BRPI0507278A - moduladores dos transportadores do cassete de ligação ao atp - Google Patents
moduladores dos transportadores do cassete de ligação ao atpInfo
- Publication number
- BRPI0507278A BRPI0507278A BRPI0507278-6A BRPI0507278A BRPI0507278A BR PI0507278 A BRPI0507278 A BR PI0507278A BR PI0507278 A BRPI0507278 A BR PI0507278A BR PI0507278 A BRPI0507278 A BR PI0507278A
- Authority
- BR
- Brazil
- Prior art keywords
- ring
- modulators
- membered
- atp
- aromatic
- Prior art date
Links
- 108010006533 ATP-Binding Cassette Transporters Proteins 0.000 title 1
- 102000005416 ATP-Binding Cassette Transporters Human genes 0.000 title 1
- 108010079245 Cystic Fibrosis Transmembrane Conductance Regulator Proteins 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004008 6 membered carbocyclic group Chemical group 0.000 abstract 1
- 102100023419 Cystic fibrosis transmembrane conductance regulator Human genes 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 102000008371 intracellularly ATP-gated chloride channel activity proteins Human genes 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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| PCT/US2005/002644 WO2005075435A1 (en) | 2004-01-30 | 2005-01-31 | Modulators of atp-binding cassette transporters |
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-
2005
- 2005-01-31 JP JP2006551487A patent/JP4960708B2/ja not_active Expired - Lifetime
- 2005-01-31 EP EP17166575.5A patent/EP3219709B1/en not_active Expired - Lifetime
- 2005-01-31 AU AU2005210474A patent/AU2005210474B2/en not_active Ceased
- 2005-01-31 EP EP05712188.1A patent/EP1716122B1/en not_active Expired - Lifetime
- 2005-01-31 BR BRPI0507278-6A patent/BRPI0507278A/pt not_active IP Right Cessation
- 2005-01-31 US US11/047,366 patent/US8759335B2/en active Active
- 2005-01-31 CA CA002554796A patent/CA2554796A1/en not_active Abandoned
- 2005-01-31 ES ES17166575T patent/ES2791303T3/es not_active Expired - Lifetime
- 2005-01-31 MX MXPA06008606A patent/MXPA06008606A/es not_active Application Discontinuation
- 2005-01-31 WO PCT/US2005/002644 patent/WO2005075435A1/en not_active Ceased
- 2005-01-31 CN CN2005800097913A patent/CN1938279B/zh not_active Expired - Fee Related
- 2005-01-31 ES ES05712188.1T patent/ES2631362T3/es not_active Expired - Lifetime
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2012
- 2012-01-20 JP JP2012009781A patent/JP5669319B2/ja not_active Expired - Lifetime
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2014
- 2014-02-07 JP JP2014021918A patent/JP5840239B2/ja not_active Expired - Lifetime
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2015
- 2015-02-04 JP JP2015019897A patent/JP2015091875A/ja active Pending
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2016
- 2016-05-16 JP JP2016097613A patent/JP6158985B2/ja not_active Expired - Lifetime
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|---|---|
| EP3219709B1 (en) | 2020-03-18 |
| JP2015091875A (ja) | 2015-05-14 |
| ES2631362T3 (es) | 2017-08-30 |
| CN1938279B (zh) | 2011-09-14 |
| JP4960708B2 (ja) | 2012-06-27 |
| JP5669319B2 (ja) | 2015-02-12 |
| JP5840239B2 (ja) | 2016-01-06 |
| MXPA06008606A (es) | 2007-04-13 |
| CA2554796A1 (en) | 2005-08-18 |
| JP2007519740A (ja) | 2007-07-19 |
| JP2016153424A (ja) | 2016-08-25 |
| AU2005210474A1 (en) | 2005-08-18 |
| EP3219709A1 (en) | 2017-09-20 |
| JP6158985B2 (ja) | 2017-07-05 |
| AU2005210474B2 (en) | 2011-07-07 |
| US20060052358A1 (en) | 2006-03-09 |
| JP2014088437A (ja) | 2014-05-15 |
| CN1938279A (zh) | 2007-03-28 |
| US8759335B2 (en) | 2014-06-24 |
| JP2012077094A (ja) | 2012-04-19 |
| EP1716122B1 (en) | 2017-04-19 |
| EP1716122A1 (en) | 2006-11-02 |
| WO2005075435A1 (en) | 2005-08-18 |
| HK1104292A1 (en) | 2008-01-11 |
| ES2791303T3 (es) | 2020-11-03 |
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