NO20061100L - Amidderivater - Google Patents

Amidderivater

Info

Publication number
NO20061100L
NO20061100L NO20061100A NO20061100A NO20061100L NO 20061100 L NO20061100 L NO 20061100L NO 20061100 A NO20061100 A NO 20061100A NO 20061100 A NO20061100 A NO 20061100A NO 20061100 L NO20061100 L NO 20061100L
Authority
NO
Norway
Prior art keywords
hsv
infection
amide derivatives
caused
famihen
Prior art date
Application number
NO20061100A
Other languages
English (en)
Other versions
NO335467B1 (no
Inventor
Toru Kontani
Junji Miyata
Wataru Hamaguchi
Tomoaki Kawano
Akio Kamikawa
Hirosh Suzuki
Kenji Dudo
Original Assignee
Rational Drug Design Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rational Drug Design Lab filed Critical Rational Drug Design Lab
Publication of NO20061100L publication Critical patent/NO20061100L/no
Publication of NO335467B1 publication Critical patent/NO335467B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/382—Heterocyclic compounds having sulfur as a ring hetero atom having six-membered rings, e.g. thioxanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

Forbindelse som er anvendelig i legemidler mot sykdommer forårsaket av infeksjon med virus tilhørende famihen herpesviridae, så som varicella forårsaket av infeksjon med varicellazoster-virus, herpes-zoster forårsaket av tilbakevendende infeksjon med persisterende varicellazoster-virus, labial herpes og herpes encifalitt forårsaket av infeksjon med HSV-1, genitalherpes forårsaket av infeksjon med HSV-2, etc. Et derivat av N-{2-[(4-substituert fenyl)amino]-2-oksoetyl}tettahydro-2H-tiopyran-4- karboksamid med en spesifikk 5- eller 6-leddet heteroaiylsubstituent i 4-posisjonen har en gunstig antiviral aktivitet og gjør det mulig å behandle sykdommer med oral administtasjon i liten dose.
NO20061100A 2003-08-08 2006-03-07 Amidderivater, og et farmasøytisk preparat derav som et medikament mot herpesvirus NO335467B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003290850 2003-08-08
PCT/JP2004/011573 WO2005014559A1 (ja) 2003-08-08 2004-08-05 アミド誘導体

Publications (2)

Publication Number Publication Date
NO20061100L true NO20061100L (no) 2006-03-07
NO335467B1 NO335467B1 (no) 2014-12-15

Family

ID=34114142

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20061100A NO335467B1 (no) 2003-08-08 2006-03-07 Amidderivater, og et farmasøytisk preparat derav som et medikament mot herpesvirus

Country Status (19)

Country Link
US (2) US7465748B2 (no)
EP (1) EP1652843B1 (no)
JP (1) JP4549974B2 (no)
KR (1) KR101157074B1 (no)
CN (1) CN100445271C (no)
AU (1) AU2004263448B2 (no)
BR (1) BRPI0413430B8 (no)
CA (1) CA2535199C (no)
CY (1) CY1115461T1 (no)
DK (1) DK1652843T3 (no)
ES (1) ES2462292T3 (no)
MX (1) MXPA06001526A (no)
NO (1) NO335467B1 (no)
PL (1) PL1652843T3 (no)
PT (1) PT1652843E (no)
RU (1) RU2336273C2 (no)
SI (1) SI1652843T1 (no)
TW (1) TW200505894A (no)
WO (1) WO2005014559A1 (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0402309A3 (en) * 2001-12-21 2008-09-29 Novo Nordisk As Amide derivatives as glucokinase activators and pharmaceutical compositions containing them
PL215132B1 (pl) * 2002-06-27 2013-10-31 Novo Nordisk As Pochodna arylokarbonylowa jako srodek terapeutyczny, jej zastosowanie i kompozycja farmaceutyczna ja zawierajaca
TW200505894A (en) * 2003-08-08 2005-02-16 Yamanouchi Pharma Co Ltd Tetrahydro-2H-thiopyran-4-carboxamide derivative
ES2399052T3 (es) 2004-01-06 2013-03-25 Novo Nordisk A/S Heteroaril-ureas y su uso como activadores de glucocinasa
JPWO2006082821A1 (ja) * 2005-02-02 2008-06-26 アステラス製薬株式会社 ヘルペスウイルスが関与する疾患の予防若しくは治療剤
DE602006013938D1 (de) * 2005-02-02 2010-06-10 Astellas Pharma Inc Wirkstoff zur prävention/behandlung von erkrankungen infolge von acyclovir-resistentem herpesvirus
DE602006016069D1 (de) * 2005-02-02 2010-09-23 Astellas Pharma Inc Therapeutischer wirkstoff zur behandlung von herpes progenitalis nach der entwicklung von läsionen
JP5011739B2 (ja) * 2005-02-03 2012-08-29 アステラス製薬株式会社 テトラヒドロ−２ｈ−チオピラン−４−カルボキサミド誘導体を含有する医薬組成物
JP2009500378A (ja) * 2005-07-08 2009-01-08 ノボ・ノルデイスク・エー／エス グルコキナーゼ活性化剤としてのジシクロアルキルカルバモイル尿素
WO2007006760A1 (en) * 2005-07-08 2007-01-18 Novo Nordisk A/S Dicycloalkyl urea glucokinase activators
KR101446973B1 (ko) * 2005-07-14 2014-10-07 트랜스테크 파르마 엘엘씨 우레아 글루코키나제 활성제
WO2008084043A1 (en) * 2007-01-09 2008-07-17 Novo Nordisk A/S Urea glucokinase activators
CA2675111C (en) 2007-01-11 2016-04-05 Novo Nordisk A\S Urea glucokinase activators
DE102008014523A1 (de) * 2008-03-15 2009-09-17 Robert Bosch Gmbh Heizgerät
JP5381978B2 (ja) * 2008-04-02 2014-01-08 アステラス製薬株式会社 アミド誘導体含有医薬組成物
SI2565191T1 (sl) * 2008-05-14 2014-12-31 Astellas Pharma Inc. Derivati 4-(indol-7-ilkarbonilaminometil)cikloheksan karboksilne kisline kot EP4 receptorski antagonisti, uporabni za zdravljenje kronične ledvične odpovedi ali diabetične nefropatije
JPWO2010047295A1 (ja) 2008-10-20 2012-03-22 アステラス製薬株式会社 帯状疱疹関連痛の予防又は治療薬
CN108623577B (zh) * 2018-05-08 2020-09-25 山东百诺医药股份有限公司 阿莫奈韦及其中间体的制备方法
EP3806852A1 (en) 2018-06-12 2021-04-21 vTv Therapeutics LLC Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs
WO2020038812A1 (en) * 2018-08-20 2020-02-27 Rijksuniversiteit Groningen New process for the preparation of amenamevir
TW202038947A (zh) 2018-11-28 2020-11-01 德商創新分子有限責任公司 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE9800154A (et) * 1995-12-29 1998-12-15 Boehringer Ingelheim Pharmaceuticals, Inc. Herpesviirusevastaste omadustega fenüültiasoolderivaadid
US6288091B1 (en) * 1995-12-29 2001-09-11 Boehringer Ingelheim Ltd. Antiherpes virus compounds and methods for their preparation and use
AU3289299A (en) * 1998-02-19 1999-09-06 Tularik Inc. Antiviral agents
WO2000029399A1 (en) * 1998-11-12 2000-05-25 Boehringer Ingelheim (Canada) Ltd. Antiherpes compounds
DE50008597D1 (de) * 1999-03-08 2004-12-16 Bayer Healthcare Ag Thiazolylharnstoff-derivate und ihre verwendung als antivirale mittel
AU5283900A (en) * 1999-05-24 2000-12-12 Cor Therapeutics, Inc. Inhibitors of factor xa
WO2000071510A2 (en) * 1999-05-24 2000-11-30 Cor Therapeutics, Inc. INHIBITORS OF FACTOR Xa
CN1473157A (zh) * 2000-11-10 2004-02-04 ֮����ҩ��ʽ���� 酰胺衍生物
DE10139060A1 (de) 2001-08-08 2003-02-20 Merck Patent Gmbh Phenylderivate
WO2003095435A1 (fr) 2002-05-09 2003-11-20 Yamanouchi Pharmaceutical Co., Ltd. Derives d'amides
TW200505894A (en) * 2003-08-08 2005-02-16 Yamanouchi Pharma Co Ltd Tetrahydro-2H-thiopyran-4-carboxamide derivative

Also Published As

Publication number Publication date
DK1652843T3 (da) 2014-05-05
NO335467B1 (no) 2014-12-15
RU2336273C2 (ru) 2008-10-20
KR20060073928A (ko) 2006-06-29
EP1652843B1 (en) 2014-04-02
TW200505894A (en) 2005-02-16
BRPI0413430B1 (pt) 2019-04-30
JP4549974B2 (ja) 2010-09-22
PL1652843T3 (pl) 2014-09-30
RU2006106922A (ru) 2006-08-27
CN1832930A (zh) 2006-09-13
CY1115461T1 (el) 2017-01-04
JPWO2005014559A1 (ja) 2006-10-05
CA2535199C (en) 2010-12-14
US7465748B2 (en) 2008-12-16
SI1652843T1 (sl) 2014-06-30
BRPI0413430B8 (pt) 2021-05-25
AU2004263448A1 (en) 2005-02-17
EP1652843A1 (en) 2006-05-03
CA2535199A1 (en) 2005-02-17
US6903125B2 (en) 2005-06-07
MXPA06001526A (es) 2006-05-25
US20050032855A1 (en) 2005-02-10
KR101157074B1 (ko) 2012-06-22
AU2004263448B2 (en) 2009-02-05
ES2462292T3 (es) 2014-05-22
CN100445271C (zh) 2008-12-24
TWI341311B (no) 2011-05-01
BRPI0413430A (pt) 2006-10-17
US20060229295A1 (en) 2006-10-12
EP1652843A4 (en) 2010-07-28
WO2005014559A1 (ja) 2005-02-17
PT1652843E (pt) 2014-06-02

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