2022024062A1 (fr) | 2020-07-30 | 2022-02-03 | Genzyme Corporation | Procédés de réduction de la concentration en glycosphingolipides dans le tissu cérébral et procédés de traitement de maladies neurodégénératives impliquant ces derniers |
WO2022215083A1 (fr) * | 2021-04-05 | 2022-10-13 | Msn Laboratories Private Limited, R&D Center | Formes à l'état solide de (s)-quinuclidin-3-yl (2-(2-(4-fluorophényl)thiazol-4-yl)propan-2-yl) carbamate ou de sels et procédé de préparation associé |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5236838A (en) | 1988-12-23 | 1993-08-17 | Genzyme Corporation | Enzymatically active recombinant glucocerebrosidase |
US5549892A (en) | 1988-12-23 | 1996-08-27 | Genzyme Corporation | Enhanced in vivo uptake of glucocerebrosidase |
US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
US5968502A (en) | 1991-11-05 | 1999-10-19 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
JP2002522509A (ja) | 1997-10-29 | 2002-07-23 | ジェンザイム・コーポレイション | リソソーム貯蔵疾患治療組成物および方法 |
GB0400812D0 (en) | 2004-01-14 | 2004-02-18 | Celltech R&D Ltd | Novel compounds |
BRPI0517701A8 (pt) | 2004-11-10 | 2018-01-23 | Genzyme Corp | métodos de tratamento de diabetes mellitus |
WO2010091104A1 (fr) | 2009-02-06 | 2010-08-12 | Exelixis, Inc. | Inhibiteurs de la glucosylcéramide synthase |
EP3482767B1 (fr) | 2009-08-28 | 2021-10-06 | Icahn School of Medicine at Mount Sinai | Thérapie de remplacement enzymatique d'escalade de doses pour le traitement du déficit en sphingomyélinase acide |
PT2685986T (pt) * | 2011-03-18 | 2020-03-05 | Genzyme Corp | Inibidor de glicosilceramida-sintase |
-
2014
- 2014-03-11 JO JOP/2014/0088A patent/JO3713B1/ar active
- 2014-03-13 AR ARP140100981A patent/AR095435A1/es unknown
- 2014-03-14 EA EA201591706A patent/EA037527B1/ru unknown
- 2014-03-14 RS RS20210607A patent/RS61852B1/sr unknown
- 2014-03-14 CA CA2906691A patent/CA2906691A1/fr not_active Abandoned
- 2014-03-14 DK DK14718854.4T patent/DK2970250T3/da active
- 2014-03-14 AU AU2014240028A patent/AU2014240028B2/en active Active
- 2014-03-14 KR KR1020157028855A patent/KR102302064B1/ko active IP Right Grant
- 2014-03-14 TW TW103109465A patent/TWI713438B/zh active
- 2014-03-14 EP EP14718854.4A patent/EP2970250B1/fr active Active
- 2014-03-14 ES ES14718854T patent/ES2872326T3/es active Active
- 2014-03-14 UY UY0001035439A patent/UY35439A/es not_active Application Discontinuation
- 2014-03-14 MA MA38488A patent/MA38488A1/fr unknown
- 2014-03-14 HU HUE14718854A patent/HUE054349T2/hu unknown
- 2014-03-14 MX MX2015012295A patent/MX370178B/es active IP Right Grant
- 2014-03-14 US US14/776,432 patent/US9518049B2/en active Active
- 2014-03-14 WO PCT/US2014/027081 patent/WO2014152215A1/fr active Application Filing
- 2014-03-14 PT PT147188544T patent/PT2970250T/pt unknown
- 2014-03-14 LT LTEP14718854.4T patent/LT2970250T/lt unknown
- 2014-03-14 SI SI201431813T patent/SI2970250T1/sl unknown
- 2014-03-14 CN CN201480025303.7A patent/CN105189490A/zh active Pending
- 2014-03-14 MY MYPI2015702973A patent/MY181766A/en unknown
- 2014-03-14 PL PL14718854T patent/PL2970250T3/pl unknown
- 2014-03-14 BR BR112015022907-7A patent/BR112015022907B1/pt active IP Right Grant
- 2014-03-14 SG SG11201507054YA patent/SG11201507054YA/en unknown
- 2014-03-14 JP JP2016502330A patent/JP6438455B2/ja active Active
-
2015
- 2015-09-06 IL IL241229A patent/IL241229B/en active IP Right Grant
- 2015-09-07 ZA ZA2015/06602A patent/ZA201506602B/en unknown
- 2015-09-09 PH PH12015502021A patent/PH12015502021A1/en unknown
- 2015-09-13 SA SA515361078A patent/SA515361078B1/ar unknown
- 2015-09-14 CL CL2015002701A patent/CL2015002701A1/es unknown
- 2015-09-15 TN TN2015000427A patent/TN2015000427A1/en unknown
-
2016
- 2016-03-10 HK HK16102769.7A patent/HK1214821A1/zh unknown
-
2021
- 2021-05-04 HR HRP20210692TT patent/HRP20210692T1/hr unknown
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