BRPI0413430A - derivados de amida - Google Patents
derivados de amidaInfo
- Publication number
- BRPI0413430A BRPI0413430A BRPI0413430-3A BRPI0413430A BRPI0413430A BR PI0413430 A BRPI0413430 A BR PI0413430A BR PI0413430 A BRPI0413430 A BR PI0413430A BR PI0413430 A BRPI0413430 A BR PI0413430A
- Authority
- BR
- Brazil
- Prior art keywords
- infection
- caused
- chickenpox
- medicines
- zoster virus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biotechnology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
"DERIVADOS DE AMIDA". O objetivo consiste em se propor um composto inédito útil em medicamentos, especialmente em medicamentos para diversas doenças causadas por infecção com vírus que pretendem à família Herpesviridae, isto é, na prevenção ou tratamento de infecções com diversos herpesvírus, mais especificamente, varicela causada pela infecção com vírus zoster de varicela, herpes zoster causado por infecção repetida com vírus zoster de varicela persistente, herpes labial, e encefalite herpética causada por infecção com HSV1, herpes genital causado por infecção com HSV-2 etc. Um derivado de N-{2-¢(4-fenil substituído)amino!-2-oxoetil} tetraidro-2H-tiopiran-4-carboxamida tendo um substituinte heteroarila específico de 5 ou 6 membros na posição 4 tem uma atividade antiviral favorável e torna possível o tratamento das doenças acima por administração oral de uma pequena dose.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003290850 | 2003-08-08 | ||
JP2003-290850 | 2003-08-08 | ||
PCT/JP2004/011573 WO2005014559A1 (ja) | 2003-08-08 | 2004-08-05 | アミド誘導体 |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0413430A true BRPI0413430A (pt) | 2006-10-17 |
BRPI0413430B1 BRPI0413430B1 (pt) | 2019-04-30 |
BRPI0413430B8 BRPI0413430B8 (pt) | 2021-05-25 |
Family
ID=34114142
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0413430A BRPI0413430B8 (pt) | 2003-08-08 | 2004-08-05 | derivados de amida os um sal destes, composição farmacêutica compreendendo os mesmos e uso destes para o tratamento de doenças em que está implicado o herpesvírus. |
Country Status (19)
Country | Link |
---|---|
US (2) | US7465748B2 (pt) |
EP (1) | EP1652843B1 (pt) |
JP (1) | JP4549974B2 (pt) |
KR (1) | KR101157074B1 (pt) |
CN (1) | CN100445271C (pt) |
AU (1) | AU2004263448B2 (pt) |
BR (1) | BRPI0413430B8 (pt) |
CA (1) | CA2535199C (pt) |
CY (1) | CY1115461T1 (pt) |
DK (1) | DK1652843T3 (pt) |
ES (1) | ES2462292T3 (pt) |
MX (1) | MXPA06001526A (pt) |
NO (1) | NO335467B1 (pt) |
PL (1) | PL1652843T3 (pt) |
PT (1) | PT1652843E (pt) |
RU (1) | RU2336273C2 (pt) |
SI (1) | SI1652843T1 (pt) |
TW (1) | TW200505894A (pt) |
WO (1) | WO2005014559A1 (pt) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ2004747A3 (cs) * | 2001-12-21 | 2004-11-10 | Novo Nordisk A/S | Deriváty amidů jako GK aktivátory |
JP4881559B2 (ja) * | 2002-06-27 | 2012-02-22 | ノボ・ノルデイスク・エー/エス | 治療薬としてのアリールカルボニル誘導体 |
TW200505894A (en) * | 2003-08-08 | 2005-02-16 | Yamanouchi Pharma Co Ltd | Tetrahydro-2H-thiopyran-4-carboxamide derivative |
DK1723128T3 (da) * | 2004-01-06 | 2013-02-18 | Novo Nordisk As | Heteroarylurinstoffer og deres anvendelse som glucokinaseaktivatorer |
WO2006082822A1 (ja) * | 2005-02-02 | 2006-08-10 | Astellas Pharma Inc. | アシクロビル耐性ヘルペスウイルスによる疾患の予防・治療剤 |
WO2006082820A1 (ja) * | 2005-02-02 | 2006-08-10 | Astellas Pharma Inc. | 性器ヘルペス治療剤 |
WO2006082821A1 (ja) * | 2005-02-02 | 2006-08-10 | Astellas Pharma Inc. | ヘルペスウイルスが関与する疾患の予防若しくは治療剤 |
JP5011739B2 (ja) * | 2005-02-03 | 2012-08-29 | アステラス製薬株式会社 | テトラヒドロ−2h−チオピラン−4−カルボキサミド誘導体を含有する医薬組成物 |
CA2614518A1 (en) * | 2005-07-08 | 2007-01-18 | Novo-Nordisk A/S | Dicycloalkyl urea glucokinase activators |
ES2382815T3 (es) * | 2005-07-08 | 2012-06-13 | Novo Nordisk A/S | Dicicloalquilcarbamoil ureas como activadores de glucoquinasa |
CA2615938C (en) | 2005-07-14 | 2014-04-29 | Novo-Nordisk A/S | Urea glucokinase activators |
WO2008084043A1 (en) * | 2007-01-09 | 2008-07-17 | Novo Nordisk A/S | Urea glucokinase activators |
EP2099777B1 (en) * | 2007-01-11 | 2015-08-12 | Novo Nordisk A/S | Urea glucokinase activators |
DE102008014523A1 (de) * | 2008-03-15 | 2009-09-17 | Robert Bosch Gmbh | Heizgerät |
EP2263671B1 (en) * | 2008-04-02 | 2016-07-20 | Astellas Pharma Inc. | Amide derivative-containing pharmaceutical composition |
EP2565191B1 (en) * | 2008-05-14 | 2014-10-08 | Astellas Pharma Inc. | 4-(Indol-7-ylcarbonylaminomethyl)cyclohexanecarboxylic acid derivatives as EP4 receptor antagonists useful for the treatment of chronic renal failure or diabetic nephropathy |
US20110201659A1 (en) * | 2008-10-20 | 2011-08-18 | Astellas Pharma Inc. | Agent for preventing or treating zoster-associated pain |
CN108623577B (zh) * | 2018-05-08 | 2020-09-25 | 山东百诺医药股份有限公司 | 阿莫奈韦及其中间体的制备方法 |
WO2019241089A1 (en) | 2018-06-12 | 2019-12-19 | Vtv Therapeutics Llc | Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs |
WO2020038812A1 (en) * | 2018-08-20 | 2020-02-27 | Rijksuniversiteit Groningen | New process for the preparation of amenamevir |
TW202038947A (zh) | 2018-11-28 | 2020-11-01 | 德商創新分子有限責任公司 | 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0871619B1 (en) * | 1995-12-29 | 2002-11-06 | Boehringer Ingelheim Pharmaceuticals Inc. | Phenyl thiazole derivatives with anti herpes virus properties |
US6288091B1 (en) * | 1995-12-29 | 2001-09-11 | Boehringer Ingelheim Ltd. | Antiherpes virus compounds and methods for their preparation and use |
AU3289299A (en) * | 1998-02-19 | 1999-09-06 | Tularik Inc. | Antiviral agents |
WO2000029399A1 (en) * | 1998-11-12 | 2000-05-25 | Boehringer Ingelheim (Canada) Ltd. | Antiherpes compounds |
JP2002539119A (ja) * | 1999-03-08 | 2002-11-19 | バイエル アクチェンゲゼルシャフト | チアゾリルウレア誘導体および抗ウイルス剤としてのそれらの使用 |
WO2000071507A2 (en) * | 1999-05-24 | 2000-11-30 | Cor Therapeutics, Inc. | INHIBITORS OF FACTOR Xa |
AU5723500A (en) * | 1999-05-24 | 2000-12-12 | Cor Therapeutics, Inc. | Inhibitors of factor xa |
CA2428184C (en) * | 2000-11-10 | 2010-03-30 | Yamanouchi Pharmaceutical Co., Ltd. | Thiazolylphenylcarbamoylmethyl amide derivative |
DE10139060A1 (de) | 2001-08-08 | 2003-02-20 | Merck Patent Gmbh | Phenylderivate |
WO2003095435A1 (fr) | 2002-05-09 | 2003-11-20 | Yamanouchi Pharmaceutical Co., Ltd. | Derives d'amides |
TW200505894A (en) * | 2003-08-08 | 2005-02-16 | Yamanouchi Pharma Co Ltd | Tetrahydro-2H-thiopyran-4-carboxamide derivative |
-
2004
- 2004-07-06 TW TW093120267A patent/TW200505894A/zh unknown
- 2004-08-05 CA CA2535199A patent/CA2535199C/en active Active
- 2004-08-05 US US10/567,565 patent/US7465748B2/en active Active
- 2004-08-05 SI SI200432152T patent/SI1652843T1/sl unknown
- 2004-08-05 JP JP2005513013A patent/JP4549974B2/ja active Active
- 2004-08-05 KR KR1020067002614A patent/KR101157074B1/ko active IP Right Grant
- 2004-08-05 WO PCT/JP2004/011573 patent/WO2005014559A1/ja active Application Filing
- 2004-08-05 ES ES04748296.3T patent/ES2462292T3/es active Active
- 2004-08-05 CN CNB2004800222586A patent/CN100445271C/zh active Active
- 2004-08-05 BR BRPI0413430A patent/BRPI0413430B8/pt active IP Right Grant
- 2004-08-05 EP EP04748296.3A patent/EP1652843B1/en active Active
- 2004-08-05 AU AU2004263448A patent/AU2004263448B2/en active Active
- 2004-08-05 RU RU2006106922/04A patent/RU2336273C2/ru active
- 2004-08-05 MX MXPA06001526A patent/MXPA06001526A/es active IP Right Grant
- 2004-08-05 PL PL04748296T patent/PL1652843T3/pl unknown
- 2004-08-05 PT PT47482963T patent/PT1652843E/pt unknown
- 2004-08-05 DK DK04748296.3T patent/DK1652843T3/da active
- 2004-08-06 US US10/912,232 patent/US6903125B2/en active Active
-
2006
- 2006-03-07 NO NO20061100A patent/NO335467B1/no unknown
-
2014
- 2014-06-11 CY CY20141100425T patent/CY1115461T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CY1115461T1 (el) | 2017-01-04 |
US20050032855A1 (en) | 2005-02-10 |
KR20060073928A (ko) | 2006-06-29 |
RU2336273C2 (ru) | 2008-10-20 |
DK1652843T3 (da) | 2014-05-05 |
AU2004263448B2 (en) | 2009-02-05 |
WO2005014559A1 (ja) | 2005-02-17 |
EP1652843B1 (en) | 2014-04-02 |
US7465748B2 (en) | 2008-12-16 |
PT1652843E (pt) | 2014-06-02 |
JPWO2005014559A1 (ja) | 2006-10-05 |
AU2004263448A1 (en) | 2005-02-17 |
CA2535199C (en) | 2010-12-14 |
CA2535199A1 (en) | 2005-02-17 |
EP1652843A1 (en) | 2006-05-03 |
NO335467B1 (no) | 2014-12-15 |
EP1652843A4 (en) | 2010-07-28 |
SI1652843T1 (sl) | 2014-06-30 |
ES2462292T3 (es) | 2014-05-22 |
CN1832930A (zh) | 2006-09-13 |
MXPA06001526A (es) | 2006-05-25 |
JP4549974B2 (ja) | 2010-09-22 |
TW200505894A (en) | 2005-02-16 |
KR101157074B1 (ko) | 2012-06-22 |
BRPI0413430B1 (pt) | 2019-04-30 |
RU2006106922A (ru) | 2006-08-27 |
CN100445271C (zh) | 2008-12-24 |
TWI341311B (pt) | 2011-05-01 |
US6903125B2 (en) | 2005-06-07 |
NO20061100L (no) | 2006-03-07 |
BRPI0413430B8 (pt) | 2021-05-25 |
US20060229295A1 (en) | 2006-10-12 |
PL1652843T3 (pl) | 2014-09-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B25G | Requested change of headquarter approved |
Owner name: ASTELLAS PHARMA INC. (JP) , RATIONAL DRUG DESIGN L |
|
B25A | Requested transfer of rights approved |
Owner name: ASTELLAS PHARMA INC. (JP) |
|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 30/04/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 30/04/2019, OBSERVADAS AS CONDICOES LEGAIS |
|
B16C | Correction of notification of the grant |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/08/2004 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |