BRPI0408962A - inibidores sulfonamidas heterocìclicos contendo flúor- e trifluoroalquila da produção de beta amilóide e seus derivados - Google Patents
inibidores sulfonamidas heterocìclicos contendo flúor- e trifluoroalquila da produção de beta amilóide e seus derivadosInfo
- Publication number
- BRPI0408962A BRPI0408962A BRPI0408962-6A BRPI0408962A BRPI0408962A BR PI0408962 A BRPI0408962 A BR PI0408962A BR PI0408962 A BRPI0408962 A BR PI0408962A BR PI0408962 A BRPI0408962 A BR PI0408962A
- Authority
- BR
- Brazil
- Prior art keywords
- optionally substituted
- hydrogen
- lower alkyl
- production
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45922803P | 2003-03-31 | 2003-03-31 | |
PCT/US2004/009268 WO2004092155A1 (en) | 2003-03-31 | 2004-03-26 | Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0408962A true BRPI0408962A (pt) | 2006-04-04 |
Family
ID=33299665
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0408962-6A BRPI0408962A (pt) | 2003-03-31 | 2004-03-26 | inibidores sulfonamidas heterocìclicos contendo flúor- e trifluoroalquila da produção de beta amilóide e seus derivados |
Country Status (22)
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60121032T2 (de) * | 2000-12-13 | 2007-01-11 | Wyeth | Heterocyclische sulfonamide als inhibitoren der beta-amyloid-produktion |
PT1465861E (pt) * | 2001-12-20 | 2009-07-08 | Bristol Myers Squibb Co | Derivados de α-(n-sulfonamido)-acetamida como inibidores β-amilóides |
RU2321394C2 (ru) * | 2002-06-11 | 2008-04-10 | Уайт | Замещенные фенилсульфонамидные ингибиторы продуцирования бета-амилоида |
WO2004092155A1 (en) * | 2003-03-31 | 2004-10-28 | Wyeth | Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof |
AU2005207835A1 (en) * | 2004-01-16 | 2005-08-11 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole |
AR059517A1 (es) | 2006-02-17 | 2008-04-09 | Wyeth Corp | N- sulfonilacion selectiva de alcoholes sustituidos con 2- aminotrifluoralquilo |
AU2007217965A1 (en) * | 2006-02-17 | 2007-08-30 | Wyeth | Methods for preparing sulfonamide substituted alcohols and intermediates thereof |
EP2010478A1 (en) | 2006-04-21 | 2009-01-07 | Wyeth | Production of chirally pure amino alcohol intermediates, derivatives thereof, and uses thereof |
US7476762B2 (en) * | 2006-04-21 | 2009-01-13 | Wyeth | Methods for preparing sulfonamide compounds |
US7550629B2 (en) * | 2006-04-21 | 2009-06-23 | Wyeth | Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors |
JP2010509235A (ja) * | 2006-11-03 | 2010-03-25 | ノースウェスタン ユニバーシティ | 多発性硬化症の治療 |
EP2193117A1 (en) * | 2007-07-16 | 2010-06-09 | Wyeth a Corporation of the State of Delaware | Inhibitors of beta amyloid production |
AR067533A1 (es) * | 2007-07-16 | 2009-10-14 | Wyeth Corp | Procesos e inetermediarios para la preparacion de compuestos de sulfonamida heterociclica |
PE20090824A1 (es) * | 2007-07-16 | 2009-07-24 | Wyeth Corp | Proceso para la preparacion de trifluoralquil-fenil sulfonamidas y de sulfonamidas heterociclicas |
US8084477B2 (en) | 2007-10-31 | 2011-12-27 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production |
US8093276B2 (en) * | 2007-10-31 | 2012-01-10 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compound as an inhibitor of beta amyloid peptide production |
AR070120A1 (es) * | 2008-01-11 | 2010-03-17 | Wyeth Corp | Derivados de aril sulfonamida que contienen o-sulfato y o-fosfato, utiles como inhibidores de beta-amiloide, proceso de preparacion de los mismos y composiciones farmaceuticas que los contienen. |
WO2009137657A1 (en) * | 2008-05-08 | 2009-11-12 | Bristol-Myers Squibb Company | 2-aryl glycinamide derivatives |
CN102143928A (zh) * | 2008-09-05 | 2011-08-03 | 马克斯普朗克科学促进协会 | 利用两个连续的结晶步骤对化合物形成的手性体系进行对映体拆分的方法 |
US8044077B2 (en) * | 2009-03-19 | 2011-10-25 | Bristol-Myers Squibb Company | Alpha-(N-sulfonamido)acetamide compounds incorporating deuterium as inhibitors of beta amyloid peptide production |
US7977362B2 (en) * | 2009-03-20 | 2011-07-12 | Bristol-Myers Squibb Company | Alpha-(N-benzenesulfonamido)cycloalkyl derivatives |
US20110071199A1 (en) * | 2009-03-20 | 2011-03-24 | Bristol-Myers Squibb Company | Thiophenyl Sulfonamides for the Treatment of Alzheimer's Disease |
TW201043269A (en) * | 2009-04-14 | 2010-12-16 | Bristol Myers Squibb Co | Bioavailable compositions of amorphous alpha-(N-sulfonamido)acetamide compound |
US8252821B2 (en) * | 2009-04-14 | 2012-08-28 | Bristol-Myers Squibb Company | Bioavailable capsule compositions of amorphous alpha-(N-sulfonamido)acetamide compound |
WO2010126002A1 (ja) * | 2009-04-28 | 2010-11-04 | 塩野義製薬株式会社 | ヘテロ環スルホンアミド化合物を含有する医薬 |
WO2011084503A1 (en) * | 2009-12-16 | 2011-07-14 | North Carolina Central University | Phenoxy thiophene sulfonamides and their use in the treatment of neurodegenerative diseases |
US9223217B2 (en) | 2010-02-19 | 2015-12-29 | International Business Machines Corporation | Sulfonamide-containing topcoat and photoresist additive compositions and methods of use |
US9223209B2 (en) * | 2010-02-19 | 2015-12-29 | International Business Machines Corporation | Sulfonamide-containing photoresist compositions and methods of use |
US9617239B2 (en) | 2010-03-10 | 2017-04-11 | North Carolina Central University | Phenoxy thiophene sulfonamides and their use as inhibitors of glucuronidase |
US20150209367A1 (en) | 2012-09-07 | 2015-07-30 | Massachusetts Eye & Ear Infirmary | Treating Hearing Loss |
JP6319912B2 (ja) | 2013-04-19 | 2018-05-09 | 国立大学法人 岡山大学 | アミロイドβ蛋白質により誘発される認知障害の治療剤およびアルツハイマー病治療薬、ならびにこれらに関連する治療方法および病態解析方法 |
US11370823B2 (en) | 2014-10-29 | 2022-06-28 | Massachusetts Eye And Ear Infirmary | Efficient delivery of therapeutic molecules to cells of the inner ear |
KR102362222B1 (ko) | 2016-05-16 | 2022-02-11 | 더 제너럴 하스피탈 코포레이션 | 폐 상피 공학에서 인간 기도 줄기 세포 |
EP3743057A4 (en) | 2018-01-26 | 2021-11-17 | Massachusetts Eye & Ear Infirmary | TREATMENT OF HEARING LOSS |
EP4299062A1 (en) | 2022-06-30 | 2024-01-03 | Vilnius University | Inhibition of protein amyloid aggregation using fluorinated benzenesulfonamides |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5571821A (en) * | 1993-05-20 | 1996-11-05 | Texas Biotechnology Corporation | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5514691A (en) * | 1993-05-20 | 1996-05-07 | Immunopharmaceutics, Inc. | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5591761A (en) * | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5464853A (en) * | 1993-05-20 | 1995-11-07 | Immunopharmaceutics, Inc. | N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
US5594021A (en) * | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
EP0510700A3 (en) | 1991-04-26 | 1992-12-16 | Takeda Chemical Industries, Ltd. | Azole compounds, their production and use |
GB9110722D0 (en) | 1991-05-17 | 1991-07-10 | Fujisawa Pharmaceutical Co | Amine derivatives |
US5766846A (en) * | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
US5968942A (en) * | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
US6376523B1 (en) * | 1994-05-20 | 2002-04-23 | Texas Biotechnology Corporation | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
IL110525A0 (en) | 1993-08-09 | 1994-11-11 | Lilly Co Eli | Identification and use of protease inhibitors |
US5519040A (en) | 1994-04-29 | 1996-05-21 | Allergan | Substituted thiazole sulfonamides as antiglaucoma agents |
US5624937A (en) * | 1995-03-02 | 1997-04-29 | Eli Lilly And Company | Chemical compounds as inhibitors of amyloid beta protein production |
WO1997021690A1 (en) * | 1995-11-28 | 1997-06-19 | Cephalon, Inc. | D-amino acid derived inhibitors of cysteine and serine proteases |
JP2000515153A (ja) | 1996-07-22 | 2000-11-14 | モンサント カンパニー | チオールスルホンアミド メタロプロテアーゼインヒビター |
US5703129A (en) * | 1996-09-30 | 1997-12-30 | Bristol-Myers Squibb Company | 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production |
US5985930A (en) | 1996-11-21 | 1999-11-16 | Pasinetti; Giulio M. | Treatment of neurodegenerative conditions with nimesulide |
AU5354398A (en) | 1996-11-22 | 1998-06-10 | Elan Pharmaceuticals, Inc. | N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions compri sing same, and methods for inhibiting beta-amyloid peptide release and/or it s synthesis by use of such compounds |
DE19650196A1 (de) * | 1996-12-04 | 1998-06-10 | Bayer Ag | Thienylsulfonylamino(thio)carbonylverbindungen |
JPH11343279A (ja) | 1998-03-16 | 1999-12-14 | Shionogi & Co Ltd | スルホンアミド誘導体およびそれらを含有するTNF―α産生抑制剤 |
US5981168A (en) * | 1998-05-15 | 1999-11-09 | The University Of British Columbia | Method and composition for modulating amyloidosis |
US7410995B1 (en) | 1998-08-14 | 2008-08-12 | Gpi Nil Holdings Inc. | N-linked sulfonamide of heterocyclic thioesters for vision and memory disorders |
US6967196B1 (en) | 1999-02-26 | 2005-11-22 | Bristol-Myers Squibb Company | Sulfonamide compounds and uses thereof |
WO2000063194A1 (fr) | 1999-04-19 | 2000-10-26 | Shionogi & Co., Ltd. | Derives de sulfonamide possedant des noyaux oxadiazole |
EP1088821A1 (en) | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonamide derivatives |
EP1088815A1 (en) | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonyl amino acid derivatives |
EP1218377A1 (en) | 1999-10-08 | 2002-07-03 | Bristol-Myers Squibb Pharma Company | AMINO LACTAM SULFONAMIDES AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION |
DE60124684T2 (de) | 2000-03-20 | 2007-09-13 | Merck Sharp & Dohme Ltd., Hoddesdon | Sulfonamido-substituierte verbrückte bicycloalkylderivative |
DE60121032T2 (de) | 2000-12-13 | 2007-01-11 | Wyeth | Heterocyclische sulfonamide als inhibitoren der beta-amyloid-produktion |
US6657070B2 (en) * | 2000-12-13 | 2003-12-02 | Wyeth | Production of chirally pure α-amino acids and N-sulfonyl α-amino acids |
JP4250529B2 (ja) | 2001-12-11 | 2009-04-08 | ワイス | キラル的に純粋なβ−アミノアルコールの合成方法 |
WO2003050062A2 (en) | 2001-12-11 | 2003-06-19 | Wyeth | PRODUCTION OF CHIRALLY PURE α-AMINO ACIDS ADN N-SULFONYL α-AMINO ACIDS |
RU2321394C2 (ru) | 2002-06-11 | 2008-04-10 | Уайт | Замещенные фенилсульфонамидные ингибиторы продуцирования бета-амилоида |
WO2004092155A1 (en) * | 2003-03-31 | 2004-10-28 | Wyeth | Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof |
AU2005207835A1 (en) | 2004-01-16 | 2005-08-11 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole |
AU2007217965A1 (en) * | 2006-02-17 | 2007-08-30 | Wyeth | Methods for preparing sulfonamide substituted alcohols and intermediates thereof |
AR059517A1 (es) * | 2006-02-17 | 2008-04-09 | Wyeth Corp | N- sulfonilacion selectiva de alcoholes sustituidos con 2- aminotrifluoralquilo |
US7550629B2 (en) * | 2006-04-21 | 2009-06-23 | Wyeth | Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors |
EP2010478A1 (en) * | 2006-04-21 | 2009-01-07 | Wyeth | Production of chirally pure amino alcohol intermediates, derivatives thereof, and uses thereof |
US7476762B2 (en) * | 2006-04-21 | 2009-01-13 | Wyeth | Methods for preparing sulfonamide compounds |
AR067533A1 (es) * | 2007-07-16 | 2009-10-14 | Wyeth Corp | Procesos e inetermediarios para la preparacion de compuestos de sulfonamida heterociclica |
EP2193117A1 (en) * | 2007-07-16 | 2010-06-09 | Wyeth a Corporation of the State of Delaware | Inhibitors of beta amyloid production |
PE20090824A1 (es) * | 2007-07-16 | 2009-07-24 | Wyeth Corp | Proceso para la preparacion de trifluoralquil-fenil sulfonamidas y de sulfonamidas heterociclicas |
-
2004
- 2004-03-26 WO PCT/US2004/009268 patent/WO2004092155A1/en active Application Filing
- 2004-03-26 UA UAA200510177A patent/UA82093C2/uk unknown
- 2004-03-26 SG SG200708961-8A patent/SG167669A1/en unknown
- 2004-03-26 NZ NZ542468A patent/NZ542468A/en not_active IP Right Cessation
- 2004-03-26 RU RU2005133434/04A patent/RU2342374C2/ru not_active IP Right Cessation
- 2004-03-26 AU AU2004230844A patent/AU2004230844B2/en not_active Expired - Fee Related
- 2004-03-26 CN CN2004800087813A patent/CN1780829B/zh not_active Expired - Fee Related
- 2004-03-26 CL CL200400647A patent/CL2004000647A1/es unknown
- 2004-03-26 JP JP2006509331A patent/JP2006522126A/ja active Pending
- 2004-03-26 BR BRPI0408962-6A patent/BRPI0408962A/pt not_active IP Right Cessation
- 2004-03-26 US US10/810,517 patent/US7300951B2/en not_active Expired - Fee Related
- 2004-03-26 TW TW093108219A patent/TWI336698B/zh not_active IP Right Cessation
- 2004-03-26 KR KR1020057018637A patent/KR20060002908A/ko not_active Application Discontinuation
- 2004-03-26 CA CA002517155A patent/CA2517155A1/en not_active Abandoned
- 2004-03-26 AR ARP040101022A patent/AR043940A1/es unknown
- 2004-03-26 MX MXPA05010368A patent/MXPA05010368A/es active IP Right Grant
- 2004-03-26 EP EP04758978A patent/EP1608638A1/en not_active Withdrawn
- 2004-03-26 CN CNA2008100013400A patent/CN101274926A/zh active Pending
-
2005
- 2005-08-19 CR CR7951A patent/CR7951A/es unknown
- 2005-09-15 NO NO20054263A patent/NO20054263L/no not_active Application Discontinuation
- 2005-09-29 ZA ZA200507896A patent/ZA200507896B/en unknown
- 2005-10-26 CO CO05109226A patent/CO5640049A2/es not_active Application Discontinuation
- 2005-10-28 EC EC2005006128A patent/ECSP056128A/es unknown
-
2007
- 2007-06-15 US US11/818,630 patent/US7547725B2/en not_active Expired - Fee Related
-
2009
- 2009-05-05 US US12/435,442 patent/US7858658B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7547725B2 (en) | 2009-06-16 |
NZ542468A (en) | 2009-01-31 |
ZA200507896B (en) | 2007-03-28 |
TWI336698B (en) | 2011-02-01 |
ECSP056128A (es) | 2006-03-01 |
CO5640049A2 (es) | 2006-05-31 |
AR043940A1 (es) | 2005-08-17 |
RU2005133434A (ru) | 2006-07-10 |
NO20054263L (no) | 2005-12-14 |
CR7951A (es) | 2008-10-29 |
AU2004230844A1 (en) | 2004-10-28 |
CN101274926A (zh) | 2008-10-01 |
CN1780829B (zh) | 2010-12-29 |
AU2004230844B2 (en) | 2010-12-09 |
EP1608638A1 (en) | 2005-12-28 |
RU2342374C2 (ru) | 2008-12-27 |
CL2004000647A1 (es) | 2005-02-04 |
US20090227667A1 (en) | 2009-09-10 |
NO20054263D0 (no) | 2005-09-15 |
SG167669A1 (en) | 2011-01-28 |
CA2517155A1 (en) | 2004-10-28 |
CN1780829A (zh) | 2006-05-31 |
KR20060002908A (ko) | 2006-01-09 |
US20040198778A1 (en) | 2004-10-07 |
US20070254929A1 (en) | 2007-11-01 |
JP2006522126A (ja) | 2006-09-28 |
US7858658B2 (en) | 2010-12-28 |
US7300951B2 (en) | 2007-11-27 |
MXPA05010368A (es) | 2005-11-17 |
TW200504047A (en) | 2005-02-01 |
UA82093C2 (uk) | 2008-03-11 |
WO2004092155A1 (en) | 2004-10-28 |
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