BRPI0511656A - combinação, produto, kit de partes, embalagem, usos de um antagonista dos receptores muscarìnicos m3 e de um inibidor de pde4, e, método para tratar um paciente sofrendo de ou susceptìvel a uma doença ou condição respiratória que responda ao antagonismo de m3 - Google Patents

combinação, produto, kit de partes, embalagem, usos de um antagonista dos receptores muscarìnicos m3 e de um inibidor de pde4, e, método para tratar um paciente sofrendo de ou susceptìvel a uma doença ou condição respiratória que responda ao antagonismo de m3

Info

Publication number
BRPI0511656A
BRPI0511656A BRPI0511656-2A BRPI0511656A BRPI0511656A BR PI0511656 A BRPI0511656 A BR PI0511656A BR PI0511656 A BRPI0511656 A BR PI0511656A BR PI0511656 A BRPI0511656 A BR PI0511656A
Authority
BR
Brazil
Prior art keywords
receptor antagonist
pde4 inhibitor
packaging
combination
product
Prior art date
Application number
BRPI0511656-2A
Other languages
English (en)
Portuguese (pt)
Inventor
Jordi Gras Escardo
Jesus Llenas Calvo
Hamish Ryder
Pio Orviz Diaz
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34956036&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0511656(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Priority claimed from PCT/EP2005/005839 external-priority patent/WO2005115465A1/en
Publication of BRPI0511656A publication Critical patent/BRPI0511656A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Wrappers (AREA)
BRPI0511656-2A 2004-05-31 2005-05-31 combinação, produto, kit de partes, embalagem, usos de um antagonista dos receptores muscarìnicos m3 e de um inibidor de pde4, e, método para tratar um paciente sofrendo de ou susceptìvel a uma doença ou condição respiratória que responda ao antagonismo de m3 BRPI0511656A (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
ES200401312A ES2257152B1 (es) 2004-05-31 2004-05-31 Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
EP2005001969 2005-02-24
GB2005000740 2005-02-25
GB2005000722 2005-02-25
PCT/EP2005/005839 WO2005115465A1 (en) 2004-05-31 2005-05-31 Combinations comprising antimuscarinic agents and pde4 inhibitors

Publications (1)

Publication Number Publication Date
BRPI0511656A true BRPI0511656A (pt) 2008-01-02

Family

ID=34956036

Family Applications (6)

Application Number Title Priority Date Filing Date
BRPI0511656-2A BRPI0511656A (pt) 2004-05-31 2005-05-31 combinação, produto, kit de partes, embalagem, usos de um antagonista dos receptores muscarìnicos m3 e de um inibidor de pde4, e, método para tratar um paciente sofrendo de ou susceptìvel a uma doença ou condição respiratória que responda ao antagonismo de m3
BRPI0511660-0A BRPI0511660A (pt) 2004-05-31 2005-05-31 combinação, produto, kit de partes, embalagem, uso de um antagonista de receptores muscarìnicos m3 e de um agonista beta2, e, método para tratar um paciente sofrendo de ou suscetìvel a uma doença ou condição respiratória que responde ao antagonismo m3
BRPI0511662A BRPI0511662B8 (pt) 2004-05-31 2005-05-31 combinação e usos de um antagonista de receptores muscarínicos m3 e de um agonista beta2 no tratamento de distúrbios respiratórios
BRPI0511669-4A BRPI0511669A (pt) 2004-05-31 2005-05-31 combinação, produto, kit de partes, embalagem, usos de um antagonista de receptores muscarìnicos m3, e de um inibidor de pde4, e, método de tratar um paciente sofrendo de ou suscetìvel a uma doença ou condição respiratória que responde ao antagonismo m3
BRPI0511667-8A BRPI0511667A (pt) 2004-05-31 2005-05-31 combinação, produto, kit de partes, embalagem, usos de um antagonista de receptores muscarìnicos m3, e de um corticosteróide, e, método de tratar um paciente humano ou animal sofrendo de ou suscetìvel a uma doença ou condição respiratória que responde ao antagonismo m3
BRPI0511666-0A BRPI0511666A (pt) 2004-05-31 2005-05-31 combinação, produto, kit de partes, embalagem, usos de um antagonista dos receptores muscarìnicos m3 e de um corticosteróide, e, método para tratar um paciente humano ou animal sofrendo de ou susceptìvel a uma doença ou condição respiratória que responda ao antagonismo de m3

Family Applications After (5)

Application Number Title Priority Date Filing Date
BRPI0511660-0A BRPI0511660A (pt) 2004-05-31 2005-05-31 combinação, produto, kit de partes, embalagem, uso de um antagonista de receptores muscarìnicos m3 e de um agonista beta2, e, método para tratar um paciente sofrendo de ou suscetìvel a uma doença ou condição respiratória que responde ao antagonismo m3
BRPI0511662A BRPI0511662B8 (pt) 2004-05-31 2005-05-31 combinação e usos de um antagonista de receptores muscarínicos m3 e de um agonista beta2 no tratamento de distúrbios respiratórios
BRPI0511669-4A BRPI0511669A (pt) 2004-05-31 2005-05-31 combinação, produto, kit de partes, embalagem, usos de um antagonista de receptores muscarìnicos m3, e de um inibidor de pde4, e, método de tratar um paciente sofrendo de ou suscetìvel a uma doença ou condição respiratória que responde ao antagonismo m3
BRPI0511667-8A BRPI0511667A (pt) 2004-05-31 2005-05-31 combinação, produto, kit de partes, embalagem, usos de um antagonista de receptores muscarìnicos m3, e de um corticosteróide, e, método de tratar um paciente humano ou animal sofrendo de ou suscetìvel a uma doença ou condição respiratória que responde ao antagonismo m3
BRPI0511666-0A BRPI0511666A (pt) 2004-05-31 2005-05-31 combinação, produto, kit de partes, embalagem, usos de um antagonista dos receptores muscarìnicos m3 e de um corticosteróide, e, método para tratar um paciente humano ou animal sofrendo de ou susceptìvel a uma doença ou condição respiratória que responda ao antagonismo de m3

Country Status (45)

Country Link
US (41) US20080051378A1 (https=)
EP (14) EP2319538A3 (https=)
JP (8) JP4928258B2 (https=)
KR (3) KR101174677B1 (https=)
CN (8) CN102755321B (https=)
AR (1) AR049066A1 (https=)
AT (3) ATE424847T1 (https=)
AU (3) AU2005247103B2 (https=)
BE (1) BE1016608A5 (https=)
BR (6) BRPI0511656A (https=)
CA (3) CA2569077C (https=)
CH (1) CH696962A5 (https=)
CL (1) CL2011000607A1 (https=)
CY (7) CY1108885T1 (https=)
DE (3) DE602005013220D1 (https=)
DK (5) DK1765404T3 (https=)
EC (6) ECSP067036A (https=)
ES (7) ES2257152B1 (https=)
FR (2) FR2870744B1 (https=)
GB (1) GB2419819B (https=)
GR (1) GR1006045B (https=)
HR (4) HRP20090107T3 (https=)
HU (2) HUP0600139A3 (https=)
IL (3) IL179684A (https=)
IT (1) ITMI20051021A1 (https=)
LT (1) LTC1763368I2 (https=)
LU (1) LU91214B1 (https=)
MC (1) MC200083A1 (https=)
ME (4) ME01670B (https=)
MX (3) MXPA06013848A (https=)
MY (1) MY142095A (https=)
NL (2) NL1029151C2 (https=)
NO (7) NO338621B1 (https=)
NZ (3) NZ544539A (https=)
PE (3) PE20081649A1 (https=)
PL (6) PL1763369T3 (https=)
PT (4) PT2292267E (https=)
RS (4) RS50717B (https=)
RU (4) RU2385721C2 (https=)
SI (5) SI1763369T1 (https=)
TW (1) TWI404530B (https=)
UA (6) UA89181C2 (https=)
UY (1) UY28933A1 (https=)
WO (3) WO2005115466A1 (https=)
ZA (6) ZA200600261B (https=)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100471016B1 (ko) * 1996-08-07 2005-07-12 스미또모 가가꾸 가부시키가이샤 살충성에어로졸조성물및이를제조하기위한살충조성물
ES2165768B1 (es) * 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
US20050026948A1 (en) * 2003-07-29 2005-02-03 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising an anticholinergic and a betamimetic
JP2007500150A (ja) * 2003-07-29 2007-01-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗コリン作用薬とステロイドとの併用剤及び吸入により呼吸障害を治療するためのその使用
ATE474601T1 (de) * 2004-05-31 2010-08-15 Almirall Sa Kombinationen mit antimuskarin-wirkstoffen und pde4-hemmern
ES2257152B1 (es) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
US20100150884A1 (en) * 2005-02-10 2010-06-17 Oncolys Biopharma Inc. Anticancer Agent to Be Combined with Telomelysin
NZ591969A (en) * 2005-12-21 2012-05-25 Meda Pharma Gmbh & Co Kg Combination of anticholinergics, glucocorticoids, beta2-adrenoceptor agonists, PDE 4 inhibitor and antileukotriene for the treatment of inflammatory diseases
WO2007096782A2 (en) * 2006-02-22 2007-08-30 Valorisation Recherche Hscm, Limited Partnership Compositions for disorders associated wtth metachromatic cell activation
US8007790B2 (en) 2006-04-03 2011-08-30 Stowers Institute For Medical Research Methods for treating polycystic kidney disease (PKD) or other cyst forming diseases
TWI436761B (zh) * 2006-06-19 2014-05-11 Otsuka Pharma Co Ltd 使用噻唑衍生物之方法
EP2359826B1 (en) 2006-07-05 2013-10-30 Takeda GmbH Combination of HMG-COA reductase inhibitor rosuvastatin with a phosphodiesterase 4 inhibitor, such as roflumilast, roflumilast-N-oxide for the treatment of inflammatory pulmonary diseases
BRPI0714463A2 (pt) 2006-07-19 2013-04-02 Astrazeneca Ab compostos de espiropiperidina tricÍclicos, sua sÍntese e seus usos como moduladores de atividade receptora de quimiocina
ES2298049B1 (es) 2006-07-21 2009-10-20 Laboratorios Almirall S.A. Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
EP2120936B1 (en) * 2007-02-21 2011-06-22 Almirall, S.A. Novel methods
CA2608561A1 (en) * 2007-10-29 2009-04-29 Carl Paluszkiewicz Motorcycle wind deflector accessory support
EP2080523A1 (en) * 2008-01-15 2009-07-22 CHIESI FARMACEUTICI S.p.A. Compositions comprising an antimuscarinic and a long-acting beta-agonist
EP2080508A1 (en) * 2008-01-15 2009-07-22 CHIESI FARMACEUTICI S.p.A. Dry powder formulation comprising an anticholinergic drug
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100598A1 (en) * 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
BRPI0909288A2 (pt) * 2008-03-14 2015-08-18 Otsuka Pharma Co Ltd Inibidores da mmp-2 e/ou da mmp-9
EP2297106B1 (en) 2008-05-27 2014-07-16 AstraZeneca AB Phenoxypyridinylamide derivatives and their use in the treatment of pde4 mediated disease states
GB0814729D0 (en) * 2008-08-12 2008-09-17 Argenta Discovery Ltd New combination
EP2156847A1 (en) * 2008-08-19 2010-02-24 Sanofi-Aventis New combination of active ingredients containing an alpha1-antagonist and a PDE 4 inhibitor.
LT2400950T (lt) 2009-02-26 2019-08-26 Glaxo Group Limited Farmacinės kompozicijos, apimančios 4-{(1 r)-2-[(6-{2-[(2,6-dichlorbenzil)oksi]etoksi}heksil)amino]-1-hidroksetil}-2-(hidroksimetil)fenolį
PT3061821T (pt) 2009-07-22 2019-09-05 PureTech Health LLC Composições para tratamento de distúrbios melhorados por ativação de recetores muscarínicos
US10265311B2 (en) 2009-07-22 2019-04-23 PureTech Health LLC Methods and compositions for treatment of disorders ameliorated by muscarinic receptor activation
GB0921075D0 (en) 2009-12-01 2010-01-13 Glaxo Group Ltd Novel combination of the therapeutic agents
DK3246016T3 (da) 2010-08-03 2025-05-19 Chiesi Farm Spa Tørpulverformulering indeholdende en fosfodiesterasehæmmer
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
CN103547575B (zh) 2011-06-10 2016-08-17 奇斯药制品公司 具有毒蕈碱受体拮抗剂和β2肾上腺素能受体激动剂活性的化合物
HRP20151317T1 (hr) 2011-06-10 2016-01-01 Chiesi Farmaceutici S.P.A. Spojevi koji pokazuju aktivnost prema antagonistima muskarinskog receptora i beta2 adrenergiäśnog receptora
AU2013211656B2 (en) * 2012-01-25 2017-07-13 Chiesi Farmaceutici S.P.A. Dry powder formulation comprising a corticosteroid and a beta-adrenergic for administration by inhalation
RU2666963C2 (ru) 2012-04-13 2018-09-13 Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Агрегированные частицы
US9156833B2 (en) 2012-07-16 2015-10-13 Barry University, Inc. Bitopic muscarinic agonists and antagonists and methods of synthesis and use thereof
NZ708738A (en) 2012-12-06 2019-02-22 Chiesi Farm Spa Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
WO2014086927A1 (en) * 2012-12-06 2014-06-12 Chiesi Farmaceutici S.P.A. Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
GB201222679D0 (en) 2012-12-17 2013-01-30 Glaxo Group Ltd Pharmaceutical combination products
EP2968313B1 (en) 2013-03-15 2018-01-31 Verona Pharma PLC Drug combination
WO2015054101A1 (en) * 2013-10-09 2015-04-16 Icon Medical Corp. Improved metal alloy for medical devices
BR112016010416B1 (pt) 2013-11-15 2021-10-05 Performance Polyamides, Sas Composição de poliamida, e componente de metal
SG10202000496XA (en) * 2014-01-10 2020-03-30 Afimmune Ltd Pharmaceutical compositions comprising 15-hepe and methods of treating asthma and lung disorders using same
TWI703138B (zh) * 2015-02-12 2020-09-01 義大利商吉斯藥品公司 具有蕈毒鹼受體拮抗劑及β２腎上腺素受體促效劑活性之化合物
AR104828A1 (es) 2015-06-01 2017-08-16 Chiesi Farm Spa COMPUESTOS CON ACTIVIDAD ANTAGONISTA DE LOS RECEPTORES MUSCARÍNICOS Y ACTIVIDAD AGONISTA DEL RECEPTOR b2 ADRENÉRGICO
WO2017093208A1 (en) 2015-12-03 2017-06-08 Chiesi Farmaceutici S.P.A. Compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
JP7015549B2 (ja) * 2016-01-08 2022-02-03 セロン ファーマシューティカルズ， インク ７－アゾニアビシクロ［２．２．１］ヘプタン誘導体の乾燥粉末吸入器組成物
WO2018011090A1 (en) 2016-07-13 2018-01-18 Chiesi Farmaceutici S.P.A. Hydroxyquinolinone compounds having muscarinic receptor antagonist and beta2 adrenergic receptor agonist activity
WO2018211530A1 (en) 2017-05-19 2018-11-22 Council Of Scientific & Industrial Research Substituted methanopyrido [2, 1-a] isoindolonesas machr modulators for treating various associated pathophysiological conditions and process for preparation thereof
US12582809B2 (en) 2018-01-26 2026-03-24 Bt Bidco, Inc. Treatment of a disease of the gastrointestinal tract with a PDE4 inhibitor
KR102408292B1 (ko) 2018-09-28 2022-06-10 카루나 세러퓨틱스 인코포레이티드 무스카린성 수용체 활성화에 의해 개선된 장애의 치료를 위한 조성물 및 방법
US20220249814A1 (en) 2018-11-19 2022-08-11 Progenity, Inc. Methods and devices for treating a disease with biotherapeutics
CN121197633A (zh) 2019-12-13 2025-12-26 比特比德科有限责任公司 用于将治疗剂递送至胃肠道的可摄取装置
IT202000006442A1 (it) 2020-03-27 2021-09-27 Genetic S P A Budesonide 21-phosphate salts and pharmaceutical compositions containing the same
US20210315851A1 (en) 2020-04-03 2021-10-14 Afimmune Limited Compositions comprising 15-hepe and methods of treating or preventing hematologic disorders, and/or related diseases
US11504332B2 (en) * 2021-03-23 2022-11-22 Vk Research Associates Inc. Phosphodiesterase-4 inhibitor combinations, methods of making, and methods of use thereof
MX2024003481A (es) * 2021-09-23 2024-04-04 Curasen Therapeutics Inc Agonista beta adrenergico y metodos de uso del mismo.

Family Cites Families (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1219606A (en) * 1968-07-15 1971-01-20 Rech S Et D Applic Scient Soge Quinuclidinol derivatives and preparation thereof
FR2414044A1 (fr) * 1978-01-10 1979-08-03 Pharmindustrie Nouveaux derives d'aza-1 bicyclo(2,2,2) octane, utilisables comme medicaments
IT7920688U1 (it) 1979-02-05 1980-08-05 Chiesi Paolo Inalatore per sostanze medicamentose pulverulente, con combinata funzione di dosatore
DE3274065D1 (de) 1981-07-08 1986-12-11 Draco Ab Powder inhalator
FR2539135B1 (fr) * 1983-01-11 1986-02-28 Essilor Int Hydrogels de polyurethane et procede de fabrication
US4570630A (en) 1983-08-03 1986-02-18 Miles Laboratories, Inc. Medicament inhalation device
GB8334494D0 (en) * 1983-12-24 1984-02-01 Tanabe Seiyaku Co Carbostyril derivatives
FI69963C (fi) 1984-10-04 1986-09-12 Orion Yhtymae Oy Doseringsanordning
US4675326A (en) * 1985-05-08 1987-06-23 Gabriel Amitai Bisquaternary antidotes
US4843074A (en) * 1988-05-17 1989-06-27 Marion Laboratories, Inc. 1-azabicyclo[2.2.2]octan-3-yl 2-aryl-3-azacyclo-2-hydroxypropionates and their quaternary salts
DE3927170A1 (de) * 1989-08-17 1991-02-21 Boehringer Ingelheim Kg Inhalator
US5290815A (en) * 1989-09-07 1994-03-01 Glaxo Group Limited Treatment of inflammation and allergy
US5610163A (en) * 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
IT1237118B (it) 1989-10-27 1993-05-18 Miat Spa Inalatore multidose per farmaci in polvere.
US5201308A (en) 1990-02-14 1993-04-13 Newhouse Michael T Powder inhaler
GB9004781D0 (en) 1990-03-02 1990-04-25 Glaxo Group Ltd Device
SG45171A1 (en) 1990-03-21 1998-01-16 Boehringer Ingelheim Int Atomising devices and methods
GB9015522D0 (en) 1990-07-13 1990-08-29 Braithwaite Philip W Inhaler
WO1992003175A1 (en) 1990-08-11 1992-03-05 Fisons Plc Inhalation device
US5507281A (en) * 1990-08-30 1996-04-16 Boehringer Ingelheim Kg Device for initiating a mechanical switching operation in synchronism with the breathing
DE4027391A1 (de) * 1990-08-30 1992-03-12 Boehringer Ingelheim Kg Treibgasfreies inhalationsgeraet
EP0640354B1 (en) 1990-09-26 2001-12-05 Pharmachemie B.V. Whirl chamber powder inhaler
GB9026025D0 (en) * 1990-11-29 1991-01-16 Boehringer Ingelheim Kg Inhalation device
US5290539A (en) * 1990-12-21 1994-03-01 Minnesota Mining And Manufacturing Company Device for delivering an aerosol
DE4108393A1 (de) * 1991-03-15 1992-09-17 Boehringer Ingelheim Kg Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln
AU650953B2 (en) * 1991-03-21 1994-07-07 Novartis Ag Inhaler
GB9202519D0 (en) * 1992-02-06 1992-03-25 Glaxo Group Ltd Medicaments
DE4239402A1 (de) 1992-11-24 1994-05-26 Bayer Ag Pulverinhalator
SK280911B6 (sk) * 1992-12-09 2000-09-12 Boehringer Ingelheim Pharmaceuticals, Inc. Farmaceutický prostriedok
WO1994014492A2 (en) 1992-12-18 1994-07-07 Schering Corporation Inhaler for powdered medications
GB9412434D0 (en) * 1994-06-21 1994-08-10 Inmos Ltd Computer instruction compression
MX9707864A (es) 1995-04-14 1997-11-29 Glaxo Wellcome Inc Inhalador de dosis medida por salmeterol.
PT837710E (pt) 1995-06-21 2002-05-31 Sofotec Gmbh & Co Kg Cartucho de po farmaceutico com dispositivo de doseamento integrado e inalador para medicamentos em po
DE19528145A1 (de) * 1995-08-01 1997-02-06 Boehringer Ingelheim Kg Neue Arzneimittel und ihre Verwendung
DE19536902A1 (de) * 1995-10-04 1997-04-10 Boehringer Ingelheim Int Vorrichtung zur Hochdruckerzeugung in einem Fluid in Miniaturausführung
US5846983A (en) * 1996-02-09 1998-12-08 Mayo Foundation For Medical Education And Research Colonic delivery of nicotine to treat inflammatory bowel disease
US6150415A (en) * 1996-08-13 2000-11-21 The Regents Of The University Of California Epoxide hydrolase complexes and methods therewith
US5885834A (en) * 1996-09-30 1999-03-23 Epstein; Paul M. Antisense oligodeoxynucleotide against phosphodiesterase
US6495167B2 (en) * 1997-03-20 2002-12-17 Schering Corporation Preparation of powder agglomerates
ITMI981671A1 (it) * 1998-07-21 2000-01-21 Zambon Spa Derivati ftalazinici inibitori della fosfodisterasi 4
CN1150890C (zh) * 1998-08-04 2004-05-26 杰格研究股份公司 药用气溶胶制剂
DE19847968A1 (de) * 1998-10-17 2000-04-20 Boehringer Ingelheim Pharma Verschlußkappe und Behälter als Zweikammer-Kartusche für Vernebler zur Erzeugung von Aerosolen
GB9902689D0 (en) * 1999-02-08 1999-03-31 Novartis Ag Organic compounds
DE19921693A1 (de) * 1999-05-12 2000-11-16 Boehringer Ingelheim Pharma Neuartige Arzneimittelkompositionen auf der Basis von anticholinergisch wirksamen Verbindungen und ß-Mimetika
GB9913083D0 (en) * 1999-06-04 1999-08-04 Novartis Ag Organic compounds
US7214687B2 (en) * 1999-07-14 2007-05-08 Almirall Ag Quinuclidine derivatives and medicinal compositions containing the same
ES2165768B1 (es) * 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
GB9928311D0 (en) * 1999-11-30 2000-01-26 Novartis Ag Organic compounds
US6410563B1 (en) * 1999-12-22 2002-06-25 Merck Frosst Canada & Co. Substituted 8-arylquinoline phosphodiesterase-4 inhibitors
FR2803378B1 (fr) * 1999-12-29 2004-03-19 Valeo Climatisation Echangeur de chaleur a tubes a plusieurs canaux, en particulier pour vehicule automobile
US20030018061A1 (en) * 2000-01-28 2003-01-23 Kohei Ogawa Novel remedies with the use of beta 3 agonist
CA2404226A1 (en) * 2000-03-23 2001-09-27 Takeda Chemical Industries, Ltd. Furoisoquinoline derivatives, process for producing the same and use thereof
GB0008485D0 (en) * 2000-04-07 2000-05-24 Glaxo Group Ltd Pharmaceutical compositions
GB0009592D0 (en) 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory combinations
GB0009583D0 (en) 2000-04-18 2000-06-07 Glaxo Group Ltd Respiratory formulations
GB0009605D0 (en) 2000-04-18 2000-06-07 Glaxo Group Ltd Medicaments
GB0009606D0 (en) 2000-04-18 2000-06-07 Glaxo Group Ltd Therapeutic combinations
JP5392880B2 (ja) * 2000-05-22 2014-01-22 キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ 加圧式定量吸入器のための安定な製薬学的溶液製剤
US20020052312A1 (en) * 2000-05-30 2002-05-02 Reiss Theodore F. Combination therapy of chronic obstructive pulmonary disease using muscarinic receptor antagonists
WO2002000241A2 (en) * 2000-06-28 2002-01-03 Aventis Pharma S.A. Compositions and methods for regulating the cell cycle using a ki gene or polypeptide
US6852728B2 (en) * 2000-10-14 2005-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics, processes for preparing them, and pharmaceutical compositions containing them
US6706726B2 (en) * 2000-10-14 2004-03-16 Boehringer Ingelheim Pharma Gmbh & Co. Kg Anticholinergics which may be used as medicaments as well as processes for preparing them
US20020137764A1 (en) * 2000-10-31 2002-09-26 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
US20020151541A1 (en) * 2000-10-31 2002-10-17 Michel Pairet Pharmaceutical compositions containing tiotropium salts and antihistamines and their use
US6608054B2 (en) * 2001-03-20 2003-08-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics and endothelin antagonists
US20020193393A1 (en) * 2001-03-07 2002-12-19 Michel Pairet Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors
US20030158196A1 (en) * 2002-02-16 2003-08-21 Boehringer Ingelheim Pharma Gmbh Co. Kg Pharmaceutical compositions based on anticholinergics and EGFR kinase inhibitors
US7776315B2 (en) * 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
US20020122773A1 (en) * 2000-12-20 2002-09-05 Michel Pairet Pharmaceutical compositions based on anticholinergics and dopamine agonists
MXPA03003751A (es) 2000-10-31 2004-10-15 Boehringer Ingelheim Pharma Nuevas composiciones de medicamentos sobre la base de agentes anticolinergicos y corticoesteroides.
DE10062712A1 (de) 2000-12-15 2002-06-20 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika und Corticosteroiden
US6620438B2 (en) * 2001-03-08 2003-09-16 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics and NK1-receptor antagonists
US20020183292A1 (en) * 2000-10-31 2002-12-05 Michel Pairet Pharmaceutical compositions based on anticholinergics and corticosteroids
DE10056104A1 (de) * 2000-11-13 2002-05-23 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols
US20020193392A1 (en) * 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
IL156558A0 (en) * 2000-12-28 2004-01-04 Almirall Prodesfarma Ag Novel quinuclidine derivatives and medicinal compositions containing the same
US20020179087A1 (en) * 2001-02-01 2002-12-05 Karl-Heinz Bozung Pharmaceutical compositions containing an oxitropium salt and a betamimetic
US20020189610A1 (en) * 2001-02-01 2002-12-19 Karl-Heinz Bozung Pharmaceutical compositions containing an ipratropium salt and a betamimetic
US6667344B2 (en) * 2001-04-17 2003-12-23 Dey, L.P. Bronchodilating compositions and methods
US20030216329A1 (en) * 2001-04-24 2003-11-20 Robinson Cynthia B. Composition, formulations & kit for treatment of respiratory & lung disease with dehydroepiandrosterone(s) steroid & an anti-muscarinic agent(s)
WO2002096423A2 (en) * 2001-05-25 2002-12-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Combination of a pde4 inhibitor and tiotropium or derivate thereof for treating obstructive airways
GB0115181D0 (en) * 2001-06-20 2001-08-15 Glaxo Group Ltd Novel use
US20030018019A1 (en) 2001-06-23 2003-01-23 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions based on anticholinergics, corticosteroids and betamimetics
DE10130371A1 (de) * 2001-06-23 2003-01-02 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Anticholinergika, Corticosteroiden und Betamimetika
US6919325B2 (en) * 2001-09-14 2005-07-19 Boehringer Ingelheim Pharma Kg Pharmaceutical compositions containing tiotropium salts and low-solubility salmeterol salts
US6974803B2 (en) * 2001-12-06 2005-12-13 Pfizer Inc Pharmaceutical combination
US6790856B2 (en) * 2002-01-31 2004-09-14 Boehringer Ingelheim Pharma Kg Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments
GB0202635D0 (en) * 2002-02-05 2002-03-20 Glaxo Wellcome Mfg Pte Ltd Formulation containing novel anti-inflammatory androstane derivative
US6756508B2 (en) * 2002-03-04 2004-06-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Cinnamic acid salts, processes for their preparation, and their use as medicaments
US7094788B2 (en) * 2002-04-13 2006-08-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Esters of hydroxyl-substituted nitrogen heterocycles, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions
ES2206021B1 (es) * 2002-04-16 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de pirrolidinio.
ES2195785B1 (es) 2002-05-16 2005-03-16 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
DK1507558T3 (da) * 2002-05-17 2011-12-05 Novartis Pharma Ag Farmaceutisk sammensætning omfattende en renininhibitor, en calciumkanalblokker og et diuretikum
AU2003276837B2 (en) * 2002-06-12 2006-07-20 Epigenesis Pharmaceuticals, Llc. Combination of anti-muscarinic agents and non-glucocorticoid steroids
AU2002345266B2 (en) * 2002-07-08 2009-07-02 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
US20040058950A1 (en) * 2002-07-09 2004-03-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors
WO2004039968A1 (ja) * 2002-10-30 2004-05-13 Japan Science And Technology Agency 骨髄由来の不死化樹状細胞株
ES2211315B1 (es) 2002-11-12 2005-10-16 Almirall Prodesfarma, S.A. Nuevos compuestos triciclicos.
CA2506949A1 (en) * 2002-11-27 2004-06-10 Altana Pharma Ag Pde4 and pde3/4 inhibitors for use in the treatment of cachexia
ES2211344B1 (es) 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
PE20040950A1 (es) * 2003-02-14 2005-01-01 Theravance Inc DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
DE10307759B3 (de) * 2003-02-19 2004-11-18 Schering Ag Trimere makrocyclisch substituierte Benzolderivate, deren Herstellung und Verwendung als Kontrastmittel sowie diese enthaltende pharmazeutische Mittel
US20040184995A1 (en) * 2003-03-17 2004-09-23 Yamanouchi Pharmaceutical Co., Ltd. Novel dry powder inhalation for lung-delivery and manufacturing method thereof
WO2004084897A1 (en) * 2003-03-28 2004-10-07 Altana Pharma Ag Synergistic combination comprising roflumilast and an anticholinergic agent selected from ipratropium, oxitropium and tiotropium salts for the treatment of respiratory diseases
DK1610787T3 (da) * 2003-03-28 2008-06-02 Nycomed Gmbh Synergistisk kombination der omfatter roflumilast og et antikolinergt middel der er valgt blandt tiotropiumsalte til behandling af respiratoriske sygdomme
MXPA06001047A (es) * 2003-07-29 2006-04-24 Boehringer Ingelheim Int Medicamentos para inhalacion que comprenden betamimeticos y un anticolinergico.
US20050026886A1 (en) * 2003-07-29 2005-02-03 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising an anticholinergic and a PDE IV inhibitor
US20050026887A1 (en) * 2003-07-29 2005-02-03 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising an anticholinergic and a steroid
US20050026948A1 (en) * 2003-07-29 2005-02-03 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising an anticholinergic and a betamimetic
EP1651224B1 (en) * 2003-07-31 2011-10-05 Boehringer Ingelheim International GmbH Medicaments for inhalation comprising an anticholinergic and a betamimetic
US20050025718A1 (en) * 2003-07-31 2005-02-03 Boehringer Ingelheim International Gmbh Medicaments for inhalation comprising an anticholinergic and a betamimetic
DE10347994A1 (de) * 2003-10-15 2005-06-16 Pari GmbH Spezialisten für effektive Inhalation Wässrige Aerosol-Zubereitung
ES2232306B1 (es) 2003-11-10 2006-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
EP1713473B1 (en) * 2004-02-06 2013-03-13 MEDA Pharma GmbH & Co. KG The combination of anticholinergics and glucocorticoids for the long-term treatment of asthma and copd
RU2438660C2 (ru) * 2004-02-06 2012-01-10 Меда Фарма Гмбх Унд Ко. Кг Комбинация и фармацевтический препарат для лечения воспалительных и обструктивных заболеваний дыхательных путей
WO2005074982A2 (en) * 2004-02-06 2005-08-18 Meda Pharma Gmbh & Co. Kg Combination of anticholinergics and inhibitors of phosphodiesterase type 4 for the treatment of respiratory diseases
US7375935B2 (en) * 2004-04-12 2008-05-20 Leviton Manufacturing Co., Inc. Ground fault circuit interrupter with enhanced radio frequency interference suppression
ES2257152B1 (es) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
US20060189551A1 (en) * 2004-10-04 2006-08-24 Duke University Combination therapies for fungal pathogens

Also Published As

Publication number Publication date
US20130035319A1 (en) 2013-02-07
ES2505329T3 (es) 2014-10-09
IE20050366A1 (en) 2005-11-30
FR15C0017I2 (fr) 2015-11-13
IL179689A0 (en) 2007-05-15
BRPI0511662A (pt) 2008-01-02
IL179687A0 (en) 2007-05-15
ES2322280T3 (es) 2009-06-18
HUS1500011I1 (hu) 2018-09-28
CN1960762A (zh) 2007-05-09
JP2012184272A (ja) 2012-09-27
EP2319538A3 (en) 2011-06-15
WO2005115467A1 (en) 2005-12-08
LU91214B1 (fr) 2006-01-26
RS50717B (sr) 2010-06-30
TW200608971A (en) 2006-03-16
CA2568566C (en) 2012-12-18
EP1765404A1 (en) 2007-03-28
RU2010129940A (ru) 2012-01-27
DK1763368T3 (da) 2009-05-04
ECSP067036A (es) 2006-12-29
DK1765404T3 (da) 2009-03-16
ZA200609986B (en) 2007-11-28
US20060154934A1 (en) 2006-07-13
JP5032984B2 (ja) 2012-09-26
EP1765404B1 (en) 2008-12-31
US20090093503A1 (en) 2009-04-09
DE602005011803D1 (de) 2009-01-29
RS50787B2 (sr) 2018-02-28
PL379660A1 (pl) 2006-11-13
CH696962A5 (fr) 2008-02-29
CN101018566A (zh) 2007-08-15
WO2005115466A1 (en) 2005-12-08
KR20070024556A (ko) 2007-03-02
ME01670B (me) 2010-06-30
FR2870744A1 (fr) 2005-12-02
US20130252928A1 (en) 2013-09-26
JP2012012407A (ja) 2012-01-19
US20110021477A1 (en) 2011-01-27
EP1891973B1 (en) 2010-07-21
HK1090306A1 (en) 2006-12-22
US20110021476A1 (en) 2011-01-27
CY1109139T1 (el) 2014-07-02
JP5049120B2 (ja) 2012-10-17
EP1763368B1 (en) 2009-03-11
US20090111785A1 (en) 2009-04-30
ZA200609987B (en) 2007-12-27
PT1763369E (pt) 2009-02-26
CA2533061C (en) 2008-07-08
SI1891973T1 (sl) 2010-11-30
US20100048616A1 (en) 2010-02-25
JP5133054B2 (ja) 2013-01-30
EP2002845A3 (en) 2009-02-25
JP2008500989A (ja) 2008-01-17
DK2292267T3 (da) 2014-09-15
EP1763369B1 (en) 2008-12-17
IL179689A (en) 2012-02-29
EP2002845A2 (en) 2008-12-17
EP2774622B1 (en) 2015-03-11
ECSP067034A (es) 2006-12-29
AU2005247103B2 (en) 2010-10-28
US20080045565A1 (en) 2008-02-21
AU2005247103A1 (en) 2005-12-08
NL300720I1 (https=) 2016-01-07
EP1761280A1 (en) 2007-03-14
JP4966192B2 (ja) 2012-07-04
US20120302532A1 (en) 2012-11-29
CN1960759B (zh) 2011-07-13
EP2002844A3 (en) 2009-03-04
US20120309726A1 (en) 2012-12-06
JP2008500990A (ja) 2008-01-17
US20050267078A1 (en) 2005-12-01
UA89184C2 (ru) 2010-01-11
US20120309727A1 (en) 2012-12-06
SI21784A (sl) 2005-12-31
BRPI0511669A (pt) 2008-01-02
IL179684A0 (en) 2007-05-15
CN1960759A (zh) 2007-05-09
RU2404771C3 (ru) 2018-03-12
UA86976C2 (ru) 2009-06-10
PT2292267E (pt) 2014-10-15
ES2257152B1 (es) 2007-07-01
EP2292267A3 (en) 2011-06-15
HRP20090215T4 (hr) 2013-12-20
EP1763368A1 (en) 2007-03-21
GR20050100269A (el) 2005-12-31
BE1016608A5 (fr) 2007-02-06
KR20070018105A (ko) 2007-02-13
RU2385721C2 (ru) 2010-04-10
KR101256417B1 (ko) 2013-04-22
RS51386B (sr) 2011-02-28
GR1006045B (el) 2008-09-08
US20170049756A1 (en) 2017-02-23
AU2005247108A1 (en) 2005-12-08
PL1763368T5 (pl) 2014-01-31
EP2292267B1 (en) 2014-07-23
NL300720I2 (https=) 2016-01-07
NO2015007I1 (no) 2015-03-09
US20140296197A1 (en) 2014-10-02
ECSP067038A (es) 2006-12-29
HRP20090215T1 (en) 2009-05-31
NZ551668A (en) 2010-06-25
RS50787B (sr) 2010-08-31
EP2774623A1 (en) 2014-09-10
PL1763369T3 (pl) 2009-06-30
US20120088743A1 (en) 2012-04-12
RU2373935C2 (ru) 2009-11-27
US20130310354A1 (en) 2013-11-21
KR20130027586A (ko) 2013-03-15
PL1763368T3 (pl) 2009-08-31
WO2005115466A8 (en) 2007-01-04
US20050267135A1 (en) 2005-12-01
NO20065479L (no) 2006-12-22
ES2348680T3 (es) 2010-12-10
EP2319538A2 (en) 2011-05-11
ITMI20051021A1 (it) 2005-12-01
PL1765404T3 (pl) 2009-06-30
HK1198120A1 (en) 2015-03-13
US20060189651A1 (en) 2006-08-24
RU2006142331A (ru) 2008-06-20
CL2011000607A1 (es) 2011-08-19
EP1891973A1 (en) 2008-02-27
UA89183C2 (ru) 2010-01-11
NO20065477L (no) 2006-12-22
CA2568566A1 (en) 2005-12-08
ME01680B (me) 2010-08-31
PL2292267T3 (pl) 2015-03-31
BRPI0511660A (pt) 2008-01-02
HK1125573A1 (en) 2009-08-14
SI1763368T2 (sl) 2013-12-31
ECSP067033A (es) 2006-12-29
CA2533061A1 (en) 2005-12-08
ZA200609985B (en) 2008-09-25
CY1110798T1 (el) 2015-06-10
EP1763369A1 (en) 2007-03-21
JP5107701B2 (ja) 2012-12-26
CA2569077C (en) 2012-12-18
ECSP067035A (es) 2006-12-29
ES2293849B2 (es) 2009-04-16
PE20060292A1 (es) 2006-04-14
UA89181C2 (ru) 2010-01-11
US20120071452A1 (en) 2012-03-22
JP4928258B2 (ja) 2012-05-09
US20150202213A1 (en) 2015-07-23
CY1108902T1 (el) 2014-07-02
CY1108885T1 (el) 2014-07-02
MXPA06013848A (es) 2007-03-01
DK1763368T4 (da) 2013-11-04
ATE417627T1 (de) 2009-01-15
JP2008500986A (ja) 2008-01-17
RU2006147250A (ru) 2008-07-20
CY2015006I2 (el) 2016-06-22
US20180200234A1 (en) 2018-07-19
EP2774622A1 (en) 2014-09-10
EP2002843A2 (en) 2008-12-17
US20120059031A1 (en) 2012-03-08
US20150306079A1 (en) 2015-10-29
GB0526502D0 (en) 2006-02-08
US20120040943A1 (en) 2012-02-16
HUP0600139A3 (en) 2010-12-28
SI2292267T1 (sl) 2014-11-28
RU2006147268A (ru) 2008-07-20
PT1763368E (pt) 2009-05-14
US20100048615A1 (en) 2010-02-25
PE20081650A1 (es) 2008-12-06
US20090176751A1 (en) 2009-07-09
ATE424847T1 (de) 2009-03-15
JP2008500988A (ja) 2008-01-17
RU2465902C2 (ru) 2012-11-10
US20110021478A1 (en) 2011-01-27
HUP0600139A2 (en) 2007-06-28
FR15C0017I1 (https=) 2015-03-04
NO2015007I2 (no) 2015-12-21
DE602005013220D1 (de) 2009-04-23
EP2138188A1 (en) 2009-12-30
MXPA06004124A (es) 2006-06-27
US20140148420A1 (en) 2014-05-29
CN102755321A (zh) 2012-10-31
JP2006527183A (ja) 2006-11-30
CY1109938T1 (el) 2014-09-10
DK1763369T3 (da) 2009-03-16
CN102755321B (zh) 2015-07-15
CN1960761A (zh) 2007-05-09
CN1960760A (zh) 2007-05-09
NO334337B1 (no) 2014-02-10
MC200083A1 (fr) 2005-12-07
GB2419819A (en) 2006-05-10
HRP20140864T1 (hr) 2014-12-05
WO2005115462A1 (en) 2005-12-08
NO20065482L (no) 2006-12-22
MXPA06013847A (es) 2007-03-01
TWI404530B (zh) 2013-08-11
US20080146603A1 (en) 2008-06-19
CA2569077A1 (en) 2005-12-08
ZA200600261B (en) 2007-04-25
BRPI0511662B8 (pt) 2021-05-25
AU2005247107A1 (en) 2005-12-08
EP1763368B2 (en) 2013-08-21
HK1095757A1 (en) 2007-05-18
NO338621B1 (no) 2016-09-19
UY28933A1 (es) 2005-08-31
NO20065478L (no) 2006-12-28
ECSP067037A (es) 2006-12-29
US20080051378A1 (en) 2008-02-28
CN102085373A (zh) 2011-06-08
NZ544539A (en) 2007-09-28
UA89182C2 (ru) 2010-01-11
US20090099148A1 (en) 2009-04-16
EP2002844B1 (en) 2010-12-29
ME02134B (me) 2015-02-27
US20050288266A1 (en) 2005-12-29
PT1891973E (pt) 2010-09-27
CN1972716A (zh) 2007-05-30
NZ551667A (en) 2010-07-30
MY142095A (en) 2010-09-15
ES2257152A1 (es) 2006-07-16
US20140094442A1 (en) 2014-04-03
NL1029151A1 (nl) 2005-12-05
BRPI0511662B1 (pt) 2019-02-19
AU2005247107B2 (en) 2010-10-28
FR2870744B1 (fr) 2006-12-08
US20070232637A1 (en) 2007-10-04
CY1115669T1 (el) 2017-01-25
KR101174677B1 (ko) 2012-08-17
HRP20100489T1 (hr) 2010-10-31
US20100056486A1 (en) 2010-03-04
JP2008500987A (ja) 2008-01-17
AR049066A1 (es) 2006-06-21
ATE474600T1 (de) 2010-08-15
ME02779B (me) 2010-06-30
IL179684A (en) 2011-11-30
ES2322280T5 (es) 2013-12-03
DE602005022497D1 (de) 2010-09-02
ES2318498T3 (es) 2009-05-01
EP2002843A3 (en) 2009-04-08
GB2419819B (en) 2007-02-21
BRPI0511667A (pt) 2008-01-02
UA89185C2 (ru) 2010-01-11
US20150080359A1 (en) 2015-03-19
JP5538485B2 (ja) 2014-07-02
PL1891973T3 (pl) 2010-11-30
RU2404771C2 (ru) 2010-11-27
NO20065476L (no) 2006-12-28
US20060205702A1 (en) 2006-09-14
NO20065483L (no) 2006-12-22
ZA200609990B (en) 2007-12-27
US20160038470A1 (en) 2016-02-11
EP2774623B1 (en) 2015-04-08
AU2005247108B2 (en) 2008-09-11
CY2015006I1 (el) 2016-06-22
DK1891973T3 (da) 2010-10-18
US20200009117A1 (en) 2020-01-09
US20070167489A1 (en) 2007-07-19
BRPI0511666A (pt) 2008-01-02
HRP20090107T3 (en) 2009-03-31
LTC1763368I2 (lt) 2016-12-27
RS53529B1 (sr) 2015-02-27
SI1763369T1 (sl) 2009-06-30
SI1763368T1 (sl) 2009-08-31
EP2002844A2 (en) 2008-12-17
ES2348558T3 (es) 2010-12-09
ES2293849A1 (es) 2008-03-16
NL1029151C2 (nl) 2006-06-22
ZA200609989B (en) 2007-11-28
EP2210613A1 (en) 2010-07-28
PE20081649A1 (es) 2008-11-28
IL179687A (en) 2011-11-30
EP2292267A2 (en) 2011-03-09

Similar Documents

Publication Publication Date Title
BRPI0511656A (pt) combinação, produto, kit de partes, embalagem, usos de um antagonista dos receptores muscarìnicos m3 e de um inibidor de pde4, e, método para tratar um paciente sofrendo de ou susceptìvel a uma doença ou condição respiratória que responda ao antagonismo de m3
EP2331095A4 (en) CYNURENINE-3-MONOOXYGENASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND METHOD OF USE THEREOF
BRPI0612072A2 (pt) inibidores da aspartil protease
BRPI0507966A (pt) uso de meloxicam para o tratamento de doenças respiratórias em porcos
BRPI0418026A (pt) derivados de fenilalanina ou sais farmaceuticamente aceitáveis destes, composição farmacêutica, antagonista de alfa4 integrina, e, agente terapêutico ou agente preventivo para doenças
WO2004002402A3 (en) Administration of acetylcholinesterase inhibitors to the cerebral spinal fluid
BRPI0417260A (pt) derivados de azepinoindol como agentes farmacêuticos
AR095197A1 (es) Combinación de un inhibidor de egfr t790m y un inhibidor de egfr para el tratamiento del cáncer pulmonar de células no pequeñas
CL2011001178A1 (es) Uso de (r)-7-cloro-niquinuclidin-3-1l)senzo[b]tiofen0-2-carboxamida o una sal de la misma o una composicion farmaceutica que la comprende para preparar un medicamento util para mejorar la cognicion en un paciente que sufre de alzheimer o esquizofrenia.
ATE474601T1 (de) Kombinationen mit antimuskarin-wirkstoffen und pde4-hemmern
BRPI0409796A (pt) uso de dipiridamol ou mopidamol para tratamento e prevenção de doenças tromboembolìticas e distúrbios provocados pela formação excessiva de trombina e/ou pela expressão elevada de receptores de trombina
BRPI0412919A (pt) combinação de antagonista de mglur2 e inibidor de ache para o tratamento de distúrbios neurológicos crÈnicos e/ou agudos
EP1786428A4 (en) PDE5 INHIBITOR COMPOSITIONS AND METHOD FOR TREATING DISEASE
BRPI0507296A (pt) derivado de uréia, composição farmacêutica, uso de um derivado de uréia, e, método de tratamento, prevenção ou alìvio de uma doença ou um distúrbio ou uma condição de um corpo de animal vivo
NO20092574L (no) Piperidinylamino-pyridaziner og deres anvendelse som raskt dissosierende dopamin-2-reseptor-antagonister
WO2008068746A3 (en) Disulfiram doses and treatment regimen suitable for treatment of angiogenesis-dependent disorders
BR112012020060B8 (pt) uso de n-((1-((4-hidroxitetrahidro-2h-piran-4-il)metil)piperidin-4-il)metil)-3-isopropil-2-oxo-2,3-dihidro-1h-benzo[d]imidazol-1-carboxamida para tratar doença de alzheimer e demência
BR112012022944A2 (pt) agente terapêutico ou agente profilático
WO2014047288A3 (en) Transglutaminase tg2 inhibitors, pharmaceutical compositions, and methods of use thereof
BR9913348A (pt) Tratamento dos distúrbios da ansiedade
BR0308517A (pt) Combinação de um antagonista do receptor de aldosterona e de um agente sequestrante de ácido biliar
ATE445633T1 (de) Die regeneration von neuronen des zentralen nervensystems stimulierende peptidsubstanz, darauf basierende pharmazeutische zusammensetzung und verfahren zu ihrer anwendung
BRPI0514303A (pt) composição farmacêutica e método para tratar distúrbios neurodegenerativos
Lecrubier Amisulpride as a model: clinical effects of a pure dopaminergic agent
Mendes et al. THE EFFECTS OF THE ATYPICAL ANTIPSYCHOTICS CLOZAPINE, REMOXIPRIDE AND RISPERIDONE ON THE CONTRACTILE CHARACTERISTICS OF RAT SKELETAL MUSCLEIN VITRO

Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: LABORATORIOS ALMIRALL, S.A. (ES)

Free format text: ALTERADO DE: ALMIRALL PRODESFARMA, S.A.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 9A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2257 DE 08/04/2014.