BRPI0414918A - compostos de benzoimidazola - Google Patents
compostos de benzoimidazolaInfo
- Publication number
- BRPI0414918A BRPI0414918A BRPI0414918-1A BRPI0414918A BRPI0414918A BR PI0414918 A BRPI0414918 A BR PI0414918A BR PI0414918 A BRPI0414918 A BR PI0414918A BR PI0414918 A BRPI0414918 A BR PI0414918A
- Authority
- BR
- Brazil
- Prior art keywords
- benzoimidazole compounds
- conditions
- benzoimidazole
- compounds
- inflammation
- Prior art date
Links
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical class C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 title abstract 2
- -1 BENZOIMIDAZOLE COMPOUNDS Chemical class 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 210000000265 leukocyte Anatomy 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000007115 recruitment Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/10—Immunoglobulin or domain(s) thereof as scaffolds for inserted non-Ig peptide sequences, e.g. for vaccination purposes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Manufacturing & Machinery (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Ceramic Engineering (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Materials Engineering (AREA)
- Structural Engineering (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50723603P | 2003-09-30 | 2003-09-30 | |
| PCT/US2004/031855 WO2005044807A2 (en) | 2003-09-30 | 2004-09-29 | Benzoimidazole compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0414918A true BRPI0414918A (pt) | 2006-11-07 |
Family
ID=38952593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0414918-1A BRPI0414918A (pt) | 2003-09-30 | 2004-09-29 | compostos de benzoimidazola |
Country Status (21)
| Country | Link |
|---|---|
| US (10) | US7432378B2 (enExample) |
| EP (1) | EP1673348B1 (enExample) |
| JP (1) | JP2007508011A (enExample) |
| KR (1) | KR20060097024A (enExample) |
| CN (1) | CN1886380B (enExample) |
| AR (1) | AR045955A1 (enExample) |
| AT (1) | ATE427303T1 (enExample) |
| AU (1) | AU2004286933B2 (enExample) |
| BR (1) | BRPI0414918A (enExample) |
| CA (1) | CA2540704A1 (enExample) |
| DE (1) | DE602004020364D1 (enExample) |
| ES (1) | ES2323178T3 (enExample) |
| HR (1) | HRP20060126A2 (enExample) |
| IL (1) | IL174677A0 (enExample) |
| NO (1) | NO20061950L (enExample) |
| NZ (1) | NZ546259A (enExample) |
| PT (1) | PT1673348E (enExample) |
| RU (1) | RU2006110561A (enExample) |
| TW (1) | TW200526637A (enExample) |
| WO (1) | WO2005044807A2 (enExample) |
| ZA (1) | ZA200603411B (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1673348B1 (en) * | 2003-09-30 | 2009-04-01 | Janssen Pharmaceutica N.V. | Benzoimidazole compounds |
| EP1737297B1 (en) | 2004-03-25 | 2012-12-19 | Janssen Pharmaceutica NV | Imidazole compounds |
| US7250427B2 (en) | 2004-06-30 | 2007-07-31 | Janssen Pharmaceutica, N.V. | Aryl-substituted benzimidazole and imidazopyridine ethers |
| RU2458056C2 (ru) | 2005-05-26 | 2012-08-10 | Тиботек Фармасьютикалз Лтд | Способ получения 4-(1,6-дигидро-6-оксо-2-пиримидинил)амино-бензонитрила |
| MX2007016508A (es) * | 2005-06-30 | 2008-03-04 | Prosidion Ltd | Agonistas del receptor acoplado a la proteina g. |
| AU2006325294B2 (en) * | 2005-10-31 | 2012-10-11 | Merck Sharp & Dohme Corp. | CETP inhibitors |
| GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| EP1961745A1 (en) * | 2005-12-12 | 2008-08-27 | Ono Pharmaceutical Co., Ltd. | Bicyclic heterocyclic compound |
| ATE479678T1 (de) * | 2006-03-31 | 2010-09-15 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyridine als modulatoren des histamin-h4-rezeptors |
| US7507737B2 (en) | 2006-03-31 | 2009-03-24 | Janssen Pharmaceutica, N.V. | Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine H4receptor |
| EP2010177A2 (en) * | 2006-04-10 | 2009-01-07 | Janssen Pharmaceutica N.V. | Combination histamine h1r and h4r antagonist therapy for treating pruritus |
| FR2903311B1 (fr) * | 2006-07-10 | 2012-06-15 | Centre Nat Rech Scient | Utilisation de ligands du recepteur h4 de l'histamine pour proteger les progeniteurs hematopoietiques contre la toxicite hematologique des agents chimiotherapeutiques |
| US7985745B2 (en) | 2006-10-02 | 2011-07-26 | Abbott Laboratories | Method for pain treatment |
| US8084466B2 (en) | 2007-12-18 | 2011-12-27 | Janssen Pharmaceutica Nv | Bicyclic heteroaryl-substituted imidazoles as modulators of the histamine H4 receptor |
| EP2077263A1 (en) | 2008-01-02 | 2009-07-08 | Vereniging voor christelijk hoger onderwijs, wetenschappelijk onderzoek en patiëntenzorg | Quinazolines and related heterocyclic compounds and their therapeutic use |
| UA100567C2 (ru) | 2008-06-12 | 2013-01-10 | Янссен Фармацевтика Нв | Использование антагонистов н4-гистаминовых рецепторов для лечения послеоперационных спаек |
| US9371311B2 (en) | 2008-06-30 | 2016-06-21 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyrimidine derivatives |
| KR20110022721A (ko) | 2008-06-30 | 2011-03-07 | 얀센 파마슈티카 엔.브이. | 벤조이미다졸-2-일 피리미딘 유도체의 제조 방법 |
| WO2010036905A1 (en) * | 2008-09-26 | 2010-04-01 | Eisai R & D Management Co., Ltd. | Benzoxazole compounds and methods of use |
| WO2010036908A1 (en) * | 2008-09-26 | 2010-04-01 | Eisai R & D Management Co., Ltd. | Use of benzoxazole compounds in the treatment of malaria |
| EP2201982A1 (en) | 2008-12-24 | 2010-06-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Histamine H4 receptor antagonists for the treatment of vestibular disorders |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| IT1395137B1 (it) * | 2009-08-05 | 2012-09-05 | Spider Biotech S R L | Nuovi peptidi antipatogeni |
| TW201111378A (en) | 2009-09-11 | 2011-04-01 | Bayer Schering Pharma Ag | Substituted (heteroarylmethyl) thiohydantoins |
| EP2531510B1 (en) | 2010-02-01 | 2014-07-23 | Novartis AG | Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists |
| WO2011092293A2 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
| WO2011095450A1 (en) | 2010-02-02 | 2011-08-11 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
| EP2447263A1 (en) | 2010-09-27 | 2012-05-02 | Bioprojet | Benzazole derivatives as histamine H4 receptor ligands |
| UY34094A (es) | 2011-05-27 | 2013-01-03 | Novartis Ag | Derivados de la piperidina 3-espirocíclica como agonistas de receptores de la ghrelina |
| DE102011122420B4 (de) | 2011-12-24 | 2016-07-28 | Volkswagen Aktiengesellschaft | Verfahren zur Feststellung der Spannungsfreiheit in einem elektrischen Hochvolt-System und ein elektrisches Hochvolt-System |
| TW201348235A (zh) | 2012-05-03 | 2013-12-01 | Novartis Ag | 作爲格瑞啉受體促效劑之３－螺環哌啶衍生物 |
| EP2671870A1 (en) | 2012-06-05 | 2013-12-11 | Bioprojet | Novel (aza)benzhydryl ether derivatives, their process of preparation and their use as H4-receptor ligands for therapeutical applications |
| US9688989B2 (en) | 2012-06-08 | 2017-06-27 | Sensorion | H4 receptor inhibitors for treating tinnitus |
| EA201591648A1 (ru) | 2013-03-06 | 2016-02-29 | Янссен Фармацевтика Нв | Бензимидазол-2-ил-пиримидиновые модуляторы рецептора гистамина h4 |
| CN112119069B (zh) * | 2018-05-22 | 2023-10-03 | 日本农药株式会社 | 苯并咪唑化合物或其盐类和含有该化合物的用于农业园艺的杀虫杀螨剂以及其使用方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2587029B1 (fr) * | 1985-09-11 | 1987-10-30 | Synthelabo | Derives de benzimidazole, leur preparation et leur application en therapeutique |
| EP0927167A1 (en) * | 1996-08-14 | 1999-07-07 | Warner-Lambert Company | 2-phenyl benzimidazole derivatives as mcp-1 antagonists |
| WO2000026192A1 (de) * | 1998-11-03 | 2000-05-11 | Basf Aktiengesellschaft | Substituierte 2-phenylbenzimidazole, deren herstellung und anwendung |
| DE19920936A1 (de) * | 1999-05-07 | 2000-11-09 | Basf Ag | Heterozyklisch substituierte Benzimidazole, deren Herstellung und Anwendung |
| AU2002336273A1 (en) | 2001-03-09 | 2002-09-24 | Ortho-Mcneil Pharmaceutical, Inc. | Heterocyclic compounds and their use as histamine h4 ligands. |
| EP1673348B1 (en) * | 2003-09-30 | 2009-04-01 | Janssen Pharmaceutica N.V. | Benzoimidazole compounds |
-
2004
- 2004-09-29 EP EP04816894A patent/EP1673348B1/en not_active Expired - Lifetime
- 2004-09-29 TW TW093129453A patent/TW200526637A/zh unknown
- 2004-09-29 PT PT04816894T patent/PT1673348E/pt unknown
- 2004-09-29 NZ NZ546259A patent/NZ546259A/en unknown
- 2004-09-29 AR ARP040103534A patent/AR045955A1/es not_active Application Discontinuation
- 2004-09-29 JP JP2006534031A patent/JP2007508011A/ja active Pending
- 2004-09-29 US US10/952,989 patent/US7432378B2/en not_active Expired - Lifetime
- 2004-09-29 WO PCT/US2004/031855 patent/WO2005044807A2/en not_active Ceased
- 2004-09-29 AU AU2004286933A patent/AU2004286933B2/en not_active Ceased
- 2004-09-29 HR HR20060126A patent/HRP20060126A2/xx not_active Application Discontinuation
- 2004-09-29 RU RU2006110561/04A patent/RU2006110561A/ru not_active Application Discontinuation
- 2004-09-29 ES ES04816894T patent/ES2323178T3/es not_active Expired - Lifetime
- 2004-09-29 AT AT04816894T patent/ATE427303T1/de not_active IP Right Cessation
- 2004-09-29 DE DE602004020364T patent/DE602004020364D1/de not_active Expired - Lifetime
- 2004-09-29 KR KR1020067008435A patent/KR20060097024A/ko not_active Withdrawn
- 2004-09-29 CA CA002540704A patent/CA2540704A1/en not_active Abandoned
- 2004-09-29 BR BRPI0414918-1A patent/BRPI0414918A/pt not_active IP Right Cessation
- 2004-09-29 CN CN2004800354157A patent/CN1886380B/zh not_active Expired - Fee Related
-
2006
- 2006-03-30 IL IL174677A patent/IL174677A0/en unknown
- 2006-04-28 ZA ZA200603411A patent/ZA200603411B/en unknown
- 2006-05-02 NO NO20061950A patent/NO20061950L/no not_active Application Discontinuation
-
2008
- 2008-08-26 US US12/229,781 patent/US7723526B2/en not_active Expired - Lifetime
- 2008-08-26 US US12/229,779 patent/US20090270611A1/en not_active Abandoned
- 2008-08-26 US US12/229,892 patent/US7662966B2/en not_active Expired - Lifetime
- 2008-08-26 US US12/229,882 patent/US7705149B2/en not_active Expired - Lifetime
- 2008-08-26 US US12/229,886 patent/US7723527B2/en not_active Expired - Lifetime
- 2008-08-26 US US12/229,890 patent/US7723359B2/en not_active Expired - Lifetime
- 2008-08-26 US US12/229,888 patent/US7705143B2/en not_active Expired - Lifetime
- 2008-08-26 US US12/229,891 patent/US20090281307A1/en not_active Abandoned
- 2008-10-23 US US12/257,362 patent/US20090247508A1/en not_active Abandoned
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B15K | Others concerning applications: alteration of classification |
Free format text: PARA INT.CL: C07D 235/18, C07D 401/04, C07D 401/12, C07D 401/14, C07D 403/12, A61K 31/454, A61K 31/4545, A61K 31/496, A61P 37/00 Ipc: C07D 235/18 (2011.01), C07D 401/12 (2011.01), C07D |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012. |