BRPI0514201A - bactéria, e, método para produzir um metabólito útil - Google Patents

bactéria, e, método para produzir um metabólito útil

Info

Publication number
BRPI0514201A
BRPI0514201A BRPI0514201-6A BRPI0514201A BRPI0514201A BR PI0514201 A BRPI0514201 A BR PI0514201A BR PI0514201 A BRPI0514201 A BR PI0514201A BR PI0514201 A BRPI0514201 A BR PI0514201A
Authority
BR
Brazil
Prior art keywords
producing
useful metabolite
bacterium
bacteria
provides
Prior art date
Application number
BRPI0514201-6A
Other languages
English (en)
Inventor
Yury Ivanovich Kozlov
Akito Chinen
Hiroshi Izui
Yoshihiko Hara
Hisashi Yasueda
Konstantin Vyacheslavovi Rybak
Ekaterina Aleksand Slivinskaya
Joanna Yosifovna Katashkina
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from RU2004124226/13A external-priority patent/RU2004124226A/ru
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of BRPI0514201A publication Critical patent/BRPI0514201A/pt
Publication of BRPI0514201B1 publication Critical patent/BRPI0514201B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/10—Citrulline; Arginine; Ornithine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/14—Glutamic acid; Glutamine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/24—Proline; Hydroxyproline; Histidine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/44—Polycarboxylic acids
    • C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

BACTéRIA, E, MéTODO PARA PRODUZIR UM METABóLITO úTIL A presente invenção proporciona uma bactéria que apresenta uma capacidade de produzir um metabólito útil derivado de acetil-coenzima A, como ácido L-glutâmico, L-glutamina, L-prolina, L-arginina, L-leucina, L-cisteína, succinato, e poli-hidroxibutirato, sendo que referida bactéria é modificada de forma a incrementar as atividades de D-xilulose-5-fosfato fosfocetolase e/ou ftutose-6-fosfato fosfocetolase. A presente invenção também proporciona um método de produzir o metabólito útil usando a bactéria.
BRPI0514201-6A 2004-08-10 2005-08-10 Bactéria, e, método para produzir um metabólito útil BRPI0514201B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
RU2004124226 2004-08-10
RU2004124226/13A RU2004124226A (ru) 2004-08-10 2004-08-10 Использование фосфокетолазы для продукции полезных метаболитов
US64456205P 2005-01-19 2005-01-19
US60/644562 2005-01-19
PCT/JP2005/014966 WO2006016705A1 (en) 2004-08-10 2005-08-10 The use of phosphoketolase for producing useful metabolites

Publications (2)

Publication Number Publication Date
BRPI0514201A true BRPI0514201A (pt) 2008-06-03
BRPI0514201B1 BRPI0514201B1 (pt) 2020-09-15

Family

ID=35106939

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514201-6A BRPI0514201B1 (pt) 2004-08-10 2005-08-10 Bactéria, e, método para produzir um metabólito útil

Country Status (10)

Country Link
EP (1) EP1789547B1 (pt)
JP (1) JP5596902B2 (pt)
KR (2) KR20090010139A (pt)
AT (1) ATE463564T1 (pt)
AU (1) AU2005272367B2 (pt)
BR (1) BRPI0514201B1 (pt)
DE (1) DE602005020469D1 (pt)
ES (1) ES2341264T3 (pt)
PE (1) PE20090104A1 (pt)
WO (1) WO2006016705A1 (pt)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101374953B (zh) 2006-01-27 2011-09-28 味之素株式会社 用于产生l-氨基酸的方法
JP2010041920A (ja) 2006-12-19 2010-02-25 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
EP2062967A1 (en) * 2007-11-21 2009-05-27 Technical University of Denmark Genetically engineered aspergillus
JP5520498B2 (ja) * 2009-02-24 2014-06-11 花王株式会社 タンパク質又はポリペプチドの製造方法
CN103328631B (zh) 2011-01-20 2017-04-26 丰田自动车株式会社 重组酵母和使用该重组酵母的物质生产方法
RU2658770C2 (ru) * 2011-07-12 2018-06-22 Сайентист Оф Фортчун С.А. Рекомбинантный микроорганизм для получения полезных метаболитов
WO2013066568A1 (en) 2011-10-07 2013-05-10 Danisco Us Inc. Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene
KR20140091742A (ko) 2011-11-11 2014-07-22 아지노모토 가부시키가이샤 발효법에 의한 목적 물질의 제조법
WO2014169144A2 (en) * 2013-04-10 2014-10-16 Danisco Us Inc. Phosphoketolases foe improved production of acetyl coenzyme a-derived metabolites, isoprene, isoprenoid precurosors, and isoprenoids
PE20150681A1 (es) 2013-05-13 2015-05-15 Ajinomoto Kk Metodo para producir l-aminoacidos
JP2016165225A (ja) 2013-07-09 2016-09-15 味の素株式会社 有用物質の製造方法
KR101500847B1 (ko) * 2013-07-23 2015-03-16 씨제이제일제당 (주) 천연 코쿠미 조미소재의 제조 방법
KR101500848B1 (ko) * 2013-07-23 2015-03-09 씨제이제일제당 (주) 천연 뉴트럴 조미소재의 제조 방법
KR101500846B1 (ko) * 2013-07-23 2015-03-16 씨제이제일제당 (주) 천연 소고기 풍미 조미소재의 제조 방법
KR101500850B1 (ko) * 2013-08-07 2015-03-18 씨제이제일제당 (주) 천연 조미소재 제조를 위한 이노신산 발효액 또는 글루탐산 발효액의 제조 방법
JP6459962B2 (ja) 2013-10-21 2019-01-30 味の素株式会社 Ｌ−アミノ酸の製造法
EP3061828B1 (en) 2013-10-23 2024-08-28 Ajinomoto Co., Inc. Method for producing target substance
PL3077501T3 (pl) * 2013-12-03 2022-01-31 Genomatica, Inc. Mikroorganizmy i sposoby poprawy wydajności produktu na metanolu z użyciem syntezy acetylo-coa
JP2017508473A (ja) * 2014-03-26 2017-03-30 サイエンティスト・オブ・フォーチュン・ソシエテ・アノニム ホルムアルデヒドからのアセチルリン酸の酵素的産生
JP6623690B2 (ja) 2015-10-30 2019-12-25 味の素株式会社 グルタミン酸系ｌ−アミノ酸の製造法
US10428359B2 (en) 2016-10-03 2019-10-01 Ajinomoto Co, Inc. Method for producing L-amino acid
KR101812016B1 (ko) 2016-10-12 2017-12-26 단국대학교 천안캠퍼스 산학협력단 락토바실러스 존소니 유래의 산성 조건에서 발현이 증가되는 프로모터 및 이의 용도
EP3354742A1 (en) 2017-01-26 2018-08-01 Metabolic Explorer Methods and microorganisms for the production of glycolic acid and/or glyoxylic acid
JP7066977B2 (ja) 2017-04-03 2022-05-16 味の素株式会社 Ｌ－アミノ酸の製造法
WO2020071538A1 (en) 2018-10-05 2020-04-09 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
CN109929883A (zh) * 2019-04-02 2019-06-25 烟台华康荣赞生物科技有限公司 重组酵母、构建方法和其在制备酪醇及衍生物中的应用
JP6917434B2 (ja) * 2019-10-25 2021-08-11 長瀬産業株式会社 好気性菌の代謝酵素破壊株およびその培養法
EP4239070A1 (en) 2020-10-28 2023-09-06 Ajinomoto Co., Inc. Method of producing l-amino acid
US20240117393A1 (en) 2022-09-30 2024-04-11 Ajinomoto Co., Inc. Method for producing l-amino acid

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55131397A (en) 1979-04-02 1980-10-13 Ajinomoto Co Inc Preparation of l-threonine by fermentation
DE2929211A1 (de) 1979-07-19 1981-02-05 Lentia Gmbh Verfahren zur herstellung von reiner cyanursaeure
FR2627508B1 (fr) 1988-02-22 1990-10-05 Eurolysine Procede pour l'integration d'un gene choisi sur le chromosome d'une bacterie et bacterie obtenue par ledit procede
WO1990004636A1 (en) 1988-10-25 1990-05-03 Vsesojuzny Nauchno-Issledovatelsky Institut Genetiki I Selektsii Promyshlennykh Mikroorganizmov (Vniigenetika) Strain of bacteria escherichia coli, producer of l-threonine
JP3239903B2 (ja) 1991-09-20 2001-12-17 味の素株式会社 エシェリヒア・コリによる新規ｌ−スレオニン生産菌の創成とそれによるｌ−スレオニンの生産方法
DE69219775T3 (de) 1992-10-14 2004-08-05 Ajinomoto Co., Inc. Neuartiges L-threoninproduzierendes Mikrobakterium und eine Herstellungsmethode für L-Threonin
JP4197754B2 (ja) * 1997-10-09 2008-12-17 三菱化学株式会社 乳酸又はコハク酸の製造方法
JP3921866B2 (ja) * 1998-03-18 2007-05-30 味の素株式会社 Ｌ−グルタミン酸生産菌及びｌ−グルタミン酸の製造法
JP2003180355A (ja) * 1999-07-02 2003-07-02 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2003180348A (ja) * 1999-07-02 2003-07-02 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2003159092A (ja) * 1999-07-02 2003-06-03 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP4265093B2 (ja) 2000-08-11 2009-05-20 味の素株式会社 スレオニン及びイソロイシンの製造法
JP4599726B2 (ja) * 2001-02-20 2010-12-15 味の素株式会社 Ｌ−グルタミン酸の製造法
DK1581617T3 (da) * 2002-02-08 2011-05-16 Danisco Us Inc Fremgangsmåder til fremstilling af slut-produkter fra kulstof-substrater
SE0200857D0 (sv) * 2002-03-19 2002-03-19 Forskarpatent I Syd Ab Metabolic engineering for improved xylose utilisation of saccharomyces cerevisiae
JP4483213B2 (ja) * 2002-07-12 2010-06-16 味の素株式会社 発酵法による目的物質の製造法
FR2862068B1 (fr) * 2003-11-06 2007-10-12 Metabolic Explorer Sa Souches de microorganismes optimisees pour des voies de biosyntheses consommatrices de nadph

Also Published As

Publication number Publication date
KR100892577B1 (ko) 2009-04-08
EP1789547B1 (en) 2010-04-07
JP2008509661A (ja) 2008-04-03
DE602005020469D1 (de) 2010-05-20
AU2005272367A1 (en) 2006-02-16
EP1789547A1 (en) 2007-05-30
ES2341264T3 (es) 2010-06-17
KR20070043877A (ko) 2007-04-25
ATE463564T1 (de) 2010-04-15
WO2006016705A1 (en) 2006-02-16
AU2005272367B2 (en) 2009-02-12
PE20090104A1 (es) 2009-03-07
KR20090010139A (ko) 2009-01-28
JP5596902B2 (ja) 2014-09-24
BRPI0514201B1 (pt) 2020-09-15

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B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

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